Matching Items (16)
Description
This dissertation shows that the central conceptual feature and explanatory motivation of theories of evolutionary directionality between 1890 and 1926 was as follows: morphological variation in the developing organism limits the possible outcomes of evolution in definite directions. Put broadly, these theories maintained a conceptual connection between development and evolution as inextricably associated phenomena. This project develops three case studies. The first addresses the Swiss-German zoologist Theodor Eimer's book Organic Evolution (1890), which sought to undermine the work of noted evolutionist August Weismann. Second, the American paleontologist Edward Drinker Cope's Primary Factors (1896) developed a sophisticated system of inheritance that included the material of heredity and the energy needed to induce and modify ontogenetic phenomena. Third, the Russian biogeographer Leo Berg's Nomogenesis (1926) argued that the biological world is deeply structured in a way that prevents changes to morphology taking place in more than one or a few directions. These authors based their ideas on extensive empirical evidence of long-term evolutionary trajectories. They also sought to synthesize knowledge from a wide range of studies and proposed causes of evolution and development within a unified causal framework based on laws of evolution. While being mindful of the variation between these three theories, this project advances "Definitely Directed Evolution" as a term to designate these shared features. The conceptual coherence and reception of these theories shows that Definitely Directed Evolution from 1890 to 1926 is an important piece in reconstructing the wider history of theories of evolutionary directionality.
ContributorsUlett, Mark Andrew (Author) / Laubichler, Manfred D (Thesis advisor) / Hall, Brian K (Committee member) / Lynch, John (Committee member) / Maienschein, Jane (Committee member) / Smocovitis, Vassiliki B (Committee member) / Arizona State University (Publisher)
Created2014
Description
The rise of meat consumption in the United States has been dramatic over
the past half century due to demographic changes. The increase in meat is visible in Mexico as well due to expanding economic interest in cattle production plus increased population and rising incomes. The worst consequences of our modern food system are in factory farming of animals, which requires a greater amount of resources than for producing grains, fruits, and vegetables. The specific effects of meat consumption highlight the importance of understanding humans as actors in the food system. In order to explore the drivers of consumer food and meat choice, my research answered the two questions: What factors influence meat consumption? and How do cultural and social norms influence decisions to consume certain types and amounts of meat?
Qualitative interviews were conducted with Mexican-American respondents between age 20 and 29 as the population of interest because of their regional dominance in the study area of Tempe, AZ and because of the high prevalence of meat in their cultural diets. Looking at millennials in particular is crucial because as the first generation born with technology and Internet as constants, they have formed unique characteristics like openness to change and new perspectives. My sample population communicated motivations and constraints to their overall consumption patterns and the frequency and types of meat consumed.
This study found that cost and convenience were the driving factors behind food choice, given the hectic schedules of the sample population, who were mostly students at Arizona State University. Culture played an important role in respondents' heavy meat consumption given their exposure to meat's centrality in traditional Mexican meals. Acculturation did not play an extensive role because prominent Mexican culture in the Southwest U.S. allowed respondents' families access to traditional food while living in the US. The lack of sustainability knowledge and its connection to food choice indicates the importance of marketing that contextualizes decreased meat consumption. Rather than focusing solely on environmental outcomes, marketing tools highlighting health, financial, and economic benefits of eating less meat would encourage more consumers to decrease consumption.
the past half century due to demographic changes. The increase in meat is visible in Mexico as well due to expanding economic interest in cattle production plus increased population and rising incomes. The worst consequences of our modern food system are in factory farming of animals, which requires a greater amount of resources than for producing grains, fruits, and vegetables. The specific effects of meat consumption highlight the importance of understanding humans as actors in the food system. In order to explore the drivers of consumer food and meat choice, my research answered the two questions: What factors influence meat consumption? and How do cultural and social norms influence decisions to consume certain types and amounts of meat?
Qualitative interviews were conducted with Mexican-American respondents between age 20 and 29 as the population of interest because of their regional dominance in the study area of Tempe, AZ and because of the high prevalence of meat in their cultural diets. Looking at millennials in particular is crucial because as the first generation born with technology and Internet as constants, they have formed unique characteristics like openness to change and new perspectives. My sample population communicated motivations and constraints to their overall consumption patterns and the frequency and types of meat consumed.
This study found that cost and convenience were the driving factors behind food choice, given the hectic schedules of the sample population, who were mostly students at Arizona State University. Culture played an important role in respondents' heavy meat consumption given their exposure to meat's centrality in traditional Mexican meals. Acculturation did not play an extensive role because prominent Mexican culture in the Southwest U.S. allowed respondents' families access to traditional food while living in the US. The lack of sustainability knowledge and its connection to food choice indicates the importance of marketing that contextualizes decreased meat consumption. Rather than focusing solely on environmental outcomes, marketing tools highlighting health, financial, and economic benefits of eating less meat would encourage more consumers to decrease consumption.
