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The amount of time series data generated is increasing due to the integration of sensor technologies with everyday applications, such as gesture recognition, energy optimization, health care, video surveillance. The use of multiple sensors simultaneously

for capturing different aspects of the real world attributes has also led to an increase in

The amount of time series data generated is increasing due to the integration of sensor technologies with everyday applications, such as gesture recognition, energy optimization, health care, video surveillance. The use of multiple sensors simultaneously

for capturing different aspects of the real world attributes has also led to an increase in dimensionality from uni-variate to multi-variate time series. This has facilitated richer data representation but also has necessitated algorithms determining similarity between two multi-variate time series for search and analysis.

Various algorithms have been extended from uni-variate to multi-variate case, such as multi-variate versions of Euclidean distance, edit distance, dynamic time warping. However, it has not been studied how these algorithms account for asynchronous in time series. Human gestures, for example, exhibit asynchrony in their patterns as different subjects perform the same gesture with varying movements in their patterns at different speeds. In this thesis, we propose several algorithms (some of which also leverage metadata describing the relationships among the variates). In particular, we present several techniques that leverage the contextual relationships among the variates when measuring multi-variate time series similarities. Based on the way correlation is leveraged, various weighing mechanisms have been proposed that determine the importance of a dimension for discriminating between the time series as giving the same weight to each dimension can led to misclassification. We next study the robustness of the considered techniques against different temporal asynchronies, including shifts and stretching.

Exhaustive experiments were carried on datasets with multiple types and amounts of temporal asynchronies. It has been observed that accuracy of algorithms that rely on data to discover variate relationships can be low under the presence of temporal asynchrony, whereas in case of algorithms that rely on external metadata, robustness against asynchronous distortions tends to be stronger. Specifically, algorithms using external metadata have better classification accuracy and cluster separation than existing state-of-the-art work, such as EROS, PCA, and naive dynamic time warping.
ContributorsGarg, Yash (Author) / Candan, Kasim Selcuk (Thesis advisor) / Chowell-Punete, Gerardo (Committee member) / Tong, Hanghang (Committee member) / Davulcu, Hasan (Committee member) / Sapino, Maria Luisa (Committee member) / Arizona State University (Publisher)
Created2015
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Description
Predicting resistant prostate cancer is critical for lowering medical costs and improving the quality of life of advanced prostate cancer patients. I formulate, compare, and analyze two mathematical models that aim to forecast future levels of prostate-specific antigen (PSA). I accomplish these tasks by employing clinical data of locally advanced

Predicting resistant prostate cancer is critical for lowering medical costs and improving the quality of life of advanced prostate cancer patients. I formulate, compare, and analyze two mathematical models that aim to forecast future levels of prostate-specific antigen (PSA). I accomplish these tasks by employing clinical data of locally advanced prostate cancer patients undergoing androgen deprivation therapy (ADT). I demonstrate that the inverse problem of parameter estimation might be too complicated and simply relying on data fitting can give incorrect conclusions, since there is a large error in parameter values estimated and parameters might be unidentifiable. I provide confidence intervals to give estimate forecasts using data assimilation via an ensemble Kalman Filter. Using the ensemble Kalman Filter, I perform dual estimation of parameters and state variables to test the prediction accuracy of the models. Finally, I present a novel model with time delay and a delay-dependent parameter. I provide a geometric stability result to study the behavior of this model and show that the inclusion of time delay may improve the accuracy of predictions. Also, I demonstrate with clinical data that the inclusion of the delay-dependent parameter facilitates the identification and estimation of parameters.
ContributorsBaez, Javier (Author) / Kuang, Yang (Thesis advisor) / Kostelich, Eric (Committee member) / Crook, Sharon (Committee member) / Gardner, Carl (Committee member) / Nagy, John (Committee member) / Arizona State University (Publisher)
Created2017