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We describe the deposition of four datasets consisting of X-ray diffraction images acquired using serial femtosecond crystallography experiments on microcrystals of human G protein-coupled receptors, grown and delivered in lipidic cubic phase, at the Linac Coherent Light Source. The receptors are: the human serotonin receptor 2B in complex with an agonist ergotamine, the human δ-opioid receptor in complex with a bi-functional peptide ligand DIPP-NH2, the human smoothened receptor in complex with an antagonist cyclopamine, and finally the human angiotensin II type 1 receptor in complex with the selective antagonist ZD7155. All four datasets have been deposited, with minimal processing, in an HDF5-based file format, which can be used directly for crystallographic processing with CrystFEL or other software. We have provided processing scripts and supporting files for recent versions of CrystFEL, which can be used to validate the data.
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The Micro-g NExT 2019 challenge set out to find a new device to replace the Apollo mission lunar contingency sampler in preparation for the 2024 Artemis mission. The 2019 challenge set a series of requirements that would enable compatibility with the new xEMU suit and enable astronauts to effectively collect and secure an initial sample upon landing. The final prototype developed by the team features a sliding plate design with each plate slightly shorter than the previous. The device utilizes the majority of the xEMU suit’s front pocket volume while still allowing space for the astronaut’s hand and the bag for the sample. Considering safety concerns, the device satisfies NASA’s requirements for manual handheld devices and poses no threat to the astronaut under standard operation. In operation, the final design experiences an acceptable level stress in the primary use direction, and an even less in the lateral direction. Using assumptions such as the depth and density of lunar soil to be sampled, the working factor of safety is about 2 for elastic deformation, but the tool can still be operated and even collapsed at roughly double that stress. Unfortunately, the scope of this thesis only covers the effectiveness of resin prototypes and simulations of aluminum models, but properly manufactured aluminum prototypes are the next step for validating this design as a successor to the design used on the Apollo missions.
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This paper outlines the design and testing of a z-scan spectrometer capable of measuring the third order refraction index of liquids. The spectrometer underwent multiple redesigns, with each explored in this paper with their benefits and drawbacks discussed. The first design was capable of measuring the third order refraction index for glass, and found a value of 8.43 +- 0.392 x 10^(-16) cm^2/W for the glass sample, with the literature stating glass has a refraction index between 1-100 x 10^(-16) cm^2/W. The second design was capable of measuring the third order refraction index of liquids, and found values of 1.23 $\pm$ 0.121 $\e{-16}$ and 9.43 +- 1.00 x 10^(-17) cm^2/W for water and ethanol respectively, with literature values of 2.7 x 10^(-16) and 5.0 x 10^(-17) cm^2/W respectively. The third design gave inconclusive results due to extreme variability in testing, and and the fourth design outlined has not been tested yet due to time constraints.
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Debris disks are a collection of dust grains and planetesimals around a star and are thought to contain the remnants of planet formation. Directly imaging debris disks and studying their morphologies is valuable for studying the planet formation process. In some stellar systems that have a directly imaged debris disk, there are also directly imaged planets. Debris disk structures like gaps and asymmetries can show the gravitational e↵ects of planets that are below the brightness threshold for being detected via direct imaging. We investigate a sample of debris disks in Scorpius-Centaurus (Sco-Cen) that were imaged with the Gemini Planet Imager (GPI), which is an adaptive optics system with a coronagraph to block starlight. We look at two GPI data sets, the GPIES campaign Sco-Cen targets, and a follow-up observing program for Sco-Cen targets. We resolve 5 debris disks in the follow-up program and 13 from the GPIES campaign. By calculating contrast curves, we determine the planet detection limit in each of the GPI images. We find that we could have detected 5 Jupiter mass planets at angular separations greater than about 0.6 arcseconds in our GPIES campaign images. In three of our images we could have detected 2 Jupiter mass planets in wide orbits, but 2 Jupiter masses below the detection limit in our other images. We identify one point source around HD 108904 as a sub-stellar companion candidate. To further check for evidence of planets that are below the detection limit, we measure the surface brightness profile of the disks to check for asymmetries in brightness. We find that one of the edge-on disks has an asymmetric surface brightness profile, HD 106906, and three other edge-on disks have symmetric surface brightness profiles. We also find that two disks, HD 106906 and HD 111520, are asymmetric in radial extent, which is possibly evidence for gravitational interactions with planets.
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About 2.5 × 106 snapshots on microcrystals of photoactive yellow protein (PYP) from a recent serial femtosecond crystallographic (SFX) experiment were reanalyzed to maximum resolution. The resolution is pushed to 1.46 Å, and a PYP structural model is refined at that resolution. The result is compared to other PYP models determined at atomic resolution around 1 Å and better at the synchrotron. By comparing subtleties such as individual isotropic temperature factors and hydrogen bond lengths, we were able to assess the quality of the SFX data at that resolution. We also show that the determination of anisotropic temperature factor ellipsoids starts to become feasible with the SFX data at resolutions better than 1.5 Å.
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efficiencies at high field strengths and prohibits anti-aligned nuclear states from transferring. We also develop a rudimentary theoretical model based on simulated results and partially validate the characteristic transfer times for spin states. This model also establishes a framework for future work including the introduction of a magnetic field.
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