Matching Items (193)
Description
Use of deductive logic and leadership/management techniques has truly impacted the way that I view and observe myself in the world around me. Through my understanding of Information Measurement Theory (IMT) and the many components of the Kashiwagi Solution Model (KSM), I have made significant progress in self-improvement as I gradually move towards self-alignment. Although this project diverges from the traditional dissertation, the personal and intellectual value instilled in my application of the concepts I have learned, clearly represents my progress towards the inner peace that I seek. Self-evaluation is a critical ability that enables one to learn from information and experience. IMT and KSM introduce concepts that refine this ability and as a result help one to discover the importance of critical thinking through applied, deductive logic. In establishing the natural laws that encompass the world around us, as well as attempting to understand any and all dominant information that is ready to be discovered, life becomes simpler and easier. Through my own understanding of the many practices of IMT and KSM, I have learned to re-evaluate the dominant components of my environment. Thus, I have managed to reach clearer and more sensible conclusions about not only myself, but more importantly about my place in the world around me.
ContributorsGuthrie, Alec N (Author) / Kashiwagi, Dean (Thesis director) / Kashiwagi, Jacob (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05
Description
Standardized testing plays a pivotal role in education. The results of standardized testing are used as performance metrics for students, teachers, and schools. The goal in education is to use performance metrics that are as accurate as possible. There are numerous measurement methods, but a popular choice is Student Growth Percentiles. This study will provide an analysis of Student Growth Percentiles in the Chandler Unified School District, located in Arizona. This study will use the Chandler Unified School District data to calculate standard error measurements and create Student Growth Percentile confidence intervals.
ContributorsSmith, Jacob (Author) / Boggess, May (Committee member) / Kashiwagi, Dean (Committee member) / Matthew, Strom (Committee member) / Barrett, The Honors College (Contributor)
Created2014-12
Description
The focus of this project was to look at alternative treatments for endocrine resistant breast cancer (ERBC), which are breast cancers that have become resistant to hormone therapies such as Tamoxifen or aromatase inhibitors. The first part of this project involves investigating the relationship between histone de-acetylase inhibitor Vorinostat and Tamoxifen in MCF7 G11 cells, Tamoxifen resistant sub-clones, according to the PSOC Time grant. The second part involves targeting the androgen receptor (AR) in MCF7 sub-clones with AR antagonists, Bicalutamide and MDV3100, and investigating the possible usage of AR as a biomarker, due to over-expression of AR in ERBC, in accordance with the Mayo ASU Seed Grant.
The synergistic effects between Vorinostat and Tamoxifen observed through a phase II study on breast cancer patients resistant to hormone therapy may involve more than the modulation of ER-alpha to reverse Tamoxifen resistance in ERBC cells. RT-qPCR of genes expressed in Tamoxifen resistant cells, trefoil factor 1(TFF1) and v-myc avian myelocytomatosis viral oncogene homolog (MYC), were evaluated along with ESR1 and Diablo as a control. MYC was observed to have increased expression in the treated cells, whereas the other genes had a decrease in their expression levels after the cells were treated for 3 days with Vorinostat IC30 of 1 µM. As for targeting the AR, MCF7 Tamoxifen sensitive and resistant cells were not affected by the AR antagonists to determine an IC50. The cell viability for all MCF7 sub-clones only decreased for high concentrations of 5.56 µM - 50 µM in Bicalutamide and 16.67 µM – 50 µM of MDV1300. Furthermore, hormone depletion of MCF7 G11 Tamoxifen resistant sub-clones did not show a great response to DHT stimulation or the AR antagonists. In the RT-qPCR, the MCF7 G11 cells showed an increase in mRNA expression for ER, AR, and PR after 4 hours of treatment with estradiol. As for the DHT treatment, ER, AR, PR, and PSA had a minimal increase in the fold change, but the fold change in AR was less than in the estradiol treatment. The Mayo Clinic will investigate the possible usage of AR as a biomarker through immunohistochemistry.
