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- All Subjects: Arizona
- Creators: Hirt, Paul
- Creators: School of Molecular Sciences
- Member of: Theses and Dissertations
- Resource Type: Text
Description
This dissertation explores vulnerability to extreme heat hazards in the Maricopa County, Arizona metropolitan region. By engaging an interdisciplinary approach, I uncover the epidemiological, historical-geographical, and mitigation dimensions of human vulnerability to extreme heat in a rapidly urbanizing region characterized by an intense urban heat island and summertime heat waves. I first frame the overall research within global climate change and hazards vulnerability research literature, and then present three case studies. I conclude with a synthesis of the findings and lessons learned from my interdisciplinary approach using an urban political ecology framework. In the first case study I construct and map a predictive index of sensitivity to heat health risks for neighborhoods, compare predicted neighborhood sensitivity to heat-related hospitalization rates, and estimate relative risk of hospitalizations for neighborhoods. In the second case study, I unpack the history and geography of land use/land cover change, urban development and marginalization of minorities that created the metropolitan region's urban heat island and consequently, the present conditions of extreme heat exposure and vulnerability in the urban core. The third study uses computational microclimate modeling to evaluate the potential of a vegetation-based intervention for mitigating extreme heat in an urban core neighborhood. Several findings relevant to extreme heat vulnerability emerge from the case studies. First, two main socio-demographic groups are found to be at higher risk for heat illness: low-income minorities in sparsely-vegetated neighborhoods in the urban core, and the elderly and socially-isolated in the expansive suburban fringe of Maricopa County. The second case study reveals that current conditions of heat exposure in the region's urban heat island are the legacy of historical marginalization of minorities and large-scale land-use/land cover transformations of natural desert land covers into heat-retaining urban surfaces of the built environment. Third, summertime air temperature reductions in the range 0.9-1.9 °C and of up to 8.4 °C in surface temperatures in the urban core can be achieved through desert-adapted canopied vegetation, suggesting that, at the microscale, the urban heat island can be mitigated by creating vegetated park cool islands. A synthesis of the three case studies using the urban political ecology framework argues that climate changed-induced heat hazards in cities must be problematized within the socio-ecological transformations that produce and reproduce urban landscapes of risk. The interdisciplinary approach to heat hazards in this dissertation advances understanding of the social and ecological drivers of extreme heat by drawing on multiple theories and methods from sociology, urban and Marxist geography, microclimatology, spatial epidemiology, environmental history, political economy and urban political ecology.
ContributorsDeclet-Barreto, Juan (Author) / Harlan, Sharon L (Thesis advisor) / Bolin, Bob (Thesis advisor) / Hirt, Paul (Committee member) / Boone, Christopher (Committee member) / Arizona State University (Publisher)
Created2013
Description
This dissertation explores how the written word and natural and cultural landscapes entwine to create a place, the process by which Arizona's landscapes affected narratives written about the place and how those narratives created representations of Arizona over time. From before Arizona became a state in 1912 to the day its citizens celebrated one hundred years as a state in 2012, words have played a role in making it the place it is. The literature about Arizona and narratives drawn from its landscapes reveal writers' perceptions, what they believe is important and useful, what motivates or attracts them to the place. Those perceptions translated into words organized in various ways create an image of Arizona for readers. I explore written works taken at twenty-five year intervals--1912 and subsequent twenty-five year anniversaries--synthesizing narratives about Arizona and examining how those representations of the place changed (or did not change). To capture one hundred years of published material, I chose sources from several genres including official state publications, newspapers, novels, poetry, autobiography, journals, federal publications, and the Arizona Highways magazine. I chose sources that would have been available to the reading public, publications that demonstrated a wide readership. In examining the words about Arizona that have been readily available to the English-reading public, the importance of the power of the printed word becomes clear. Arizona became the place it is in the twenty-first century, in part, because people with power--in the federal and state governments, boosters, and business leaders--wrote about it in such a way as to influence growth and tourism sometimes at the expense of minority groups and the environment. Minority groups' narratives in their own words were absent from Arizona's written narrative landscape until the second half of the twentieth century when they began publishing their own stories. The narratives about Arizona changed over time, from literature dominated by boosting and promotion to a body of literature with many layers, many voices. Women, Native American, and Hispanic narratives, and environmentalists' and boosters' words created a more complex representation of Arizona in the twenty-first century, and more accurately reflected its cultural landscape, than the Arizona represented in earlier narratives.
