Matching Items (83)
Description
Cases of heroin use and overdose are on the rise in the United States which has created what some call a public health crisis. Previous studies have investigated the beneficial effect of social interaction recovering addicts, and in animal models of addiction, social interaction can prevent or reverse the conditioned rewarding effects of cocaine. This study sought to determine if social interaction would prevent or diminish a conditioned preference for a heroin-paired context. Following establishment of baseline place preference, adult male Sprague-Dawley rats underwent once daily conditioning with either saline, heroin (1 mg/kg), or the animal's cage-mate for a total of 8 conditioning sessions. Assessment of post-conditioning place preference revealed that both the heroin injections and the presence of the cage-mate produced a place preference . In contrast to the findings of previous studies using cocaine as the conditioning drug, it was determined that rats preferred the heroin-paired context over that paired with the cage-mate.. These findings suggest that the protective effects of social interaction found in prior studies using cocaine as the conditioning drug may not extend to opiates, perhaps a result of stronger contextual conditioning and/or rewarding effects of this class of abused drugs.
ContributorsMarble, Krista Lillian (Author) / Olive, M. Foster (Thesis director) / Tomek, Seven (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
The RAS/MAPK (RAS/Mitogen Activated Protein Kinase) pathway is a highly conserved, canonical signaling cascade that is highly involved in cellular growth and proliferation as well as cell migration. As such, it plays an important role in development, specifically in development of the nervous system. Activation of ERK is indispensable for the differentiation of Embryonic Stem Cells (ESC) into neuronal precursors (Li z et al, 2006). ERK signaling has also shown to mediate Schwann cell myelination of the peripheral nervous system (PNS) as well as oligodendrocyte proliferation (Newbern et al, 2011). The class of developmental disorders that result in the dysregulation of RAS signaling are known as RASopathies. The molecular and cell-specific consequences of these various pathway mutations remain to be elucidated. While there is evidence for altered DNA transcription in RASopathies, there is little work examining the effects of the RASopathy-linked mutations on protein translation and post-translational modifications in vivo. RASopathies have phenotypic and molecular similarities to other disorders such as Fragile X Syndrome (FXS) and Tuberous Sclerosis (TSC) that show evidence of aberrant protein synthesis and affect related pathways. There are also well-defined downstream RAS pathway elements involved in translation. Additionally, aberrant corticospinal axon outgrowth has been observed in disease models of RASopathies (Xing et al, 2016). For these reasons, this present study examines a subset of proteins involved in translation and translational regulation in the context of RASopathy disease states. Results indicate that in both of the tested RASopathy model systems, there is altered mTOR expression. Additionally the loss of function model showed a decrease in rps6 activation. This data supports a role for the selective dysregulation of translational control elements in RASopathy models. This data also indicates that the primary candidate mechanism for control of altered translation in these modes is through the altered expression of mTOR.
ContributorsHilbert, Alexander Robert (Author) / Newbern, Jason (Thesis director) / Olive, M. Foster (Committee member) / Bjorklund, Reed (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
This paper explores the idea of xenophilia and the circumstances under which it may occur. Xenophilia is the preference for an outgroup member over an ingroup member. This preference does not have to be amicable, and in fact can be exploitative under certain circumstances. Previous research indicates that xenophobia is much more common, but a few researchers have found support for the existence of xenophilia. To experimentally test the circumstances under which xenophilia might occur, I conducted a survey-based experiment on Amazon’s Mechanical Turk. This consisted of directed visualizations that manipulated participant goal (self-protection vs. mate acquisition) and the resources offered by both a fictitious outgroup and the hometown ingroup, followed by measures of ingroup/outgroup preference. I hypothesized that when the resource offered by the group addressed the participants’ goal, they would prefer the group with the “matched” resource—even if it was the outgroup providing that resource. My hypothesis was not supported, as the univariate analysis of variance for preference for the outgroup was not significant, F (2, 423) = .723, p = .486. This may have occurred because the goal manipulations were not strong enough to counteract the strong natural preference for ingroup members.