ContributorsNamugayi, Deborah (Author) / Larson, Kelli L (Thesis advisor) / Klinsky, Sonja (Committee member) / Redman, Erin (Committee member) / Arizona State University (Publisher)
Created2014
Description
Studies of governance have focused on the interactions among diverse actors while implicitly recognizing the role of power within those relationships. Explicit power analyses of water governance coordination are needed to better understand the conditions for and barriers to sustainability. I therefore utilized a novel conceptual framework to analyze vertical and horizontal governance, along with power, to address how governance interactions affect water sustainability in terms of (1) interactions among governance actors across local to state levels; (2) coordination among actors at the local level; and (3) the exercise of power among assorted actors. I adopted a qualitative case study methodology that involved triangulating interview transcripts, policy documents, and other data in the case study area of Prescott, Arizona.
Across governance scales, my analysis found that informational and contentious interactions occur around water management plans, groundwater withdrawal fees, and growth debates due to the stipulations of Arizona’s Groundwater Management Act. Locally, municipalities in different groundwater basins coordinate by pooling resources for water development due to shared growth visions. However, municipalities within the same groundwater basin are divided in their pursuit of the state-mandated goal of safe yield due to discontent arising from differing growth visions, libertarian values of water control, and unequal responsibilities among actors in conserving water or monitoring use. Finally, local and state actors exercise power through litigation, legislation, and political processes to pursue their interests, thereby limiting coordination for water sustainability.
My explicit analysis of power reveals that coordination occurs not just because of water policies but due to interest-based water narratives (growth and libertarian). The emphasis of growth proponents on supply augmentation and libertarian opposition to regulations pose significant barriers to water sustainability. Successful policy-based pursuits of water sustainability will, thus, require an acknowledgment of these management asymmetries and commitments to addressing them.
Across governance scales, my analysis found that informational and contentious interactions occur around water management plans, groundwater withdrawal fees, and growth debates due to the stipulations of Arizona’s Groundwater Management Act. Locally, municipalities in different groundwater basins coordinate by pooling resources for water development due to shared growth visions. However, municipalities within the same groundwater basin are divided in their pursuit of the state-mandated goal of safe yield due to discontent arising from differing growth visions, libertarian values of water control, and unequal responsibilities among actors in conserving water or monitoring use. Finally, local and state actors exercise power through litigation, legislation, and political processes to pursue their interests, thereby limiting coordination for water sustainability.
My explicit analysis of power reveals that coordination occurs not just because of water policies but due to interest-based water narratives (growth and libertarian). The emphasis of growth proponents on supply augmentation and libertarian opposition to regulations pose significant barriers to water sustainability. Successful policy-based pursuits of water sustainability will, thus, require an acknowledgment of these management asymmetries and commitments to addressing them.
ContributorsAyodele, Deborah Olufunmilola (Author) / Larson, Kelli L (Thesis advisor) / Bolin, Robert (Committee member) / Manuel-Navarrete, David (Committee member) / Arizona State University (Publisher)
Created2017
Description
Understanding changes and trends in biomedical knowledge is crucial for individuals, groups, and institutions as biomedicine improves people’s lives, supports national economies, and facilitates innovation. However, as knowledge changes what evidence illustrates knowledge changes? In the case of microbiome, a multi-dimensional concept from biomedicine, there are significant increases in publications, citations, funding, collaborations, and other explanatory variables or contextual factors. What is observed in the microbiome, or any historical evolution of a scientific field or scientific knowledge, is that these changes are related to changes in knowledge, but what is not understood is how to measure and track changes in knowledge. This investigation highlights how contextual factors from the language and social context of the microbiome are related to changes in the usage, meaning, and scientific knowledge on the microbiome. Two interconnected studies integrating qualitative and quantitative evidence examine the variation and change of the microbiome evidence are presented. First, the concepts microbiome, metagenome, and metabolome are compared to determine the boundaries of the microbiome concept in relation to other concepts where the conceptual boundaries have been cited as overlapping. A collection of publications for each concept or corpus is presented, with a focus on how to create, collect, curate, and analyze large data collections. This study concludes with suggestions on how to analyze biomedical concepts using a hybrid approach that combines results from the larger language context and individual words. Second, the results of a systematic review that describes the variation and change of microbiome research, funding, and knowledge are examined. A corpus of approximately 28,000 articles on the microbiome are characterized, and a spectrum of microbiome interpretations are suggested based on differences related to context. The collective results suggest the microbiome is a separate concept from the metagenome and metabolome, and the variation and change to the microbiome concept was influenced by contextual factors. These results provide insight into how concepts with extensive resources behave within biomedicine and suggest the microbiome is possibly representative of conceptual change or a preview of new dynamics within science that are expected in the future.
