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Description
Since its inception in the early 1990s, the concept of gene vaccines, particularly DNA vaccines, has enticed researchers across the board due to its simple design, flexible modification, and overall inexpensive cost of manufacturing. However, the past three decades have proven to be less fruitful than anticipated as scientists have yet to tackle the issue of inducing a strong enough response in humans and non-human primates to protect against foreign pathogens, an issue that has since been coined as the “simian barrier.” This appears to be a human/primate barrier as protective vaccines have been produced for other mammals. Despite millions of dollars in research along with some of the world’s brightest minds chipping in to resolve this, there has yet to be any truly viable solution to overcoming this barrier. With current research illustrating effective applications of RNA vaccines in humans, these studies may be uncovering the solution to the largely unsolved simian barrier dilemma. If vaccines using RNA, the transcribed version of DNA, are effective in humans, the problem may be inefficient transcription of the DNA. This may be attributable to a DNA promoter that has insufficient activity in primates. Additionally, with DNA vaccines being even cheaper and easier to manufacture than RNA vaccines, along with having no required cold chain for distribution, this concept remains more promising than RNA vaccines that are further along in clinical trials.
ContributorsWillis, Joshua Aaron (Author) / Johnston, Stephen (Thesis director) / Sykes, Kathryn (Committee member) / Shen, Luhui (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
In June 2016, the Arizona Department of Health Services (ADHS) with researchers from Arizona State University (ASU) convened a one-day workshop of public health professionals and experts from Arizona’s county and state agencies to advance statewide preparedness for extreme weather events and climate change. The United States Centers for Disease Control and Prevention (CDC) sponsors the Climate-Ready Cities and States Initiative, which aims to help communities across the country prepare for and prevent projected disease burden associated with climate change. Arizona is one of 18 public health jurisdictions funded under this initiative. ADHS is deploying the CDC’s five-step Building Resilience Against Climate Effects (BRACE) framework to assist counties and local public health partners with becoming better prepared to face challenges associated with the impacts of climate-sensitive hazards. Workshop participants engaged in facilitated exercises designed to rigorously consider social vulnerability to hazards in Arizona and to prioritize intervention activities for extreme heat, wildfire, air pollution, and flooding.
This report summarizes the proceedings of the workshop focusing primarily on two sessions: the first related to social vulnerability mapping and the second related to the identification and prioritization of interventions necessary to address the impacts of climate-sensitive hazards.
This report summarizes the proceedings of the workshop focusing primarily on two sessions: the first related to social vulnerability mapping and the second related to the identification and prioritization of interventions necessary to address the impacts of climate-sensitive hazards.
ContributorsRoach, Matthew (Author) / Hondula, David M. (Author) / Putnam, Hana (Author) / Chhetri, Nalini (Author) / Chakalian, Paul (Author) / Watkins, Lance (Author) / Dufour, Brigette (Author)
Created2016-11-28