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Description
US Senate is the venue of political debates where the federal bills are formed and voted. Senators show their support/opposition along the bills with their votes. This information makes it possible to extract the polarity of the senators. Similarly, blogosphere plays an increasingly important role as a forum for public

US Senate is the venue of political debates where the federal bills are formed and voted. Senators show their support/opposition along the bills with their votes. This information makes it possible to extract the polarity of the senators. Similarly, blogosphere plays an increasingly important role as a forum for public debate. Authors display sentiment toward issues, organizations or people using a natural language.

In this research, given a mixed set of senators/blogs debating on a set of political issues from opposing camps, I use signed bipartite graphs for modeling debates, and I propose an algorithm for partitioning both the opinion holders (senators or blogs) and the issues (bills or topics) comprising the debate into binary opposing camps. Simultaneously, my algorithm scales the entities on a univariate scale. Using this scale, a researcher can identify moderate and extreme senators/blogs within each camp, and polarizing versus unifying issues. Through performance evaluations I show that my proposed algorithm provides an effective solution to the problem, and performs much better than existing baseline algorithms adapted to solve this new problem. In my experiments, I used both real data from political blogosphere and US Congress records, as well as synthetic data which were obtained by varying polarization and degree distribution of the vertices of the graph to show the robustness of my algorithm.

I also applied my algorithm on all the terms of the US Senate to the date for longitudinal analysis and developed a web based interactive user interface www.PartisanScale.com to visualize the analysis.

US politics is most often polarized with respect to the left/right alignment of the entities. However, certain issues do not reflect the polarization due to political parties, but observe a split correlating to the demographics of the senators, or simply receive consensus. I propose a hierarchical clustering algorithm that identifies groups of bills that share the same polarization characteristics. I developed a web based interactive user interface www.ControversyAnalysis.com to visualize the clusters while providing a synopsis through distribution charts, word clouds, and heat maps.
ContributorsGokalp, Sedat (Author) / Davulcu, Hasan (Thesis advisor) / Sen, Arunabha (Committee member) / Liu, Huan (Committee member) / Woodward, Mark (Committee member) / Arizona State University (Publisher)
Created2015
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Description
Analysis of social networks has the potential to provide insights into wide range of applications. As datasets continue to grow, a key challenge is the lack of a widely applicable algorithmic framework for detection of statistically anomalous networks and network properties. Unlike traditional signal processing, where models of truth or

Analysis of social networks has the potential to provide insights into wide range of applications. As datasets continue to grow, a key challenge is the lack of a widely applicable algorithmic framework for detection of statistically anomalous networks and network properties. Unlike traditional signal processing, where models of truth or empirical verification and background data exist and are often well defined, these features are commonly lacking in social and other networks. Here, a novel algorithmic framework for statistical signal processing for graphs is presented. The framework is based on the analysis of spectral properties of the residuals matrix. The framework is applied to the detection of innovation patterns in publication networks, leveraging well-studied empirical knowledge from the history of science. Both the framework itself and the application constitute novel contributions, while advancing algorithmic and mathematical techniques for graph-based data and understanding of the patterns of emergence of novel scientific research. Results indicate the efficacy of the approach and highlight a number of fruitful future directions.
ContributorsBliss, Nadya Travinin (Author) / Laubichler, Manfred (Thesis advisor) / Castillo-Chavez, Carlos (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2015
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Description
In visualizing information hierarchies, icicle plots are efficient diagrams in that they provide the user a straightforward layout for different levels of data in a hierarchy and enable the user to compare items based on the item width. However, as the size of the hierarchy grows large, the items in

In visualizing information hierarchies, icicle plots are efficient diagrams in that they provide the user a straightforward layout for different levels of data in a hierarchy and enable the user to compare items based on the item width. However, as the size of the hierarchy grows large, the items in an icicle plot end up being small and indistinguishable. In this thesis, by maintaining the positive characteristics of traditional

icicle plots and incorporating new features such as dynamic diagram and active layer, we developed an interactive visualization that allows the user to selectively drill down or roll up to review different levels of data in a large hierarchy, to change the hierarchical

structure to detect potential patterns, and to maintain an overall understanding of the

current hierarchical structure.
ContributorsWu, Bi (Author) / Maciejewski, Ross (Thesis advisor) / Runger, George C. (Committee member) / Davulcu, Hasan (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Advances in data collection technologies have made it cost-effective to obtain heterogeneous data from multiple data sources. Very often, the data are of very high dimension and feature selection is preferred in order to reduce noise, save computational cost and learn interpretable models. Due to the multi-modality nature of heterogeneous

