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Description
Genomic and proteomic sequences, which are in the form of deoxyribonucleic acid (DNA) and amino acids respectively, play a vital role in the structure, function and diversity of every living cell. As a result, various genomic and proteomic sequence processing methods have been proposed from diverse disciplines, including biology, chemistry,

Genomic and proteomic sequences, which are in the form of deoxyribonucleic acid (DNA) and amino acids respectively, play a vital role in the structure, function and diversity of every living cell. As a result, various genomic and proteomic sequence processing methods have been proposed from diverse disciplines, including biology, chemistry, physics, computer science and electrical engineering. In particular, signal processing techniques were applied to the problems of sequence querying and alignment, that compare and classify regions of similarity in the sequences based on their composition. However, although current approaches obtain results that can be attributed to key biological properties, they require pre-processing and lack robustness to sequence repetitions. In addition, these approaches do not provide much support for efficiently querying sub-sequences, a process that is essential for tracking localized database matches. In this work, a query-based alignment method for biological sequences that maps sequences to time-domain waveforms before processing the waveforms for alignment in the time-frequency plane is first proposed. The mapping uses waveforms, such as time-domain Gaussian functions, with unique sequence representations in the time-frequency plane. The proposed alignment method employs a robust querying algorithm that utilizes a time-frequency signal expansion whose basis function is matched to the basic waveform in the mapped sequences. The resulting WAVEQuery approach is demonstrated for both DNA and protein sequences using the matching pursuit decomposition as the signal basis expansion. The alignment localization of WAVEQuery is specifically evaluated over repetitive database segments, and operable in real-time without pre-processing. It is demonstrated that WAVEQuery significantly outperforms the biological sequence alignment method BLAST for queries with repetitive segments for DNA sequences. A generalized version of the WAVEQuery approach with the metaplectic transform is also described for protein sequence structure prediction. For protein alignment, it is often necessary to not only compare the one-dimensional (1-D) primary sequence structure but also the secondary and tertiary three-dimensional (3-D) space structures. This is done after considering the conformations in the 3-D space due to the degrees of freedom of these structures. As a result, a novel directionality based 3-D waveform mapping for the 3-D protein structures is also proposed and it is used to compare protein structures using a matched filter approach. By incorporating a 3-D time axis, a highly-localized Gaussian-windowed chirp waveform is defined, and the amino acid information is mapped to the chirp parameters that are then directly used to obtain directionality in the 3-D space. This mapping is unique in that additional characteristic protein information such as hydrophobicity, that relates the sequence with the structure, can be added as another representation parameter. The additional parameter helps tracking similarities over local segments of the structure, this enabling classification of distantly related proteins which have partial structural similarities. This approach is successfully tested for pairwise alignments over full length structures, alignments over multiple structures to form a phylogenetic trees, and also alignments over local segments. Also, basic classification over protein structural classes using directional descriptors for the protein structure is performed.
ContributorsRavichandran, Lakshminarayan (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Spanias, Andreas S (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Lacroix, Zoé (Committee member) / Arizona State University (Publisher)
Created2011
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Description
This dissertation considers two different kinds of two-hop multiple-input multiple-output (MIMO) relay networks with beamforming (BF). First, "one-way" amplify-and-forward (AF) and decode-and-forward (DF) MIMO BF relay networks are considered, in which the relay amplifies or decodes the received signal from the source and forwards it to the destination, respectively, where

This dissertation considers two different kinds of two-hop multiple-input multiple-output (MIMO) relay networks with beamforming (BF). First, "one-way" amplify-and-forward (AF) and decode-and-forward (DF) MIMO BF relay networks are considered, in which the relay amplifies or decodes the received signal from the source and forwards it to the destination, respectively, where all nodes beamform with multiple antennas to obtain gains in performance with reduced power consumption. A direct link from source to destination is included in performance analysis. Novel systematic upper-bounds and lower-bounds to average bit or symbol error rates (BERs or SERs) are proposed. Second, "two-way" AF MIMO BF relay networks are investigated, in which two sources exchange their data through a relay, to improve the spectral efficiency compared with one-way relay networks. Novel unified performance analysis is carried out for five different relaying schemes using two, three, and four time slots in sum-BER, the sum of two BERs at both sources, in two-way relay networks with and without direct links. For both kinds of relay networks, when any node is beamforming simultaneously to two nodes (i.e. from source to relay and destination in one-way relay networks, and from relay to both sources in two-way relay networks), the selection of the BF coefficients at a beamforming node becomes a challenging problem since it has to balance the needs of both receiving nodes. Although this "BF optimization" is performed for BER, SER, and sum-BER in this dissertation, the solution for optimal BF coefficients not only is difficult to implement, it also does not lend itself to performance analysis because the optimal BF coefficients cannot be expressed in closed-form. Therefore, the performance of optimal schemes through bounds, as well as suboptimal ones such as strong-path BF, which beamforms to the stronger path of two links based on their received signal-to-noise ratios (SNRs), is provided for BERs or SERs, for the first time. Since different channel state information (CSI) assumptions at the source, relay, and destination provide different error performance, various CSI assumptions are also considered.
ContributorsKim, Hyunjun (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Duman, Tolga M. (Committee member) / Hui, Yu (Committee member) / Zhang, Junshan (Committee member) / Arizona State University (Publisher)
Created2012
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Description
Insertion and deletion errors represent an important category of channel impairments. Despite their importance and much work over the years, channels with such impairments are far from being fully understood as they proved to be difficult to analyze. In this dissertation, a promising coding scheme is investigated over independent and

