Matching Items (104)
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Description
In an increasingly interconnected world, the 17 Sustainable Development Goals are the United Nations’ framework for ensuring we continue to transform our world for the better, leaving no population behind. This study examines how the terminology of Sustainable Development Goal 17 for global partnership affects its implementation, focusing on “building

In an increasingly interconnected world, the 17 Sustainable Development Goals are the United Nations’ framework for ensuring we continue to transform our world for the better, leaving no population behind. This study examines how the terminology of Sustainable Development Goal 17 for global partnership affects its implementation, focusing on “building capacity”—a widely referenced target in the development arena—and the involvement of the private sector. Key informant interviews with experts in the fields of conflict of interest, ethics, and development revealed a wide variety of (often conflicting) notions about partnership, frameworks for capacity development, and the interactions between public and private actors. A literature review of key policy documents examined the terminology and implementation of multistakeholder partnerships, and analysis offered considerations for risks and suggestions in policy terminology. Results indicate a need for increased attention to the use of partnership terminology as a catch-all term to encompass development work, and makes several recommendations for changes to combat misuse of the partnership label. Finally, this study acknowledges that there is a continued need for research-based evidence for effectiveness of the partnership-based development approach.
ContributorsThomson, Azalea Mae (Author) / Gaughan, Monica (Thesis director) / Hruschka, Daniel (Committee member) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
The development of safe and effective vaccines has been one of the greatest public achievements of the 20th century. However, there is still considerable public debate about the relative health costs and benefits of vaccines, and the information and misinformation spread through these debates can have a direct impact on

The development of safe and effective vaccines has been one of the greatest public achievements of the 20th century. However, there is still considerable public debate about the relative health costs and benefits of vaccines, and the information and misinformation spread through these debates can have a direct impact on vaccination and whether or not herd immunity will continue in the United States for different diseases. To understand perceptions of vaccine risks and effectiveness among young adults in the U.S., this study describes Arizona State University students' perceptions of the harms and benefits of vaccines. A preliminary free list (n=30) identified what vaccines ASU college students were most likely to recall spontaneously. The six vaccines most commonly mentioned by ASU students were: influenza (flu), chickenpox, HPV, polio, MMR, and smallpox. Using these top six vaccines, we then developed a second survey about the knowledge and perceptions of each of these vaccines and vaccines as a whole. We found that students generally perceived vaccines as safe and important to their health, but they maintained an overall lack of understanding of how vaccines work and what they protect against. While this study is only a preliminary investigation into the perceptions of ASU college students on six commonly mentioned vaccines, this could lead to investigations on how to educate and promote the usage of vaccines to college students.
ContributorsGilson, Jacob (Co-author) / Sutton, Carly (Co-author) / Hruschka, Daniel (Thesis director) / Ruth, Alissa (Committee member) / W. P. Carey School of Business (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
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Description
A major recurring issue with aid-providing nonprofit organizations is the lack of accountability to recipients. In many cases, there are not clear-cut ways of measuring the efficiency or effectiveness of aid or to determine when and how the aid is failing to meet the needs of recipients. This study focused

