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Description

This survey takes information on a participant’s beliefs on privacy security, the general digital knowledge, demographics, and willingness-to-pay points on if they would delete information on their social media, to see how an information treatment affects those payment points. This information treatment is meant to make half of the participants

This survey takes information on a participant’s beliefs on privacy security, the general digital knowledge, demographics, and willingness-to-pay points on if they would delete information on their social media, to see how an information treatment affects those payment points. This information treatment is meant to make half of the participants think about the deeper ramifications of the information they reveal. The initial hypothesis is that this information will make people want to pay more to remove their information from the web, but the results find a surprising negative correlation with the treatment.

ContributorsDeitrick, Noah Sumner (Author) / Silverman, Daniel (Thesis director) / Kuminoff, Nicolai (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
Identifying disease biomarkers may aid in the early detection of breast cancer and improve patient outcomes. Recent evidence suggests that tumors are immunogenic and therefore patients may launch an autoantibody response to tumor associated antigens. Single-chain variable fragments of autoantibodies derived from regional lymph node B cells of breast cancer

Identifying disease biomarkers may aid in the early detection of breast cancer and improve patient outcomes. Recent evidence suggests that tumors are immunogenic and therefore patients may launch an autoantibody response to tumor associated antigens. Single-chain variable fragments of autoantibodies derived from regional lymph node B cells of breast cancer patients were used to discover these tumor associated biomarkers on protein microarrays. Six candidate biomarkers were discovered from 22 heavy chain-only variable region antibody fragments screened. Validation tests are necessary to confirm the tumorgenicity of these antigens. However, the use of single-chain variable autoantibody fragments presents a novel platform for diagnostics and cancer therapeutics.
ContributorsSharman, M. Camila (Author) / Magee, Dewey (Mitch) (Thesis director) / Wallstrom, Garrick (Committee member) / Petritis, Brianne (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor) / Virginia G. Piper Center for Personalized Diagnostics (Contributor) / Biodesign Institute (Contributor)
Created2012-12
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Description
Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths in females worldwide, accounting for 23% of all new cancer cases and 14% of all total cancer deaths in 2008. Five tumor-normal pairs of primary breast epithelial cells were treated for infinite proliferation by

Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths in females worldwide, accounting for 23% of all new cancer cases and 14% of all total cancer deaths in 2008. Five tumor-normal pairs of primary breast epithelial cells were treated for infinite proliferation by using a ROCK inhibitor and mouse feeder cells. Methods: Raw paired-end, 100x coverage RNA-Seq data was aligned to the Human Reference Genome Version 19 using BWA and Tophat. Gene differential expression analysis was completed using Cufflinks and Cuffdiff. Interactive Genome Viewer was used for data visualization. Results: 15 genes were found to be down-regulated by at least one log-fold change in 4/5 of tumor samples. 75 genes were found to be down-regulated in 3/5 of our tumor samples by at least one log-fold change. 11 genes were found to be up-regulated in 4/5 of our tumor samples, and 68 genes were identified to be up-regulated in 3/5 of the tumor samples by at least one-fold change. Conclusion: Expression changes in genes such as AZGP1, AGER, ALG11, and S1007 suggest a disruption in the glycosylation pathway. No correlation was found between Cufflink's Her2 gene-expression and DAKO score classification.
ContributorsHernandez, Fernando (Author) / Anderson, Karen (Thesis director) / Mangone, Marco (Committee member) / Park, Jin (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor)
Created2013-05
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Description
In order to better understand how the national legislative body works, this research examines the factors that influence the level of productivity in the U.S. Congress. By mapping these characteristics into the classical framework of an economic production function, this model serves to produce a more transparent image of the

