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- Genre: Doctoral Dissertation
Description
The entire history of HIV-1 is hidden in its ten thousand bases, where information regarding its evolutionary traversal through the human population can only be unlocked with fine-scale sequence analysis. Measurable footprints of mutation and recombination have imparted upon us a wealth of knowledge, from multiple chimpanzee-to-human transmissions to patterns of neutralizing antibody and drug resistance. Extracting maximum understanding from such diverse data can only be accomplished by analyzing the viral population from many angles. This body of work explores two primary aspects of HIV sequence evolution, point mutation and recombination, through cross-sectional (inter-individual) and longitudinal (intra-individual) investigations, respectively. Cross-sectional Analysis: The role of Haiti in the subtype B pandemic has been hotly debated for years; while there have been many studies, up to this point, no one has incorporated the well-known mechanism of retroviral recombination into their biological model. Prior to the use of recombination detection, multiple analyses produced trees where subtype B appears to have first entered Haiti, followed by a jump into the rest of the world. The results presented here contest the Haiti-first theory of the pandemic and instead suggest simultaneous entries of subtype B into Haiti and the rest of the world. Longitudinal Analysis: Potential N-linked glycosylation sites (PNGS) are the most evolutionarily dynamic component of one of the most evolutionarily dynamic proteins known to date. While the number of mutations associated with the increase or decrease of PNGS frequency over time is high, there are a set of relatively stable sites that persist within and between longitudinally sampled individuals. Here, I identify the most conserved stable PNGSs and suggest their potential roles in host-virus interplay. In addition, I have identified, for the first time, what may be a gp-120-based environmental preference for N-linked glycosylation sites.
ContributorsHepp, Crystal Marie, 1981- (Author) / Rosenberg, Michael S. (Thesis advisor) / Hedrick, Philip (Committee member) / Escalante, Ananias (Committee member) / Kumar, Sudhir (Committee member) / Arizona State University (Publisher)
Created2013
Collective action among non-governmental organizations working in maternal and child health in Haiti
Description
This mixed-methods research study examined the level of collective action that is occurring among non-governmental organizations (NGOs) working in maternal and child health in Haiti. This study takes the view that health, and by extension, maternal and child health, is a global public good; global public goods are most efficiently provided by the means of collective action. Therefore, to the extent that maternal and child health services are provided efficiently in Haiti, collective action should be occurring.
This study utilized a semi-structured interview approach to gather both qualitative and quantitative data. A total of 17 participants who were managers or executives of NGOs working in maternal and child health in Haiti were interviewed. The interviews also gathered quantitative data that characterized types of cooperation that were occurring among NGOs. The qualitative data that were collected in these interviews were analyzed using thematic analysis, and quantitative data were analyzed using social network analysis. The findings concluded that while there is cooperation occurring among NGOs in Haiti, the cooperation levels are low, networks are not very dense and there is overall general consensus that more cooperation is needed
This study utilized a semi-structured interview approach to gather both qualitative and quantitative data. A total of 17 participants who were managers or executives of NGOs working in maternal and child health in Haiti were interviewed. The interviews also gathered quantitative data that characterized types of cooperation that were occurring among NGOs. The qualitative data that were collected in these interviews were analyzed using thematic analysis, and quantitative data were analyzed using social network analysis. The findings concluded that while there is cooperation occurring among NGOs in Haiti, the cooperation levels are low, networks are not very dense and there is overall general consensus that more cooperation is needed
ContributorsMcCool, Sarah (Author) / Gaughan, Monica (Thesis advisor) / Wutich, Amber (Committee member) / York, Abigail (Committee member) / Arizona State University (Publisher)
Created2017
Description
Great disasters can often serve as birthing grounds for national transformation. As communities work to recover and rebuild, opportunities to reassess of prevailing development theories and programs may arise. As traditional development programs, supported by top-down development theories and billions in foreign aid, have not changed Haiti's impoverished status, such an opportunity has been presented to the Caribbean nation. Just a few months removed from the devastating 7.0 earthquake of Jan 12, 2010, this study identified the emergent thinking about development as expressed by key informants (N=21) from six entity types involved in Haiti's rebuilding efforts - government agencies, social ventures, grassroots, diaspora, foreign, and hybrid nonprofits. Findings were supplemented by participant observation of a civil society meeting in Port-au-Prince, Haiti. The Sustainable Livelihoods (SL) Framework was used as a lens with which to understand the causes of Haiti's social, institutional, environmental, and economic vulnerabilities. Modified grounded theory was used as the qualitative data analytical method from which five themes emerged: Haitian government, rebuilding, aid work and its effects, Haitian society, and international interference. Participants called for a refoundation, the building a nation from the ground up, of Haiti. Based on these findings, four transformative processes were identified as fundamental to Haiti's refoundation: 1) communication and collaboration with the Haitian government, 2) engagement of the Haitian people and the Haitian diaspora in the redevelopment work, 3) a broad vision of development for the nation, and 4) coordination and collaboration among NGOs.
ContributorsInnocent, Darlye Élise (Author) / Knopf, Richard (Thesis advisor) / Phillips, Rhonda (Committee member) / Aggarwal, Rimjhim (Committee member) / Wang, Lili (Committee member) / Arizona State University (Publisher)
Created2010