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Native American communities face an ongoing challenge of effectively addressing cancer health disparities, as well as environmental racism issues that may compound these inequities. This dissertation identified the shared cultural knowledge and beliefs about cancer in a southwest American Indian community utilizing a cultural consensus method, an approach that combines qualitative and quantitative data. A community-based participatory research (CBPR) approach was applied at all stages of the study. The three phases of research that were undertaken included: 1) ethnographic interviews - to identifying the themes or the content of the participants' cultural model, 2A) ranking of themes - to provide an understanding of the relative importance of the content of the cultural model, 2B) pile sorts - identify the organization of items within specific domains, and 3) a community survey - access whether the model is shared in the greater community. The cultural consensus method has not been utilized to date in identifying the collective cultural beliefs about cancer prevention, treatment or survivorship in a Native American community. Its use represents a methodological step forward in two areas: 1) the traditional ethnographic inferences used in identifying and defining cultural meaning as it relates to health can be tested more rigorously than in the past, and 2) it addresses the challenge of providing reliable results based on a small number of community informants. This is especially significant when working with smaller tribal/cultural groups where the small sample size has led to questions concerning the reliability and validity of health-related research. Results showed that the key consultants shared strong agreement or consensus on a cultural model regarding the importance of environmental and lifestyle causes of cancer. However, there was no consensus found among the key consultants on the prevention and treatment of cancer. The results of the community survey indicated agreement or consensus in the sub-domains of descriptions of cancer, risk/cause, prevention, treatment, remission/cure and living with cancer. Identifying cultural beliefs and models regarding cancer could contribute to the effective development of culturally responsive cancer prevention education and treatment programs.
ContributorsClaus, Cynthia (Author) / Koss, Joan (Thesis advisor) / Brandt, Elizabeth, (Thesis advisor) / Joe, Jennie (Committee member) / Maupin, Jonathan (Committee member) / Arizona State University (Publisher)
Created2011
Description
The use of synthetic cathinones or "bath salts" has risen dramatically in recent years with one of the most popular being Methylendioxypyrovalerone (MDPV). Following the temporary legislative ban on the sale and distribution of this compound , a multitude of other cathinone derivatives have been synthesized. The current study seeks to compare the abuse potential of MDPV with one of the emergent synthetic cathinones 4-methylethcathinone (4-MEC), based on their respective ability to lower current thresholds in an intracranial self-stimulation (ICSS) paradigm. Following acute administration (0.1, 0.5, 1 and 2 mg/kg i.p.) MDPV was found to significantly lower ICSS thresholds at all doses tested (F4,35=11.549, p<0.001). However, following acute administration (0.3,1,3,10,30 mg/kg i.p) 4-MEC produced no significant ICSS threshold depression (F5,135= 0.622, p = 0.684). Together these findings suggest that while MDPV may possess significant abuse potential, other synthetic cathinones such as 4-MEC may have a drastically reduced potential for abuse.
ContributorsWegner, Scott Andrew (Author) / Olive, M. Foster (Thesis director) / Presson, Clark (Committee member) / Sanabria, Federico (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
Chronic restraint stress impairs hippocampal-mediated spatial learning and memory, which improves following a post-stress recovery period. Here, we investigated whether brain derived neurotrophic factor (BDNF), a protein important for hippocampal function, would alter the recovery from chronic stress-induced spatial memory deficits. Adult male Sprague-Dawley rats were infused into the hippocampus with adeno- associated viral vectors containing the coding sequence for short interfering (si)RNA directed against BDNF or a scrambled sequence (Scr), with both containing the coding information for green fluorescent protein to aid in anatomical localization. Rats were then chronically restrained (wire mesh, 6h/d/21d) and assessed for spatial learning and memory using a radial arm water maze (RAWM) either immediately after stressor cessation (Str-Imm) or following a 21-day post-stress recovery period (Str-Rec). All groups learned the RAWM task similarly, but differed on the memory retention trial. Rats in the Str-Imm group, regardless of viral vector contents, committed more errors in the spatial reference memory domain than did non-stressed controls. Importantly, the typical improvement in spatial memory following recovery from chronic stress was blocked with the siRNA against BDNF, as Str-Rec-siRNA performed worse on the RAWM compared to the non-stressed controls or Str-Rec-Scr. These effects were specific for the reference memory domain as repeated entry errors that reflect spatial working memory were unaffected by stress condition or viral vector contents. These results demonstrate that hippocampal BDNF is necessary for the recovery from stress-induced hippocampal dependent spatial memory deficits in the reference memory domain.
