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Shade plays an important role in designing pedestrian-friendly outdoor spaces in hot desert cities. This study investigates the impact of photovoltaic canopy shade and tree shade on thermal comfort through meteorological observations and field surveys at a pedestrian mall on Arizona State University’s Tempe campus. During the course of 1

Shade plays an important role in designing pedestrian-friendly outdoor spaces in hot desert cities. This study investigates the impact of photovoltaic canopy shade and tree shade on thermal comfort through meteorological observations and field surveys at a pedestrian mall on Arizona State University’s Tempe campus. During the course of 1 year, on selected clear calm days representative of each season, we conducted hourly meteorological transects from 7:00 a.m. to 6:00 p.m. and surveyed 1284 people about their thermal perception, comfort, and preferences. Shade lowered thermal sensation votes by approximately 1 point on a semantic differential 9-point scale, increasing thermal comfort in all seasons except winter. Shade type (tree or solar canopy) did not significantly impact perceived comfort, suggesting that artificial and natural shades are equally efficient in hot dry climates. Globe temperature explained 51 % of the variance in thermal sensation votes and was the only statistically significant meteorological predictor. Important non-meteorological factors included adaptation, thermal comfort vote, thermal preference, gender, season, and time of day. A regression of subjective thermal sensation on physiological equivalent temperature yielded a neutral temperature of 28.6 °C. The acceptable comfort range was 19.1 °C–38.1 °C with a preferred temperature of 20.8 °C. Respondents exposed to above neutral temperature felt more comfortable if they had been in air-conditioning 5 min prior to the survey, indicating a lagged response to outdoor conditions. Our study highlights the importance of active solar access management in hot urban areas to reduce thermal stress.

ContributorsMiddel, Ariane (Author) / Selover, Nancy (Author) / Hagen, Bjorn (Author) / Chhetri, Nalini (Author)
Created2016-05-18
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Description

We generated 5-meter resolution SVF maps for two neighborhoods in Phoenix, Arizona to illustrate fine-scale variations of intra-urban horizon limitations due to urban form and vegetation.

ContributorsMiddel, Ariane (Author) / Lukasczyk, Jonas (Author) / Maciejewski, Ross (Author) / University of Kaiserslautern (Contributor)
Created2017-03-17
Description

Every season from September to March in Taiji, Japan, around 23,000 dolphins, and other small cetaceans are slaughtered or sold to dolphinariums in the name of a 400-year-old tradition. The word ‘tradition’ is often used to rationalize and justify the terrible acts of animal cruelty, as seen in many countries

Every season from September to March in Taiji, Japan, around 23,000 dolphins, and other small cetaceans are slaughtered or sold to dolphinariums in the name of a 400-year-old tradition. The word ‘tradition’ is often used to rationalize and justify the terrible acts of animal cruelty, as seen in many countries such as bullfighting in Spain, fox hunting in Britain, Thanksgiving in America, and drive hunting in Japan. However, just because something is deemed as a tradition, does not mean it should not be challenged and judged against the standards of morality. Whale and dolphin hunting has stopped becoming a proud cultural tradition of small-scale subsistence whaling and has become a business run on wholesale slaughter and the exploitation of another species. The disconnect between the past and present has led to an evil distortion of the past.
However, this event cannot simply be explained by blaming solely greed and selfishness for driving this long-lasting tradition. By analyzing poems by Misuzu Kaneko, early hunting methods, memorial services, and graves built in the past and comparing them to the current hunting methods, dolphin shows, and the Taiji Whale Museum, one can determine the variety of factors driving these actions and find the point in time when the intentions of these practices shifted. By having a better understanding of the past and the present, one can follow a once-proud tradition becoming a source to justify unethical and cruel behavior.