Advances in data collection technologies have made it cost-effective to obtain heterogeneous data from multiple data sources. Very often, the data are of very high dimension and feature selection is preferred in order to reduce noise, save computational cost and learn interpretable models. Due to the multi-modality nature of heterogeneous data, it is interesting to design efficient machine learning models that are capable of performing variable selection and feature group (data source) selection simultaneously (a.k.a bi-level selection). In this thesis, I carry out research along this direction with a particular focus on designing efficient optimization algorithms. I start with a unified bi-level learning model that contains several existing feature selection models as special cases. Then the proposed model is further extended to tackle the block-wise missing data, one of the major challenges in the diagnosis of Alzheimer's Disease (AD). Moreover, I propose a novel interpretable sparse group feature selection model that greatly facilitates the procedure of parameter tuning and model selection. Last but not least, I show that by solving the sparse group hard thresholding problem directly, the sparse group feature selection model can be further improved in terms of both algorithmic complexity and efficiency. Promising results are demonstrated in the extensive evaluation on multiple real-world data sets.
ContributorsXiang, Shuo (Author) / Ye, Jieping (Thesis advisor) / Mittelmann, Hans D (Committee member) / Davulcu, Hasan (Committee member) / He, Jingrui (Committee member) / Arizona State University (Publisher)
Created2014
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Description
A new algebraic system, Test Algebra (TA), is proposed for identifying faults in combinatorial testing for SaaS (Software-as-a-Service) applications. In the context of cloud computing, SaaS is a new software delivery model, in which mission-critical applications are composed, deployed, and executed on cloud platforms. Testing SaaS applications is challenging because

A new algebraic system, Test Algebra (TA), is proposed for identifying faults in combinatorial testing for SaaS (Software-as-a-Service) applications. In the context of cloud computing, SaaS is a new software delivery model, in which mission-critical applications are composed, deployed, and executed on cloud platforms. Testing SaaS applications is challenging because new applications need to be tested once they are composed, and prior to their deployment. A composition of components providing services yields a configuration providing a SaaS application. While individual components

in the configuration may have been thoroughly tested, faults still arise due to interactions among the components composed, making the configuration faulty. When there are k components, combinatorial testing algorithms can be used to identify faulty interactions for t or fewer components, for some threshold 2 <= t <= k on the size of interactions considered. In general these methods do not identify specific faults, but rather indicate the presence or absence of some fault. To identify specific faults, an adaptive testing regime repeatedly constructs and tests configurations in order to determine, for each interaction of interest, whether it is faulty or not. In order to perform such testing in a loosely coupled distributed environment such as

the cloud, it is imperative that testing results can be combined from many different servers. The TA defines rules to permit results to be combined, and to identify the faulty interactions. Using the TA, configurations can be tested concurrently on different servers and in any order. The results, using the TA, remain the same.
ContributorsQi, Guanqiu (Author) / Tsai, Wei-Tek (Thesis advisor) / Davulcu, Hasan (Committee member) / Sarjoughian, Hessam S. (Committee member) / Yu, Hongyu (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Interactive remote e-learning is one of the youngest and most popular methods that is used in today's teaching method. WebRTC, on the other hand, has become the popular concept and method in real time communication. Unlike the old fashioned Adobe Flash, user will communicate directly to each other rather than

Interactive remote e-learning is one of the youngest and most popular methods that is used in today's teaching method. WebRTC, on the other hand, has become the popular concept and method in real time communication. Unlike the old fashioned Adobe Flash, user will communicate directly to each other rather than calling server as the middle man. The world is changing from plug-in to web-browser. However, the WebRTC have not been widely used for school education.

By taking into consideration of the WebRTC solution for data transferring, we propose a new Cloud based interactive multimedia which enables virtual lab learning environment. Three modules were proposed along with an efficient solution for achieving optimized network bandwidth. The One-to-Many communication was introduced in the video conferencing and scalability was tested for the application. The key technical contribution is to establish a sufficient system that designed to utilize the WebRTC in its best way in educational world in the Vlab platform and reduces the tool cost and improves online learning experience.
ContributorsLi, Qingyun (Author) / Huang, Dijiang (Thesis advisor) / Davulcu, Hasan (Committee member) / Dasgupta, Partha (Committee member) / Arizona State University (Publisher)
Created2014
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Description
The healthcare system in this country is currently unacceptable. New technologies may contribute to reducing cost and improving outcomes. Early diagnosis and treatment represents the least risky option for addressing this issue. Such a technology needs to be inexpensive, highly sensitive, highly specific, and amenable to adoption in a clinic.

