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The goal of this project was to design and create a genetic construct that would allow for <br/>tumor growth to be induced in the center of the wing imaginal disc of Drosophila larvae, the <br/>R85E08 domain, using a heat shock. The resulting transgene would be combined with other <br/>transgenes in a single fly that would allow for simultaneous expression of the oncogene and, in <br/>the surrounding cells, other genes of interest. This system would help establish Drosophila as a <br/>more versatile and reliable model organism for cancer research. Furthermore, pilot studies were <br/>performed, using elements of the final proposed system, to determine if tumor growth is possible <br/>in the center of the disc, which oncogene produces the best results, and if oncogene expression <br/>induced later in development causes tumor growth. Three different candidate genes were <br/>investigated: RasV12, PvrACT, and Avli.
ContributorsSt Peter, John Daniel (Author) / Harris, Rob (Thesis director) / Varsani, Arvind (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
A void exists in public administration, criminology, and criminal justice research as it relates to the study of power in American policing agencies. This has significant ramifications for academia and practitioners in terms of how they view, address, study, and interpret behaviors/actions in American policing agencies and organizations in general. In brief, mainstream research on power in organizations does not take into account relationships of power that do not act directly, and immediately, on others. By placing its emphasis on an agency centric perspective of power, the mainstream approach to the study of power fails to recognize indirect power relationships that influence discourse, pedagogy, mechanisms of communication, knowledge, and individual behavior/actions. In support of a more holistic inquiry, this study incorporates a Foucauldian perspective of power along with an ethnographical methodology and methods to build a greater understanding of power in policing organizations. This ethnography of an American policing organization illuminates the relationship between the exercise of power and the objectification of the subject through the interplay of relationships of communication, goal oriented activities, and relationships of power. Specifically, the findings demonstrate that sworn officers and civilian employees are objectified distinctly and dissimilarly. In summary, this study argues that the exercise of power in this American policing organization objectifies the civilian employee as a second class citizen.
ContributorsBentley, Paul C (Author) / Catlaw, Thomas (Thesis advisor) / Musheno, Michael (Committee member) / Lucio, Joanna (Committee member) / Arizona State University (Publisher)
Created2013
Description
Mixed-income housing policy has been an approach to address the problem of concentrated poverty since the 1990s. The idea of income mix in housing is founded on the proposition that economic opportunities of the poor can be expanded through the increasing of their social capital. The current in-depth case study of Vineyard Estates, a mixed-income housing development in Phoenix, AZ tests a hypothesis that low-income people improve their chances of upward social mobility by building ties with more affluent residents within the development. This study combines qualitative and quantitative methods to collect and analyze information including analysis of demographic data, resident survey and in-depth semi-structured interviews with residents, as well as direct observations. It focuses on examining the role of social networks established within the housing development in generating positive economic outcomes of the poor. It also analyzes the role of factors influencing interactions across income groups and barriers to upward social mobility. Study findings do not support that living in mixed-income housing facilitates residents' upward social mobility. The study concludes that chances of upward social mobility are restrained by structural factors and indicates a need to rethink the effectiveness of mixed-income housing as an approach for alleviating poverty.
ContributorsDurova, Aleksandra (Author) / Kamel, Nabil (Committee member) / Pfeiffer, Deirdre (Committee member) / Lucio, Joanna (Committee member) / Arizona State University (Publisher)
Created2013
Description
Government performance and accountability have grown to be predominant areas within public administration literature over the last forty years. The research presented in this dissertation examines the relationship between citizen satisfaction and local government performance. Citizen review of service delivery provides vital feedback that facilitates better resource management within local government. Using data from a single jurisdiction, two aspects of citizen satisfaction are reviewed. This includes citizen review of overall city performance, and citizen satisfaction with individual service delivery. Logit regression analysis is used to test several factors that affect citizen evaluation of service delivery in local government, while ordinary least squares regression is used to test the relationship between personal factors and citizen evaluation of specific local services. The results generated four major findings that contribute to the scholarly body of knowledge and local government knowledge application. First, citizens who are predisposed to supporting the local jurisdiction are more likely to rate service delivery high. Second, customer service is important. Third, those who experience government services similarly will collectively react similarly to the service experience. Finally, the length of residency has an impact on satisfaction levels with specific services. Implications for the literature as well as for practice are discussed.
