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A variety of studies have shown that the tendency toward nicotine dependence has a genetic component. The work described in this thesis addresses three separate questions: i) are there unidentified SNPs in the nicotinic receptors or other genes that contribute to the risk for nicotine dependence; ii) is there evidence

A variety of studies have shown that the tendency toward nicotine dependence has a genetic component. The work described in this thesis addresses three separate questions: i) are there unidentified SNPs in the nicotinic receptors or other genes that contribute to the risk for nicotine dependence; ii) is there evidence of ongoing selection at nicotinic receptor loci; and, iii) since nicotine dependence is unlikely to be the phenotype undergoing selection, is a positive effect on memory or cognition the selected phenotype. I first undertook a genome –wide association scan of imputed data using samples from the Collaborative Study of the Genetics of Nicotine Dependence (COGEND). A novel association was found between nicotine dependence and SNPs at 13q31. The genes at this newly associated locus on chromosome 13 encode a group of micro-RNAs and a member of the glypican gene family. These are among the first findings to implicate a non-candidate gene in risk for nicotine dependence. I applied several complimentary methods to sequence data from the 1000 Genomes Project to test for evidence of selection at the nicotinic receptor loci. I found strong evidence for selection for alleles in the nicotinic receptor cluster on chromosome 8 that confer risk of nicotine dependence. I then used the dataset from the Collaborative Studies on the Genetics of Alcoholism (COGA) and looked for an association between neuropsychological phenotypes and SNPs conferring risk of nicotine dependence. One SNP passed multiple test correction for association with WAIS digit symbol score. This SNP is not itself associated with nicotine dependence but is in reasonable (r 2 = 0.75) LD with SNPs that are associated with nicotine dependence. These data suggest at best, a weak correlation between nicotine dependence and any of the tested cognitive phenotypes. Given the reproducible finding of an inverse relationship between SNPs associated with risk for nicotine dependence and cocaine dependence, I hypothesize that the apparently detrimental phenotype of nicotine dependence may confer decreased risk for cocaine dependence. As cocaine use impairs the positive rewards associated with social interactions, reducing the risk of cocaine addiction may be beneficial to both the individual and the group.
ContributorsSadler, Brooke (Author) / Hurtado, Ana Magdalena (Thesis advisor) / Goate, Alison (Thesis advisor) / Hill, Kim (Committee member) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2014
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A researcher reflects using a close reading of interview transcripts and description to share what happened while participating in multiple roles in a larger ethnographic study of the acculturation process of deaf students in kindergarten classrooms in three countries. The course of this paper will focus on three instances that

A researcher reflects using a close reading of interview transcripts and description to share what happened while participating in multiple roles in a larger ethnographic study of the acculturation process of deaf students in kindergarten classrooms in three countries. The course of this paper will focus on three instances that took place in Japan and America. The analysis of these examples will bring to light the concept of taking on multiple roles, including graduate research assistant, interpreter, cultural mediator, and sociolinguistic consultant within a research project serving to uncover challenging personal and professional dilemmas and crossing boundaries; the dual roles, interpreter and researcher being the primary focus. This analysis results in a brief look at a thought provoking, yet evolving task of the researcher/interpreter. Maintaining multiple roles in the study the researcher is able to potentially identify and contribute "hidden" knowledge that may have been overlooked by other members of the research team. Balancing these different roles become key implications when interpreting practice, ethical boundaries, and participant research at times the lines of separation are blurred.
ContributorsHensley, Jennifer Scarboro (Author) / Tobin, Joseph (Thesis advisor) / Artiles, Alfredo (Committee member) / Horejes, Thomas (Committee member) / Arizona State University (Publisher)
Created2011
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Under-representation of women doctors in medical work force despite their overwhelming majority in medical schools is an intriguing social issue for Pakistan raising important questions related to evolving gender relations in Pakistani society. Previous research on the broader issue of under-representation of women in science has focused primarily on the

Under-representation of women doctors in medical work force despite their overwhelming majority in medical schools is an intriguing social issue for Pakistan raising important questions related to evolving gender relations in Pakistani society. Previous research on the broader issue of under-representation of women in science has focused primarily on the structural barriers to women’s advancement. It does not account for the underlying subtle (and changing) gendered power relations that permeate everyday life and which can constrain (or enable) the choices of women. It also does not address how women are not simply constructed as subjects within intersecting power relations, but actively construct meaning in relation to them. It raises interesting questions about the cultural shaping of subjectivities, identities and agency of women within the web of power relations in a society such as Pakistan.