ContributorsDrury, Margaret E. (Author) / Neuberg, Steven (Thesis director) / Davis, Mary (Committee member) / Kenrick, Douglas (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
People experience challenges and conflicts in their romantic relationships. Such difficulties yield different outcomes: these events can make us into better partners and strengthen our romantic relationships, or they can weaken us and threaten those relationships. Thus, some conflicts might be positive for couples in the long-term despite short-term stress. The current study sought to address this possibility. Across two studies (total N = 600), I found three main components that were related to perceptions of strength outcomes across couple conflict types. First, conflict between romantic partners involving commitment, sex, trust, infidelity, and controlling behavior were generally associated with perceptions of less positive outcomes than other conflicts. On the other hand, conflict between romantic partners involving addiction, finance, grief, family stress, illness, or jobs and education were associated with perceptions of relatively more positive outcomes. Additionally, I find communication is associated with conflicts that were related to long-distance, household chores, and sex. The nature of this work is exploratory, and other research is needed to confirm these results. Nonetheless, our study demonstrates differences in how people characterize the difficulties and conflicts that occur in romantic relationships.
ContributorsBaron, Cora (Author) / Kenrick, Douglas (Thesis director) / Corbin, William (Committee member) / Neuberg, Steven (Committee member) / Barlev, Michael (Committee member) / Kirsch, Amanda (Committee member) / Barrett, The Honors College (Contributor) / School of Social Transformation (Contributor) / Department of Psychology (Contributor)
Created2021-12
Description
This dissertation describes a series of four studies on cognitive aging, working memory, and cognitive flexibility in dogs (Canis lupus familiaris) and their wild relatives. In Chapters 2 and 3, I designed assessments for age-related cognitive deficits in pet dogs which can be deployed rapidly using inexpensive and accessible materials. These novel tests can be easily implemented by owners, veterinarians, and clinicians and therefore, may improve care for elderly dogs by aiding in the diagnosis of dementia. In addition, these widely deployable tests may facilitate the use of dementia in pet dogs as a naturally occurring model of Alzheimer’s Disease in humans.In Chapters 4 and 5, I modified one of these tests to demonstrate for the first time that coyotes (Canis latrans) and wolves (Canis lupus lupus) develop age-related deficits in cognitive flexibility. This was an important first step towards differentiating between the genetic and environmental components of dementia in dogs and in turn, humans. Unexpectedly, I also detected cognitive deficits in young, adult dogs and wolves but not coyotes. These finding add to a recent shift in understanding cognitive development in dogs which may improve cognitive aging tests as well as training, care, and use of working and pet dogs. These findings also suggest that the ecology of coyotes may select for flexibility earlier in development.
In Chapter 5, I piloted the use of the same cognitive flexibility test for red and gray foxes so that future studies may test for lifespan changes in the cognition of small-bodied captive canids. More broadly, this paradigm may accommodate physical and behavioral differences between diverse pet and captive animals. In Chapters 4 and 5, I examined which ecological traits drive the evolution of behavioral flexibility and in turn, species resilience. I found that wolves displayed less flexibility than dogs and coyotes suggesting that species which do not rely heavily on unstable resources may be ill-equipped to cope with human habitat modification. Ultimately, this comparative work may help conservation practitioners to identify and protect species that cannot cope with rapid and unnatural environmental change.