ContributorsMcNamara, Catherine (Author) / Alozie, Nicholas O (Thesis advisor) / Cayer, Joseph (Thesis advisor) / Lucio, Joanna (Committee member) / Arizona State University (Publisher)
Created2012
Description
With more than one third of Americans considered to be obese, obesity is a public health issue in the United States. While obesity is linked to and caused by a number of factors, sugar sweetened beverage (SSB) consumption is a major contributor to increased obesity rates. For the purposes of this paper, SSBs will include any beverage in which sugar is added. This includes juices that are not 100% fruit juice, coffee or tea drinks that are sugar sweetened, energy or sport drinks, and most commonly, soda. Excess sugar in the diet is substantially linked to obesity and negative health effects. SSBs represent the primary source of added sugar in the average American diet. Part I of this paper will discuss obesity as a public health problem and establish the link between consumption of SSBs and poor health effects. Part II will discuss the public policy instrument families and the strengths and weaknesses of each policy approach. Part III will identify current policies specifically focused on curbing SSB consumption. Each policy will be analyzed for efficacy based on available scientific research. Lastly, Part IV will propose new policy alternatives and ways to improve current policies. A final policy recommendation will be presented as an ideal roadmap for policy makers looking to address the link between SSB consumption and obesity.
ContributorsSaria, Matthew Ricardo (Author) / Lucio, Joanna (Thesis director) / Holland, Thomas (Committee member) / School of Public Affairs (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The objective of this study was to access whether there were any associations between food insecurity, weight status and emotional eating for adults and youth, and to discover whether emotional eating was prevalent for both age groups. By gathering participants from six various low-income housing communities throughout the Phoenix, Arizona, the researchers were able to gather data from 114 participants, 57 adults and 57 youth. The participants were a convenience sample, and were recruited by flyers sent via the mail and door-to-door announcements in the spring and summer of 2014. The adult and youth were asked to complete a survey that was part of a larger study, which included the Weight-Related Eating Questionnaire to access the participants' emotional eating. The participants' height and weight were measured manually and were integrated into the BMI system, and the participants' food insecurity statuses were validated using the US Household Food Security Survey. The results of the study illustrated associations between food insecurity and emotional eating for adults, but not for youth. In addition, there were no associations between adults' emotional eating and their child's emotional eating. The results from this study were consisted with the current research examining the associations of food insecurity and emotional eating, where there is only a correlation between food insecurity and emotional eating for adults. However, this study was not consistent with past research accessing the associations between adults' emotional eating and their child's emotional eating since this study found no relationship between the two. Being that a cross-sectional survey-based research was incorporated into this study, further research needs to explore on food insecurity, weight status and emotional eating to determine their causality.
ContributorsVannortrick, Taylor Michelle (Author) / Bruening, Meg (Thesis director) / Lucio, Joanna (Committee member) / School of Nutrition and Health Promotion (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
Based upon personal involvement from August 2010 to July 2014 as a Marine Option Midshipman within the ASU Naval Reserves Officer Training Corps (NROTC), being a student of leadership training within my degree plan, and gender difference research I conducted, this creative project addresses potential issues that reside within the ASU NROTC and the ways in which the program overall can be changed for the Marine Options in order to bring about proper success and organization. In order to officially become a Marine within the Unites States Marine Corps, it is necessary for Marine Option students to fulfill Officer Candidate School (OCS) at Quantico, Virginia. As the first female to go through OCS as a midshipman from the ASU NROTC, I found that there is an inadequate amount of preparation and training given in regards to the gender differences and what is to be expected for successful completion. I will offer a brief history regarding the NROTC across the Unites States and the ASU NROTC itself. These subjects will cover the program layouts as well as the leadership training that is required and provided within it and the ways in which this is conducted. I will then compare and contrast this to the leadership training given to me within my study of Leadership and Ethics regarding the transformational leadership, gender-based leadership, and coercive leadership. Finally, I end my thesis with a reflection of personal experiences taken away from these avenues and offer recommendations to better equip the ASU NROTC program in having successful retention and success of the female Marine Option midshipman.