A major recurring issue with aid-providing nonprofit organizations is the lack of accountability to recipients. In many cases, there are not clear-cut ways of measuring the efficiency or effectiveness of aid or to determine when and how the aid is failing to meet the needs of recipients. This study focused on one particular non-governmental organization, Project C.U.R.E., that provides medical aid to developing countries in the form of devices and equipment. It investigated the causes of misalignments observed in Project C.U.R.E.'s medical aid process, specifically with three loads that were shipped to the Ahwiaa, Akoti, Bassengele, Chirano, Humjibre, Ntrentrenso, Paboase, and Wenchi clinics as well as the Bibiani hospital in Ghana between June 2015 and May 2016. The medical aid donation process was observed at the each of its steps. Data was collected through interviews with Project C.U.R.E. employees and associates, and was organized and analyzed using Lean Six Sigma tools in order to find areas where the process broke down or failed. These tools included process mapping, root cause analysis through the use of Pareto charts and process failure mode and effects analysis (PFMEA). Once all of the issues from the shipment were categorized, it was found that the three most common types of issues were the preparation of the device being unclear or being unloaded incorrectly, power issues, and misalignment in terms training, needs, and infrastructure. The PFMEAs identified high-priority issues with missing fields in the Needs Assessment Booklet in the needs assessment step, misaligned products in terms of power availability in the planning step, and a lack of standardization in the warehouse operations step. 50 unique solutions were brainstormed in order to address these issues, as well as others. This means that Lean Six Sigma tools such as Pareto charts and PFMEA can be used to identify problems, identify causes and effects of problems, and help to produce solutions to the identified problems. In the future, more in-depth research into Project C.U.R.E.'s impact evaluation process could be pursued.
ContributorsFisk, Nicole Diane (Author) / Hruschka, Daniel (Thesis director) / Walters, Danielle (Committee member) / School of Human Evolution and Social Change (Contributor) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
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Description
Through a standpoint feminist perspective (Harding 2009) I conducted a situational analysis (Clarke, 2015) that examined academic literature and cancer support discussion boards (DBs) to identify how Western biomedicine, specifically oncology, can integrate complementary and alternative medicine (CAM) to improve cancer treatment in children. The aims of this project were:

Through a standpoint feminist perspective (Harding 2009) I conducted a situational analysis (Clarke, 2015) that examined academic literature and cancer support discussion boards (DBs) to identify how Western biomedicine, specifically oncology, can integrate complementary and alternative medicine (CAM) to improve cancer treatment in children. The aims of this project were: 1) to identify the CAM treatments that are being used to alleviate the side effects from oncological treatments and/or treat pediatric cancers; 2) to compare the subjective experience of CAM to Western biomedicine of cancer patients who leave comments on Group Loop, Cancer Compass and Cancer Forums, which are online support groups (N=20). I used grounded theory and situational mapping to analyze discussion threads. The participants identified using the following CAM treatments: herbs, imagery, prayer, stinging nettle, meditation, mind-body therapies and supplements. The participants turned to CAM treatments when their cancer was late-stage or terminal, often as an integrative and not exclusively to treat their cancer. CAM was more "effective" than biomedical oncology treatment at improving their overall quality of life and functionality. We found that youth on discussion boards did not discuss CAM treatments like the adult participants, but all participants visited these sites for support and verification of their cancer treatments. My main integration recommendation is to combine mind-body CAM therapies with biomedical treatment. This project fills the gap in literature that ignores the ideas of vulnerable populations by providing the experiences of adult and pediatric cancer patients, and that of their families. It is applicable to areas of the social studies of medicine, patient care, and families suffering from cancer. KEYWORDS: Cancer; Complementary and Alternative Medicine; Situational Analysis; Standpoint Feminism
ContributorsEsposito, Sydney Maria (Author) / Martinez, Airín (Thesis director) / Hruschka, Daniel (Committee member) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
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Description

Background

The transition from the home to college is a phase in which emerging adults shift toward more unhealthy eating and physical activity patterns, higher body mass indices, thus increasing risk of overweight/obesity. Currently, little is understood about how changing friendship networks shape weight gain behaviors. This paper describes the

Background

The transition from the home to college is a phase in which emerging adults shift toward more unhealthy eating and physical activity patterns, higher body mass indices, thus increasing risk of overweight/obesity. Currently, little is understood about how changing friendship networks shape weight gain behaviors. This paper describes the recruitment, data collection, and data analytic protocols for the SPARC (Social impact of Physical Activity and nutRition in College) study, a longitudinal examination of the mechanisms by which friends and friendship networks influence nutrition and physical activity behaviors and weight gain in the transition to college life.