ContributorsEngel-Pearson, Kimberli (Author) / Pyne, Stephen (Thesis advisor) / Hirt, Paul (Thesis advisor) / Adamson, Joni (Committee member) / Arizona State University (Publisher)
Created2014
Description
Almost every form of cancer deregulates the expression and activity of anabolic glycosyltransferase (GT) enzymes, which incorporate particular monosaccharides in a donor acceptor as well as linkage- and anomer-specific manner to assemble complex and diverse glycans that significantly affect numerous cellular events, including tumorigenesis and metastasis. Because glycosylation is not template-driven, GT deregulation yields heterogeneous arrays of aberrant intact glycan products, some in undetectable quantities in clinical bio-fluids (e.g., blood plasma). Numerous glycan features (e.g., 6 sialylation, β-1,6-branching, and core fucosylation) stem from approximately 25 glycan “nodes:” unique linkage specific monosaccharides at particular glycan branch points that collectively confer distinguishing features upon glycan products. For each node, changes in normalized abundance (Figure 1) may serve as nearly 1:1 surrogate measure of activity for culpable GTs and may correlate with particular stages of carcinogenesis. Complementary to traditional top down glycomics, the novel bottom-up technique applied herein condenses each glycan node and feature into a single analytical signal, quantified by two GC-MS instruments: GCT (time-of-flight analyzer) and GCMSD (transmission quadrupole analyzers). Bottom-up analysis of stage 3 and 4 breast cancer cases revealed better overall precision for GCMSD yet comparable clinical performance of both GC MS instruments and identified two downregulated glycan nodes as excellent breast cancer biomarker candidates: t-Gal and 4,6-GlcNAc (ROC AUC ≈ 0.80, p < 0.05). Resulting from the activity of multiple GTs, t-Gal had the highest ROC AUC (0.88) and lowest ROC p‑value (0.001) among all analyzed nodes. Representing core-fucosylation, glycan node 4,6-GlcNAc is a nearly 1:1 molecular surrogate for the activity of α-(1,6)-fucosyltransferase—a potential target for cancer therapy. To validate these results, future projects can analyze larger sample sets, find correlations between breast cancer stage and changes in t-Gal and 4,6-GlcNAc levels, gauge the specificity of these nodes for breast cancer and their potential role in other cancer types, and develop clinical tests for reliable breast cancer diagnosis and treatment monitoring based on t-Gal and 4,6-GlcNAc.
ContributorsZaare, Sahba (Author) / Borges, Chad (Thesis director) / LaBaer, Joshua (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
As Arizona enters its fifteenth year of drought and Lake Mead hits historic lows, water management and policy planning will become increasingly important to ensure future water security in the Southwestern region of the United States. This thesis compares water demand trends and policies at the municipal level in Phoenix and Tucson, Arizona over the time period from 1980-2010. By analyzing gallons per capita per day (GPCD) trends for each city in the context of population growth, drought, and major state and local policies over the twenty year period, reasons for declines in per capita water demand were explored. Despite differences in their available water sources and political cultures, both the City of Phoenix and the City of Tucson have successfully reduced their per capita water consumption levels between 1980 and 2010. However, this study suggests that each city's measured success at reducing GPCD has been more a result of external events (supply augmentation, drought, and differing development trends) rather than conservation and demand reduction regulations adopted under the auspices of the Groundwater Management Act.
ContributorsSnyder, Rachel Claire (Author) / Larson, Kelli (Thesis director) / Hirt, Paul (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Sustainability (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05
Cultural Perceptions of Leisure and Well-being in Rock Climbing Communities of Peru and Arizona, USA
Description
In December of 2015, I made my way to rural Peru for a few weeks, my first visit to South America. While I was there, I observed a devotion to family and leisure activity, topics that were not heavily prioritized in my experience in Arizona. Upon my return, I became more involved in leisure activities, particularly running, hiking, yoga, and climbing. These involvements noticeably benefitted my health and well-being. The way the Peruvians I met prioritized these subjects fascinated me, and I wanted to study this difference between Arizona and Peru. In July of 2017, I returned to Peru for a semester abroad with my bags packed and the following research questions: 1) Are differences in motivation for rock climbing between Arizona and Peruvian climbers associated with cultural values? 2) Do leisure activities and the amount of time spent on them have an effect on quality of life? 3) Does the degree of climbing specialization impact perceptions of well-being? 4) What characteristics impact perceptions of quality of life among climbers? Are these characteristics affected by country of origin? My prediction was that Peruvians had higher quality of life due to their emphasis on leisure. Through this study, I learned that this conclusion was not as simple as I anticipated.
ContributorsMatta, Samantha Tania (Author) / Hultsman, Wendy (Thesis director) / Sampson, David (Committee member) / Lee, Rebecca (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Molecular Sciences (Contributor) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The growing Hispanic population in Phoenix, Arizona frequently lacks financial resources which may limit their access to health care. The goal of this study was to identify the ideal factors in a health insurance plan for the Hispanic/Latino population in Phoenix, AZ. A survey was designed to gather information regarding demographics, health insurance, preferences, and affordability. The survey was completed by 260 participants. Several multivariate regressions were run using SAS Statistical Software. The final model generated explained 4.48% of the variation in the data set. It showed that an individual who identified as Hispanic/Latino was 8.2% less likely to have health insurance. In addition, an individual who identified as a US Citizen was 23% more likely to have health insurance. To improve access and enrollment among the Hispanic/Latino population, further investigation is needed to identify relevant communication techniques that increase enrollment among this high-risk community.
