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Description
The influenza virus is the main cause of thousands of deaths each year in the United States, and far more hospitalizations. Immunization has helped in protecting people from this virus and there are a number of therapeutics which have proven effective in aiding people infected with the virus. However, these therapeutics are subject to various limitations including increased resistance, limited supply, and significant side effects. A new therapeutic is needed which addresses these problems and protects people from the influenza virus. Synbodies, synthetic antibodies, may provide a means to achieve this goal. Our group has produced a synbody, the 5-5 synbody, which has been shown to bind to and inhibit the influenza virus. The direct pull down and western blot techniques were utilized to investigate how the synbody bound to the influenza virus. Our research showed that the 5-5 synbody bound to the influenza nucleoprotein (NP) with a KD of 102.9 ± 74.48 nM. It also showed that the synbody bound strongly to influenza viral extract from two different strains of the virus, the Puerto Rico (H1N1) and Sydney (H3N2) strains. This research demonstrated that the 5-5 synbody binds with high affinity to NP, which is important because influenza NP is highly conserved between various strains of the virus and plays an important role in the replication of the viral genome. It also demonstrated that this binding is conserved between various strains of the virus, indicating that the 5-5 synbody potentially could bind many different influenza strains. This synbody may have potential as a therapeutic in the future if it is able to demonstrate similar binding in vivo.
ContributorsKombe, Albert E. (Author) / Diehnelt, Chris (Thesis director) / Woodbury, Neal (Committee member) / Legutki, Bart (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of International Letters and Cultures (Contributor)
Created2014-05
Description
Patients receive electroconvulsive therapy every day in the United States but negative media representations of the therapy put doubts in the minds of potential patients as to whether or not they should go through with the therapy or not. The purpose of this study was to explore how health care providers perceive the influence of media on patient decision-making regarding whether or not to receive electroconvulsive therapy (ECT) and how they might address the perceived effects of said media. A total of 16 articles were analyzed in a literature review regarding the media's portrayal of ECT and/or how it affected patients and one interview with a physician was conducted. It was found that while the current literature still largely focuses on the negative media and its implications on patient decision-making, the physician had a more positive viewpoint. As a whole, the literature and physician agreed that media played a role in patients' decisions, but the media's portrayal of the therapy was not seen as negatively by the physician.
ContributorsIssar, Stephanie Marie (Author) / Pickens, Judith (Thesis director) / Sayles, Judy (Committee member) / Fargotstein, Barbara (Committee member) / Barrett, The Honors College (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / Department of Psychology (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2013-05
Description
The purpose of this study was to explore how the phenomenon of familismo effects behavioral change within the Mexican-American family if one member of the family participates in an obesity prevention curriculum. The qualitative approach findings indicate that the principle of familismo regarding perceived responsibility to provide emotional support to family members regarding changes in physical activity and dietary habits. Participants reported that their families are eating healthier, since, they started the obesity prevention curriculum. The findings regarding physical activity were inconclusive. This study can help nurses, because it emphasizes the importance of promoting family involvement as a motivator for behavioral change, in terms of physical activity and healthy diet eating, within Mexican-American populations.
ContributorsRodriguez, Manuela (Author) / Stevens, Carol (Thesis director) / Perez, Adriana (Committee member) / Luft, Linda (Committee member) / Barrett, The Honors College (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor)
Created2013-05
Description
Family planning educational programs offer a list of artificial contraceptive methods to couples wishing to avoid a pregnancy; however, many of these methods have disadvantages: many lead to negative individual and environmental health outcomes, do not promote a sense of fertility awareness in women and men, may be culturally incompatible with certain religious beliefs and worldviews, and do not take into account the full extent of family planning, which includes the ability to achieve as well as to avoid a pregnancy. Natural Family Planning (NFP) is a true method of family planning in that it offers to the couple the option to achieve as well as avoid a pregnancy. NFP methods holistically approach fertility by taking into account the woman's unique fertility cycle and patterns, the need for the couple to understand complex fertility issues, and the needs and family planning intentions of the couple as a whole. This thesis utilizes Evidence Based Practice in an effort to search the best literature regarding the effectiveness of Natural Family Planning methods to avoid a pregnancy, in comparison to the effectiveness of artificial contraceptive methods to avoid a pregnancy. If effectiveness rates are similar, it is reasonable for the health care profession to consider Natural Family Planning as a valid and reliable family planning method, to move towards further research on its effectiveness and benefits, and to implement a practice change by including it in family planning client education programs.