Methods

The SPARC study aims to follow 1450 university freshmen from a large university over an academic year, collecting data on multiple aspects of friends and friendship networks. Integrating multiple types of data related to student lives, ecological momentary assessments (EMAs) are administered via a cell phone application, devilSPARC. EMAs collected in four 1-week periods (a total of 4 EMA waves) are integrated with linked data from web-based surveys and anthropometric measurements conducted at four times points (for a total of eight data collection periods including EMAs, separated by ~1 month). University databases will provide student card data, allowing integration of both time-dated data on food purchasing, use of physical activity venues, and geographical information system (GIS) locations of these activities relative to other students in their social networks.

Discussion

Findings are intended to guide the development of more effective interventions to enhance behaviors among college students that protect against weight gain during college.

ContributorsBruening, Meg (Author) / Ohri-Vachaspati, Punam (Author) / Brewis, Alexandra (Author) / Laska, Melissa (Author) / Todd, Michael (Author) / Hruschka, Daniel (Author) / Schaefer, David (Author) / Whisner, Corrie M (Author) / Dunton, Genevieve (Author)
Created2016-08-30
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Description
Mycobacterial infections, as represented by leprosy and tuberculosis, have persisted as human pathogens for millennia. Their environmental counterparts, nontuberculous mycobacteria (NTM), are commodious infectious agents endowed with extensive innate and acquired antimicrobial resistance. The current drug development process selects for antibiotics with high specificity for definitive targets within bacterial metabolic

Mycobacterial infections, as represented by leprosy and tuberculosis, have persisted as human pathogens for millennia. Their environmental counterparts, nontuberculous mycobacteria (NTM), are commodious infectious agents endowed with extensive innate and acquired antimicrobial resistance. The current drug development process selects for antibiotics with high specificity for definitive targets within bacterial metabolic and replication pathways. Because these compounds demonstrate limited efficacy against mycobacteria, novel antimycobacterial agents with unconventional mechanisms of action were identified. Two highly resistant NTMs, Mycobacterium abscessus (Mabs) a rapid-growing respiratory, skin, and soft tissue pathogen, and Mycobacterium ulcerans (MU), the causative agent of Buruli ulcer, were selected as targets. Compounds that indicated antimicrobial activity against other highly resistant pathogens were selected for initial screening. Antimicrobial peptides (AMPs) have demonstrated activity against a variety of bacterial pathogens, including mycobacterial species. Designed antimicrobial peptides (dAMPs), rationally-designed and synthetic contingents, combine iterative features of natural AMPs to achieve superior antimicrobial activity in resistant pathogens. Initial screening identified two dAMPs, RP554 and RP557, with bactericidal activity against Mabs. Clay-associated ions have previously demonstrated bactericidal activity against MU. Synthetic and customizable aluminosilicates have also demonstrated adsorption of bacterial cells and toxins. On this basis, two aluminosilicate materials, geopolymers (GP) and ion-exchange nanozeolites (IE-nZeos), were screened for antimicrobial activity against MU and its fast-growing relative, Mycobacterium marinum (Mmar). GPs demonstrated adsorption of MU cells and mycolactone, a secreted, lipophilic toxin, whereas Cu-nZeos and Ag-nZeos demonstrated antibacterial activity against MU and Mmar. Cumulatively, these results indicate that an integrative drug selection process may yield a new generation of antimycobacterial agents.
ContributorsDermody, Roslyn June (Author) / Haydel, Shelley E (Thesis advisor) / Bean, Heather (Committee member) / Nickerson, Cheryl (Committee member) / Stephanopoulos, Nicholas (Committee member) / Arizona State University (Publisher)
Created2022
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Description
Mycobacterium tuberculosis (Mtb), the etiological agent of the tuberculosis disease, is estimated to infect one-fourth of the human population and is responsible for 1.5 million deaths annually. The increased emergence of bacterial resistance to clinical interventions highlights the lack in development of novel antimicrobial therapeutics. Prototypical bacterial two-component systems (TCS)