Insertion and deletion errors represent an important category of channel impairments. Despite their importance and much work over the years, channels with such impairments are far from being fully understood as they proved to be difficult to analyze. In this dissertation, a promising coding scheme is investigated over independent and identically distributed (i.i.d.) insertion/deletion channels, i.e., interleaved concatenation of an outer low-density parity-check (LDPC) code with error-correction capabilities and an inner marker code for synchronization purposes. Marker code structures which offer the highest achievable rates are found with standard bit-level synchronization is performed. Then, to exploit the correlations in the likelihoods corresponding to different transmitted bits, a novel symbol-level synchronization algorithm that works on groups of consecutive bits is introduced. Extrinsic information transfer (EXIT) charts are also utilized to analyze the convergence behavior of the receiver, and to design LDPC codes with degree distributions matched to these channels. The next focus is on segmented deletion channels. It is first shown that such channels are information stable, and hence their channel capacity exists. Several upper and lower bounds are then introduced in an attempt to understand the channel capacity behavior. The asymptotic behavior of the channel capacity is also quantified when the average bit deletion rate is small. Further, maximum-a-posteriori (MAP) based synchronization algorithms are developed and specific LDPC codes are designed to match the channel characteristics. Finally, in addition to binary substitution errors, coding schemes and the corresponding detection algorithms are also studied for several other models with synchronization errors, including inter-symbol interference (ISI) channels, channels with multiple transmit/receive elements and multi-user communication systems.
ContributorsWang, Feng (Author) / Duman, Tolga M. (Thesis advisor) / Tepedelenlioğlu, Cihan (Committee member) / Reisslein, Martin (Committee member) / Zhang, Junshan (Committee member) / Arizona State University (Publisher)
Created2012
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Description
Fully distributed wireless sensor networks (WSNs) without fusion center have advantages such as scalability in network size and energy efficiency in communications. Each sensor shares its data only with neighbors and then achieves global consensus quantities by in-network processing. This dissertation considers robust distributed parameter estimation methods, seeking global consensus

Fully distributed wireless sensor networks (WSNs) without fusion center have advantages such as scalability in network size and energy efficiency in communications. Each sensor shares its data only with neighbors and then achieves global consensus quantities by in-network processing. This dissertation considers robust distributed parameter estimation methods, seeking global consensus on parameters of adaptive learning algorithms and statistical quantities.

Diffusion adaptation strategy with nonlinear transmission is proposed. The nonlinearity was motivated by the necessity for bounded transmit power, as sensors need to iteratively communicate each other energy-efficiently. Despite the nonlinearity, it is shown that the algorithm performs close to the linear case with the added advantage of power savings. This dissertation also discusses convergence properties of the algorithm in the mean and the mean-square sense.

Often, average is used to measure central tendency of sensed data over a network. When there are outliers in the data, however, average can be highly biased. Alternative choices of robust metrics against outliers are median, mode, and trimmed mean. Quantiles generalize the median, and they also can be used for trimmed mean. Consensus-based distributed quantile estimation algorithm is proposed and applied for finding trimmed-mean, median, maximum or minimum values, and identification of outliers through simulation. It is shown that the estimated quantities are asymptotically unbiased and converges toward the sample quantile in the mean-square sense. Step-size sequences with proper decay rates are also discussed for convergence analysis.