ContributorsOrtiz, J. Bryce (Author) / Conrad, Cheryl D. (Thesis advisor) / Olive, M. Foster (Committee member) / Taylor, Sara (Committee member) / Bimonte-Nelson, Heather A. (Committee member) / Arizona State University (Publisher)
Created2013
Description
The brain is a fundamental target of the stress response that promotes adaptation and survival but the repeated activation of the stress response has the potential alter cognition, emotion, and motivation, key functions of the limbic system. Three structures of the limbic system in particular, the hippocampus, medial prefrontal cortex (mPFC), and amygdala, are of special interest due to documented structural changes and their implication in post-traumatic stress disorder (PTSD). One of many notable chronic stress-induced changes include dendritic arbor restructuring, which reflect plasticity patterns in parallel with the direction of alterations observed in functional imaging studies in PTSD patients. For instance, chronic stress produces dendritic retraction in the hippocampus and mPFC, but dendritic hypertrophy in the amygdala, consistent with functional imaging in patients with PTSD. Some have hypothesized that these limbic region's modifications contribute to one's susceptibility to develop PTSD following a traumatic event. Consequently, we used a familiar chronic stress procedure in a rat model to create a vulnerable brain that might develop traits consistent with PTSD when presented with a challenge. In adult male rats, chronic stress by wire mesh restraint (6h/d/21d) was followed by a variety of behavioral tasks including radial arm water maze (RAWM), fear conditioning and extinction, and fear memory reconsolidation to determine chronic stress effects on behaviors mediated by these limbic structures. In chapter 2, we corroborated past findings that chronic stress caused hippocampal CA3 dendritic retraction. Importantly, we present new findings that CA3 dendritic retraction corresponded with poor spatial memory in the RAWM and that these outcomes reversed after a recovery period. In chapter 3, we also showed that chronic stress impaired mPFC-mediated extinction memory, findings that others have reported. Using carefully assessed behavior, we present new findings that chronic stress impacted nonassociative fear by enhancing contextual fear during extinction that generalized to a new context. Moreover, the generalization behavior corresponded with enhanced functional activation in the hippocampus and amygdala during fear extinction memory retrieval. In chapter 5, we showed for the first time that chronic stress enhanced amygdala functional activation during fear memory retrieval, i.e., reactivation. Moreover, these enhanced fear memories were resistant to protein synthesis interference to disrupt a previously formed memory, called reconsolidation in a novel attempt to weaken chronic stress enhanced traumatic memory. Collectively, these studies demonstrated the plastic and dynamic effects of chronic stress on limbic neurocircuitry implicated in PTSD. We showed that chronic stress created a structural and functional imbalance across the hippocampus, mPFC, and amygdala, which lead to a PTSD-like phenotype with persistent and exaggerated fear following fear conditioning. These behavioral disruptions in conjunction with morphological and functional imaging data reflect a chronic stress-induced imbalance between hippocampal and mPFC regulation in favor of amygdala function overdrive, and supports a novel approach for traumatic memory processing in PTSD.