The synergistic effects between Vorinostat and Tamoxifen observed through a phase II study on breast cancer patients resistant to hormone therapy may involve more than the modulation of ER-alpha to reverse Tamoxifen resistance in ERBC cells. RT-qPCR of genes expressed in Tamoxifen resistant cells, trefoil factor 1(TFF1) and v-myc avian myelocytomatosis viral oncogene homolog (MYC), were evaluated along with ESR1 and Diablo as a control. MYC was observed to have increased expression in the treated cells, whereas the other genes had a decrease in their expression levels after the cells were treated for 3 days with Vorinostat IC30 of 1 µM. As for targeting the AR, MCF7 Tamoxifen sensitive and resistant cells were not affected by the AR antagonists to determine an IC50. The cell viability for all MCF7 sub-clones only decreased for high concentrations of 5.56 µM - 50 µM in Bicalutamide and 16.67 µM – 50 µM of MDV1300. Furthermore, hormone depletion of MCF7 G11 Tamoxifen resistant sub-clones did not show a great response to DHT stimulation or the AR antagonists. In the RT-qPCR, the MCF7 G11 cells showed an increase in mRNA expression for ER, AR, and PR after 4 hours of treatment with estradiol. As for the DHT treatment, ER, AR, PR, and PSA had a minimal increase in the fold change, but the fold change in AR was less than in the estradiol treatment. The Mayo Clinic will investigate the possible usage of AR as a biomarker through immunohistochemistry.
ContributorsVorachitti, Merica (Author) / LaBaer, Joshua (Thesis director) / Anderson, Karen (Committee member) / Gonzalez, Laura (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-05
Description
The purpose of this creative thesis project is to create the framework of an educational class package based off of a course offered at Arizona State University. The course chosen for this project is an honors course titled Deductive Logic: Leadership and Management Techniques and is taught by Dean Kashiwagi, PhD. The class package is designed to be published over an online platform so students and professors from various institutions can access the material. Currently the platform is in its final stages of development and is slated to go live on July of 2014. The future development of the package will be geared towards facilitating interdisciplinary collaboration between institutions based off of course concepts.
ContributorsGunnoe, Jake Alan (Author) / Kashiwagi, Dean (Thesis director) / Kashiwagi, Jacob (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor) / Del E. Webb Construction (Contributor)
Created2014-05
Description
A coincidence reporter construct, consisting of the p21-promoter and two luciferase genes (Firefly and Renilla), was constructed for the screening of drugs that might inhibit Olig2's tumorigenic role in glioblastoma. The reporter construct was tested using an Olig2 inhibitor, HSP990, as well as short hairpin RNA targeting Olig2. Further confirmatory analysis is needed before the reporter cell line is ready for high-throughput screening at the NIH and lead compound selection.
ContributorsCusimano, Joseph Michael (Author) / LaBaer, Joshua (Thesis director) / Mangone, Marco (Committee member) / Mehta, Shwetal (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-05
Description
The Information Measurement Theory (IMT) is a revolutionary thinking paradigm. Its principles allow an individual to accurately perceive reality and simplify the complexities of life. To understand IMT, individuals start by first recognizing that everything must follow natural law and cause and effect, that there is no randomness, and that everyone changes at a certain rate. They then move on to understanding that individuals are described by certain characteristics that can be used to predict their future behavior. And finally, they discover that they must learn to understand, accept, and improve themselves while understanding and accepting others. The author, who has spent a considerable amount of time studying and utilizing IMT, believes that IMT can be used within the field of psychology. The extraordinary results that IMT has produced in the construction industry can potentially be produced in a similar fashion within the psychology field. One of the most important principles of IMT teaches that control or influence over others does not exist. This principle alone differentiates IMT from the traditional model of psychology, which is dedicated to changing an individual (through influence). Five case studies will be presented in which individuals have used the principles of IMT to overcome severe issues such as substance abuse and depression. Each case study is unique and exhibits a remarkable change within each individual.
