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Almost every form of cancer deregulates the expression and activity of anabolic glycosyltransferase (GT) enzymes, which incorporate particular monosaccharides in a donor acceptor as well as linkage- and anomer-specific manner to assemble complex and diverse glycans that significantly affect numerous cellular events, including tumorigenesis and metastasis. Because glycosylation is not

Almost every form of cancer deregulates the expression and activity of anabolic glycosyltransferase (GT) enzymes, which incorporate particular monosaccharides in a donor acceptor as well as linkage- and anomer-specific manner to assemble complex and diverse glycans that significantly affect numerous cellular events, including tumorigenesis and metastasis. Because glycosylation is not template-driven, GT deregulation yields heterogeneous arrays of aberrant intact glycan products, some in undetectable quantities in clinical bio-fluids (e.g., blood plasma). Numerous glycan features (e.g., 6 sialylation, β-1,6-branching, and core fucosylation) stem from approximately 25 glycan “nodes:” unique linkage specific monosaccharides at particular glycan branch points that collectively confer distinguishing features upon glycan products. For each node, changes in normalized abundance (Figure 1) may serve as nearly 1:1 surrogate measure of activity for culpable GTs and may correlate with particular stages of carcinogenesis. Complementary to traditional top down glycomics, the novel bottom-up technique applied herein condenses each glycan node and feature into a single analytical signal, quantified by two GC-MS instruments: GCT (time-of-flight analyzer) and GCMSD (transmission quadrupole analyzers). Bottom-up analysis of stage 3 and 4 breast cancer cases revealed better overall precision for GCMSD yet comparable clinical performance of both GC MS instruments and identified two downregulated glycan nodes as excellent breast cancer biomarker candidates: t-Gal and 4,6-GlcNAc (ROC AUC ≈ 0.80, p < 0.05). Resulting from the activity of multiple GTs, t-Gal had the highest ROC AUC (0.88) and lowest ROC p‑value (0.001) among all analyzed nodes. Representing core-fucosylation, glycan node 4,6-GlcNAc is a nearly 1:1 molecular surrogate for the activity of α-(1,6)-fucosyltransferase—a potential target for cancer therapy. To validate these results, future projects can analyze larger sample sets, find correlations between breast cancer stage and changes in t-Gal and 4,6-GlcNAc levels, gauge the specificity of these nodes for breast cancer and their potential role in other cancer types, and develop clinical tests for reliable breast cancer diagnosis and treatment monitoring based on t-Gal and 4,6-GlcNAc.
ContributorsZaare, Sahba (Author) / Borges, Chad (Thesis director) / LaBaer, Joshua (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
In December of 2015, I made my way to rural Peru for a few weeks, my first visit to South America. While I was there, I observed a devotion to family and leisure activity, topics that were not heavily prioritized in my experience in Arizona. Upon my return, I became

In December of 2015, I made my way to rural Peru for a few weeks, my first visit to South America. While I was there, I observed a devotion to family and leisure activity, topics that were not heavily prioritized in my experience in Arizona. Upon my return, I became more involved in leisure activities, particularly running, hiking, yoga, and climbing. These involvements noticeably benefitted my health and well-being. The way the Peruvians I met prioritized these subjects fascinated me, and I wanted to study this difference between Arizona and Peru. In July of 2017, I returned to Peru for a semester abroad with my bags packed and the following research questions: 1) Are differences in motivation for rock climbing between Arizona and Peruvian climbers associated with cultural values? 2) Do leisure activities and the amount of time spent on them have an effect on quality of life? 3) Does the degree of climbing specialization impact perceptions of well-being? 4) What characteristics impact perceptions of quality of life among climbers? Are these characteristics affected by country of origin? My prediction was that Peruvians had higher quality of life due to their emphasis on leisure. Through this study, I learned that this conclusion was not as simple as I anticipated.
ContributorsMatta, Samantha Tania (Author) / Hultsman, Wendy (Thesis director) / Sampson, David (Committee member) / Lee, Rebecca (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Molecular Sciences (Contributor) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
The growing Hispanic population in Phoenix, Arizona frequently lacks financial resources which may limit their access to health care. The goal of this study was to identify the ideal factors in a health insurance plan for the Hispanic/Latino population in Phoenix, AZ. A survey was designed to gather information regarding

The growing Hispanic population in Phoenix, Arizona frequently lacks financial resources which may limit their access to health care. The goal of this study was to identify the ideal factors in a health insurance plan for the Hispanic/Latino population in Phoenix, AZ. A survey was designed to gather information regarding demographics, health insurance, preferences, and affordability. The survey was completed by 260 participants. Several multivariate regressions were run using SAS Statistical Software. The final model generated explained 4.48% of the variation in the data set. It showed that an individual who identified as Hispanic/Latino was 8.2% less likely to have health insurance. In addition, an individual who identified as a US Citizen was 23% more likely to have health insurance. To improve access and enrollment among the Hispanic/Latino population, further investigation is needed to identify relevant communication techniques that increase enrollment among this high-risk community.
ContributorsToo, Rachel Yun-May (Author) / Whisner, Corrie (Thesis director) / Calvin, Samantha (Committee member) / Cook, Aaron (Committee member) / Economics Program in CLAS (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description

As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational

As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.