ContributorsHoffman, Ann (Author) / Conrad, Cheryl D. (Thesis advisor) / Olive, M. Foster (Committee member) / Hammer, Jr., Ronald P. (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Created2013
Description
Culture informs ideas about healthy and acceptable body types. Through globalization the U.S.-European body model has become increasingly significant in local contexts, influencing local body models. While Puerto Ricans have historically valued plump bodies - a biocultural legacy of a historically food scarce environment - this dissertation investigated shifts in these ideals across generations to a stronger preference for thinness. A sample of 23 intergenerational family triads of women, and one close male relative or friend per woman, were administered quantitative questionnaires. Ethnographic interviews were conducted with a sub-sample of women from 16 triads and 1 quintet. Questions about weight history and body sizes were used to address cultural changes in body models. Findings indicate the general trend for all generations has been a reduction in the spectrum of acceptable bodies to an almost singular idealized thin body. Female weight gain during puberty and influence of media produced varied responses across age groups. Overall, Puerto Ricans find it acceptable to gain weight with ageing, during a divorce, and postpartum. Thin bodies are associated with beauty and health, but healthy women that do not resemble the thin ideal, submit themselves to dangerous weight loss practices to achieve self and social acceptance. Further research and direct interventions need to be conducted to alter perceptions that conflate beauty with health in order to address the `normative discontent' women of all ages experience. Weight discrimination and concern with being overweight were evident in Puerto Rican everyday life, indicated by the role of media and acculturation in this study. Anti-fat attitudes were stronger for individuals that identified closely with United States culture. Exposure to drama and personal transformation television programs are associated with increased body image dissatisfaction, and increased exposure to variety shows and celebrity news shows is associated with increased anti-fat attitudes and body dissatisfaction. In sum, the positive valuation of fat in the Puerto Rican cultural body size model in the 1970s has shifted toward a negative valuation of fat and a preference for thin body size.
ContributorsRodriguez-Soto, Isa (Author) / Maupin, Jonathan (Thesis advisor) / Wutich, Amber (Committee member) / Walters-Pacheco, Kattia (Committee member) / Arizona State University (Publisher)
Created2013
Description
"Culture talk" figures prominently in the discussions of and about Muslims, both locally and globally. Culture, in these discussions, is considered to be the underlying cause of gender and generational divides giving rise to an alleged "identity crisis." Culture also presumably conceals and contaminates "pure/true Islam." Culture serves as the scaffold on which all that divides Muslim American immigrants and converts is built; furthermore, the fear of a Muslim cultural takeover underpins the "Islamization of America" narrative. This dissertation engages these generational and "immigrant"-"indigenous" fissures and the current narratives that dominate Muslim and public spheres. It does so through the perspectives of the offspring of converts and immigrants. As the children and grandchildren of immigrants and converts come of age, and distant as they are from historical processes and experiences that shaped the parents' generations while having shared a socialization process as both Muslim and American, what role do they play in the current chapter of Islam in post-9/11 America? Will the younger generation be able to cross the divides, mend the fissures, and play a pivotal role in an "American Muslim community"? Examining how younger generations of both backgrounds view each other and their respective roles in forging an American Muslim belonging, agenda and discourse is a timely and much needed inquiry. This project aims to contribute by shedding more light on the identities, perspectives and roles of these younger generations through the four dominant narratives of identity crisis, pure/true Islam vs. Cultural Islam, the Islamization of America, and creation of an American Muslim community/identity/culture. These narratives are both part of public discourse and themes generated from interviews, a questionnaire\survey, and personal observation. This ethnographic study examines how American born and/or raised offspring of both converts to Islam and immigrant Muslims in the Phoenix and Chicago metropolitan areas define self and community, how they negotiate fissures and fault lines (ethnicity, race, class, gender, and religious interpretation) within their communities, and how their faith informs daily life and envisions a future. I utilize participant observation, interviews, and surveys and examine digital, visual and published media to answer these questions.