ContributorsMinotto, Aoi (Author) / Middel, Ariane (Thesis director) / Hagen, Bjoern (Committee member) / Arts, Media and Engineering Sch T (Contributor) / School of Music, Dance and Theatre (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

This study examines the impact of spatial landscape configuration (e.g., clustered, dispersed) on land-surface temperatures (LST) over Phoenix, Arizona, and Las Vegas, Nevada, USA. We classified detailed land-cover types via object-based image analysis (OBIA) using Geoeye-1 at 3-m resolution (Las Vegas) and QuickBird at 2.4-m resolution (Phoenix). Spatial autocorrelation (local

This study examines the impact of spatial landscape configuration (e.g., clustered, dispersed) on land-surface temperatures (LST) over Phoenix, Arizona, and Las Vegas, Nevada, USA. We classified detailed land-cover types via object-based image analysis (OBIA) using Geoeye-1 at 3-m resolution (Las Vegas) and QuickBird at 2.4-m resolution (Phoenix). Spatial autocorrelation (local Moran’s I ) was then used to test for spatial dependence and to determine how clustered or dispersed points were arranged. Next, we used Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data acquired over Phoenix (daytime on 10 June and nighttime on 17 October 2011) and Las Vegas (daytime on 6 July and nighttime on 27 August 2005) to examine day- and nighttime LST with regard to the spatial arrangement of anthropogenic and vegetation features. Local Moran’s I values of each land-cover type were spatially correlated to surface temperature. The spatial configuration of grass and trees shows strong negative correlations with LST, implying that clustered vegetation lowers surface temperatures more effectively. In contrast, clustered spatial arrangements of anthropogenic land-cover types, especially impervious surfaces and open soil, elevate LST. These findings suggest that city planners and managers should, where possible, incorporate clustered grass and trees to disperse unmanaged soil and paved surfaces, and fill open unmanaged soil with vegetation. Our findings are in line with national efforts to augment and strengthen green infrastructure, complete streets, parking management, and transit-oriented development practices, and reduce sprawling, unwalkable housing development.

ContributorsMyint, Soe Win (Author) / Zheng, Baojuan (Author) / Talen, Emily (Author) / Fan, Chao (Author) / Kaplan, Shari (Author) / Middel, Ariane (Author) / Smith, Martin (Author) / Huang, Huei-Ping (Author) / Brazel, Anthony J. (Author)
Created2015-06-29
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Description

This study seeks to determine the role of land architecture—the composition and configuration of land cover—as well as cadastral/demographic/economic factors on land surface temperature (LST) and the surface urban heat island effect of Phoenix, Arizona. It employs 1 m National Agricultural Imagery Program data of land-cover with 120mLandsat-derived land surface

This study seeks to determine the role of land architecture—the composition and configuration of land cover—as well as cadastral/demographic/economic factors on land surface temperature (LST) and the surface urban heat island effect of Phoenix, Arizona. It employs 1 m National Agricultural Imagery Program data of land-cover with 120mLandsat-derived land surface temperature, decomposed to 30 m, a new measure of configuration, the normalized moment of inertia, and U.S. Census data to address the question for two randomly selected samples comprising 523 and 545 residential neighborhoods (census blocks) in the city. The results indicate that, contrary to most other studies, land configuration has a stronger influence on LST than land composition. In addition, both land configuration and architecture combined with cadastral, demographic, and economic variables, capture a significant amount of explained variance in LST. The results indicate that attention to land architecture in the development of or reshaping of neighborhoods may ameliorate the summer extremes in LST.

ContributorsLi, Xiaoxiao (Author) / Li, Wenwen (Author) / Middel, Ariane (Author) / Harlan, Sharon L. (Author) / Brazel, Anthony J. (Author) / Turner II, B. L. (Author)
Created2015-12-29
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Description

Objectives: To provide novel quantification and advanced measurements of surface temperatures (Ts) in playgrounds, employing multiple scales of data, and provide insight into hot-hazard mitigation techniques and designs for improved environmental and public health.

Methods: We conduct an analysis of Ts in two Metro-Phoenix playgrounds at three scales: neighborhood (1 km

Objectives: To provide novel quantification and advanced measurements of surface temperatures (Ts) in playgrounds, employing multiple scales of data, and provide insight into hot-hazard mitigation techniques and designs for improved environmental and public health.

Methods: We conduct an analysis of Ts in two Metro-Phoenix playgrounds at three scales: neighborhood (1 km resolution), microscale (6.8 m resolution), and touch-scale (1 cm resolution). Data were derived from two sources: airborne remote sensing (neighborhood and microscale) and in situ (playground site) infrared Ts (touch-scale). Metrics of surface-to-air temperature deltas (Ts–a) and scale offsets (errors) are introduced.

