Matching Items (34)
Description
The challenge of radiation therapy is to maximize the dose to the tumor while simultaneously minimizing the dose elsewhere. Proton therapy is well suited to this challenge due to the way protons slow down in matter. As the proton slows down, the rate of energy loss per unit path length continuously increases leading to a sharp dose near the end of range. Unlike conventional radiation therapy, protons stop inside the patient, sparing tissue beyond the tumor. Proton therapy should be superior to existing modalities, however, because protons stop inside the patient, there is uncertainty in the range. “Range uncertainty” causes doctors to take a conservative approach in treatment planning, counteracting the advantages offered by proton therapy. Range uncertainty prevents proton therapy from reaching its full potential.
A new method of delivering protons, pencil-beam scanning (PBS), has become the new standard for treatment over the past few years. PBS utilizes magnets to raster scan a thin proton beam across the tumor at discrete locations and using many discrete pulses of typically 10 ms duration each. The depth is controlled by changing the beam energy. The discretization in time of the proton delivery allows for new methods of dose verification, however few devices have been developed which can meet the bandwidth demands of PBS.
In this work, two devices have been developed to perform dose verification and monitoring with an emphasis placed on fast response times. Measurements were performed at the Mayo Clinic. One detector addresses range uncertainty by measuring prompt gamma-rays emitted during treatment. The range detector presented in this work is able to measure the proton range in-vivo to within 1.1 mm at depths up to 11 cm in less than 500 ms and up to 7.5 cm in less than 200 ms. A beam fluence detector presented in this work is able to measure the position and shape of each beam spot. It is hoped that this work may lead to a further maturation of detection techniques in proton therapy, helping the treatment to reach its full potential to improve the outcomes in patients.
A new method of delivering protons, pencil-beam scanning (PBS), has become the new standard for treatment over the past few years. PBS utilizes magnets to raster scan a thin proton beam across the tumor at discrete locations and using many discrete pulses of typically 10 ms duration each. The depth is controlled by changing the beam energy. The discretization in time of the proton delivery allows for new methods of dose verification, however few devices have been developed which can meet the bandwidth demands of PBS.
In this work, two devices have been developed to perform dose verification and monitoring with an emphasis placed on fast response times. Measurements were performed at the Mayo Clinic. One detector addresses range uncertainty by measuring prompt gamma-rays emitted during treatment. The range detector presented in this work is able to measure the proton range in-vivo to within 1.1 mm at depths up to 11 cm in less than 500 ms and up to 7.5 cm in less than 200 ms. A beam fluence detector presented in this work is able to measure the position and shape of each beam spot. It is hoped that this work may lead to a further maturation of detection techniques in proton therapy, helping the treatment to reach its full potential to improve the outcomes in patients.
ContributorsHolmes, Jason M (Author) / Alarcon, Ricardo (Thesis advisor) / Bues, Martin (Committee member) / Galyaev, Eugene (Committee member) / Chamberlin, Ralph (Committee member) / Arizona State University (Publisher)
Created2019
Description
Observations of four times ionized iron and nickel (Fe V & Ni V) in the G191-B2B white dwarf spectrum have been used to test for variations in the fine structure constant, α, in the presence of strong gravitational fields. The laboratory wavelengths for these ions were thought to be the cause of inconsistent conclusions regarding the
variation of α as observed through the white dwarf spectrum. This thesis presents 129 revised Fe V wavelengths (1200 Å to 1600 Å) and 161 revised Ni V wavelengths (1200 Å to 1400 Å) with uncertainties of approximately 3 mÅ. A systematic calibration error
is identified in the previous Ni V wavelengths and is corrected in this work. The evaluation of the fine structure variation is significantly improved with the results
found in this thesis.
variation of α as observed through the white dwarf spectrum. This thesis presents 129 revised Fe V wavelengths (1200 Å to 1600 Å) and 161 revised Ni V wavelengths (1200 Å to 1400 Å) with uncertainties of approximately 3 mÅ. A systematic calibration error
is identified in the previous Ni V wavelengths and is corrected in this work. The evaluation of the fine structure variation is significantly improved with the results
found in this thesis.