ContributorsMalladi, Basavanth (Author) / Kashiwagi, Dean (Thesis director) / Sullivan, Kenneth (Committee member) / Kashiwagi, Jacob (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2014-05
Description
Abstract The purpose of this project is to utilize the models and concepts from Information Measurement Theory (IMT) to help minimize future decision making with respect to my career path. When I began this project, my future was clouded, my initial conditions were unknown, my stress over future career-path decisions was high, and I had eight possible career paths in mind. I have narrowed my career-path options from eight to four. In addition, I have determined a one-year plan that enables me to be prepared to pursue any of the four career paths that I have found align with me. In this project, I explored my dominant initial conditions with respect to my career path. I tracked the job history of my grandparents and parents. These efforts allowed me to identify the strengths and weaknesses that I was exhibiting by the age of three. Natural law dictates that the strengths and weaknesses of my younger self will be the same strengths and weakness that I excel at and struggle with today. I then used my understanding of natural law and the event model process to map the strengths and weaknesses of my parents and grandparents and to compare and contrast these to my strengths and weaknesses, including those that were apparent by the time that I was three years old. Focusing in on what I really want from a job, four main goals were established to grade the various future career-path options. Finally, I documented my transition from uncertainty to clarity. It began with my sobriety and ended with a milestone one-year plan that will give me information that I need to commit to my career path. This transition has had significant impact. The elusive "who am I" has been addressed, not completely but addressed sufficiently so that the question no longer plagues me. I know from where I have come. I have gained significant insight from those around me who know me. All of this has been documented for my own personal use, and for my children someday. This process permitted me to eliminate outliers from my eight original career paths, reducing them to four. In addition, application of IMT models and concepts has allowed me to see one year into the future. With my new-found knowledge, I will listen and watch the doors close on three of the remaining four career paths, as there is only one path I am meant to take.
ContributorsRichardson, Trevor Woods (Author) / Kashiwagi, Dean (Thesis director) / Kashiwagi, Jacob (Committee member) / Industrial, Systems (Contributor) / Barrett, The Honors College (Contributor) / Del E. Webb Construction (Contributor)
Created2014-05
Description
The pathogenesis of type 1 diabetes (T1D) is still not fully understood in the scientific community. Evidence has shown that viral infections are one of the important environmental factors associated with the disease development. Seven of the top T1D related viruses were selected to study the prevalence of viral humoral response in T1D patients using our innovative protein array platform called Nucleic Acid Programmable Protein Array (NAPPA). In this study, each viral gene was individually captured using various PCR based techniques, cloned into a protein expression vector, and assembled as the first version of T1D viral protein array. Humoral responses of IgG, IgA, and IgM were examined. Although each class of immunoglobulin generated a wide-range of reactivity, responses to various viral proteins from different proteins were observed. In summary, we captured most of the T1D related viral genes, established viral protein expression on the protein array, and displayed the serum response on the viral protein array. The successful progress will help to fulfill the long term goal of testing the viral infection hypothesis in T1D development.
ContributorsDavis, Amy Darlene (Author) / LaBaer, Joshua (Thesis director) / Qiu, Ji (Committee member) / Desi, Paul (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2013-05
Description
This study analyzes the impact of incentive programs on performance. Agency theory and Information Measurement theory are used to hypothesize about the impact of incentives upon performance. Empirical evidence from the case study shows that incentives are ineffective at increasing performance, but the statistical significance of the data is too low to generalize the findings beyond that of short term cold call sales. Several avenues for continued research are suggested.
ContributorsCarlson, Andrew Wayne (Author) / Lee, Peggy (Thesis director) / Kashiwagi, Dean (Committee member) / Totscheck, Chaz (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor) / Department of Management (Contributor)
Created2013-05
Description
In an increasingly global economy, companies face challenges with implementing successful business and marketing strategies in cultures different from their own. This paper calls upon previous research to compile a per-country outline of general behaviors and expectations when doing business overseas. Using categorical definitions from Hofstede's 1984 study and those found in the Handbook of Global and Multicultural Negotiation, a table has been prepared to group similar countries based on their cultural biases.
ContributorsPetruccelli, Lauren Taylor (Author) / Shunk, Dan (Thesis director) / Kashiwagi, Dean (Committee member) / McCarville, Daniel R. (Committee member) / Industrial, Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2013-05