Results: Select in situ Ts in direct sunlight are shown to approach or surpass values likely to result in burns to children at touch-scales much finer than Ts resolved by airborne remote sensing. Scale offsets based on neighbourhood and microscale ground observations are 3.8 ◦C and 7.3 ◦C less than the Ts–a at the 1 cm touch-scale, respectively, and 6.6 ◦C and 10.1 ◦C lower than touch-scale playground equipment Ts, respectively. Hence, the coarser scales underestimate high Ts within playgrounds. Both natural (tree) and artificial (shade sail) shade types are associated with significant reductions in Ts.

Conclusions: A scale mismatch exists based on differing methods of urban Ts measurement. The sub-meter touch-scale is the spatial scale at which data must be collected and policies of urban landscape design and health must be executed in order to mitigate high Ts in high-contact environments such as playgrounds. Shade implementation is the most promising mitigation technique to reduce child burns, increase park usability, and mitigate urban heating.

ContributorsVanos, Jennifer K. (Author) / Middel, Ariane (Author) / McKercher, Grant R. (Author) / Kuras, Evan R. (Author) / Ruddell, Benjamin L. (Author)
Created2015-11-10
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Description
As the world energy demand increases, semiconductor devices with high energy conversion efficiency become more and more desirable. The energy conversion consists of two distinct processes, namely energy generation and usage. In this dissertation, novel multi-junction solar cells and light emitting diodes (LEDs) are proposed and studied for

As the world energy demand increases, semiconductor devices with high energy conversion efficiency become more and more desirable. The energy conversion consists of two distinct processes, namely energy generation and usage. In this dissertation, novel multi-junction solar cells and light emitting diodes (LEDs) are proposed and studied for high energy conversion efficiency in both processes, respectively. The first half of this dissertation discusses the practically achievable energy conversion efficiency limit of solar cells. Since the demonstration of the Si solar cell in 1954, the performance of solar cells has been improved tremendously and recently reached 41.6% energy conversion efficiency. However, it seems rather challenging to further increase the solar cell efficiency. The state-of-the-art triple junction solar cells are analyzed to help understand the limiting factors. To address these issues, the monolithically integrated II-VI and III-V material system is proposed for solar cell applications. This material system covers the entire solar spectrum with a continuous selection of energy bandgaps and can be grown lattice matched on a GaSb substrate. Moreover, six four-junction solar cells are designed for AM0 and AM1.5D solar spectra based on this material system, and new design rules are proposed. The achievable conversion efficiencies for these designs are calculated using the commercial software package Silvaco with real material parameters. The second half of this dissertation studies the semiconductor luminescence refrigeration, which corresponds to over 100% energy usage efficiency. Although cooling has been realized in rare-earth doped glass by laser pumping, semiconductor based cooling is yet to be realized. In this work, a device structure that monolithically integrates a GaAs hemisphere with an InGaAs/GaAs quantum-well thin slab LED is proposed to realize cooling in semiconductor. The device electrical and optical performance is calculated. The proposed device then is fabricated using nine times photolithography and eight masks. The critical process steps, such as photoresist reflow and dry etch, are simulated to insure successful processing. Optical testing is done with the devices at various laser injection levels and the internal quantum efficiency, external quantum efficiency and extraction efficiency are measured.
ContributorsWu, Songnan (Author) / Zhang, Yong-Hang (Thesis advisor) / Menéndez, Jose (Committee member) / Ponce, Fernando (Committee member) / Belitsky, Andrei (Committee member) / Schroder, Dieter (Committee member) / Arizona State University (Publisher)
Created2010
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Description

As life expectancy increases worldwide, age related diseases are becoming greater health concerns. One of the most prevalent age-related diseases in the United States is dementia, with Alzheimer’s disease (AD) being the most common form, accounting for 60-80% of cases. Genetics plays a large role in a person’s risk of

As life expectancy increases worldwide, age related diseases are becoming greater health concerns. One of the most prevalent age-related diseases in the United States is dementia, with Alzheimer’s disease (AD) being the most common form, accounting for 60-80% of cases. Genetics plays a large role in a person’s risk of developing AD. Familial AD, which makes up less than 1% of all AD cases, is caused by autosomal dominant gene mutations and has almost 100% penetrance. Genetic risk factors are believed to make up about 49%-79% of the risk in sporadic cases. Many different genetic risk factors for both familial and sporadic AD have been identified, but there is still much work to be done in the field of AD, especially in non-Caucasian populations. This review summarizes the three major genes responsible for familial AD, namely APP, PSEN1 and PSEN2. Also discussed are seven identified genetic risk factors for sporadic AD, single nucleotide polymorphisms in the APOE, ABCA7, NEDD9, CASS4, PTK2B, CLU, and PICALM genes. An overview of the main function of the proteins associated with the genes is given, along with the supposed connection to AD pathology.