In order to better understand how the national legislative body works, this research examines the factors that influence the level of productivity in the U.S. Congress. By mapping these characteristics into the classical framework of an economic production function, this model serves to produce a more transparent image of the aspects of Members of Congress that are desirable to form a productive legislative body.
ContributorsMcKenna, Ryan Michael (Author) / Roberts, Nancy (Thesis director) / Kuminoff, Nicolai (Committee member) / Espino, Rodolfo (Committee member) / Barrett, The Honors College (Contributor) / Department of Economics (Contributor) / Department of Finance (Contributor) / Sandra Day O'Connor College of Law (Contributor)
Created2013-05
Description
Did the amount of media attention to the H1N1 flu or the information that the Centers for Disease Control (CDC) disseminates about the H1N1 flu, influence individuals' decisions to avoid public locations during the 2009-2010 H1N1 Influenza pandemic? I investigate this question using weekly-confirmed H1N1 cases from the CDC, the

Did the amount of media attention to the H1N1 flu or the information that the Centers for Disease Control (CDC) disseminates about the H1N1 flu, influence individuals' decisions to avoid public locations during the 2009-2010 H1N1 Influenza pandemic? I investigate this question using weekly-confirmed H1N1 cases from the CDC, the American Time Use Survey (ATUS), and the Google Trends weekly search volume index for certain key terms. I found that individuals did exhibit some avoidance behaviour during the flu pandemic in response to the CDC data, but not the measures of media attention. However, the magnitudes of these adjustments are small in comparison to other measures of avoidance behaviour, such as reduced time in public during extreme weather events.
ContributorsGunn, Quentin Lee (Author) / Kuminoff, Nicolai (Thesis director) / Abbott, Joshua (Committee member) / Fenichel, Eli (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Economics Program in CLAS (Contributor)
Created2013-12
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Description

Amid the fast-growing market of plant-based alternatives to conventional meat, there still lies uncertainty about consumers’ preferences for these new products. Through an online survey using a Becker-DeGroot-Marschak mechanism, I test the effect that environmental information provision has on consumers’ immediate and long-term willingness- to-pay for the Whopper and Impossible

Amid the fast-growing market of plant-based alternatives to conventional meat, there still lies uncertainty about consumers’ preferences for these new products. Through an online survey using a Becker-DeGroot-Marschak mechanism, I test the effect that environmental information provision has on consumers’ immediate and long-term willingness- to-pay for the Whopper and Impossible Whopper from Burger King. Respondents were randomly assigned to either a control group or a treatment group, and both received information on taste in an attempt to isolate the effect of environmental information. Results show that certain groups respond to the information differently. Specifically, consumers who care about climate change are affected greatly by environmental in- formation suggesting these “climate advocates” are not fully informed despite the efforts of Impossible Foods. Vegetarians and highly educated individuals have relatively stronger preferences for the plant-based burger, in line with previous studies. Results also show a lasting effect of information on WTP, suggesting little need for repeated interventions.

ContributorsStreff, Adam (Author) / Silverman, Daniel (Thesis director) / Kuminoff, Nicolai (Committee member) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

This study estimates the effect of district wealth on Arizona Empowerment Scholarship Account program participation using data from the Arizona Department of Education. We find that students from poor districts are not more likely to participate as school performance decreases.Conversely, those from wealthy districts do increase participation as school

This study estimates the effect of district wealth on Arizona Empowerment Scholarship Account program participation using data from the Arizona Department of Education. We find that students from poor districts are not more likely to participate as school performance decreases.Conversely, those from wealthy districts do increase participation as school performance decreases. We briefly try to explain the observed heterogeneity through survey results and commenting on the program design.

