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- Genre: Doctoral Dissertation
Description
Online social networks are the hubs of social activity in cyberspace, and using them to exchange knowledge, experiences, and opinions is common. In this work, an advanced topic modeling framework is designed to analyse complex longitudinal health information from social media with minimal human annotation, and Adverse Drug Events and Reaction (ADR) information is extracted and automatically processed by using a biased topic modeling method. This framework improves and extends existing topic modelling algorithms that incorporate background knowledge. Using this approach, background knowledge such as ADR terms and other biomedical knowledge can be incorporated during the text mining process, with scores which indicate the presence of ADR being generated. A case control study has been performed on a data set of twitter timelines of women that announced their pregnancy, the goals of the study is to compare the ADR risk of medication usage from each medication category during the pregnancy.
In addition, to evaluate the prediction power of this approach, another important aspect of personalized medicine was addressed: the prediction of medication usage through the identification of risk groups. During the prediction process, the health information from Twitter timeline, such as diseases, symptoms, treatments, effects, and etc., is summarized by the topic modelling processes and the summarization results is used for prediction. Dimension reduction and topic similarity measurement are integrated into this framework for timeline classification and prediction. This work could be applied to provide guidelines for FDA drug risk categories. Currently, this process is done based on laboratory results and reported cases.
Finally, a multi-dimensional text data warehouse (MTD) to manage the output from the topic modelling is proposed. Some attempts have been also made to incorporate topic structure (ontology) and the MTD hierarchy. Results demonstrate that proposed methods show promise and this system represents a low-cost approach for drug safety early warning.
In addition, to evaluate the prediction power of this approach, another important aspect of personalized medicine was addressed: the prediction of medication usage through the identification of risk groups. During the prediction process, the health information from Twitter timeline, such as diseases, symptoms, treatments, effects, and etc., is summarized by the topic modelling processes and the summarization results is used for prediction. Dimension reduction and topic similarity measurement are integrated into this framework for timeline classification and prediction. This work could be applied to provide guidelines for FDA drug risk categories. Currently, this process is done based on laboratory results and reported cases.
Finally, a multi-dimensional text data warehouse (MTD) to manage the output from the topic modelling is proposed. Some attempts have been also made to incorporate topic structure (ontology) and the MTD hierarchy. Results demonstrate that proposed methods show promise and this system represents a low-cost approach for drug safety early warning.
ContributorsYang, Jian (Author) / Gonzalez, Graciela (Thesis advisor) / Davulcu, Hasan (Thesis advisor) / Liu, Huan (Committee member) / Papotti, Paolo (Committee member) / Arizona State University (Publisher)
Created2017
Description
Reasoning with commonsense knowledge is an integral component of human behavior. It is due to this capability that people know that a weak person may not be able to lift someone. It has been a long standing goal of the Artificial Intelligence community to simulate such commonsense reasoning abilities in machines. Over the years, many advances have been made and various challenges have been proposed to test their abilities. The Winograd Schema Challenge (WSC) is one such Natural Language Understanding (NLU) task which was also proposed as an alternative to the Turing Test. It is made up of textual question answering problems which require resolution of a pronoun to its correct antecedent.
In this thesis, two approaches of developing NLU systems to solve the Winograd Schema Challenge are demonstrated. To this end, a semantic parser is presented, various kinds of commonsense knowledge are identified, techniques to extract commonsense knowledge are developed and two commonsense reasoning algorithms are presented. The usefulness of the developed tools and techniques is shown by applying them to solve the challenge.
In this thesis, two approaches of developing NLU systems to solve the Winograd Schema Challenge are demonstrated. To this end, a semantic parser is presented, various kinds of commonsense knowledge are identified, techniques to extract commonsense knowledge are developed and two commonsense reasoning algorithms are presented. The usefulness of the developed tools and techniques is shown by applying them to solve the challenge.
ContributorsSharma, Arpita (Author) / Baral, Chitta (Thesis advisor) / Lee, Joohyung (Committee member) / Papotti, Paolo (Committee member) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2019