To analyze the underlying dynamics of this issue, this dissertation empirically examines the individual, institutional and social factors which enable or affect the career choices of Pakistani women doctors. Based on the ethnographic data obtained from in-depth, person centered, open ended interviews with sixty women doctors and their families, as well as policy makers and the stake holders in medical education and health administration in Lahore, Pakistan this dissertation seeks to address the complex issues of empowerment and agency in the context of Pakistani women, both in individual and collective sense.

Participation in medical education is ostensibly an empowering act, but dissecting the social relations in which this decision takes place reveals that becoming a doctor actually enmeshes women further in the disciplinary relations within their families and society. Similarly, the medical workplaces of Pakistan are marked by entrenched gendered hierarchies constraining women’s access to resources and their progression through medical career. Finally, the political implications of defining work in medicine, and devaluing care in capitalist economies is explored.
ContributorsMasood, Ayesha (Author) / Tsuda, Takeyuki (Thesis advisor) / Wutich, Amber (Committee member) / Gaughan, Monica (Committee member) / Arizona State University (Publisher)
Created2017
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Description
According to traditional Chinese medicine, the month following childbirth is an important period marked by an imbalance of two opposing forces that together make up one’s health and wellbeing. A set of specialized practices called zuoyuezi (sitting the month) aid both the woman’s recovery and restoration of the balance, and

According to traditional Chinese medicine, the month following childbirth is an important period marked by an imbalance of two opposing forces that together make up one’s health and wellbeing. A set of specialized practices called zuoyuezi (sitting the month) aid both the woman’s recovery and restoration of the balance, and require the help of someone else, usually the woman’s mother or mother-in-law. While studies conducted on the practice’s psychosocial and physical benefits have produced varied results, zuoyuezi continues to persist in Hong Kong, China, and Taiwan. Since the late twentieth century, professional zuoyuezi centers have become very popular as a commercial health care business. While the month experiences of Taiwanese and Chinese women have been widely studied, there is little research on physicians’ opinions regarding the practice, especially in Western medical settings. Taiwanese physicians, who have been trained in the Western medical tradition, present interesting case studies as both experts in Western medicine and citizens in traditional Taiwanese society. The purpose of this project is to observe how Taiwanese physicians negotiate primarily cultural practices with their professional training, and whether there is a conflict between physicians’ beliefs about zuoyuezi and physicians’ personal experiences with the practice. Twenty-seven semi-structured interviews of Taiwanese physicians were conducted at two sites in Taiwan regarding their perspective and understanding of zuoyuezi and their personal experiences with it. Following qualitative analysis, the findings showed that physicians used their Western medical training to explain the traditional worldview that holds zuoyuezi. Secondly, physicians acknowledged the benefits of zuoyuezi and the influence of culture as two primary factors in its continued existence. Finally, physicians incorporated zuoyuezi into their personal lives while modifying the traditional practices. Overall, Taiwanese physicians did not appear to have direct conflict with the cultural practice, zuoyuezi, using their medical expertise to rationalize its existence while becoming active participants and co-creators in the practice.
ContributorsChou, Cecilia (Author) / Maienschein, Jane (Thesis advisor) / Gaughan, Monica (Committee member) / Ellison, Karin (Committee member) / Arizona State University (Publisher)
Created2017
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Description
Evolutionary and economic theories of fertility variation argue that novel subsistence opportunities associated with market economies shape reproduction in ways that both increase parental investment per child and lower overall fertility. I use demographic and ethnographic data from Guatemala as a case study to illustrate how ethnic inequalities in accessing

Evolutionary and economic theories of fertility variation argue that novel subsistence opportunities associated with market economies shape reproduction in ways that both increase parental investment per child and lower overall fertility. I use demographic and ethnographic data from Guatemala as a case study to illustrate how ethnic inequalities in accessing market opportunities have shaped demographic variation and the perceptions of parental investments. I then discuss two projects that use secondary data sets to address issues of conceptualizing and operationalizing market opportunities in national and cross-population comparative work. The first argues that social relationships are critical means of accessing market opportunities, and uses Guatemala household stocks of certain forms of relational wealth are associated with greater parental investments in education. The second focuses on a methodological issue in how common measures of wealth in comparative demographic studies conflate economic capacity with market opportunities, and how this conceptual confusion biases our interpretations of the observed links between wealth and fertility over the course of the demographic transition.
ContributorsHackman, Joseph Victor (Author) / Hruschka, Daniel J (Thesis advisor) / Maupin, Jonathan (Committee member) / Hill, Kim (Committee member) / Arizona State University (Publisher)
Created2019
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Description
For most of human history hunting has been the primary economic activity of men. Hunted animals are valued for their food energy and nutrients, however, hunting is associated with a high risk of failure. Additionally, large animals cannot be consumed entirely by the nuclear family, so much of the harvest

For most of human history hunting has been the primary economic activity of men. Hunted animals are valued for their food energy and nutrients, however, hunting is associated with a high risk of failure. Additionally, large animals cannot be consumed entirely by the nuclear family, so much of the harvest may be shared to others. This has led some researchers to ask why men hunt large and difficult game. The “costly signaling” and “show-off” hypotheses propose that large prey are hunted because the difficulty of finding and killing them is a reliable costly signal of the phenotypic quality of the hunter.

