Traumatic brain injury (TBI) is defined as an injury to the head that disrupts normal brain function. TBI has been described as a disease process that can lead to an increased risk for developing chronic neurodegenerative diseases, like frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). A pathological hallmark of FTLD and a hallmark of ALS is the nuclear mislocalization of TAR DNA Binding Protein 43 (TDP-43). This project aims to explore neurodegenerative effects of TBI on cortical lesion area using immunohistochemical markers of TDP-43 proteinopathies. We analyzed the total percent of NEUN positive cells displaying TDP-43 nuclear mislocalization. We found that the percent of NEUN positive cells displaying TDP-43 nuclear mislocalization was significantly higher in cortical tissue following TBI when compared to the age-matched control brains. The cortical lesion area was analyzed for each injured brain sample, with respect to days post-injury (DPI), and it was found that there were no statistically significant differences between cortical lesion areas across time points. The percent of NEUN positive cells displaying TDP-43 nuclear mislocalization was analyzed for each cortical tissue sample, with respect to cortical lesion area, and it was found that there were no statistically significant differences between the percent of NEUN positive cells displaying TDP-43 nuclear mislocalization, with respect to cortical lesion area. In conclusion, we found no correlation between the percent of cortical NEUN positive cells displaying TDP-43 nuclear mislocalization with respect to the size of the cortical lesion area.
The ASU School of Dance presents Emerging Artists I, February 9-12, with works by guest artists, dance faculty, and students, performed at Dance Studio Theatre, PEBE 132.
The ASU School of Dance presents Moving Ground, November 16-19, with works by dance faculty, graduate, and visiting artists, performed at the Dance Studio Theatre, PEBE 132.
The ASU School of Dance presents Emerging Artists II, February 14-17, with works by dance BA and MFA students Cassie Roberts, Katie McCaskill, Lydia Sakolsky-Basquill, Kelly Doherty, and Kristin Tovson, performed at the Dance Studio Theatre.
The ASU School of Dance presents Emerging Artists I, October 24-26, with works by dance MFA candidates Sara Malan-McDonald and Holly Woodridge, performed at the Dance Studio Theatre, PEBE 132.
The ASU School of Dance presents New Dance Works 3, January 24-27, with works by dance MFA candidates C-c Braun, Janie D. Ross, and Julia Vessey, performed at the Dance Studio Theatre.
The ASU School of Dance presents Emerging Artists II, November 14-16, with works by Samantha Basting and Kristin Tovson, performed at Dance Studio Theatre, PEBE 132.
The ASU School of Dance presents Emerging Artists II, February 22-24, with works by dance undergraduates and visiting artists, performed at the Dance Studio Theatre, PEBE 132.
The ASU School of Dance presents Lyric Reflections, November 15-18, with works by dance faculty, undergraduates, graduates, and visiting artists, performed at Galvin Playhouse Theatre.
The ASU School of Dance presents Nova, A New Trajectory, September 20-23, with works by dance faculty, alumni, graduate, undergraduate, and visiting artists, performed at Galvin Playhouse Theatre and Plaza.