Mycobacterium tuberculosis (Mtb), the etiological agent of the tuberculosis disease, is estimated to infect one-fourth of the human population and is responsible for 1.5 million deaths annually. The increased emergence of bacterial resistance to clinical interventions highlights the lack in development of novel antimicrobial therapeutics. Prototypical bacterial two-component systems (TCS) allow for sensing of extracellular stimuli and relay thereof to create a transcriptional response. The prrAB TCS is essential for viability in Mtb, presenting itself as an attractive novel drug target. In Mtb, PrrAB is involved in the adaptation to the intra-macrophage environment and recent work implicates PrrAB in the dosR-dependent hypoxia adaptation. This work defines a direct molecular and regulatory connection between Mtb PrrAB and the dosR-dependent hypoxia response. Using electrophoretic mobility shift assays combined with surface plasmon resonance, the Mtb dosR gene is established as a specific target of PrrA, corroborated by fluorescence reporter assays demonstrating a regulatory relationship. Considering the scarce understanding of prrAB essentiality in nontuberculous mycobacteria and the presence of multiple prrAB orthologs in Mycobacterium smegmatis and Mycobacterium abscessus, CRISPR interference was utilized to evaluate the essentiality of PrrAB beyond Mtb. prrAB was found to be inessential for viability in M. smegmatis yet required for in vitro growth. Conversely, M. abscessus prrAB repression led to enhanced in vitro growth. Diarylthiazole-48 (DAT-48) displayed decreased selectivity against M. abscessus but demonstrated enhanced intrinsic activity upon prrAB repression in M. abscessus. Lastly, to aid in the rapid determination of mycobacterial drug susceptibility and the detection of mycobacterial heteroresistance, the large volume scattering imaging (LVSim) platform was adapted for mycobacteria. Using LVSim, Mtb drug susceptibility was detected phenotypically within 6 hours, and clinically relevant mycobacterial heteroresistance was detected phenotypically within 10 generations. The data generated in these studies provide insight into the essential role of PrrAB in Mtb and its involvement in the dosR-dependent hypoxia adaptation, advance the understanding of mycobacterial PrrAB essentiality and PrrAB-associated mycobacterial growth dependency. These studies further establish molecular and mechanistic connection between PrrAB and DAT-48 in Mtb and M. abscessus and develop a rapid phenotypic drug susceptibility testing platform for mycobacteria.
ContributorsHaller, Yannik Alex (Author) / Haydel, Shelley E (Thesis advisor) / Bean, Heather (Committee member) / Nickerson, Cheryl (Committee member) / Plaisier, Christopher (Committee member) / Acharya, Abhinav (Committee member) / Arizona State University (Publisher)
Created2023
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Description
Social norms are unwritten behavioral codes. They direct individual behaviors, facilitate interpersonal coordination and cooperation, and lead to variation among human populations. Understanding how norms are maintained and how they change is critical for understanding human evolutionary psychology, social organization, and cultural change. This dissertation uses a mathematical model and

Social norms are unwritten behavioral codes. They direct individual behaviors, facilitate interpersonal coordination and cooperation, and lead to variation among human populations. Understanding how norms are maintained and how they change is critical for understanding human evolutionary psychology, social organization, and cultural change. This dissertation uses a mathematical model and a field study to answer two questions: First, what factors determine the content and dynamics of a social norm? Second, how do people make decisions in a normative context? The mathematical model finds that contrary to the popular belief that even arbitrary or deleterious social norms can be maintained once established because deviants suffer coordination failures and social sanctions, norms with continuously varying options cannot be maintained by the pressure to do what others do. Instead, continuous norms evolve to the optimum determined by environmental pressure, individual preferences, or cognitive processes. Therefore, the content of norms across human societies may be less historically constrained than previously assumed. The field study shows that unlike what rational choice theory predicts, people in a small-scale subsistence society do not calculate the ecological and social payoffs of different behaviors in a normative context, even when they have the information to do so. Instead, they rely heavily on social information about what others do. This decision-making algorithm, together with mental categorization that ignores small deviations, and cognitive biases that favor the division prescribed by the norm, maintain an ecologically inefficient and widely disliked cooperative surplus division norm in a Derung village, Dizhengdang, in Yunnan, China.
ContributorsYan, Minhua (Author) / Boyd, Robert (Thesis advisor) / Mathew, Sarah (Thesis advisor) / Hruschka, Daniel (Committee member) / Arizona State University (Publisher)
Created2023
Description

Existing research has shown that both ethnic discrimination and household wealth can shape child well-being and development. However, little work examines ethnic discrimination and its relation to income in predicting childhood health globally. This study explores two possible explanations for disparities in infant mortality between ethnic groups across countries worldwide.

