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Demand for biosensor research applications is growing steadily. According to a new report by Frost & Sullivan, the biosensor market is expected to reach $14.42 billion by 2016. Clinical diagnostic applications continue to be the largest market for biosensors, and this demand is likely to continue through 2016 and beyond.

Demand for biosensor research applications is growing steadily. According to a new report by Frost & Sullivan, the biosensor market is expected to reach $14.42 billion by 2016. Clinical diagnostic applications continue to be the largest market for biosensors, and this demand is likely to continue through 2016 and beyond. Biosensor technology for use in clinical diagnostics, however, requires translational research that moves bench science and theoretical knowledge toward marketable products. Despite the high volume of academic research to date, only a handful of biomedical devices have become viable commercial applications. Academic research must increase its focus on practical uses for biosensors. This dissertation is an example of this increased focus, and discusses work to advance microfluidic-based protein biosensor technologies for practical use in clinical diagnostics. Four areas of work are discussed: The first involved work to develop reusable/reconfigurable biosensors that are useful in applications like biochemical science and analytical chemistry that require detailed sensor calibration. This work resulted in a prototype sensor and an in-situ electrochemical surface regeneration technique that can be used to produce microfluidic-based reusable biosensors. The second area of work looked at non-specific adsorption (NSA) of biomolecules, which is a persistent challenge in conventional microfluidic biosensors. The results of this work produced design methods that reduce the NSA. The third area of work involved a novel microfluidic sensing platform that was designed to detect target biomarkers using competitive protein adsorption. This technique uses physical adsorption of proteins to a surface rather than complex and time-consuming immobilization procedures. This method enabled us to selectively detect a thyroid cancer biomarker, thyroglobulin, in a controlled-proteins cocktail and a cardiovascular biomarker, fibrinogen, in undiluted human serum. The fourth area of work involved expanding the technique to produce a unique protein identification method; Pattern-recognition. A sample mixture of proteins generates a distinctive composite pattern upon interaction with a sensing platform consisting of multiple surfaces whereby each surface consists of a distinct type of protein pre-adsorbed on the surface. The utility of the "pattern-recognition" sensing mechanism was then verified via recognition of a particular biomarker, C-reactive protein, in the cocktail sample mixture.
ContributorsChoi, Seokheun (Author) / Chae, Junseok (Thesis advisor) / Tao, Nongjian (Committee member) / Yu, Hongyu (Committee member) / Forzani, Erica (Committee member) / Arizona State University (Publisher)
Created2011
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Description

Analyzing Incident Rates of COVID-19 Before and After Stay-At-Home Orders Throughout the Southwestern U.S. with Respect to Limited Mobility Models

ContributorsTilleman, Karl Benson (Author) / Albuquerque, Fabio Suzart de (Thesis director) / Powers, Brian (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

This thesis worked towards the development of a parameterized 3D model off a cover that could go over any specific prosthesis depending on the parameters that had been entered. It also focused on gathering user inputs, which was done with the aid of the Amputee Coalition, that could be used

This thesis worked towards the development of a parameterized 3D model off a cover that could go over any specific prosthesis depending on the parameters that had been entered. It also focused on gathering user inputs, which was done with the aid of the Amputee Coalition, that could be used to create an aesthetic design on this cover. The Amputee Coalition helped to recruit participants through its website and social media platforms. Finally, multiple methods of creating a design were developed to increase the amount of customization that a user could have for their cover.

ContributorsFusaro, Gerard Anthony (Co-author) / Riley, Nicholas (Co-author) / Sugar, Thomas (Thesis director) / Redkar, Sangram (Committee member) / College of Integrative Sciences and Arts (Contributor) / Engineering Programs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Mathematical and analytical approach at the floor and diffuser of a Formula 1 vehicle and how they produce downforce. Reaches a conclusion about how engineers and aerodynamicists creates the desired effects underneath the vehicle to produce substantial downforce.

ContributorsMarcantonio, Nicholas Joseph (Author) / Rajadas, John (Thesis director) / Hillery, Scott (Committee member) / College of Integrative Sciences and Arts (Contributor) / Engineering Programs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

This podcast explores the life of Cendraini, growing up in the developing country of Indonesia as well as her eventual immigration to America. It delves into prominent topics and history of Indonesia in regards to Cen's life. The podcast focuses on family, and how no matter the challenges that life

This podcast explores the life of Cendraini, growing up in the developing country of Indonesia as well as her eventual immigration to America. It delves into prominent topics and history of Indonesia in regards to Cen's life. The podcast focuses on family, and how no matter the challenges that life may bring, family will be there for you.

