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- Genre: Doctoral Dissertation
Description
Generative models are deep neural network-based models trained to learn the underlying distribution of a dataset. Once trained, these models can be used to sample novel data points from this distribution. Their impressive capabilities have been manifested in various generative tasks, encompassing areas like image-to-image translation, style transfer, image editing, and more. One notable application of generative models is data augmentation, aimed at expanding and diversifying the training dataset to augment the performance of deep learning models for a downstream task. Generative models can be used to create new samples similar to the original data but with different variations and properties that are difficult to capture with traditional data augmentation techniques. However, the quality, diversity, and controllability of the shape and structure of the generated samples from these models are often directly proportional to the size and diversity of the training dataset. A more extensive and diverse training dataset allows the generative model to capture overall structures present in the data and generate more diverse and realistic-looking samples.
In this dissertation, I present innovative methods designed to enhance the robustness and controllability of generative models, drawing upon physics-based, probabilistic, and geometric techniques. These methods help improve the generalization and controllability of the generative model without necessarily relying on large training datasets. I enhance the robustness of generative models by integrating classical geometric moments for shape awareness and minimizing trainable parameters. Additionally, I employ non-parametric priors for the generative model's latent space through basic probability and optimization methods to improve the fidelity of interpolated images. I adopt a hybrid approach to address domain-specific challenges with limited data and controllability, combining physics-based rendering with generative models for more realistic results.
These approaches are particularly relevant in industrial settings, where the training datasets are small and class imbalance is common. Through extensive experiments on various datasets, I demonstrate the effectiveness of the proposed methods over conventional approaches.
ContributorsSingh, Rajhans (Author) / Turaga, Pavan (Thesis advisor) / Jayasuriya, Suren (Committee member) / Berisha, Visar (Committee member) / Fazli, Pooyan (Committee member) / Arizona State University (Publisher)
Created2023
Description
This dissertation centers on the development of Bayesian methods for learning differ- ent types of variation in switching nonlinear gene regulatory networks (GRNs). A new nonlinear and dynamic multivariate GRN model is introduced to account for different sources of variability in GRNs. The new model is aimed at more precisely capturing the complexity of GRN interactions through the introduction of time-varying kinetic order parameters, while allowing for variability in multiple model parameters. This model is used as the drift function in the development of several stochastic GRN mod- els based on Langevin dynamics. Six models are introduced which capture intrinsic and extrinsic noise in GRNs, thereby providing a full characterization of a stochastic regulatory system. A Bayesian hierarchical approach is developed for learning the Langevin model which best describes the noise dynamics at each time step. The trajectory of the state, which are the gene expression values, as well as the indicator corresponding to the correct noise model are estimated via sequential Monte Carlo (SMC) with a high degree of accuracy. To address the problem of time-varying regulatory interactions, a Bayesian hierarchical model is introduced for learning variation in switching GRN architectures with unknown measurement noise covariance. The trajectory of the state and the indicator corresponding to the network configuration at each time point are estimated using SMC. This work is extended to a fully Bayesian hierarchical model to account for uncertainty in the process noise covariance associated with each network architecture. An SMC algorithm with local Gibbs sampling is developed to estimate the trajectory of the state and the indicator correspond- ing to the network configuration at each time point with a high degree of accuracy. The results demonstrate the efficacy of Bayesian methods for learning information in switching nonlinear GRNs.
ContributorsVélez-Cruz, Nayely (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Moraffah, Bahman (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2023
Description
In the standard pipeline for machine learning model development, several design decisions are made largely based on trial and error. Take the classification problem as an example. The starting point for classifier design is a dataset with samples from the classes of interest. From this, the algorithm developer must decide which features to extract, which hypothesis class to condition on, which hyperparameters to select, and how to train the model. The design process is iterative with the developer trying different classifiers, feature sets, and hyper-parameters and using cross-validation to pick the model with the lowest error. As there are no guidelines for when to stop searching, developers can continue "optimizing" the model to the point where they begin to "fit to the dataset". These problems are amplified in the active learning setting, where the initial dataset may be unlabeled and label acquisition is costly. The aim in this dissertation is to develop algorithms that provide ML developers with additional information about the complexity of the underlying problem to guide downstream model development. I introduce the concept of "meta-features" - features extracted from a dataset that characterize the complexity of the underlying data generating process. In the context of classification, the complexity of the problem can be characterized by understanding two complementary meta-features: (a) the amount of overlap between classes, and (b) the geometry/topology of the decision boundary. Across three complementary works, I present a series of estimators for the meta-features that characterize overlap and geometry/topology of the decision boundary, and demonstrate how they can be used in algorithm development.