ContributorsAli, Muna (Author) / Eder, James (Thesis advisor) / Jackson, Sherman (Committee member) / Hjorleifur Jonsson (Committee member) / Tsuda, Takeyuki (Committee member) / Arizona State University (Publisher)
Created2013
Description
Food system and health characteristics were evaluated across the last Waorani hunter-gatherer group in Amazonian Ecuador and a remote neighboring Kichwa indigenous subsistence agriculture community. Hunter-gatherer food systems like the Waorani foragers may not only be nutritionally, but also pharmaceutically beneficial because of high dietary intake of varied plant phytochemical compounds. A modern diet that reduces these dietary plant defense phytochemicals below levels typical in human evolutionary history may leave humans vulnerable to diseases that were controlled through a foraging diet. Few studies consider the health impact of the recent drastic reduction of plant phytochemical content in the modern global food system, which has eliminated essential components of food because they are not considered "nutrients". The antimicrobial and anti-inflammatory nature of the food system may not only regulate infectious pathogens and inflammatory disease, but also support beneficial microbes in human hosts, reducing vulnerability to chronic diseases. Waorani foragers seem immune to certain infections with very low rates of chronic disease. Does returning to certain characteristics of a foraging food system begin to restore the human body microbe balance and inflammatory response to evolutionary norms, and if so, what implication does this have for the treatment of disease? Several years of data on dietary and health differences across the foragers and the farmers was gathered. There were major differences in health outcomes across the board. In the Waorani forager group there were no signs of infection in serious wounds such as 3rd degree burns and spear wounds. The foragers had one-degree lower body temperature than the farmers. The Waorani had an absence of signs of chronic diseases including vision and blood pressure that did not change markedly with age while Kichwa farmers suffered from both chronic diseases and physiological indicators of aging. In the Waorani forager population, there was an absence of many common regional infectious diseases, from helminthes to staphylococcus. Study design helped control for confounders (exercise, environment, genetic factors, non-phytochemical dietary intake). This study provides evidence of the major role total phytochemical dietary intake plays in human health, often not considered by policymakers and nutritional and agricultural scientists.
ContributorsLondon, Douglas (Author) / Tsuda, Takeyuki (Thesis advisor) / Beezhold, Bonnie L (Committee member) / Hruschka, Daniel (Committee member) / Eder, James (Committee member) / Arizona State University (Publisher)
Created2012
Description
This dissertation examines incidents of conflict and violence amid communities of the Maya Tzotzil Chamula in Chiapas, Mexico. Despite ostensible homogeneity, or more social and cultural resemblances than differences, conflicts arise between many Chamula because of how they acquire desire according to others who mediate what is desirable. These conflicts relate well to Rene Girard's hypothesis that mimetic desire influences identity yet generates conflict as imitation fosters rivalry. Qualitative methods of participant observation, interviews, and document research depict how desire, identity, and conflict interrelate. Ethnographic cases show how conflict emerges "interdividually" as rivals compete to obtain objects imputed desirable. The study begins with how young Tzotzils today appropriate the desires of others, becoming lawyer, spiritual guide, rock and roll singer, or anthropologist. Complex examples exhibit groups struggling for power and privilege within or between members of communities as they vie over "objects of desire" such as status, land, water, or representations of power and pecuniary interests. For some Chamula, mimetic rivalry works to deny resemblances with others despite being alike as neighbor, relative, farmer, carpenter, or member of the same political or religious affiliation. The study also highlights mimetic interactions that have shaped Maya struggles in the past, such as the uprisings of 1712, 1867, and 1911. Interpretive analysis explores how identity formation (structures), imitative desire (motivated interaction), and practice (habitual agency) together galvanize material and psychosocial variables for conflict. Imitative desire is worth observing because of its long-term implications for human adaptation and social change. As a contribution to social conflict theory, this dissertation offers a critical perspective to current research on mimetic desire as a significant force in human relations.