ContributorsGoldstein, Rachel (Author) / Schmidt, Peter (Thesis director) / Levin, Irina (Committee member) / School of International Letters and Cultures (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Preeclampsia is a disease that occurs during pregnancy and affects upwards of 10% of pregnancies around the world (Osungbade & Ige, 2011). African American pregnant women are particularly vulnerable and die at a disproportionate rate compared to other races. In this literature review, three research studies were analyzed to determine

Preeclampsia is a disease that occurs during pregnancy and affects upwards of 10% of pregnancies around the world (Osungbade & Ige, 2011). African American pregnant women are particularly vulnerable and die at a disproportionate rate compared to other races. In this literature review, three research studies were analyzed to determine if African American pregnant women were included in preeclampsia Studies. Only one of the studies included in this review met all criteria by including African American pregnant women. One research study met half of the criteria; however, the authors noted that there was not enough evidence for Black Americans. The third research article also only met half of the criteria. We conclude that further studies are needed that include African American women in studies on preeclampsia.

ContributorsCheeks, Maiya (Author) / Lateef, Dalya (Thesis director) / Briggs, Georgette (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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A research project turned creative project focusing on the narrative of the student's perspective in the Next Generation Service Corps scholarship program. Using survey results from the program members, narratives of their experiences were compiled to offer insight and direction for the growth of the program.<br/><br/>A video of the defense

A research project turned creative project focusing on the narrative of the student's perspective in the Next Generation Service Corps scholarship program. Using survey results from the program members, narratives of their experiences were compiled to offer insight and direction for the growth of the program.<br/><br/>A video of the defense can be found at this link: https://youtu.be/O63NRz0z1Ys

ContributorsJanezic, John Henry (Author) / Hunt, Brett (Thesis director) / Smith, Jacqueline (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

The purpose of this creative project was to create a stereo sound system in a unique medium. As a team, we decided to integrate a Tesla Coil with a bluetooth audio source. These high frequency, high voltage systems can be configured to emit their electrical discharge in a manner that

The purpose of this creative project was to create a stereo sound system in a unique medium. As a team, we decided to integrate a Tesla Coil with a bluetooth audio source. These high frequency, high voltage systems can be configured to emit their electrical discharge in a manner that resembles playing tunes. Originally the idea was to split the audio into left and right, then to further segregate the signals to have a treble, mid, and base emitter for each side. Due to time, budget, and scope constraints, we decided to complete the project with only two coils.<br/><br/>For this project, the team decided to use a solid-state coil kit. This kit was purchased from OneTelsa and would help ensure everyone’s safety and the project’s success. The team developed our own interrupting or driving circuit through reverse-engineering the interrupter provided by oneTesla and discussing with other engineers. The custom interpreter was controlled by the PSoC5 LP and communicated with an audio source through the DFRobot Bluetooth module. Utilizing the left and right audio signals it can drive the two Tesla Coils in stereo to play the music.

ContributorsPinkowski, Olivia N (Co-author) / Hutcherson, Cree (Co-author) / Jordan, Shawn (Thesis director) / Sugar, Thomas (Committee member) / Engineering Programs (Contributor, Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

An X class solar flare has the potential to remove our satellites from orbit, permanently deactivate our main forms of communication and bring humanity into a technology-free age. By using Geant4, it is possible to simulate several layers of the Earth's atmosphere and send a simulated solar flare and coronal

An X class solar flare has the potential to remove our satellites from orbit, permanently deactivate our main forms of communication and bring humanity into a technology-free age. By using Geant4, it is possible to simulate several layers of the Earth's atmosphere and send a simulated solar flare and coronal mass ejection. This thesis will show the interaction of photons and protons of various energies with several kilometers of atmosphere.

ContributorsDolghier, Kristian Adrian (Author) / Shovkovy, Igor (Thesis director) / Steinkamp, Brian (Committee member) / Economics Program in CLAS (Contributor) / College of Integrative Sciences and Arts (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The Founders lab is a year-long program that gives its students an opportunity to participate in a unique team-based, experiential Barrett honors thesis project to design and apply marketing and sales strategies, as well as business and financial models to start up and launch a new business. This honors thesis

The Founders lab is a year-long program that gives its students an opportunity to participate in a unique team-based, experiential Barrett honors thesis project to design and apply marketing and sales strategies, as well as business and financial models to start up and launch a new business. This honors thesis project focuses on increasing the rate of vaccination outcomes in a country where people are increasingly busy (less time) and unwilling to get a needle through a new business venture that provides a service that brings vaccinations straight to businesses, making them available for their employees. Through our work with the Founders Lab, our team was able to create this pitch deck.

ContributorsGomez, Isaias Abraham (Co-author) / Hanzlick, Emily (Co-author) / Zatonskiy, Albert (Co-author) / Byrne, Jared (Thesis director) / Hall, Rick (Committee member) / Silverstein, Taylor (Committee member) / College of Integrative Sciences and Arts (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05