ContributorsLi, Weizhi (Author) / Berisha, Visar (Thesis advisor) / Dasarathy, Gautam (Thesis advisor) / Natesan Ramamurthy, Karthikeyan (Committee member) / Turaga, Pavan (Committee member) / Arizona State University (Publisher)
Created2022
Description
Severe forms of mental illness, such as schizophrenia and bipolar disorder, are debilitating conditions that negatively impact an individual's quality of life. Additionally, they are often difficult and expensive to diagnose and manage, placing a large burden on society. Mental illness is typically diagnosed by the use of clinical interviews and a set of neuropsychiatric batteries; a key component of nearly all of these evaluations is some spoken language task. Clinicians have long used speech and language production as a proxy for neurological health, but most of these assessments are subjective in nature. Meanwhile, technological advancements in speech and natural language processing have grown exponentially over the past decade, increasing the capacity of computer models to assess particular aspects of speech and language. For this reason, many have seen an opportunity to leverage signal processing and machine learning applications to objectively assess clinical speech samples in order to automatically compute objective measures of neurological health. This document summarizes several contributions to expand upon this body of research. Mainly, there is still a large gap between the theoretical power of computational language models and their actual use in clinical applications. One of the largest concerns is the limited and inconsistent reliability of speech and language features used in models for assessing specific aspects of mental health; numerous methods may exist to measure the same or similar constructs and lead researchers to different conclusions in different studies. To address this, a novel measurement model based on a theoretical framework of speech production is used to motivate feature selection, while also performing a smoothing operation on features across several domains of interest. Then, these composite features are used to perform a much wider range of analyses than is typical of previous studies, looking at everything from diagnosis to functional competency assessments. Lastly, potential improvements to address practical implementation challenges associated with the use of speech and language technology in a real-world environment are investigated. The goal of this work is to demonstrate the ability of speech and language technology to aid clinical practitioners toward improvements in quality of life outcomes for their patients.
ContributorsVoleti, Rohit Nihar Uttam (Author) / Berisha, Visar (Thesis advisor) / Liss, Julie M (Thesis advisor) / Turaga, Pavan (Committee member) / Spanias, Andreas (Committee member) / Arizona State University (Publisher)
Created2022
Description
In the era of big data, more and more decisions and recommendations are being made by machine learning (ML) systems and algorithms. Despite their many successes, there have been notable deficiencies in the robustness, rigor, and reliability of these ML systems, which have had detrimental societal impacts. In the next generation of ML, these significant challenges must be addressed through careful algorithmic design, and it is crucial that practitioners and meta-algorithms have the necessary tools to construct ML models that align with human values and interests. In an effort to help address these problems, this dissertation studies a tunable loss function called α-loss for the ML setting of classification. The alpha-loss is a hyperparameterized loss function originating from information theory that continuously interpolates between the exponential (alpha = 1/2), log (alpha = 1), and 0-1 (alpha = infinity) losses, hence providing a holistic perspective of several classical loss functions in ML. Furthermore, the alpha-loss exhibits unique operating characteristics depending on the value (and different regimes) of alpha; notably, for alpha > 1, alpha-loss robustly trains models when noisy training data is present. Thus, the alpha-loss can provide robustness to ML systems for classification tasks, and this has bearing in many applications, e.g., social media, finance, academia, and medicine; indeed, results are presented where alpha-loss produces more robust logistic regression models for COVID-19 survey data with gains over state of the art algorithmic approaches.
ContributorsSypherd, Tyler (Author) / Sankar, Lalitha (Thesis advisor) / Berisha, Visar (Committee member) / Dasarathy, Gautam (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2022
Description
Dealing with relational data structures is central to a wide-range of applications including social networks, epidemic modeling, molecular chemistry, medicine, energy distribution, and transportation. Machine learning models that can exploit the inherent structural/relational bias in the graph structured data have gained prominence in recent times. A recurring idea that appears in all approaches is to encode the nodes in the graph (or the entire graph) as low-dimensional vectors also known as embeddings, prior to carrying out downstream task-specific learning. It is crucial to eliminate hand-crafted features and instead directly incorporate the structural inductive bias into the deep learning architectures.