ContributorsAiello, Kenneth (Author) / Laubichler, Manfred D (Thesis advisor) / Simeone, Michael (Committee member) / Buetow, Kenneth (Committee member) / Walker, Sara I (Committee member) / Arizona State University (Publisher)
Created2018
Description
This research investigates the biophysical and institutional mechanisms affecting the distribution of metals in the Sonoran Desert of Arizona. To date, a long-term, interdisciplinary perspective on metal pollution in the region has been lacking. To address this gap, I integrated approaches from environmental chemistry, historical geography, and institutional economics to study the history of metal pollution in the desert. First, by analyzing the chemistry embodied in the sequentially-grown spines of long-lived cacti, I created a record of metal pollution that details biogeochemical trends in the desert since the 1980s. These data suggest that metal pollution is not simply a legacy of early industrialization. Instead, I found evidence of recent metal pollution in both the heart of the city and a remote, rural location. To understand how changing land uses may have contributed to this, I next explored the historical geography of industrialization in the desert. After identifying cities and mining districts as hot spots for airborne metals, I used a mixture of historical reports, maps, and memoirs to reconstruct the industrial history of these polluted landscapes. In the process, I identified three key transitions in the energy-metal nexus that drove the redistribution of metals from mineral deposits to urban communities. These transitions coincided with the Columbian exchange, the arrival of the railroads, and the economic restructuring that accompanied World War II. Finally, to determine how legal and political forces may be influencing the fate of metals, I studied the evolution of the rights and duties affecting metals in their various forms. This allowed me to track changes in the institutions regulating metals from the mining laws of the 19th century through their treatment as occupational and public health hazards in the 20th century. In the process, I show how Arizona’s environmental and resource institutions were often transformed by extra-territorial concerns. Ultimately, this created an institutional system that compartmentalizes metals and fails to appreciate their capacity to mobilize across legal and biophysical boundaries to accumulate in the environment. Long-term, interdisciplinary perspectives such as this are critical for untangling the complex web of elements and social relations transforming the modern world.
ContributorsHester, Cyrus M (Author) / Larson, Kelli L (Thesis advisor) / Laubichler, Manfred D (Thesis advisor) / MacFadyen, Joshua (Committee member) / Arizona State University (Publisher)
Created2019
Description
Studies in neocortical neurogenesis have experienced an explosive growth since the early 2000s, measured by the increasing number of publications each year. I examine here the influence of Arnold Kriegstein in the field using Topic Modeling, a set of algorithms that can be applied to a collection of texts to elucidate the central themes of said collection. Using a Java-based software called MALLET, I obtained data for his corpus, and compared it to the texts of other researchers in the field. This latter collection, which I dub "General Corpus", was separated by year from 2000 to 2014. I found that Kriegstein's most frequently discussed topic concerned highly unique terms such as GABA, glutamate, and receptor, which did not appear in any of the primary topics of the General Corpus. This was in contrast to my initial hypothesis that Kriegstein's importance stemmed from his examination of different phenomena that constitute the broader aspect of neocortical neurogenesis. I predicted that the terms in Kriegstein's primary topic would appear many times throughout the topics of the General Corpus, but it was not so, aside from the common ones such as neurons, cortical, and development. Taken in tandem with NIH Reporter data, these results suggest that Kriegstein obtains a large amount of research funding because his studies concern unique topics when compared to others in the field. The implications of these findings are especially relevant in a world where funding is becoming increasingly difficult to come by.