The healthcare system in this country is currently unacceptable. New technologies may contribute to reducing cost and improving outcomes. Early diagnosis and treatment represents the least risky option for addressing this issue. Such a technology needs to be inexpensive, highly sensitive, highly specific, and amenable to adoption in a clinic. This thesis explores an immunodiagnostic technology based on highly scalable, non-natural sequence peptide microarrays designed to profile the humoral immune response and address the healthcare problem. The primary aim of this thesis is to explore the ability of these arrays to map continuous (linear) epitopes. I discovered that using a technique termed subsequence analysis where epitopes could be decisively mapped to an eliciting protein with high success rate. This led to the discovery of novel linear epitopes from Plasmodium falciparum (Malaria) and Treponema palladium (Syphilis), as well as validation of previously discovered epitopes in Dengue and monoclonal antibodies. Next, I developed and tested a classification scheme based on Support Vector Machines for development of a Dengue Fever diagnostic, achieving higher sensitivity and specificity than current FDA approved techniques. The software underlying this method is available for download under the BSD license. Following this, I developed a kinetic model for immunosignatures and tested it against existing data driven by previously unexplained phenomena. This model provides a framework and informs ways to optimize the platform for maximum stability and efficiency. I also explored the role of sequence composition in explaining an immunosignature binding profile, determining a strong role for charged residues that seems to have some predictive ability for disease. Finally, I developed a database, software and indexing strategy based on Apache Lucene for searching motif patterns (regular expressions) in large biological databases. These projects as a whole have advanced knowledge of how to approach high throughput immunodiagnostics and provide an example of how technology can be fused with biology in order to affect scientific and health outcomes.
ContributorsRicher, Joshua Amos (Author) / Johnston, Stephen A. (Thesis advisor) / Woodbury, Neal (Committee member) / Stafford, Phillip (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Peptide microarrays have been used in molecular biology to profile immune responses and develop diagnostic tools. When the microarrays are printed with random peptide sequences, they can be used to identify antigen antibody binding patterns or immunosignatures. In this thesis, an advanced signal processing method is proposed to estimate

Peptide microarrays have been used in molecular biology to profile immune responses and develop diagnostic tools. When the microarrays are printed with random peptide sequences, they can be used to identify antigen antibody binding patterns or immunosignatures. In this thesis, an advanced signal processing method is proposed to estimate epitope antigen subsequences as well as identify mimotope antigen subsequences that mimic the structure of epitopes from random-sequence peptide microarrays. The method first maps peptide sequences to linear expansions of highly-localized one-dimensional (1-D) time-varying signals and uses a time-frequency processing technique to detect recurring patterns in subsequences. This technique is matched to the aforementioned mapping scheme, and it allows for an inherent analysis on how substitutions in the subsequences can affect antibody binding strength. The performance of the proposed method is demonstrated by estimating epitopes and identifying potential mimotopes for eight monoclonal antibody samples.

The proposed mapping is generalized to express information on a protein's sequence location, structure and function onto a highly localized three-dimensional (3-D) Gaussian waveform. In particular, as analysis of protein homology has shown that incorporating different kinds of information into an alignment process can yield more robust alignment results, a pairwise protein structure alignment method is proposed based on a joint similarity measure of multiple mapped protein attributes. The 3-D mapping allocates protein properties into distinct regions in the time-frequency plane in order to simplify the alignment process by including all relevant information into a single, highly customizable waveform. Simulations demonstrate the improved performance of the joint alignment approach to infer relationships between proteins, and they provide information on mutations that cause changes to both the sequence and structure of a protein.