ContributorsVan Bourg, Joshua (Author) / Wynne, Clive D (Thesis advisor) / Aktipis, C. Athena (Committee member) / Gilby, Ian C (Committee member) / Young, Julie K (Committee member) / Arizona State University (Publisher)
Created2022
Description
Stereotype humor is a highly prevalent but particularly divisive phenomenon, with the potential for both negative and positive social implications. While highly subjective, interpretations of stereotype humor's subtext (support/challenge of stereotype) have major implications for reactions to this type of humor. This experimental study (N = 104) represents a novel investigation of the effect of two facets of stereotype humor, explicitness of stereotyping and stereotype distortion, on judgments of stereotype endorsement (support) versus subversion (challenge) in memes about four different groups (Asian, Hispanic, Irish, White) and associated group stereotypes. In this completely within-subjects design, participants viewed several memes about the target groups which varied systematically by the two factors of interest and provided judgments of stereotype endorsement versus subversion, ratings of funniness, and ratings of offensiveness. Multilevel models were used to determine the effect of explicitness, distortion, and their interaction, as well as target group, on judgements of stereotype humor while accounting for nesting of responses within participants. Results showed that stereotype distortion (e.g., exaggeration) and explicit stereotyping (e.g., overtly linking group to stereotype) both significantly predicted greater ratings of subversion. Unexpectedly, stereotype distortion also predicted greater levels of offense. Interestingly, marginalized group membership (i.e., Asian, Hispanic) significantly predicted lower ratings of subversion, lower funny ratings, and higher offense ratings. Findings highlight the significant role of explicitness and distortion when considering how individuals interpret the subtext of stereotype humor. Furthermore, findings underscore the major influence of group status on judgments and social implications of this type of humor. Overall, this study contributes to a better understanding of the mechanisms by which individuals interpret stereotype humor, providing valuable insights for promoting better intergroup relations and communication.
ContributorsLangley, Erika Beatrice (Author) / Shiota, Michelle (Thesis advisor) / Neuberg, Steven (Committee member) / Maddox, Keith (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2024
Description
Access to testing for the human immunodeficiency virus (HIV), as well as other care services related to HIV/AIDS, have greatly improved in Tanzania over the last decade. Despite the country’s efforts to increase the number of individuals who get tested for HIV annually, it is estimated that only 52.2-70.0% of people living with HIV (PLWH) knew their HIV positive status at the end of 2017. In addition, research in Tanzania has shown that HIV-related stigma and discrimination are widespread and contribute to low uptake of HIV testing and non-adherence to antiretroviral treatment (ART). In order to achieve the goals set forth by the Government of Tanzania and the Joint United Nations Programme on HIV/AIDS (UNAIDS), as well as move towards an AIDS-free generation, a deeper understanding of the stigma-related barriers to seeking an HIV test is necessary. This research aims to better understand the relationship between HIV-related stigma and attitudes towards HIV testing among community members in Northern Tanzania. In addition, it looked at the specific barriers that contribute to low uptake of HIV testing, as well as the impact of social networks on an individual’s motivation and willingness to get tested for HIV. In this research, community members in Meru District (N = 108, male = 69.4%, female = 28.7%) were surveyed using various validated instruments that covered a range of topics, including knowledge of HIV/AIDS, testing attitudes, and perceived risk of HIV infection. The mean overall score for correct answers on the knowledge measure was 69.8% (SD = 16.4). There were no significant group differences between individuals who had ever tested and individuals who had not tested in relation to HIV/AIDS knowledge or HIV testing attitudes. The factors that were significantly associated with getting an HIV test were knowing someone who had previously tested (p = 0.003), as well as openly discussing HIV testing within one’s social group (p = 0.017). Participants also provided qualitative responses for barriers to receiving an HIV test, motivations for getting tested, and suggested interventions for improving HIV testing uptake. The goal of this research is to develop recommendations for interventions that are better informed by attitudes and motivations for testing.