Existing research has shown that both ethnic discrimination and household wealth can shape child well-being and development. However, little work examines ethnic discrimination and its relation to income in predicting childhood health globally. This study explores two possible explanations for disparities in infant mortality between ethnic groups across countries worldwide. The first is an explanation based on wealth differentials across ethnic groups. The second is the impact of forms of ethnic discrimination such as past lethal violence or forced labor experienced by the group. This study examines the correlation between ethnic discrimination and infant mortality using household wealth as a covariate. Analyses focused on 266 ethnicities in 40 low- and middle-income countries globally, drawing on infant mortality data from Demographic and Health Surveys and data on ethnic discrimination compiled by the Inclusive Human Learning Lab at Arizona State University. Findings without the inclusion of household wealth show that ethnic groups that predominantly spoke the state language had significantly lower rates of infant mortality. However, this trend disappears when income is added as a covariate. No other measures of discrimination or privilege were associated with infant mortality. Across all analyses, the wealth of the ethnic group was a significant predictor of infant mortality. Future studies should examine whether these trends persist in high-income countries, and whether the general lack of association of discrimination and privilege variables with infant mortality is influenced by how the variables were coded.

ContributorsUn, Anthony (Author) / Hruschka, Daniel (Thesis director) / Drake, Alexandria (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2023-05
Description

For African countries during the 1960s and 70s, decolonization marked the first step in a slow crawl toward complete independence. For Western powers and the Soviet Union, however, decolonization presented an opportunity to exert new influence over countries in desperate need of aid, investment, experts, and trade. Amidst the backdro

For African countries during the 1960s and 70s, decolonization marked the first step in a slow crawl toward complete independence. For Western powers and the Soviet Union, however, decolonization presented an opportunity to exert new influence over countries in desperate need of aid, investment, experts, and trade. Amidst the backdrop of increasing Cold War tensions, the US and USSR used foreign aid to pressure development according to either capitalist or Marxist agendas. Thus, sub-Saharan Africa became a battleground of proxy wars and neocolonialism. The Cold War superpowers would back opposing regimes in Angola and prop up, oust, or assassinate leaders in Ghana, Democratic Republic of the Congo, and Tanzania. This disrupted natural political development and created instability and violence, which was compounded by the arrival of the AIDS epidemic in the mid-1980s. AIDS ravaged African societies and destroyed the remaining fibers of leadership. The disease illuminated harsh historical realities as it spread among the conflict-stricken countries of sub-Saharan Africa. The goal of this thesis is to analyze the motivations behind US and USSR foreign aid during the Cold War, understand how their involvement halted the natural progression of pan-Africanism and leadership in newly-independent African countries, and link the resulting violence to the devastation of the AIDS crisis twenty years later. It begins with a look at European colonization in sub-Saharan Africa and traces the legacy of western influence in the region. The paper will then analyze specific examples of the consequences of historical interference, such as in the Angolan Civil War, the Congo Crisis, and the Rwandan genocide. It will introduce the AIDS crisis—coincident with major civil conflict and the end of the Cold War—and reveal the foreign aid response of the international community in the late 1990s and early 2000s, once Cold War-era pressures were gone. Through realizing the continued impact and spread of HIV/AIDS, the objective of this paper is to present a comprehensive view of the modern-day consequences of historical interference.

ContributorsStaker, Gabrielle (Author) / Niebuhr, Robert (Thesis director) / Hruschka, Daniel (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2023-05