ContributorsChhetri, Chandra Divyash (Author) / Laubichler, Manfred (Thesis director) / Maienschein, Jane (Committee member) / Aiello, Kenneth (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
As a result of growing populations and uncertain resource availability, urban areas are facing pressure from federal and state agencies, as well as residents, to promote conservation programs that provide services for people and mitigate environmental harm. Current strategies in US cities aim to reduce the impact of municipal and household resource use, including programs to promote water conservation. One common conservation program incentivizes the replacement of water-intensive turfgrass lawns with landscapes that use less water consisting of interspersed drought-tolerant shrubs and trees with rock or mulch groundcover (e.g. xeriscapes, rain gardens, water-wise landscapes). A handful of previous studies in experimental landscapes have shown that converting a turfgrass yard to a shrub-dominated landscape has the potential to increase rates of nitrate (NO3-) leaching. However, no studies have examined the drivers or patterns across diverse management practices. In this research, I compared soil nutrient retention and cycling in turfgrass and lawn-alternative xeriscaped yards along a chronosequence of time since land cover change in Tempe, Arizona, in the semi-arid US Southwest. Soil inorganic extractable nitrogen (N) pools were greater in xeriscapes compared to turfgrass lawns. On average xeriscapes contained 2.5±0.4 g NO3--N/m2 in the first 45 cm of soil, compared to 0.6±0.7 g NO3--N/m2 in lawns. Soil NO3--N pools in xeriscaped yards also varied significantly with time: pools were largest 9-13 years after cover change and declined to levels comparable to turfgrass at 18-21 years. Variation in soil extractable NO3--N with landscape age was strongly influenced by management practices that control soil water availability, including shrub cover, the presence of sub-surface plastic sheeting, and the frequency of irrigation. This research is the first to explore the ecological outcomes and temporal dynamics of an increasingly common, ‘sustainable’ land use practice that is universally promoted in US cities. Our findings show that transitioning from turfgrass to water-efficient residential landscaping can lead to an accumulation of NO3--N that may be lost from the soil rooting zone over time, through leaching following irrigation or rainfall. These results have implications for best management practices to optimize the benefits of water-conserving residential yards.
ContributorsHeavenrich, Hannah (Author) / Hall, Sharon J (Thesis advisor) / Larson, Kelli L (Committee member) / Potaki, Diane E (Committee member) / Arizona State University (Publisher)
Created2015
Description
How fast is evolution? In this dissertation I document a profound change that occurred around the middle of the 20th century in the way that ecologists conceptualized the temporal and spatial scales of adaptive evolution, through the lens of British plant ecologist Anthony David Bradshaw (1926–2008). In the early 1960s, one prominent ecologist distinguished what he called “ecological time”—around ten generations—from “evolutionary time”— around half of a million years. For most ecologists working in the first half of the 20th century, evolution by natural selection was indeed a slow and plodding process, tangible in its products but not in its processes, and inconsequential for explaining most ecological phenomena. During the 1960s, however, many ecologists began to see evolution as potentially rapid and observable. Natural selection moved from the distant past—a remote explanans for both extant biological diversity and paleontological phenomena—to a measurable, quantifiable mechanism molding populations in real time.
The idea that adaptive evolution could be rapid and highly localized was a significant enabling condition for the emergence of ecological genetics in the second half of the 20th century. Most of what historians know about that conceptual shift and the rise of ecological genetics centers on the work of Oxford zoologist E. B. Ford and his students on polymorphism in Lepidotera, especially industrial melanism in Biston betularia. I argue that ecological genetics in Britain was not the brainchild of an infamous patriarch (Ford), but rather the outgrowth of a long tradition of pastureland research at plant breeding stations in Scotland and Wales, part of a discipline known as “genecology” or “experimental taxonomy.” Bradshaw’s investigative activities between 1948 and 1968 were an outgrowth of the specific brand of plant genecology practiced at the Welsh and Scottish Plant Breeding stations. Bradshaw generated evidence that plant populations with negligible reproductive isolation—separated by just a few meters—could diverge and adapt to contrasting environmental conditions in just a few generations. In Bradshaw’s research one can observe the crystallization of a new concept of rapid adaptive evolution, and the methodological and conceptual transformation of genecology into ecological genetics.
The idea that adaptive evolution could be rapid and highly localized was a significant enabling condition for the emergence of ecological genetics in the second half of the 20th century. Most of what historians know about that conceptual shift and the rise of ecological genetics centers on the work of Oxford zoologist E. B. Ford and his students on polymorphism in Lepidotera, especially industrial melanism in Biston betularia. I argue that ecological genetics in Britain was not the brainchild of an infamous patriarch (Ford), but rather the outgrowth of a long tradition of pastureland research at plant breeding stations in Scotland and Wales, part of a discipline known as “genecology” or “experimental taxonomy.” Bradshaw’s investigative activities between 1948 and 1968 were an outgrowth of the specific brand of plant genecology practiced at the Welsh and Scottish Plant Breeding stations. Bradshaw generated evidence that plant populations with negligible reproductive isolation—separated by just a few meters—could diverge and adapt to contrasting environmental conditions in just a few generations. In Bradshaw’s research one can observe the crystallization of a new concept of rapid adaptive evolution, and the methodological and conceptual transformation of genecology into ecological genetics.
