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- Language: English
Fluoroquinolone antibiotics have been known to cause severe, multisystem adverse side effects, termed fluoroquinolone toxicity (FQT). This toxicity syndrome can present with adverse effects that vary from individual to individual, including effects on the musculoskeletal and nervous systems, among others. The mechanism behind FQT in mammals is not known, although various possibilities have been investigated. Among the hypothesized FQT mechanisms, those that could potentially explain multisystem toxicity include off-target mammalian topoisomerase interactions, increased production of reactive oxygen species, oxidative stress, and oxidative damage, as well as metal chelating properties of FQs. This review presents relevant information on fluoroquinolone antibiotics and FQT and explores the mechanisms that have been proposed. A fluoroquinolone-induced increase in reactive oxygen species and subsequent oxidative stress and damage presents the strongest evidence to explain this multisystem toxicity syndrome. Understanding the mechanism of FQT in mammals is important to aid in the prevention and treatment of this condition.
The report is divided into several sections:
• Traditional Leadership style and rewards
• Existing literature on job relational design
• Servant leadership
• Surveys
• Data analysis
• Conclusion
From this research, it can be concluded that certain leadership qualities can contribute to an increase in intrinsic motivation to subordinates. Also, there are certain traits that allow managers to have a positive impact on subordinates. This study also provides leaders with suggestions on how to increase subordinates’ concerns for customers, which will translate into more productive work from employees.