Another measure of central tendency is a mode which represents the most probable value and also be robust to outliers and other contaminations in data. The proposed distributed mode estimation algorithm achieves a global mode by recursively shifting conditional mean of the measurement data until it converges to stationary points of estimated density function. It is also possible to estimate the mode by utilizing grid vector as well as kernel density estimator. The densities are estimated at each grid point, while the points are updated until they converge to a global mode.
ContributorsLee, Jongmin (Electrical engineer) (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Spanias, Andreas (Thesis advisor) / Tsakalis, Konstantinos (Committee member) / Reisslein, Martin (Committee member) / Arizona State University (Publisher)
Created2017
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Description
Modern machine learning systems leverage data and features from multiple modalities to gain more predictive power. In most scenarios, the modalities are vastly different and the acquired data are heterogeneous in nature. Consequently, building highly effective fusion algorithms is at the core to achieve improved model robustness and inferencing performance.

Modern machine learning systems leverage data and features from multiple modalities to gain more predictive power. In most scenarios, the modalities are vastly different and the acquired data are heterogeneous in nature. Consequently, building highly effective fusion algorithms is at the core to achieve improved model robustness and inferencing performance. This dissertation focuses on the representation learning approaches as the fusion strategy. Specifically, the objective is to learn the shared latent representation which jointly exploit the structural information encoded in all modalities, such that a straightforward learning model can be adopted to obtain the prediction.

We first consider sensor fusion, a typical multimodal fusion problem critical to building a pervasive computing platform. A systematic fusion technique is described to support both multiple sensors and descriptors for activity recognition. Targeted to learn the optimal combination of kernels, Multiple Kernel Learning (MKL) algorithms have been successfully applied to numerous fusion problems in computer vision etc. Utilizing the MKL formulation, next we describe an auto-context algorithm for learning image context via the fusion with low-level descriptors. Furthermore, a principled fusion algorithm using deep learning to optimize kernel machines is developed. By bridging deep architectures with kernel optimization, this approach leverages the benefits of both paradigms and is applied to a wide variety of fusion problems.

In many real-world applications, the modalities exhibit highly specific data structures, such as time sequences and graphs, and consequently, special design of the learning architecture is needed. In order to improve the temporal modeling for multivariate sequences, we developed two architectures centered around attention models. A novel clinical time series analysis model is proposed for several critical problems in healthcare. Another model coupled with triplet ranking loss as metric learning framework is described to better solve speaker diarization. Compared to state-of-the-art recurrent networks, these attention-based multivariate analysis tools achieve improved performance while having a lower computational complexity. Finally, in order to perform community detection on multilayer graphs, a fusion algorithm is described to derive node embedding from word embedding techniques and also exploit the complementary relational information contained in each layer of the graph.
ContributorsSong, Huan (Author) / Spanias, Andreas (Thesis advisor) / Thiagarajan, Jayaraman (Committee member) / Berisha, Visar (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2018
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Description
Both two-way relays (TWR) and full-duplex (FD) radios are spectrally efficient, and their integration shows great potential to further improve the spectral efficiency, which offers a solution to the fifth generation wireless systems. High quality channel state information (CSI) are the key components for the implementation and the performance of

Both two-way relays (TWR) and full-duplex (FD) radios are spectrally efficient, and their integration shows great potential to further improve the spectral efficiency, which offers a solution to the fifth generation wireless systems. High quality channel state information (CSI) are the key components for the implementation and the performance of the FD TWR system, making channel estimation in FD TWRs crucial.

The impact of channel estimation on spectral efficiency in half-duplex multiple-input-multiple-output (MIMO) TWR systems is investigated. The trade-off between training and data energy is proposed. In the case that two sources are symmetric in power and number of antennas, a closed-form for the optimal ratio of data energy to total energy is derived. It can be shown that the achievable rate is a monotonically increasing function of the data length. The asymmetric case is discussed as well.

Efficient and accurate training schemes for FD TWRs are essential for profiting from the inherent spectrally efficient structures of both FD and TWRs. A novel one-block training scheme with a maximum likelihood (ML) estimator is proposed to estimate the channels between the nodes and the residual self-interference (RSI) channel simultaneously. Baseline training schemes are also considered to compare with the one-block scheme. The Cramer-Rao bounds (CRBs) of the training schemes are derived and analyzed by using the asymptotic properties of Toeplitz matrices. The benefit of estimating the RSI channel is shown analytically in terms of Fisher information.

To obtain fundamental and analytic results of how the RSI affects the spectral efficiency, one-way FD relay systems are studied. Optimal training design and ML channel estimation are proposed to estimate the RSI channel. The CRBs are derived and analyzed in closed-form so that the optimal training sequence can be found via minimizing the CRB. Extensions of the training scheme to frequency-selective channels and multiple relays are also presented.