ContributorsCamarena, Leonor Jimenez (Author) / Lucio, Joanna (Thesis director) / Warnicke, Margaretha (Committee member) / Barrett, The Honors College (Contributor) / School of Public Affairs (Contributor)
Created2014-12
Description
ABSTRACT This research examines what contextual elements shape a community court. In the past several decades, the court system has lost trust with the American public. Citizens thought the courts were too complex, expensive, didn't address the issues of crime, and were out of touch with their communities. A movement called community justice began to grow in the 1990s. As part of this movement the concept of problem solving courts grew. Community focused courts were part of this. Community courts are unique in that the courts reach out to the community to help solve problems identified by citizens, businesses, and others in that area. Various stakeholders are involved in the planning, implementation, and operation of these courts, working together to address issues that arise from those who commit a crime and come before the court. Four community courts were examined using the case study method, examining the literature and conducting interviews, and a model was developed based on these courts. Two additional courts were examined, having been established after judges from their respective communities had attended a national seminar on community focused courts. These two courts were then compared to the model. Based on the model, areas most likely to develop a community court were identified. Additionally, the model can be utilized to indicate how these courts can be successful or fail. Other issues that were examined were how community courts differ from traditional courts and how this could impact judicial impartiality and independence, and the traditional adversary system.
ContributorsDicus, Bonnie Carol (Author) / Cayer, N. J. (Thesis advisor) / Alozie, Nicolas (Committee member) / Lucio, Joanna (Committee member) / Arizona State University (Publisher)
Created2010
Description
Members of the Delphinidae family are widely distributed across the world’s oceans. We used a viral metagenomic approach to identify viruses in orca (Orcinus orca) and short-finned pilot whale (Globicephala macrorhynchus) muscle, kidney, and liver samples from deceased animals. From orca tissue samples (muscle, kidney, and liver), we identified a novel polyomavirus (Polyomaviridae), three cressdnaviruses, and two genomoviruses (Genomoviridae). In the short-finned pilot whale we were able to identify one genomovirus in a kidney sample. The presence of unclassified cressdnavirus within two samples (muscle and kidney) of the same animal supports the possibility these viruses might be widespread within the animal. The orca polyomavirus identified here is the first of its species and is not closely related to the only other dolphin polyomavirus previously discovered. The identification and verification of these viruses expands the current knowledge of viruses that are associated with the Delphinidae family.
ContributorsSmith, Kendal Ryan (Author) / Varsani, Arvind (Thesis director) / Kraberger, Simona (Committee member) / Dolby, Greer (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Phage therapy has been around for more than a century, but has regained interest in the field of medicine and holds significant potential to act as a treatment against a deadly bacterial infection in various cactus species. It was discovered that bacteriophages isolated from soil samples of potato plants were able to suppress Pectobacterium carotovorum, ‘Pectobacterium’ being within the family Pectobacteriaceae which contains the ‘Erwinia’ genus that causes soft rot diseases in various plants (Jones, 2012). The two scientists had co-inoculated “... the phage with the phytobacterium” (Jones, 2012) in order to suppress the growth and prevent the infection from occurring.
ContributorsFry, Danielle Elizabeth (Author) / Geiler-Samerotte, Kerry (Thesis director) / Pfeifer, Susanne (Committee member) / Varsani, Arvind (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05