ContributorsBevilacqua, Angela Marie (Author) / Uriri-Glover, Johannah (Thesis director) / Milowski, Meredith (Committee member) / Barrett, The Honors College (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor)
Created2013-12
Description
Abstract
Objective: The purpose of this literature review is to examine the most psychometrically sound (e.g., valid and reliable) instruments measuring physical activity (PA) so that reflection of preschool children’s activity and documentation of intervention effects on preschool child PA is accurate.
Methods: Rigorous validation and calibration studies and those studies designed to test the psychometric properties of PA measurement instruments were specifically sought out to include in this review. Articles were excluded if they did not include specific information about the validity and reliability of the PA measures used with preschool children.
Discussion: Of the six articles reviewed, the systematic review used the most rigorous protocols to conduct its review, yielding the highest level of evidence appraising several validation studies. Because Pfeiffer et al. (2006) utilized the most valid and reliable criterion measure (Cosmed® portable metabolic system), the validation study this research team conducted is deemed to have identified the most valid and reliable cut points to utilize when reducing accelerometry data.
Conclusion: Current cut-points vary widely and greatly affect the reported results of a study. Therefore, it is critical that authors reference validation studies used to support the cut-points that were employed in the data-reduction phase. Currently, validation methods have been identified using high quality criterion measures in rigorous validation studies and thus it is strongly recommended that those cut points be used in data reduction processes.
Objective: The purpose of this literature review is to examine the most psychometrically sound (e.g., valid and reliable) instruments measuring physical activity (PA) so that reflection of preschool children’s activity and documentation of intervention effects on preschool child PA is accurate.
Methods: Rigorous validation and calibration studies and those studies designed to test the psychometric properties of PA measurement instruments were specifically sought out to include in this review. Articles were excluded if they did not include specific information about the validity and reliability of the PA measures used with preschool children.
Discussion: Of the six articles reviewed, the systematic review used the most rigorous protocols to conduct its review, yielding the highest level of evidence appraising several validation studies. Because Pfeiffer et al. (2006) utilized the most valid and reliable criterion measure (Cosmed® portable metabolic system), the validation study this research team conducted is deemed to have identified the most valid and reliable cut points to utilize when reducing accelerometry data.
Conclusion: Current cut-points vary widely and greatly affect the reported results of a study. Therefore, it is critical that authors reference validation studies used to support the cut-points that were employed in the data-reduction phase. Currently, validation methods have been identified using high quality criterion measures in rigorous validation studies and thus it is strongly recommended that those cut points be used in data reduction processes.
ContributorsAcuna, Kelsey Manique (Author) / Jacobson, Diana (Thesis director) / Small, Leigh (Committee member) / Barrett, The Honors College (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / W. P. Carey School of Business (Contributor)
Created2014-05
Description
One of the major challenges that were yet to be solved for solid phase peptide synthesis was the lack of an efficient peptide sequencing technique that was less hazardous, easier to perform , and was more cost-effective. Sequencing peptides were held important in the field of Chemistry and Biochemistry because it aided in drug discovery, finding ligands that bind to a specific target protein and finding alternative agents in transporting molecules to its desired location. Therefore, the overall purpose of this experiment was to develop a method of solid phase sequencing technique that was more environmental friendly, sequences at a faster rate, and was more cost-effective.
ContributorsCordovez, Lalaine Anne Ordiz (Author) / Woodbury, Neal (Thesis director) / Zhao, Zhan-Gong (Committee member) / Legutki, Joseph Barten (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-05
Description
This blog is to be used as a resource for communication
etworking and a tool for stress coping methods.
With this blog, it is my objective to aid my peers who might need help recognizing and coping with stress by the following methods:
a) Actualize the burden of Stress—Chronic stress is a burden and can be overwhelming if not managed. By disclosing my own stressors, it is my hope that peers will identify with me, so that I can then change the way they view and handle the stress.
b) Discuss the psychological and physical effects of stress on the body—It is my intent to clarify how unmanaged chronic stress can affect the physical and mental health and how acute stress is normal and healthy.
c) Share my coping methods that I have found effective in five minute or less videos with blurbs about how and why they are effective. I believe showing them to you in these mostly raw and unedited videos help maintain the current theme I am going for—keep things as real and raw as possible. Hopefully, these raw videos will help peers visualize working coping methods!
etworking and a tool for stress coping methods.