Simultaneously sensing and transmission in an FD cognitive radio system with MIMO is considered. The trade-off between the transmission rate and the detection accuracy is characterized by the sum-rate of the primary and the secondary users. Different beamforming and combining schemes are proposed and compared.
ContributorsLi, Xiaofeng (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Bliss, Daniel W (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2018
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Description
Cognitive radio (CR) and device-to-device (D2D) systems are two promising dynamic spectrum access schemes in wireless communication systems to provide improved quality-of-service, and efficient spectrum utilization. This dissertation shows that both CR and D2D systems benefit from properly designed cooperation scheme.

In underlay CR systems, where secondary users (SUs)

Cognitive radio (CR) and device-to-device (D2D) systems are two promising dynamic spectrum access schemes in wireless communication systems to provide improved quality-of-service, and efficient spectrum utilization. This dissertation shows that both CR and D2D systems benefit from properly designed cooperation scheme.

In underlay CR systems, where secondary users (SUs) transmit simultaneously with primary users (PUs), reliable communication is by all means guaranteed for PUs, which likely deteriorates SUs’ performance. To overcome this issue, cooperation exclusively among SUs is achieved through multi-user diversity (MUD), where each SU is subject to an instantaneous interference constraint at the primary receiver. Therefore, the active number of SUs satisfying this constraint is random. Under different user distributions with the same mean number of SUs, the stochastic ordering of SU performance metrics including bit error rate (BER), outage probability, and ergodic capacity are made possible even without observing closed form expressions. Furthermore, a cooperation is assumed between primary and secondary networks, where those SUs exceeding the interference constraint facilitate PU’s transmission by relaying its signal. A fundamental performance trade-off between primary and secondary networks is observed, and it is illustrated that the proposed scheme outperforms non-cooperative underlay CR systems in the sense of system overall BER and sum achievable rate.

Similar to conventional cellular networks, CR systems suffer from an overloaded receiver having to manage signals from a large number of users. To address this issue, D2D communications has been proposed, where direct transmission links are established between users in close proximity to offload the system traffic. Several new cooperative spectrum access policies are proposed allowing coexistence of multiple D2D pairs in order to improve the spectral efficiency. Despite the additional interference, it is shown that both the cellular user’s (CU) and the individual D2D user's achievable rates can be improved simultaneously when the number of D2D pairs is below a certain threshold, resulting in a significant multiplexing gain in the sense of D2D sum rate. This threshold is quantified for different policies using second order approximations for the average achievable rates for both the CU and the individual D2D user.
ContributorsZeng, Ruochen (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Bliss, Daniel (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2017
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Description
In the past half century, low-power wireless signals from portable radar sensors, initially continuous-wave (CW) radars and more recently ultra-wideband (UWB) radar systems, have been successfully used to detect physiological movements of stationary human beings.

The thesis starts with a careful review of existing signal processing techniques and state

In the past half century, low-power wireless signals from portable radar sensors, initially continuous-wave (CW) radars and more recently ultra-wideband (UWB) radar systems, have been successfully used to detect physiological movements of stationary human beings.

The thesis starts with a careful review of existing signal processing techniques and state of the art methods possible for vital signs monitoring using UWB impulse systems. Then an in-depth analysis of various approaches is presented.

Robust heart-rate monitoring methods are proposed based on a novel result: spectrally the fundamental heartbeat frequency is respiration-interference-limited while its higher-order harmonics are noise-limited. The higher-order statistics related to heartbeat can be a robust indication when the fundamental heartbeat is masked by the strong lower-order harmonics of respiration or when phase calibration is not accurate if phase-based method is used. Analytical spectral analysis is performed to validate that the higher-order harmonics of heartbeat is almost respiration-interference free. Extensive experiments have been conducted to justify an adaptive heart-rate monitoring algorithm. The scenarios of interest are, 1) single subject, 2) multiple subjects at different ranges, 3) multiple subjects at same range, and 4) through wall monitoring.

A remote sensing radar system implemented using the proposed adaptive heart-rate estimation algorithm is compared to the competing remote sensing technology, a remote imaging photoplethysmography system, showing promising results.

State of the art methods for vital signs monitoring are fundamentally related to process the phase variation due to vital signs motions. Their performance are determined by a phase calibration procedure. Existing methods fail to consider the time-varying nature of phase noise. There is no prior knowledge about which of the corrupted complex signals, in-phase component (I) and quadrature component (Q), need to be corrected. A precise phase calibration routine is proposed based on the respiration pattern. The I/Q samples from every breath are more likely to experience similar motion noise and therefore they should be corrected independently. High slow-time sampling rate is used to ensure phase calibration accuracy. Occasionally, a 180-degree phase shift error occurs after the initial calibration step and should be corrected as well. All phase trajectories in the I/Q plot are only allowed in certain angular spaces. This precise phase calibration routine is validated through computer simulations incorporating a time-varying phase noise model, controlled mechanic system, and human subject experiment.
ContributorsRong, Yu (Author) / Bliss, Daniel W (Thesis advisor) / Richmond, Christ D (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Alkhateeb, Ahmed (Committee member) / Arizona State University (Publisher)
Created2018
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Description
The research on the topology and dynamics of complex networks is one of the most focused area in complex system science. The goals are to structure our understanding of the real-world social, economical, technological, and biological systems in the aspect of networks consisting a large number of interacting units and

