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Drosophila melanogaster, as an important model organism, is used to explore the mechanism which governs cell differentiation and embryonic development. Understanding the mechanism will help to reveal the effects of genes on other species or even human beings. Currently, digital camera techniques make high quality Drosophila gene expression imaging possible.

Drosophila melanogaster, as an important model organism, is used to explore the mechanism which governs cell differentiation and embryonic development. Understanding the mechanism will help to reveal the effects of genes on other species or even human beings. Currently, digital camera techniques make high quality Drosophila gene expression imaging possible. On the other hand, due to the advances in biology, gene expression images which can reveal spatiotemporal patterns are generated in a high-throughput pace. Thus, an automated and efficient system that can analyze gene expression will become a necessary tool for investigating the gene functions, interactions and developmental processes. One investigation method is to compare the expression patterns of different developmental stages. Recently, however, the expression patterns are manually annotated with rough stage ranges. The work of annotation requires professional knowledge from experienced biologists. Hence, how to transfer the domain knowledge in biology into an automated system which can automatically annotate the patterns provides a challenging problem for computer scientists. In this thesis, the problem of stage annotation for Drosophila embryo is modeled in the machine learning framework. Three sparse learning algorithms and one ensemble algorithm are used to attack the problem. The sparse algorithms are Lasso, group Lasso and sparse group Lasso. The ensemble algorithm is based on a voting method. Besides that the proposed algorithms can annotate the patterns to stages instead of stage ranges with high accuracy; the decimal stage annotation algorithm presents a novel way to annotate the patterns to decimal stages. In addition, some analysis on the algorithm performance are made and corresponding explanations are given. Finally, with the proposed system, all the lateral view BDGP and FlyFish images are annotated and several interesting applications of decimal stage value are revealed.
ContributorsPan, Cheng (Author) / Ye, Jieping (Thesis advisor) / Li, Baoxin (Committee member) / Farin, Gerald (Committee member) / Arizona State University (Publisher)
Created2012
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Description
Social networking platforms have redefined communication, serving as conduits forswift global information dissemination on contemporary topics and trends. This research probes information cascade (IC) dynamics, focusing on viral IC, where user-shared information gains rapid, widespread attention. Implications of IC span advertising, persuasion, opinion-shaping, and crisis response. First, this dissertation aims to unravel the context

Social networking platforms have redefined communication, serving as conduits forswift global information dissemination on contemporary topics and trends. This research probes information cascade (IC) dynamics, focusing on viral IC, where user-shared information gains rapid, widespread attention. Implications of IC span advertising, persuasion, opinion-shaping, and crisis response. First, this dissertation aims to unravel the context behind viral content, particularly in the realm of the digital world, introducing a semi-supervised taxonomy induction framework (STIF). STIF employs state-of-the-art term representation, topical phrase detection, and clustering to organize terms into a two-level topic taxonomy. Social scientists then assess the topic clusters for coherence and completeness. STIF proves effective, significantly reducing human coding efforts (up to 74%) while accurately inducing taxonomies and term-to-topic mappings due to the high purity of its topics. Second, to profile the drivers of virality, this study investigates messaging strategies influencing message virality. Three content-based hypotheses are formulated and tested, demonstrating that incorporation of “negativity bias,” “causal arguments,” and “threats to personal or societal core values” - singularly and jointly - significantly enhances message virality on social media, quantified by retweet counts. Furthermore, the study highlights framing narratives’ pivotal role in shaping discourse, particularly in adversarial campaigns. An innovative pipeline for automatic framing detection is introduced, and tested on a collection of texts on the Russia-Ukraine conflict. Integrating representation learning, overlapping graph-clustering, and a unique Topic Actor Graph (TAG) synthesis method, the study achieves remarkable framing detection accuracy. The developed scoring mechanism maps sentences to automatically detect framing signatures. This pipeline attains an impressive F1 score of 92% and a 95% weighted accuracy for framing detection on a real-world dataset. In essence, this dissertation focuses on the multidimensional exploration of information cascade, uncovering the context and drivers of content virality, and automating framing detection. Through innovative methodologies like STIF, messaging strategy analysis, and TAG Frames, the research contributes valuable insights into the mechanics of viral content spread and framing nuances within the digital landscape, enriching fields such as advertisement, communication, public discourse, and crisis response strategies.
ContributorsMousavi, Maryam (Author) / Davulcu, Hasan HD (Thesis advisor) / Li, Baoxin (Committee member) / Corman, Steven (Committee member) / McDaniel, Troy (Committee member) / Arizona State University (Publisher)
Created2023
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Description
This thesis presents robust and novel solutions using knowledge distillation with geometric approaches and multimodal data that can address the current challenges in deep learning, providing a comprehensive understanding of the learning process involved in knowledge distillation. Deep learning has attained significant success in various applications, such as health and

This thesis presents robust and novel solutions using knowledge distillation with geometric approaches and multimodal data that can address the current challenges in deep learning, providing a comprehensive understanding of the learning process involved in knowledge distillation. Deep learning has attained significant success in various applications, such as health and wellness promotion, smart homes, and intelligent surveillance. In general, stacking more layers or increasing the number of trainable parameters causes deep networks to exhibit improved performance. However, this causes the model to become large, resulting in an additional need for computing and power resources for training, storage, and deployment. These are the core challenges in incorporating such models into small devices with limited power and computational resources. In this thesis, robust solutions aimed at addressing the aforementioned challenges are presented. These proposed methodologies and algorithmic contributions enhance the performance and efficiency of deep learning models. The thesis encompasses a comprehensive exploration of knowledge distillation, an approach that holds promise for creating compact models from high-capacity ones, while preserving their performance. This exploration covers diverse datasets, including both time series and image data, shedding light on the pivotal role of augmentation methods in knowledge distillation. The effects of these methods are rigorously examined through empirical experiments. Furthermore, the study within this thesis delves into the efficient utilization of features derived from two different teacher models, each trained on dissimilar data representations, including time-series and image data. Through these investigations, I present novel approaches to knowledge distillation, leveraging geometric techniques for the analysis of multimodal data. These solutions not only address real-world challenges but also offer valuable insights and recommendations for modeling in new applications.
ContributorsJeon, Eunsom (Author) / Turaga, Pavan (Thesis advisor) / Li, Baoxin (Committee member) / Lee, Hyunglae (Committee member) / Jayasuriya, Suren (Committee member) / Arizona State University (Publisher)
Created2023