In this dissertation, deep learning models that directly operate on graph structured data are proposed for effective representation learning. A literature review on existing graph representation learning is provided in the beginning of the dissertation. The primary focus of dissertation is on building novel graph neural network architectures that are robust against adversarial attacks. The proposed graph neural network models are extended to multiplex graphs (heterogeneous graphs). Finally, a relational neural network model is proposed to operate on a human structural connectome. For every research contribution of this dissertation, several empirical studies are conducted on benchmark datasets. The proposed graph neural network models, approaches, and architectures demonstrate significant performance improvements in comparison to the existing state-of-the-art graph embedding strategies.
ContributorsShanthamallu, Uday Shankar (Author) / Spanias, Andreas (Thesis advisor) / Thiagarajan, Jayaraman J (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2021
Description
Speech analysis for clinical applications has emerged as a burgeoning field, providing valuable insights into an individual's physical and physiological state. Researchers have explored speech features for clinical applications, such as diagnosing, predicting, and monitoring various pathologies. Before presenting the new deep learning frameworks, this thesis introduces a study on conventional acoustic feature changes in subjects with post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI). This work demonstrates the effectiveness of using speech signals to assess the pathological status of individuals. At the same time, it highlights some of the limitations of conventional acoustic and linguistic features, such as low repeatability and generalizability. Two critical characteristics of speech features are (1) good robustness, as speech features need to generalize across different corpora, and (2) high repeatability, as speech features need to be invariant to all confounding factors except the pathological state of targets. This thesis presents two research thrusts in the context of speech signals in clinical applications that focus on improving the robustness and repeatability of speech features, respectively. The first thrust introduces a deep learning framework to generate acoustic feature embeddings sensitive to vocal quality and robust across different corpora. A contrastive loss combined with a classification loss is used to train the model jointly, and data-warping techniques are employed to improve the robustness of embeddings. Empirical results demonstrate that the proposed method achieves high in-corpus and cross-corpus classification accuracy and generates good embeddings sensitive to voice quality and robust across different corpora. The second thrust introduces using the intra-class correlation coefficient (ICC) to evaluate the repeatability of embeddings. A novel regularizer, the ICC regularizer, is proposed to regularize deep neural networks to produce embeddings with higher repeatability. This ICC regularizer is implemented and applied to three speech applications: a clinical application, speaker verification, and voice style conversion. The experimental results reveal that the ICC regularizer improves the repeatability of learned embeddings compared to the contrastive loss, leading to enhanced performance in downstream tasks.
ContributorsZhang, Jianwei (Author) / Jayasuriya, Suren (Thesis advisor) / Berisha, Visar (Thesis advisor) / Liss, Julie (Committee member) / Spanias, Andreas (Committee member) / Arizona State University (Publisher)
Created2023
Description
This dissertation explores applications of machine learning methods in service of the design of screening tests, which are ubiquitous in applications from social work, to criminology, to healthcare. In the first part, a novel Bayesian decision theory framework is presented for designing tree-based adaptive tests. On an application to youth delinquency in Honduras, the method produces a 15-item instrument that is almost as accurate as a full-length 150+ item test. The framework includes specific considerations for the context in which the test will be administered, and provides uncertainty quantification around the trade-offs of shortening lengthy tests. In the second part, classification complexity is explored via theoretical and empirical results from statistical learning theory, information theory, and empirical data complexity measures. A simulation study that explicitly controls two key aspects of classification complexity is performed to relate the theoretical and empirical approaches. Throughout, a unified language and notation that formalizes classification complexity is developed; this same notation is used in subsequent chapters to discuss classification complexity in the context of a speech-based screening test. In the final part, the relative merits of task and feature engineering when designing a speech-based cognitive screening test are explored. Through an extensive classification analysis on a clinical speech dataset from patients with normal cognition and Alzheimer’s disease, the speech elicitation task is shown to have a large impact on test accuracy; carefully performed task and feature engineering are required for best results. A new framework for objectively quantifying speech elicitation tasks is introduced, and two methods are proposed for automatically extracting insights into the aspects of the speech elicitation task that are driving classification performance. The dissertation closes with recommendations for how to evaluate the obtained insights and use them to guide future design of speech-based screening tests.