With this blog, it is my objective to aid my peers who might need help recognizing and coping with stress by the following methods:
a) Actualize the burden of Stress—Chronic stress is a burden and can be overwhelming if not managed. By disclosing my own stressors, it is my hope that peers will identify with me, so that I can then change the way they view and handle the stress.
b) Discuss the psychological and physical effects of stress on the body—It is my intent to clarify how unmanaged chronic stress can affect the physical and mental health and how acute stress is normal and healthy.
c) Share my coping methods that I have found effective in five minute or less videos with blurbs about how and why they are effective. I believe showing them to you in these mostly raw and unedited videos help maintain the current theme I am going for—keep things as real and raw as possible. Hopefully, these raw videos will help peers visualize working coping methods!
ContributorsLilley, Angela Marie (Author) / Stevens, Carol (Thesis director) / Borgiali, Daniela (Committee member) / Flucker, Ruth (Committee member) / Barrett, The Honors College (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor)
Created2013-05
Description
The purpose of this study is to learn about registered nurses' thoughts and experiences about the use of music and music therapy in the nursing field and whether or not nurses believe that there is supporting evidence practicing music therapy. Through an online survey administered to a local chapter of Sigma Theta Tau International Nursing Honors Society via SurveyMonkey, the study will 1) Assess the awareness and knowledge that registered nurses have regarding the use of music in the medical field. 2) Understand bedside nurses' willingness to use music as a complementary medicine in their own practices. 3) Ascertain where and how bedside nurses get knowledge about the use of music in the medical field. 4) Determine what constraints or barriers may influence bedside nurses' utilization of music in their practice. 5) The study will also examine the extent to which bedside nurses have had experience with observing music therapy or have utilized music therapists in their own practice.
ContributorsVintilescu, Maria Oana (Author) / Kenny, Katherine (Thesis director) / Jacobson, Diana (Committee member) / Barrett, The Honors College (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor)
Created2013-12
Description
This project focused on determining the nursing influences on first-time mothers during labor. Postpartum women at a local hospital participated by completing a reliable and valid questionnaire to rate the importance of specific nursing supportive behaviors during their labors. The data gathered from this research will provide insight to labor and delivery nurses about how to best care for their patients' emotional, physical, and informational needs
ContributorsKinney, Meghan Marie (Author) / Floegel, Theresa (Thesis director) / Jasper, Marcia (Committee member) / Barrett, The Honors College (Contributor) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor)
Created2013-12
Description
Historically, the study of cognition has focused on species-specific learning, memory, problem-solving and decision-making capabilities, and emphasis was placed on the few high-performing individuals who successfully completed cognitive tasks. Studies often deemed the success of a small fraction of individuals as suggestive of the cognitive capacity of the entire species. Recently though, interest in individual variation in cognitive ability within species has increased. This interest has emerged concomitantly with studies of variation in animal personalities (i.e. behavioral syndromes). Cognitive ability may be closely tied to personality because the mechanisms by which an individual perceives and uses environmental input (cognition) should influence how that individual consistently responds to various ecological demands (personality). However, empirical support for links between animal cognition and behavioral syndromes is currently lacking. I examined individual variation in cognition and personality in male veiled chameleons, Chamaeleo calyptratus. I considered three axes of personality (aggression, activity, and exploratory behavior) and cognition in a foraging context using visual cues − specifically, the ability to associate a color with a food reward. I found that aggression was positively correlated with the proportion of correct choices and number of consecutive correct choices. Also, one measure of exploration (the number of vines touched in a novel environment) was correlated negatively with the proportion of correct choices and positively with the number of consecutive incorrect decisions. My investigation suggests that more aggressive, less exploratory chameleons were more successful learners, and that there exists a shared pathway between these personality traits and cognitive ability.
ContributorsBruemmer, Sarah Adele (Author) / McGraw, Kevin (Thesis director) / Rutowski, Ronald (Committee member) / Ligon, Russell (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2013-05