ContributorsPeirson, Bruce Richard Erick (Author) / Laubichler, Manfred D (Thesis advisor) / Maienschein, Jane (Thesis advisor) / Creath, Richard (Committee member) / Collins, James (Committee member) / Arizona State University (Publisher)
Created2015
Fisheries in the news: how the media sets the agenda for seafood sustainability in the United States
Description
The media is a powerful force in shaping public discussions about marine issues. Many people lack first-hand experiences and direct sources of information about fisheries topics, so they rely heavily on the information presented to them in the news. Thus, the media has the potential to influence public agendas based on their selective coverage of topics, which primes people to take certain information into account when making decisions. This study examines the contents of 412 newspaper articles from five national newspapers to determine which topics are receiving the most coverage and how they are being communicated to the public. The analysis considers fisheries and seafood discussions overall, as well as focusing on the three most commonly consumed seafood items in the United States: salmon, shrimp, and tuna. Systematic coding of newspaper articles shows that economic and social fisheries concerns are emphasized more than environmental concerns. Additionally, fisheries articles tend to be emphasize the importance of fishermen’s livelihoods, the dangers of international seafood trade, the economic utility of fish, and a consumer’s right to make informed decisions about seafood. Overall, there are a number of conflicts and weaknesses in the media’s coverage of fisheries, which would likely make it challenging for Americans to make informed, sustainability-minded decisions about seafood purchases and fisheries policies.
ContributorsChipman, Danielle (Author) / Larson, Kelli L (Thesis advisor) / White, Dave (Committee member) / Klinsky, Sonja (Committee member) / Arizona State University (Publisher)
Created2016
Description
A central task for historians and philosophers of science is to characterize and analyze the epistemic practices in a given science. The epistemic practice of a science includes its explanatory goals as well as the methods used to achieve these goals. This dissertation addresses the epistemic practices in gene expression research spanning the mid-twentieth century to the twenty-first century. The critical evaluation of the standard historical narratives of the molecular life sciences clarifies certain philosophical problems with respect to reduction, emergence, and representation, and offers new ways with which to think about the development of scientific research and the nature of scientific change.
The first chapter revisits some of the key experiments that contributed to the development of the repression model of genetic regulation in the lac operon and concludes that the early research on gene expression and genetic regulation depict an iterative and integrative process, which was neither reductionist nor holist. In doing so, it challenges a common application of a conceptual framework in the history of biology and offers an alternative framework. The second chapter argues that the concept of emergence in the history and philosophy of biology is too ambiguous to account for the current research in post-genomic molecular biology and it is often erroneously used to argue against some reductionist theses. The third chapter investigates the use of network representations of gene expression in developmental evolution research and takes up some of the conceptual and methodological problems it has generated. The concluding comments present potential avenues for future research arising from each substantial chapter.
In sum, this dissertation argues that the epistemic practices of gene expression research are an iterative and integrative process, which produces theoretical representations of the complex interactions in gene expression as networks. Moreover, conceptualizing these interactions as networks constrains empirical research strategies by the limited number of ways in which gene expression can be controlled through general rules of network interactions. Making these strategies explicit helps to clarify how they can explain the dynamic and adaptive features of genomes.
The first chapter revisits some of the key experiments that contributed to the development of the repression model of genetic regulation in the lac operon and concludes that the early research on gene expression and genetic regulation depict an iterative and integrative process, which was neither reductionist nor holist. In doing so, it challenges a common application of a conceptual framework in the history of biology and offers an alternative framework. The second chapter argues that the concept of emergence in the history and philosophy of biology is too ambiguous to account for the current research in post-genomic molecular biology and it is often erroneously used to argue against some reductionist theses. The third chapter investigates the use of network representations of gene expression in developmental evolution research and takes up some of the conceptual and methodological problems it has generated. The concluding comments present potential avenues for future research arising from each substantial chapter.
In sum, this dissertation argues that the epistemic practices of gene expression research are an iterative and integrative process, which produces theoretical representations of the complex interactions in gene expression as networks. Moreover, conceptualizing these interactions as networks constrains empirical research strategies by the limited number of ways in which gene expression can be controlled through general rules of network interactions. Making these strategies explicit helps to clarify how they can explain the dynamic and adaptive features of genomes.
ContributorsRacine, Valerie (Author) / Maienschein, Jane (Thesis advisor) / Laubichler, Manfred D (Thesis advisor) / Creath, Richard (Committee member) / Newfeld, Stuart (Committee member) / Morange, Michel (Committee member) / Arizona State University (Publisher)
Created2016