ContributorsToo, Rachel Yun-May (Author) / Whisner, Corrie (Thesis director) / Calvin, Samantha (Committee member) / Cook, Aaron (Committee member) / Economics Program in CLAS (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Since the late 1990s thousands of new Border Patrol agents, hundreds of miles of fencing, and additional immigration checkpoints have been added to the Mexico-U.S. border region. This unprecedented increase in boundary enforcement has strained existing relationships and created new separations between people and places in the borderlands. Southwestern Arizona has been impacted in especially dramatic ways, as the “hardening” of the international boundary has transformed conservation and indigenous spaces into theaters of drug interdiction and immigration control. This dissertation explores this transformation in southwestern Arizona, a region that was known by Spanish Colonial administrators as the Papaguería. With the community of Ajo at the center of the narrative, this dissertation explores the ways that industry and conservation have long shaped the social relations and the landscape of the region. The destruction of old borders, the creation of new borders, and the redefinition of space has been an ongoing process that continues to define some groups of people as insiders and other groups as outsiders. In the current era of border security echoes from earlier colonial encounters reverberate into the present, shaping landscapes and the lives of local residents in the contemporary Papaguería in significant ways.
ContributorsWarren, Scott (Author) / Arreola, Daniel D (Thesis advisor) / Klett, Mark (Committee member) / Hirt, Paul (Committee member) / McHugh, Kevin E (Committee member) / Arizona State University (Publisher)
Created2015
Description
As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.
ContributorsLeung, Michael (Co-author) / Kandan, Mani (Co-author) / Knox, Garrett (Co-author) / Woo, Sabrina (Co-author) / Compton, Carolyn (Thesis director) / Dudley, Sean (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
The act of moving water across basins is a recent phenomenon in Arizona water policy. This thesis creates a narrative arc for understanding the long-term issues that set precedents for interbasin water transportation and the immediate causes--namely the passage of the seminal Groundwater Management Act (GMA) in 1980--that motivated Scottsdale, Mesa, and Phoenix to acquire rural farmlands in the mid-1980s with the intent of transporting the underlying groundwater back to their respective service areas in the immediate future. Residents of rural areas were active participants in not only the sales of these farmlands, but also in how municipalities would economically develop these properties in the years to come. Their role made these municipal "water farm" purchases function as exchanges. Fears about the impact of these properties and the water transportation they anticipated on communities-of-origin; the limited nature of economic, fiscal, and hydrologic data at the time; and the rise of private water speculators turned water farms into a major political controversy. The six years it took the legislature to wrestle with the problem at the heart this issue--the value of water to rural communities--were among its most tumultuous. The loss of key lawmakers involved in GMA negotiations, the impeachment of Governor Evan Mecham, and a bribery scandal called AZScam collectively sidetracked negotiations. Even more critical was the absence of a mutual recognition that these water farms posed a problem and the external pressure that had forced all parties involved in earlier groundwater-related negotiations to craft compromise. After cities and speculators failed to force a bill favorable to their interests in 1989, a re-alignment among blocs occurred: cities joined with rural interests to craft legislation that grandfathered in existing urban water farms and limited future water farms to several basins. In exchange, rural interests supported a bill to create a Phoenix-area groundwater replenishment district that enabled cooperative management of water supplies. These two bills, which were jointly signed into law in June 1991, tentatively resolved the water farm issue. The creation of a groundwater replenishment district that has subsidized growth in Maricopa, Pinal, and Pima Counties, the creation water bank to store unused Central Arizona Project water for times of drought, and a host of water conservation measures and water leases enabled by the passage of several tribal water rights settlements have set favorable conditions such that Scottsdale, Mesa, and Phoenix never had any reason to transport any water from their water farms. The legacy of these properties then is that they were the product of the intense urgency and uncertainty in urban planning premised on assumptions of growing populations and complementary, inelastic demand. But even as per capita water consumption has declined throughout the Phoenix-area, continued growth has increased demand, beyond the capacity of available supplies so that there will likely be a new push for rural water farms in the foreseeable future.
ContributorsBergelin, Paul (Author) / Hirt, Paul (Thesis advisor) / Vandermeer, Philip (Committee member) / Smith, Karen (Committee member) / Arizona State University (Publisher)
Created2013
Description
This study identifies and examines healthcare barriers experienced by the Hispanic1 population in Phoenix, Arizona. A cross-sectional survey was used to explore these barriers for 123 members of the community, and the findings reveal that the main impediments to healthcare faced by the Hispanic population are structured by their language, immigration status, education level, and access to health insurance. The results of the survey were then analyzed to explore possible mechanisms of the origin or intensification of the barriers, as well as potential solutions such as educating future providers to be culturally competent, usage of integrated medical settings, and the advertisement and extension of Promotoras to the community.
ContributorsMusch, Cristina Lizbeth (Author) / Rosales, Jesus (Thesis director) / Estevez, Dulce (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05