ContributorsAngel, Joseph Michael (Author) / Kostol, Andreas (Thesis director) / Kuminoff, Nicolai (Committee member) / Economics Program in CLAS (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
Mathematical epidemiology, one of the oldest and richest areas in mathematical biology, has significantly enhanced our understanding of how pathogens emerge, evolve, and spread. Classical epidemiological models, the standard for predicting and managing the spread of infectious disease, assume that contacts between susceptible and infectious individuals depend on their relative

Mathematical epidemiology, one of the oldest and richest areas in mathematical biology, has significantly enhanced our understanding of how pathogens emerge, evolve, and spread. Classical epidemiological models, the standard for predicting and managing the spread of infectious disease, assume that contacts between susceptible and infectious individuals depend on their relative frequency in the population. The behavioral factors that underpin contact rates are not generally addressed. There is, however, an emerging a class of models that addresses the feedbacks between infectious disease dynamics and the behavioral decisions driving host contact. Referred to as “economic epidemiology” or “epidemiological economics,” the approach explores the determinants of decisions about the number and type of contacts made by individuals, using insights and methods from economics. We show how the approach has the potential both to improve predictions of the course of infectious disease, and to support development of novel approaches to infectious disease management.
Created2015-12-01
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Nutrient recycling by fish can be an important part of nutrient cycles in both freshwater and marine ecosystems. As a result, understanding the mechanisms that influence excretion elemental ratios of fish is of great importance to a complete understanding of aquatic nutrient cycles. As fish consume a wide range of

Nutrient recycling by fish can be an important part of nutrient cycles in both freshwater and marine ecosystems. As a result, understanding the mechanisms that influence excretion elemental ratios of fish is of great importance to a complete understanding of aquatic nutrient cycles. As fish consume a wide range of diets that differ in elemental composition, stoichiometric theory can inform predictions about dietary effects on excretion ratios.
We conducted a meta-analysis to test the effects of diet elemental composition on consumption and nutrient excretion by fish. We examined the relationship between consumption rate and diet N : P across all laboratory studies and calculated effect sizes for each excretion metric to test for significant effects.
Consumption rate of N, but not P, was significantly negatively affected by diet N : P. Effect sizes of diet elemental composition on consumption-specific excretion N, P and N : P in laboratory studies were all significantly different from 0, but effect size for raw excretion N : P was not significantly different from zero in laboratory or field surveys.
Our results highlight the importance of having a mechanistic understanding of the drivers of consumer excretion rates and ratios. We suggest that more research is needed on how consumption and assimilation efficiency vary with N : P and in natural ecosystems in order to further understand mechanistic processes in consumer-driven nutrient recycling.

ContributorsMoody, Eric (Author) / Corman, Jessica (Author) / Elser, James (Author) / Sabo, John (Author) / College of Liberal Arts and Sciences (Contributor) / School of Life Sciences (Contributor) / Julie Ann Wrigley Global Institute of Sustainability (Contributor)
Created2015-03-01
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Description
Preserving a system’s viability in the presence of diversity erosion is critical if the goal is to sustainably support biodiversity. Reduction in population heterogeneity, whether inter- or intraspecies, may increase population fragility, either decreasing its ability to adapt effectively to environmental changes or facilitating the survival and success of ordinarily

Preserving a system’s viability in the presence of diversity erosion is critical if the goal is to sustainably support biodiversity. Reduction in population heterogeneity, whether inter- or intraspecies, may increase population fragility, either decreasing its ability to adapt effectively to environmental changes or facilitating the survival and success of ordinarily rare phenotypes. The latter may result in over-representation of individuals who may participate in resource utilization patterns that can lead to over-exploitation, exhaustion, and, ultimately, collapse of both the resource and the population that depends on it. Here, we aim to identify regimes that can signal whether a consumer–resource system is capable of supporting viable degrees of heterogeneity. The framework used here is an expansion of a previously introduced consumer–resource type system of a population of individuals classified by their resource consumption. Application of the Reduction Theorem to the system enables us to evaluate the health of the system through tracking both the mean value of the parameter of resource (over)consumption, and the population variance, as both change over time. The article concludes with a discussion that highlights applicability of the proposed system to investigation of systems that are affected by particularly devastating overly adapted populations, namely cancerous cells. Potential intervention approaches for system management are discussed in the context of cancer therapies.
Created2015-02-01