The research on the topology and dynamics of complex networks is one of the most focused area in complex system science. The goals are to structure our understanding of the real-world social, economical, technological, and biological systems in the aspect of networks consisting a large number of interacting units and to develop corresponding detection, prediction, and control strategies. In this highly interdisciplinary field, my research mainly concentrates on universal estimation schemes, physical controllability, as well as mechanisms behind extreme events and cascading failure for complex networked systems.

Revealing the underlying structure and dynamics of complex networked systems from observed data without of any specific prior information is of fundamental importance to science, engineering, and society. We articulate a Markov network based model, the sparse dynamical Boltzmann machine (SDBM), as a universal network structural estimator and dynamics approximator based on techniques including compressive sensing and K-means algorithm. It recovers the network structure of the original system and predicts its short-term or even long-term dynamical behavior for a large variety of representative dynamical processes on model and real-world complex networks.

One of the most challenging problems in complex dynamical systems is to control complex networks.

Upon finding that the energy required to approach a target state with reasonable precision

is often unbearably large, and the energy of controlling a set of networks with similar structural properties follows a fat-tail distribution, we identify fundamental structural ``short boards'' that play a dominant role in the enormous energy and offer a theoretical interpretation for the fat-tail distribution and simple strategies to significantly reduce the energy.

Extreme events and cascading failure, a type of collective behavior in complex networked systems, often have catastrophic consequences. Utilizing transportation and evolutionary game dynamics as prototypical

settings, we investigate the emergence of extreme events in simplex complex networks, mobile ad-hoc networks and multi-layer interdependent networks. A striking resonance-like phenomenon and the emergence of global-scale cascading breakdown are discovered. We derive analytic theories to understand the mechanism of

control at a quantitative level and articulate cost-effective control schemes to significantly suppress extreme events and the cascading process.
ContributorsChen, Yuzhong (Author) / Lai, Ying-Cheng (Thesis advisor) / Spanias, Andreas (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Ying, Lei (Committee member) / Arizona State University (Publisher)
Created2016
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Description
Distributed wireless sensor networks (WSNs) have attracted researchers recently due to their advantages such as low power consumption, scalability and robustness to link failures. In sensor networks with no fusion center, consensus is a process where

all the sensors in the network achieve global agreement using only local transmissions. In this

Distributed wireless sensor networks (WSNs) have attracted researchers recently due to their advantages such as low power consumption, scalability and robustness to link failures. In sensor networks with no fusion center, consensus is a process where

all the sensors in the network achieve global agreement using only local transmissions. In this dissertation, several consensus and consensus-based algorithms in WSNs are studied.

Firstly, a distributed consensus algorithm for estimating the maximum and minimum value of the initial measurements in a sensor network in the presence of communication noise is proposed. In the proposed algorithm, a soft-max approximation together with a non-linear average consensus algorithm is used. A design parameter controls the trade-off between the soft-max error and convergence speed. An analysis of this trade-off gives guidelines towards how to choose the design parameter for the max estimate. It is also shown that if some prior knowledge of the initial measurements is available, the consensus process can be accelerated.

Secondly, a distributed system size estimation algorithm is proposed. The proposed algorithm is based on distributed average consensus and L2 norm estimation. Different sources of error are explicitly discussed, and the distribution of the final estimate is derived. The CRBs for system size estimator with average and max consensus strategies are also considered, and different consensus based system size estimation approaches are compared.

Then, a consensus-based network center and radius estimation algorithm is described. The center localization problem is formulated as a convex optimization problem with a summation form by using soft-max approximation with exponential functions. Distributed optimization methods such as stochastic gradient descent and diffusion adaptation are used to estimate the center. Then, max consensus is used to compute the radius of the network area.

Finally, two average consensus based distributed estimation algorithms are introduced: distributed degree distribution estimation algorithm and algorithm for tracking the dynamics of the desired parameter. Simulation results for all proposed algorithms are provided.
ContributorsZhang, Sai (Electrical engineer) (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Spanias, Andreas (Thesis advisor) / Tsakalis, Kostas (Committee member) / Bliss, Daniel (Committee member) / Arizona State University (Publisher)
Created2017