ContributorsAllen, Megan (Author) / Jacobs, Bertram (Thesis advisor) / Neuberg, Steven (Committee member) / Ellison, Karin (Committee member) / Arizona State University (Publisher)
Created2019
Description
Evidence from the 20th century demonstrated that early life stress (ELS) produces long lasting neuroendocrine and behavioral effects related to an increased vulnerability towards psychiatric illnesses such as major depressive disorder, post-traumatic stress disorder, schizophrenia, and substance use disorder. Substance use disorders (SUDs) are complex neurological and behavioral psychiatric illnesses. The development, maintenance, and relapse of SUDs involve multiple brain systems and are affected by many variables, including socio-economic and genetic factors. Pre-clinical studies demonstrate that ELS affects many of the same systems, such as the reward circuitry and executive function involved with addiction-like behaviors. Previous research has focused on cocaine, ethanol, opiates, and amphetamine, while few studies have investigated ELS and methamphetamine (METH) vulnerability. METH is a highly addictive psychostimulant that when abused, has deleterious effects on the user and society. However, a critical unanswered question remains; how do early life experiences modulate both neural systems and behavior in adulthood? The emerging field of neuroepigenetics provides a potential answer to this question. Methyl CpG binding protein 2 (MeCP2), an epigenetic tag, has emerged as one possible mediator between initial drug use and the transition to addiction. Additionally, there are various neural systems that undergo long lasting epigenetics changes after ELS, such as the response of the hypothalamo-pituitary-adrenal (HPA) axis to stressors. Despite this, little attention has been given to the interactions between ELS, epigenetics, and addiction vulnerability. The studies described herein investigated the effects of ELS on METH self-administration (SA) in adult male rats. Next, we investigated the effects of ELS and METH SA on MeCP2 expression in the nucleus accumbens and dorsal striatum. Additionally, we investigated the effects of virally-mediated knockdown of MeCP2 expression in the nucleus accumbens core on METH SA, motivation to obtain METH under conditions of increasing behavioral demand, and reinstatement of METH-seeking in rats with and without a history of ELS. The results of these studies provide insights into potential epigenetic mechanisms by which ELS can produce an increased vulnerability to addiction in adulthood. Moreover, these studies shed light on possible novel molecular targets for treating addiction in individuals with a history of ELS.
ContributorsLewis, Candace (Author) / Olive, M. Foster (Thesis advisor) / Hammer, Ronald (Committee member) / Neisewander, Janet (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Created2015
Description
Anti-Semitism is a recurrent phenomenon in modern history, but has garnered relatively little focus among research psychologists compared to prejudice toward other groups. The present work frames anti-Semitism as a strategy for managing the implications of Jews’ extraordinary achievements compared to other groups. Anti-Semitic beliefs are sorted into two types: stereotypes that undercut the merit of Jews’ achievements by attributing them to unfair advantages such as power behind the scenes; and stereotypes that offset Jews’ achievements by attaching unfavorable traits or defects to Jews, which are unrelated to the achievement domains, e.g. irritating personalities or genetically-specific health problems. The salience of Jews’ disproportionate achievements was hypothesized as driving greater endorsement of anti-Semitic stereotypes, and envy was hypothesized as mediating this effect. Individual differences in narcissistic self-esteem and moral intuitions around in-group loyalty and equity-based fairness were hypothesized as moderating the effect of Jewish achievement on anti-Semitic beliefs. The results showed greater endorsement of undercutting – but not offsetting – stereotypes after reading about Jewish achievements, compared to Jewish culture or general American achievement conditions. Envy did not significantly mediate this effect. The moral foundation of in-group loyalty predicted greater endorsement of anti-Semitic stereotypes in the Jewish Achievement condition, and lesser endorsement in the Jewish Culture condition. Fairness intuitions did not significantly predict stereotype endorsement. Limitations of the sample and next steps are discussed.
ContributorsDuarte, Jose Leopoldo (Author) / Cohen, Adam B. (Thesis advisor) / Neuberg, Steven (Committee member) / Karoly, Paul (Committee member) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2015
Description
Previous research on experiences of the endowment effect and buyer's remorse has often failed to compare the two seemingly related phenomena. The current study attempts to provide a framework in which the two can be compared and to offer a possible suggestion as to when it may be beneficial to experience either the endowment effect or buyer's remorse, namely situations of resource scarcity versus abundance. The current study employed an online dating paradigm in which resource scarcity was operationalized as the sex ratio of users on the site. Two hundred and one participants were exposed to a favorable sex ratio, an unfavorable sex ratio, or a no information control condition and asked to bid on potential dates. Once matched with a potential date, participants were asked how willing they would be to give up their date and the minimum amount of points they would request to do so. These dependent variables served as indicators of experiences of the endowment effect or buyer's remorse. Results indicated that the sex ratio of the online dating site did not influence experiences of the endowment effect versus buyer's remorse. Potential mediators and moderators were also investigated although no significant effects were found. Possible reasons for the null results are discussed as well as future directions.
ContributorsMeyer, Kaitlin (Author) / Cohen, Adam B. (Thesis advisor) / Kenrick, Douglas (Committee member) / Neuberg, Steven (Committee member) / Arizona State University (Publisher)
Created2014