In addition to the biology-based signal processing methods, a statistical method is considered that uses a physics-based model to improve processing performance. In particular, an externally developed physics-based model for sea clutter is examined when detecting a low radar cross-section target in heavy sea clutter. This novel model includes a process that generates random dynamic sea clutter based on the governing physics of water gravity and capillary waves and a finite-difference time-domain electromagnetics simulation process based on Maxwell's equations propagating the radar signal. A subspace clutter suppression detector is applied to remove dominant clutter eigenmodes, and its improved performance over matched filtering is demonstrated using simulations.
ContributorsO'Donnell, Brian (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Johnston, Stephen A. (Committee member) / Kovvali, Narayan (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Skyline queries extract interesting points that are non-dominated and help paint the bigger picture of the data in question. They are valuable in many multi-criteria decision applications and are becoming a staple of decision support systems.

An assumption commonly made by many skyline algorithms is that a skyline query is applied

Skyline queries extract interesting points that are non-dominated and help paint the bigger picture of the data in question. They are valuable in many multi-criteria decision applications and are becoming a staple of decision support systems.

An assumption commonly made by many skyline algorithms is that a skyline query is applied to a single static data source or data stream. Unfortunately, this assumption does not hold in many applications in which a skyline query may involve attributes belonging to multiple data sources and requires a join operation to be performed before the skyline can be produced. Recently, various skyline-join algorithms have been proposed to address this problem in the context of static data sources. However, these algorithms suffer from several drawbacks: they often need to scan the data sources exhaustively to obtain the skyline-join results; moreover, the pruning techniques employed to eliminate tuples are largely based on expensive tuple-to-tuple comparisons. On the other hand, most data stream techniques focus on single stream skyline queries, thus rendering them unsuitable for skyline-join queries.

Another assumption typically made by most of the earlier skyline algorithms is that the data is complete and all skyline attribute values are available. Due to this constraint, these algorithms cannot be applied to incomplete data sources in which some of the attribute values are missing and are represented by NULL values. There exists a definition of dominance for incomplete data, but this leads to undesirable consequences such as non-transitive and cyclic dominance relations both of which are detrimental to skyline processing.

Based on the aforementioned observations, the main goal of the research described in this dissertation is the design and development of a framework of skyline operators that effectively handles three distinct types of skyline queries: 1) skyline-join queries on static data sources, 2) skyline-window-join queries over data streams, and 3) strata-skyline queries on incomplete datasets. This dissertation presents the unique challenges posed by these skyline queries and addresses the shortcomings of current skyline techniques by proposing efficient methods to tackle the added overhead in processing skyline queries on static data sources, data streams, and incomplete datasets.
ContributorsNagendra, Mithila (Author) / Candan, Kasim Selcuk (Thesis advisor) / Chen, Yi (Committee member) / Davulcu, Hasan (Committee member) / Silva, Yasin N. (Committee member) / Sundaram, Hari (Committee member) / Arizona State University (Publisher)
Created2014
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Description
With the rise of social media, hundreds of millions of people spend countless hours all over the globe on social media to connect, interact, share, and create user-generated data. This rich environment provides tremendous opportunities for many different players to easily and effectively reach out to people, interact with them,

With the rise of social media, hundreds of millions of people spend countless hours all over the globe on social media to connect, interact, share, and create user-generated data. This rich environment provides tremendous opportunities for many different players to easily and effectively reach out to people, interact with them, influence them, or get their opinions. There are two pieces of information that attract most attention on social media sites, including user preferences and interactions. Businesses and organizations use this information to better understand and therefore provide customized services to social media users. This data can be used for different purposes such as, targeted advertisement, product recommendation, or even opinion mining. Social media sites use this information to better serve their users.

Despite the importance of personal information, in many cases people do not reveal this information to the public. Predicting the hidden or missing information is a common response to this challenge. In this thesis, we address the problem of predicting user attributes and future or missing links using an egocentric approach. The current research proposes novel concepts and approaches to better understand social media users in twofold including, a) their attributes, preferences, and interests, and b) their future or missing connections and interactions. More specifically, the contributions of this dissertation are (1) proposing a framework to study social media users through their attributes and link information, (2) proposing a scalable algorithm to predict user preferences; and (3) proposing a novel approach to predict attributes and links with limited information. The proposed algorithms use an egocentric approach to improve the state of the art algorithms in two directions. First by improving the prediction accuracy, and second, by increasing the scalability of the algorithms.
ContributorsAbbasi, Mohammad Ali, 1975- (Author) / Liu, Huan (Thesis advisor) / Davulcu, Hasan (Committee member) / Ye, Jieping (Committee member) / Agarwal, Nitin (Committee member) / Arizona State University (Publisher)
Created2014