ContributorsWard, Jacob Wolfgang (Author) / Treacy, Michael (Thesis director) / Alarcon, Ricardo (Committee member) / Nave, Gillian (Committee member) / Department of Physics (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
A search is underway to find baryon resonances that have been predicted, but yet remain unobserved. Nucleon resonances, due to their broad energy widths, overlap and must be disentangled in order to be identified. Meson photoproduction observables related to the orientation of the spin of the incoming photon and the spin of the target proton are useful tools to deconvolve the nucleon resonance spectrum. These observables are particularly sensitive to interference between phases of the complex amplitudes. A set of these observables has been measured using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab with linearly-polarized photons having energies from 725 to 1575 MeV with polar angle values of cos(theta) between -0.8 and 0.9 and transversely-polarized protons in the Jefferson Lab FRozen Spin Target (FROST). By fitting neutron yields from gamma p -> pi^+ n over azimuthal scattering angle, the observables \H and P have been extracted. These observables manifest as azimuthal modulations in the yields for the double-polarization experiment. Preliminary results for these observables will be presented and compared with predictions provided by the SAID Partial-Wave Analysis Facility.
ContributorsLee, Robert John (Author) / Dugger, Michael (Thesis director) / Ritchie, Barry (Committee member) / Department of Physics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
With the discovery of the Higgs Boson in 2012, particle physics has decidedly moved beyond the Standard Model into a new epoch. Though the Standard Model particle content is now completely accounted for, there remain many theoretical issues about the structure of the theory in need of resolution. Among these is the hierarchy problem: since the renormalized Higgs mass receives quadratic corrections from a higher cutoff scale, what keeps the Higgs boson light? Many possible solutions to this problem have been advanced, such as supersymmetry, Randall-Sundrum models, or sub-millimeter corrections to gravity. One such solution has been advanced by the Lee-Wick Standard Model. In this theory, higher-derivative operators are added to the Lagrangian for each Standard Model field, which result in propagators that possess two physical poles and fall off more rapidly in the ultraviolet regime. It can be shown by an auxiliary field transformation that the higher-derivative theory is identical to positing a second, manifestly renormalizable theory in which new fields with opposite-sign kinetic and mass terms are found. These so-called Lee-Wick fields have opposite-sign propagators, and famously cancel off the quadratic divergences that plague the renormalized Higgs mass. The states in the Hilbert space corresponding to Lee-Wick particles have negative norm, and implications for causality and unitarity are examined.
This dissertation explores a variant of the theory called the N = 3 Lee-Wick
Standard Model. The Lagrangian of this theory features a yet-higher derivative operator, which produces a propagator with three physical poles and possesses even better high-energy behavior than the minimal Lee-Wick theory. An analogous auxiliary field transformation takes this higher-derivative theory into a renormalizable theory with states of alternating positive, negative, and positive norm. The phenomenology of this theory is examined in detail, with particular emphasis on the collider signatures of Lee-Wick particles, electroweak precision constraints on the masses that the new particles can take on, and scenarios in early-universe cosmology in which Lee-Wick particles can play a significant role.
This dissertation explores a variant of the theory called the N = 3 Lee-Wick
Standard Model. The Lagrangian of this theory features a yet-higher derivative operator, which produces a propagator with three physical poles and possesses even better high-energy behavior than the minimal Lee-Wick theory. An analogous auxiliary field transformation takes this higher-derivative theory into a renormalizable theory with states of alternating positive, negative, and positive norm. The phenomenology of this theory is examined in detail, with particular emphasis on the collider signatures of Lee-Wick particles, electroweak precision constraints on the masses that the new particles can take on, and scenarios in early-universe cosmology in which Lee-Wick particles can play a significant role.
