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- Genre: Masters Thesis
Description
Economic inequality is always presented as how economic metrics vary amongst individuals in a group, amongst groups in a population, or amongst some regions. Economic inequality can substantially impact the social environment, socioeconomics as well as human living standard. Since economic inequality always plays an important role in our social environment, its study has attracted much attention from scholars in various research fields, such as development economics, sociology and political science. On the other hand, economic inequality can result from many factors, phenomena, and complex procedures, including policy, ethnic, education, globalization and etc. However, the spatial dimension in economic inequality research did not draw much attention from scholars until early 2000s. Spatial dependency, perform key roles in economic inequality analysis. The spatial econometric methods do not merely convey a consequence of the characters of the data exclusively. More importantly, they also respect and quantify the spatial effects in the economic inequality. As aforementioned, although regional economic inequality starts to attract scholars' attention in both economy and regional science domains, corresponding methodologies to examine such regional inequality remain in their preliminary phase, which need substantial further exploration. My thesis aims at contributing to the body of knowledge in the method development to support economic inequality studies by exploring the feasibility of a set of new analytical methods in use of regional inequality analysis. These methods include Theil's T statistic, geographical rank Markov and new methods applying graph theory. The thesis will also leverage these methods to compare the inequality between China and US, two large economic entities in the world, because of the long history of economic development as well as the corresponding evolution of inequality in US; the rapid economic development and consequent high variation of economic inequality in China.
ContributorsWang, Sizhe (Author) / Rey, Sergio J (Thesis advisor) / Li, Wenwen (Committee member) / Salon, Deborah (Committee member) / Arizona State University (Publisher)
Created2016
Description
The past decade has seen a drastic increase in collaboration between Computer Science (CS) and Molecular Biology (MB). Current foci in CS such as deep learning require very large amounts of data, and MB research can often be rapidly advanced by analysis and models from CS. One of the places where CS could aid MB is during analysis of sequences to find binding sites, prediction of folding patterns of proteins. Maintenance and replication of stem-like cells is possible for long terms as well as differentiation of these cells into various tissue types. These behaviors are possible by controlling the expression of specific genes. These genes then cascade into a network effect by either promoting or repressing downstream gene expression. The expression level of all gene transcripts within a single cell can be analyzed using single cell RNA sequencing (scRNA-seq). A significant portion of noise in scRNA-seq data are results of extrinsic factors and could only be removed by customized scRNA-seq analysis pipeline. scRNA-seq experiments utilize next-gen sequencing to measure genome scale gene expression levels with single cell resolution.
Almost every step during analysis and quantification requires the use of an often empirically determined threshold, which makes quantification of noise less accurate. In addition, each research group often develops their own data analysis pipeline making it impossible to compare data from different groups. To remedy this problem a streamlined and standardized scRNA-seq data analysis and normalization protocol was designed and developed. After analyzing multiple experiments we identified the possible pipeline stages, and tools needed. Our pipeline is capable of handling data with adapters and barcodes, which was not the case with pipelines from some experiments. Our pipeline can be used to analyze single experiment scRNA-seq data and also to compare scRNA-seq data across experiments. Various processes like data gathering, file conversion, and data merging were automated in the pipeline. The main focus was to standardize and normalize single-cell RNA-seq data to minimize technical noise introduced by disparate platforms.
Almost every step during analysis and quantification requires the use of an often empirically determined threshold, which makes quantification of noise less accurate. In addition, each research group often develops their own data analysis pipeline making it impossible to compare data from different groups. To remedy this problem a streamlined and standardized scRNA-seq data analysis and normalization protocol was designed and developed. After analyzing multiple experiments we identified the possible pipeline stages, and tools needed. Our pipeline is capable of handling data with adapters and barcodes, which was not the case with pipelines from some experiments. Our pipeline can be used to analyze single experiment scRNA-seq data and also to compare scRNA-seq data across experiments. Various processes like data gathering, file conversion, and data merging were automated in the pipeline. The main focus was to standardize and normalize single-cell RNA-seq data to minimize technical noise introduced by disparate platforms.
ContributorsBalachandran, Parithi (Author) / Wang, Xiao (Thesis advisor) / Brafman, David (Committee member) / Lockhart, Thurmon (Committee member) / Arizona State University (Publisher)
Created2017
Description
It has been identified in the literature that there exists a link between the built environment and non-motorized transport. This study aims to contribute to existing literature on the effects of the built environment on cycling, examining the case of the whole State of California. Physical built environment features are classified into six groups as: 1) local density, 2) diversity of land use, 3) road connectivity, 4) bike route length, 5) green space, 6) job accessibility. Cycling trips in one week for all children, school children, adults and employed-adults are investigated separately. The regression analysis shows that cycling trips is significantly associated with some features of built environment when many socio-demographic factors are taken into account. Street intersections, bike route length tend to increase the use of bicycle. These effects are well-aligned with literature. Moreover, both local and regional job accessibility variables are statistically significant in two adults' models. However, residential density always has a significant negatively effect on cycling trips, which is still need further research to confirm. Also, there is a gap in literature on how green space affects cycling, but the results of this study is still too unclear to make it up. By elasticity analysis, this study concludes that street intersections is the most powerful predictor on cycling trips. From another perspective, the effects of built environment on cycling at workplace (or school) are distinguished from at home. This study implies that a wide range of measures are available for planners to control vehicle travel by improving cycling-level in California.
ContributorsWang, Kailai, M.U.E.P (Author) / Salon, Deborah (Thesis advisor) / Rey, Sergio (Committee member) / Li, Wenwen (Committee member) / Arizona State University (Publisher)
Created2015