ContributorsKrantsevich, Chelsea (Author) / Hahn, P. Richard (Thesis advisor) / Berisha, Visar (Committee member) / Lopes, Hedibert (Committee member) / Renaut, Rosemary (Committee member) / Zheng, Yi (Committee member) / Arizona State University (Publisher)
Created2023
Description
The past decade witnessed the success of deep learning models in various applications of computer vision and natural language processing. This success can be predominantly attributed to the (i) availability of large amounts of training data; (ii) access of domain aware knowledge; (iii) i.i.d assumption between the train and target distributions and (iv) belief on existing metrics as reliable indicators of performance. When any of these assumptions are violated, the models exhibit brittleness producing adversely varied behavior. This dissertation focuses on methods for accurate model design and characterization that enhance process reliability when certain assumptions are not met. With the need to safely adopt artificial intelligence tools in practice, it is vital to build reliable failure detectors that indicate regimes where the model must not be invoked. To that end, an error predictor trained with a self-calibration objective is developed to estimate loss consistent with the underlying model. The properties of the error predictor are described and their utility in supporting introspection via feature importances and counterfactual explanations is elucidated. While such an approach can signal data regime changes, it is critical to calibrate models using regimes of inlier (training) and outlier data to prevent under- and over-generalization in models i.e., incorrectly identifying inliers as outliers and vice-versa. By identifying the space for specifying inliers and outliers, an anomaly detector that can effectively flag data of varying semantic complexities in medical imaging is next developed. Uncertainty quantification in deep learning models involves identifying sources of failure and characterizing model confidence to enable actionability. A training strategy is developed that allows the accurate estimation of model uncertainties and its benefits are demonstrated for active learning and generalization gap prediction. This helps identify insufficiently sampled regimes and representation insufficiency in models. In addition, the task of deep inversion under data scarce scenarios is considered, which in practice requires a prior to control the optimization. By identifying limitations in existing work, data priors powered by generative models and deep model priors are designed for audio restoration. With relevant empirical studies on a variety of benchmarks, the need for such design strategies is demonstrated.
ContributorsNarayanaswamy, Vivek Sivaraman (Author) / Spanias, Andreas (Thesis advisor) / J. Thiagarajan, Jayaraman (Committee member) / Berisha, Visar (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2023
Description
Speech intelligibility measures how much a speaker can be understood by a listener. Traditional measures of intelligibility, such as word accuracy, are not sufficient to reveal the reasons of intelligibility degradation. This dissertation investigates the underlying sources of intelligibility degradations from both perspectives of the speaker and the listener. Segmental phoneme errors and suprasegmental lexical boundary errors are developed to reveal the perceptual strategies of the listener. A comprehensive set of automated acoustic measures are developed to quantify variations in the acoustic signal from three perceptual aspects, including articulation, prosody, and vocal quality. The developed measures have been validated on a dysarthric speech dataset with various severity degrees. Multiple regression analysis is employed to show the developed measures could predict perceptual ratings reliably. The relationship between the acoustic measures and the listening errors is investigated to show the interaction between speech production and perception. The hypothesize is that the segmental phoneme errors are mainly caused by the imprecise articulation, while the sprasegmental lexical boundary errors are due to the unreliable phonemic information as well as the abnormal rhythm and prosody patterns. To test the hypothesis, within-speaker variations are simulated in different speaking modes. Significant changes have been detected in both the acoustic signals and the listening errors. Results of the regression analysis support the hypothesis by showing that changes in the articulation-related acoustic features are important in predicting changes in listening phoneme errors, while changes in both of the articulation- and prosody-related features are important in predicting changes in lexical boundary errors. Moreover, significant correlation has been achieved in the cross-validation experiment, which indicates that it is possible to predict intelligibility variations from acoustic signal.
ContributorsJiao, Yishan (Author) / Berisha, Visar (Thesis advisor) / Liss, Julie (Thesis advisor) / Zhou, Yi (Committee member) / Arizona State University (Publisher)
Created2019