ContributorsTerBeek, Russell Henry (Author) / Lebed, Richard F (Thesis advisor) / Alarcon, Ricardo (Committee member) / Belitsky, Andrei (Committee member) / Chamberlin, Ralph (Committee member) / Parikh, Maulik (Committee member) / Arizona State University (Publisher)
Created2015
Description
A series of experiments using a polarized beam incident on a polarized frozen spin target
(FROST) was conducted at Jefferson Lab in 2010. Results presented here were taken
during the second running period with the FROST target using the CEBAF Large Acceptance
Spectrometer (CLAS) detector at Jefferson Lab, which used transversely-polarized
protons in a butanol target and a circularly-polarized incident tagged photon beam with
energies between 0.62 and 2.93 GeV. Data are presented for the F and T polarization observables
for h meson photoproduction on the proton from W = 1.55 GeV to 1.80 GeV.
The data presented here will improve the world database and refine theoretical approaches
of nucleon structure.
(FROST) was conducted at Jefferson Lab in 2010. Results presented here were taken
during the second running period with the FROST target using the CEBAF Large Acceptance
Spectrometer (CLAS) detector at Jefferson Lab, which used transversely-polarized
protons in a butanol target and a circularly-polarized incident tagged photon beam with
energies between 0.62 and 2.93 GeV. Data are presented for the F and T polarization observables
for h meson photoproduction on the proton from W = 1.55 GeV to 1.80 GeV.
The data presented here will improve the world database and refine theoretical approaches
of nucleon structure.
ContributorsTucker, Ross (Author) / Ritchie, Barry (Thesis advisor) / Dugger, Michael (Committee member) / Alarcon, Ricardo (Committee member) / Lebed, Richard (Committee member) / Arizona State University (Publisher)
Created2016
Description
The muon problem of flavor physics presents a rich opportunity to study beyond standard model physics. The as yet undiscovered bound state (μ+μ-), called true muonium, presents a unique opportunity to investigate the muon problem. The near-future experimental searches for true muonium will produce it relativistically, preventing the easy application of non-relativistic quantum mechanics. In this thesis, quantum field theory methods based on light-front quantization are used to solve an effective Hamiltonian for true muonium in the Fock space of |μ+μ-> , |μ+μ-γ> , |e+e->, |e+e-γ>, |τ+τ-> , and |τ+τ-γ> . To facilitate these calculations a new parallel code, True Muonium Solver With Front-Form Techniques (TMSWIFT), has been developed. Using this code, numerical results for the wave functions, energy levels, and decay constants of true muonium have been obtained for a range of coupling constants α. Work is also presented for deriving the effective interaction arising from the |γγ sector’s inclusion into the model.
ContributorsLamm, Henry (Author) / Lebed, Richard F (Thesis advisor) / Belitsky, Andrei (Committee member) / Alarcon, Ricardo (Committee member) / Easson, Damien (Committee member) / Arizona State University (Publisher)
Created2016
Description
The OLYMPUS experiment measured the two-photon exchange contribution to elastic electron-proton scattering, over a range of four-momentum transfer from \(0.6 < Q^2 < 2.2\) \((\mathrm{GeV/c})^2\). The motivation for the experiment stemmed from measurements of the electric-to-magnetic form factor ratio of the proton \(\mu G_E/G_M\) extracted from polarization observables in polarized electron-proton scattering. Polarized electron-proton scattering experiments have revealed a significant decrease in \(\mu G_E/G_M\) at large \(Q^2\), in contrast to previous measurements from unpolarized electron-proton scattering. The commonly accepted hypothesis is that the discrepancy in the form factor ratio is due to neglected higher-order terms in the elastic electron-proton scattering cross section, in particular the two-photon exchange amplitude.
The goal of OLYMPUS was to measure the two-photon exchange contribution by measuring the positron-proton to electron-proton elastic scattering cross section ratio, \(\sigma_{e^+p}/\sigma_{e^-p}\). The two-photon exchange contribution is correlated to the deviation of the cross section ratio from unity.