These hypotheses were tested using original interview data from Aché (hunter gatherer; n=52, age range 50-76, 46% female) and Tsimané (horticulturalist; n=40, age range 15-77, 45% female) informants. Ranking tasks and paired comparison tasks were used to determine the association between the costs of killing an animal and its value as a signal of hunter phenotypic quality for attracting mates and allies. Additional tasks compared individual large animals to groups of smaller animals to determine whether assessments of hunters’ phenotypes and preferred status were more impacted by the signal value of the species or by the weight and number of animals killed.

Aché informants perceived hunters who killed larger or harder to kill animals as having greater provisioning ability, strength, fighting ability, and disease susceptibility, and preferred them as mates and allies. Tsimané informants held a similar preference for hunters who killed large game, but not for hunters targeting hard to kill species. When total biomass harvested was controlled, both populations considered harvesting more animals in a given time period to be a better signal of preferred phenotypes than killing a single large and impressive species. Male and female informants both preferred hunters who consistently brought back small game over hunters who sometimes killed large animals and sometimes killed nothing. No evidence was found that hunters should forgo overall food return rates in order to signal phenotypic qualities by specializing on large game. Nutrient provisioning rather than costly phenotypic signaling was the strategy preferred by potential mates and allies.
ContributorsBishop, Andrew Phillip Carson (Author) / Hill, Kim (Thesis advisor) / Boyd, Robert (Committee member) / Trumble, Benjamin (Committee member) / Arizona State University (Publisher)
Created2019
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Description
In this dissertation, I examine how social perceptions of physical disability shape interactions in healthcare. Drawing upon the lived experience and insights of Diné (Navajo) individuals with physical disabilities, family members, and Diné
on-indigenous healthcare workers and service providers, I explore the interrelationship of social perceptions of physical disability with understandings

In this dissertation, I examine how social perceptions of physical disability shape interactions in healthcare. Drawing upon the lived experience and insights of Diné (Navajo) individuals with physical disabilities, family members, and Diné
on-indigenous healthcare workers and service providers, I explore the interrelationship of social perceptions of physical disability with understandings of identity and performance of personhood. Embedded within discourses and critiques of ableism/disablism, narratives highlight the interconnection of constructs of personhood and productivity.

Findings show that social perceptions of physical disability are closely linked to broader cultural norms surrounding concepts of health/illness. I offer a critical analysis of contemporary impacts of colonization and historical trauma on the physical, emotional, sociocultural and economic wellbeing of Diné people and those who fill service provision roles for this diverse population. Situated within broader contexts of defining constructs of ‘Whiteness’ and ‘Indigeneity’, the role of culture and discourses regarding stereotypes are particularly prominent factors in shaping relationships.

This interdisciplinary ethnography brings together contributions from Anthropology, Disability Studies, and Indigenous paradigms. Placing a particular emphasis on the social dynamics in two urban centers in the state of Arizona, this ethnography centers on analyzing areas of medical practice that work well, as well as gaps in the provision of healthcare services, with a particular focus on systemic and infrastructural barriers. These concerns are shared not only by Diné individuals with

physical disabilities and family members, but also by non-indigenous service providers and healthcare professionals.
ContributorsVarvarezou, Dimitra (Author) / Maupin, Jonathan N (Thesis advisor) / Gaughan, Monica (Committee member) / Williams, Deborah (Committee member) / Arizona State University (Publisher)
Created2020
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Description
Contact tracing was deployed widely during the COVID-19 pandemic to attempt to stop the spread of SARS Co-V-2. This dissertation investigates the research on contact tracing from a scientometric perspective and looks qualitatively at how case investigators and contact tracers conducted public health practice during the pandemic. Through

Contact tracing was deployed widely during the COVID-19 pandemic to attempt to stop the spread of SARS Co-V-2. This dissertation investigates the research on contact tracing from a scientometric perspective and looks qualitatively at how case investigators and contact tracers conducted public health practice during the pandemic. Through approaching the public health practice of contact tracing from both a broad, top-down angle, and an on the ground experiential approach, this dissertation provides insight into the issues facing contact tracing as a public health tool.
ContributorsWhite, Alexandra C. (Author) / Jehn, Megan (Thesis advisor) / Hruschka, Daniel (Committee member) / Gaughan, Monica (Committee member) / Arizona State University (Publisher)
Created2022