Matching Items (213)
Description
De Oriendo is a project devoted to a better understanding of the word "original" as it pertains to musical composition. It began as a way for me to try to tackle a twofold fascination that has been with me for the duration of my time at ASU, though I have not always been aware of it. The first half of this fascination is an enduring interest in tracing borrowed material used by composers and other artists throughout history. It seems that almost every research project I have undertaken in the last four years has had something to do with this concept. Scholars like Winton Dean, J. Peter Burkholder, and Sigmund Spaeth have spent parts of their careers charting out the genealogy of historical compositions, uncovering reused melodies and harmonic progressions in the process; the cases of it are countless, even among the most identifiable composers and songwriters. Since there is scholarship clearly demonstrating secondhand ideas in music, it becomes problematic to assume that the word "original" simply describes something completely new, that is, something that does not use material heard or seen before. The second half is more of a personal ambition: I thought that if I truly knew what composers and critics meant when they labeled a piece or an artist as original, then I could somehow find a way to achieve this distinction in my own attempts at composition and avoid that uninteresting, derivative sound I have always feared.
ContributorsLang, Jonathan (Author) / Levy, Benjamin (Thesis director) / Mook, Richard (Committee member) / Rockmaker, Jody (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor)
Created2012-12
ContributorsBingham, Tucker (Author) / Setlow, Jennifer (Thesis director) / Melo, Carla (Committee member) / Danowski, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Herberger Institute for Design and the Arts (Contributor)
Created2012-12
Description
Human Papillomavirus (HPV) is the most commonly transmitted STI and isresponsible for an estimated 5% of cancer cases worldwide. HPV infection is implicated
in 70% of cervical cancer incidence and is also responsible for a variety of oropharyngeal
and anogenital cancers. While vaccination has greatly reduced the cervical cancer
burden in developed countries, HPV infection remains high in developing countries due
to high cost and poor access to healthcare. Several studies have highlighted the
presence of anti-HPV antibodies following infection and their potential use as
biomarkers for developing novel screening methods. Progression from initial infection to
cancer is slow, thus presenting an opportunity for effective screening programs.
Biomarker screening is an important area of cancer detection and Lateral Flow Assays
(LFA) are a low cost, easy to use alternative to other screening methods that require
extensive training and laboratory space. Therefore, this project proposes as a hypothesis
that the development of an LFA screening for HPV specific IgG can provide clinically
relevant data for the early detection of cervical dysplasia. This project adapts an LFA in a
multiplexed format for fluorescence-based serologic detection of HPV specific IgG in
patient plasma.
ContributorsJohns, William (Author) / Anderson, Karen (Thesis advisor) / Lake, Douglas (Committee member) / Hogue, Brenda (Committee member) / Arizona State University (Publisher)
Created2023