In 2012, the OLYMPUS experiment collected over 4 fb\(^{-1}\) of \(e^+p\) and \(e^-p\) scattering data using electron and positron beams incident on a hydrogen gas target. The scattered leptons and protons were measured exclusively with a large acceptance spectrometer. OLYMPUS observed a slight rise in \(\sigma_{e^+p}/\sigma_{e^-p}\) of at most 1-2\% over a \(Q^2\) range of \(0.6 < Q^2 < 2.2\) \((\mathrm{GeV/c})^2\). This work discusses the motivations, experiment, analysis method, and the preliminary results for the cross section ratio as measured by OLYMPUS.
The goal of OLYMPUS was to measure the two-photon exchange contribution by measuring the positron-proton to electron-proton elastic scattering cross section ratio, \(\sigma_{e^+p}/\sigma_{e^-p}\). The two-photon exchange contribution is correlated to the deviation of the cross section ratio from unity.
In 2012, the OLYMPUS experiment collected over 4 fb\(^{-1}\) of \(e^+p\) and \(e^-p\) scattering data using electron and positron beams incident on a hydrogen gas target. The scattered leptons and protons were measured exclusively with a large acceptance spectrometer. OLYMPUS observed a slight rise in \(\sigma_{e^+p}/\sigma_{e^-p}\) of at most 1-2\% over a \(Q^2\) range of \(0.6 < Q^2 < 2.2\) \((\mathrm{GeV/c})^2\). This work discusses the motivations, experiment, analysis method, and the preliminary results for the cross section ratio as measured by OLYMPUS.
ContributorsIce, Lauren (Author) / Alarcon, Ricardo O (Thesis advisor) / Dugger, Michael (Committee member) / Lebed, Richard (Committee member) / Ritchie, Barry (Committee member) / Arizona State University (Publisher)
Created2016
Description
Our group has constructed a ring-imaging Cherenkov (RICH) detector with the goal of testing the performance of aerogel tiles in charged particle detectors. In previous work, tiles produced by Aspen Aerogels were tested as radiators in Cherenkov threshold counters and compared to commercial-grade samples. As an extension of this work we built a counter of the RICH type, which is used in practice to extract more particle identification information than threshold counters, and we have studied the images resulting from various aerogel samples.
The detector was designed for use in table-top experiments in which our particle source would be cosmic rays. Due to the vast energy range of cosmic rays, the window in which we can discriminate velocities is relatively small. Since the particles we do detect generally have β≈1, the relativistic limit β→1 motivates imaging by the Focusing Aerogel RICH (FARICH) technique, in which photons from multiple tiles are focused together at a detection plane.
Our detection plane is an array of flat-panel, multi-anode photomultiplier tubes (PMTs). Readout consists of multiplexing the anode outputs, recording the digitized signal, and converting this into a matrix of integrated charge values. The charge distribution in that matrix should directly imply the particle's speed; however, in practice, final recorded images are the influenced by many intermediate processes, so we have attempted to make meaningful measurements by averaging over numerous events.
For a given configuration and data collection, we produce the spatial distribution of observed signals relative to the cosmic ray's point of impact. These distributions have the expected form of a ring and their characteristics compare favorably with the predictions of geometric optics. Our confidence in the images is increased by verifying that changes to the configuration are reflected by the changes in the rings. We find that FARICH improves the sharpness of our ring images, but tiles must be used individually for actual aerogel analysis. So far we have shown that the Aspen tiles behave as one would expect for the purposes of RICH. Their images do resemble those produced by commercial-grade tiles, but we do not have tiles sufficiently similar for side-by-side comparison. A method of quantifying tile performance has proven difficult and is the only remaining task for our group.
The detector was designed for use in table-top experiments in which our particle source would be cosmic rays. Due to the vast energy range of cosmic rays, the window in which we can discriminate velocities is relatively small. Since the particles we do detect generally have β≈1, the relativistic limit β→1 motivates imaging by the Focusing Aerogel RICH (FARICH) technique, in which photons from multiple tiles are focused together at a detection plane.