ContributorsRichey, Alexandra Emmeline (Author) / Brafman, David (Thesis director) / Raman, Sreedevi (Committee member) / School of International Letters and Cultures (Contributor) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
Cell viability is an important assessment in cell culture to characterize the health of the cell population and confirm if cells are alive. Morphology or end-line assays are used to determine cell viability of entire populations. Intracellular pO2 levels is indicative of cell health and metabolism that can be used

Cell viability is an important assessment in cell culture to characterize the health of the cell population and confirm if cells are alive. Morphology or end-line assays are used to determine cell viability of entire populations. Intracellular pO2 levels is indicative of cell health and metabolism that can be used as a factor to asses cell viability in an in-line assay. Siloxane based pO2 sensing nanoprobes present a modality to visualize intracellular pO2. Using fluorescent lifetime imaging microscopy (FLIM), pO2 levels can be mapped intracellular as a highly functional in-line assay for cell viability. FLIM is an imaging modality that reconstructs an image based of its fluorescent lifetime. Nanoprobes were synthesized in different manufacturing/storage conditions. The nanoprobes for both long- and short-term storage were characterized in a cell free environment testing for changes in fluorescent intensity, average and maximum nanoprobe diameter. The nanoprobes were validated in two different culture systems, 2D and microcarrier culture systems, for human derived neural progenitor cells (NPCs) and neurons. Long- and short-term storage nanoprobes were used to label different neuronal based culture systems to asses labeling efficiency through fluorescent microscopy and flow cytometry. NPCs and neurons in each culture system was tested to see if nanoprobe labeling effected cellular phenotype for traits such as: cell proliferation, gene expression, and calcium imaging. Long-term and short-term storage nanoprobes were successfully validated for both NPCs and neurons in all culture systems. Assessments of the pO2 sensing nanoprobes will be further developed to create a highly functional and efficient in-line test for cell viability.
ContributorsLeyasi, Salma (Author) / Brafman, David (Thesis director) / Kodibagkar, Vikram (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Description
Over 5.8 million people are currently living with Alzheimer’s disease (AD), with the sixth highest mortality rate in the United States. No known cure or substantially life-extending treatment exists. With the growing aging population these numbers are only expected to increase to about 13.8 million by the year 2050. Alzheimer’s

Over 5.8 million people are currently living with Alzheimer’s disease (AD), with the sixth highest mortality rate in the United States. No known cure or substantially life-extending treatment exists. With the growing aging population these numbers are only expected to increase to about 13.8 million by the year 2050. Alzheimer’s is a multifactorial disease, giving rise to two main types: familial AD (FAD) and sporadic AD (SAD). Although there are different factors associated with each type of the disease, both FAD and SAD result in neuronal and synaptic loss and remain difficult to model in-vitro and treat overall.

Current advances in cellular models of neurodegenerative diseases overcome a variety of limitations possessed in animal and post-mortem human models. Human-induced pluripotent stem cells (hiPSCs) provide a platform with cells that can self-renew and differentiate into mature and functional cell types. HiPSCs are at the forefront of neurodegenerative disease research because of their ability to differentiate into neural cell types. Apolipoprotein E (ApoE) is a protein encoded by the APOE gene found on chromosome 19 of the human genome. There are three common polymorphisms in the APOE gene, resulting from a single amino acid change in the protein. The presence of these polymorphisms are studied as associated risk factors of developing AD. Different combinations of these alleles closely relate to the risk a patient has in developing Alzheimer’s disease. The risk associated effects of this gene are primarily investigated, however the protective effects are not examined to the same extent.

This research aims to overcome the existing limitations in cell differentiations and improve cell population purity that limits the variables present in the culture. To do this, this study optimized a differentiation protocol by separating and purifying neuronal cell populations to study the potential protective effects associated with ApoE, a risk factor seen in SAD. This platform aims to use a purified cell population to effectively analyze cell type specific affects of the ApoE risk factor, specifically in neurons.
ContributorsFrisch, Carlye Arin (Author) / Brafman, David (Thesis director) / Tian, Xiaojun (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05