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- All Subjects: Women--Health and hygiene.
- Creators: Gutierrez, Megan
- Creators: Hayford, Sarah
Description
Background: Research in animal models suggests that fish oil ingestion may impair immunity and increase risk for infection. To date there are no studies examining this relationship between fish oil ingestion and risk for infection in humans. Objective: The primary aim of this randomized, placebo-controlled, double-blind, parallel-arm study was to examine the effect of 400 mg of EPA and 200 mg of DHA, the main components of fish oil (FO) supplements, on the incidence of symptoms related to upper respiratory tract infections in healthy young females, at a large southwestern university. Design: Healthy young women between 18 and 38 years of age who were non-obese (mean BMI 23.7 ± 0.6 kg/m2) were recruited from an urban southwestern university campus. Subjects were non-vegetarians, non-smokers, and reported consuming less than one serving (3.5 oz) of fish per week. Participants (n=26) were randomized according to age, body weight, BMI, and daily n-3 fatty acid (FA) intake into two groups: FO (one gel capsule of 600 mg EPA/DHA per day) or CO (one placebo gel capsule of 1000 mg coconut oil per day). Participants completed a validated daily cold symptom survey, the Wisconsin Upper Respiratory Symptom Survey-21 for 8 weeks. Fasting blood samples measuring TNF-α concentrations were taken at weeks 1 and 8, when 24-hour dietary recalls were also performed. Anthropometric measurements were recorded via bioelectrical impedance at trial weeks 1, 4, and 8. Results: The 8-week trial of FO supplementation did not significantly change the average score for perception of cold symptoms between FO and CO groups (167 ± 71 and 185 ± 56, p=0.418, respectively). Plasma TNF-α levels (pg/mL) did not differ between groups (p=0.482). TNF-α levels were significantly correlated with body weight (r=0.480, p=0.037), BMI (r=0.481, p=0.037, and percent body fat (r=0.511, p=0.025) at baseline. Conclusions: Healthy young women taking a fish oil supplement of 400 mg EPA and 200 mg DHA per day over 8 weeks does not impose unintentional health consequences. These findings do not refute the American Heart Association's current recommendations for all Americans to consume two servings (3.5 oz) of a variety of oily fish per week. Depending on the type of fish, this current recommendation equates to approximately 200-300 mg per day of EPA and DHA n-3 polyunsaturated fatty acids. Additional research is needed to investigate the effects of higher dosages of fish oils on daily cold symptoms.
ContributorsGutierrez, Megan (Author) / Johnston, Carol (Thesis advisor) / Appel, Christy (Committee member) / Martin, Keith (Committee member) / Arizona State University (Publisher)
Created2013
Description
Health-seeking behaviors are influenced by multiple factors including an assessment of the symptoms, what degree of personal commitment is involved in treatment, and what, if any, alternative methods of treatment are available. In the case of infertility, seeking treatment is likely to occur after the inability to get pregnant or carry a pregnancy to term persists for longer then a year or more. This is after prolonged exposure to the risk of pregnancy fails to provide a successful pregnancy, and the desire for children remains. Most research on health-seeking behaviors for infertility focus on the nulliparous woman who is at risk of primary infertility. This research furthers this examination by comparing the rates of health-seeking behaviors for women at risk of primary infertility to women at risk of secondary infertility. A woman at risk of primary infertility is identified as nulliparous in that she has never been pregnant, or has never had a pregnancy end in live birth. A woman at risk of secondary infertility is identified as parous and has already had one pregnancy end in live birth. Using three pathways that include social factors, biological mechanisms, and contextual effects, I hypothesize that the rates of health-seeking behaviors will vary by infertility risk and that women at risk of primary infertility will have higher rates of health-seeking behaviors for infertility. These hypotheses are based on the Behavioral Model of Health Services Utilization and the Health Belief Model that states health-seeking behaviors are influenced by the presence of enabling and predisposing factors, combined with internal and external cues. Findings from this dissertation suggest that the rates of health-seeking behaviors do indeed vary by infertility risk.
ContributorsWeller, Nicole Maki (Author) / Yabiku, Scott T (Thesis advisor) / Hayford, Sarah (Committee member) / Kronenfeld, Jennie (Committee member) / Arizona State University (Publisher)
Created2012