Our detection plane is an array of flat-panel, multi-anode photomultiplier tubes (PMTs). Readout consists of multiplexing the anode outputs, recording the digitized signal, and converting this into a matrix of integrated charge values. The charge distribution in that matrix should directly imply the particle's speed; however, in practice, final recorded images are the influenced by many intermediate processes, so we have attempted to make meaningful measurements by averaging over numerous events.
For a given configuration and data collection, we produce the spatial distribution of observed signals relative to the cosmic ray's point of impact. These distributions have the expected form of a ring and their characteristics compare favorably with the predictions of geometric optics. Our confidence in the images is increased by verifying that changes to the configuration are reflected by the changes in the rings. We find that FARICH improves the sharpness of our ring images, but tiles must be used individually for actual aerogel analysis. So far we have shown that the Aspen tiles behave as one would expect for the purposes of RICH. Their images do resemble those produced by commercial-grade tiles, but we do not have tiles sufficiently similar for side-by-side comparison. A method of quantifying tile performance has proven difficult and is the only remaining task for our group.
ContributorsStryker, Jesse R. (Author) / Alarcon, Ricardo (Thesis director) / Schmidt, kevin E. (Committee member) / Barrett, The Honors College (Contributor)
Created2014-05
Description
Treatment log files for spot scanning proton therapy provide a record of delivery accuracy, but they also contain diagnostic information for machine performance. A collection of patient log files can identify machine performance trends over time. This facilitates the identification of machine issues before they cause downtime or degrade treatment quality. At Mayo Clinic Arizona, all patient treatment logs are stored in a database. These log files contain information including the gantry, beam position, monitor units (MUs), and gantry angle. This data was analyzed to identify trends, which were then correlated with quality assurance measurements and maintenance records.
ContributorsGrayson, Madison Emily (Author) / Alarcon, Ricardo (Thesis director) / Robertson, Daniel (Committee member) / Department of Physics (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
The spectra of predicted particles from elementary quark models (CQMs) are expansive, accurate for the low-lying spectra, but incomplete. The GlueX experiment at Jefferson Lab is a vehicle to study medium energy photoproduction of hadronic states. The primary goal of the GlueX collaboration is to study Quantum Chromodynamics (QCD, also known as the strong nuclear force) and the nature of quark confinement. The GlueX collaboration uses a polarized photon beam incident on a liquid hydrogen target (LH2) to investigate the aftermath of photon-proton interactions.The cascade baryons, denoted by Ξ, are defined by having two, second-generation, strange quarks with an additional first-generation light quark (u or d). Experimentally, few cascades have been discovered, which is the antithesis of what most models expect. The cascades have some favorable attributes but are difficult to detect because the production cross sections are small and direct production is unlikely. Fortunately, in the 12 GeV era of the GlueX experiment, there is sufficient energy, beam time and data analysis tools for the detection of excited cascade states and their properties.
From the reaction γp→K^+ K^+ Ξ^- π^0, the invariant mass spectra of Ξ^- π^0 system was surveyed for new possible resonances. The invariant mass spectrum has a strong Ξ(1530) signal with other smaller resonances throughout the spectrum. Preliminary cross sections for the Ξ(1530) that was photoproduced from the proton are presented at energies never before explored.
While the Ξ(1530) couples almost exclusively to the Ξπ channel, there is an easily identifiable Ξ(1690) signal decaying Ξπ. Through the use of a simultaneous fitting routing of the Ξ*- mass spectra, I was able to observe the Ξ(1690) decaying to the KΛ, as well as to the Ξ-π0 branch. With additional statistics, a measurement of the branching ratio should be possible.
Lastly, a partial wave analysis (PWA) was completed to verify that the total angular momentum of Ξ(1530) is J = 3/2 and consistent with having positive parity. Additionally, there is evidence of a potentially interesting feature slightly above the mass of the Ξ(1530) that should be more fully explored as new GlueX data becomes available.
ContributorsSumner, Brandon Christopher Lamont (Author) / Dugger, Michael (Thesis advisor) / Ritchie, Barry (Committee member) / Lebed, Richard (Committee member) / Alarcon, Ricardo (Committee member) / Arizona State University (Publisher)
Created2022