ContributorsRolland, Michael (Author) / Chance, John K. (Thesis advisor) / Eder, James (Committee member) / Hjorleifur Jonsson (Committee member) / Rus Iii, Jan (Committee member) / Arizona State University (Publisher)
Created2012
Description
The children of immigrants who arrived in the United States in the 1980s now make up one of the fastest growing components of American society. They face unique and interesting pressures as they incorporate aspects of their parents' heritage into their contemporary American lives. The purpose of this dissertation is to offer an in-depth look at the 1.5 and second generation by examining how the immigrant descendants negotiate assimilative pressures, transnational practices, and ethnic identification. Using ethnographic research methods, such as participant observation and in-depth interviews, I researched the children of immigrants, ages 18-30, living in northwest Arkansas, who have at least one immigrant parent from Latin America. This research is important because non-traditional receiving towns, especially more rural localities, are often overlooked by scholarly studies of migration in favor of larger metropolitan centers (e.g., Los Angeles, Chicago). Studying immigrant descendants in smaller towns that are becoming increasingly populated by Hispanic/Latinos will create a better understanding of how a new generation of immigrants is assimilating into American society and culture. To increase awareness on the Hispanic/Latino 1.5 and second generation living in small town America and to offer potential solutions to facilitate an upwardly mobile future for this population, my dissertation explores a number of research questions. First, how is this population assimilating to the U.S.? Second, are members of the 1.5 and second generation transnational? How active is this transnational lifestyle? Will transnationalism persist as they grow older? Third, how does this population identify themselves ethnically? I also pay particular attention to the relationships among assimilation, transnationalism, and ethnic identity. My dissertation documents the lived experiences of the 1.5 and second generation in northwest Arkansas. The children of immigrants are one of the fastest growing groups nationwide. To understand their world and the lives they lead is to understand the new fabric of American society. I anticipate that the results from this research can be used to facilitate easier transitions to the U.S. among current and prospective immigrant generations, ensuring a brighter outlook for the future of the newest members of U.S. society.
ContributorsSmith, Claire M. (Author) / Tsuda, Takeyuki (Thesis advisor) / Eder, James (Committee member) / Chance, John K. (Committee member) / Arizona State University (Publisher)
Created2014
Description
The dissertation is based on 15 months of ethnographically-informed qualitative research at a liberal arts college in the Himalayan nation of Bhutan. It seeks to provide a sense of daily life and experience of schooling in general and for female students in particular. Access to literacy and the opportunities that formal education can provide are comparatively recent for most Bhutanese women. This dissertation will look at how state-sponsored schooling has shaped gender relations and experiences in Bhutan where non-monastic, co-educational institutions were unknown before the 1960s. While Bhutanese women continue to be under-represented in politics, upper level government positions and public life in general, it is frequently claimed at a variety of different levels (for instance in local media and government reports), that Bhutan, unlike it South Asian neighbors, has a high degree of gender equity. It is argued that any under-representation does not reflect access or opportunity but is instead the result of women's decision not to "come up" and participate. However this dissertation will dispute the claim that female students could choose to be more visible, vocal and mobile in classrooms and on campus without being challenged or discouraged. I will show that school is a gendered context, in which female students are consistently reminded of their "limitations" and their "appropriate place" through the use of familiar social practices such as teasing, gossip, and harassment. Schooling, particularly in developing nations like Bhutan, is usually implicitly and uncritically understood to be a neutral resource, often evaluated in relation to development aims such as creating a more educated and skilled workforce. While Bhutanese schools do seem to promote new kind of opportunity and new understandings of success, they also continue to recognize, maintain and reproduce conventional values around hierarchy, knowledge transmission, cooperation (or group identity) and gender norms. This dissertation will also show how emergent disparities in wealth and opportunity in the nation at large are beginning to be reflected and reproduced in both the experience of schooling and the job market in ways that Bhutanese development policy is not yet able to adequately address.
ContributorsRoder, Dolma Choden (Author) / Eder, James (Thesis advisor) / Hjorleifur Jonsson (Committee member) / Mccarty, Teresa (Committee member) / Arizona State University (Publisher)
Created2012