ContributorsLeung, Michael (Co-author) / Kandan, Mani (Co-author) / Knox, Garrett (Co-author) / Woo, Sabrina (Co-author) / Compton, Carolyn (Thesis director) / Dudley, Sean (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The history of Arizona is filled with ambitious pioneers, courageous Natives, and loyal<br/>soldiers, but there is a seeming disconnect between those who came before us and many of those<br/>who currently inhabit this space. Many historic locations that are vital to discovering the past in<br/>Arizona are both hard to find and

The history of Arizona is filled with ambitious pioneers, courageous Natives, and loyal<br/>soldiers, but there is a seeming disconnect between those who came before us and many of those<br/>who currently inhabit this space. Many historic locations that are vital to discovering the past in<br/>Arizona are both hard to find and lacking in information pertaining to what happened there.<br/>However, despite the apparent lack of history and knowledge pertaining to these locations, they<br/>are vitally present in the public memory of the region, and we wish to shed some much-needed<br/>light on a few of these locations and the historical takeaways that can be gleaned from their<br/>study. This thesis argues the significance of three concepts: place-making, public memory, and<br/>stories. Place-making is the reinvention of history in the theater of mind which creates a<br/>plausible reality of the past through what is known in the present. Public memory is a way to<br/>explain how events in a location affect the public consciousness regarding that site and further<br/>events that stem from it. Lastly, stories about a place and event help to explain its overall impact<br/>and what can be learned from the occurrences there. Throughout this thesis we will be discussing<br/>seven sites across Arizona, the events that occurred there, and how these three aspects of study<br/>can be used to experience history in a personal way that gives us a special perspective on the<br/>land around us. The importance of personalizing history lies in finding our own identity as<br/>inhabitants of this land we call home and knowing the stories gives us greater attachment to the<br/>larger narrative of humanity as it has existed in this space.

ContributorsMartin, Trevor James (Co-author) / Martin, Austin (Co-author) / Fixico, Donald (Thesis director) / O'Donnell, Catherine (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The privatization of prisons within Arizona has been a hot button issue and needs to be further analyzed to determine their benefits and expenses. To begin this investigation into the effectiveness of private prisons within Arizona and possible steps that need to be taken for its rehabilitation certain definitions and

The privatization of prisons within Arizona has been a hot button issue and needs to be further analyzed to determine their benefits and expenses. To begin this investigation into the effectiveness of private prisons within Arizona and possible steps that need to be taken for its rehabilitation certain definitions and prior research need to be understood. Following this explanation, areas such as costs analysis across different types of prisons, liability rates across differing types of prison guards, and the differing psychology of different types of prisons can be examined to gain an overall assessment of the current performance of privatized prisons within Arizona. After this in-depth analysis of the current private prison system within Arizona, the flaws of the system will become abundantly clear and the solutions that should be implemented to alleviate these problems will be discussed.

ContributorsPeters, Grayson Allen (Author) / Rigoni, Adam (Thesis director) / Schuh, Carl (Committee member) / Dean, W.P. Carey School of Business (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
Over the past few years, legislation legalizing sports betting in many states has been voted into effect. In the spring of 2021, Arizona legislators approved a bill that would legalize sports betting for anyone over the age of 21 in Arizona, and with Governor Doug Ducey signing the bill into

Over the past few years, legislation legalizing sports betting in many states has been voted into effect. In the spring of 2021, Arizona legislators approved a bill that would legalize sports betting for anyone over the age of 21 in Arizona, and with Governor Doug Ducey signing the bill into law, September 9, 2021, marked the first day of legal sports betting in Arizona. Due to this new major avenue of business, sports betting became a very popular topic in both the news and social media, creating a buzz for new users in Arizona. This study will focus on the sports betting industry and the major companies involved in creating sports betting infrastructure in Arizona. Data will be collected and analyzed from multiple sources including company financial statements, news articles, and independent research focusing on the financial impact of Arizona sports bettors on the sports betting industry’s market profitability. It is expected that there will be a correlation between money gambled in Arizona and a rapid increase in profitability for sports betting companies. This study will provide an overview of the economic impact that sports betting had in Arizona in 2021, and look towards the future of betting in years to come.
ContributorsMorici, Samuel (Author) / Kramer, Michael (Co-author) / Bonfiglio, Thomas (Thesis director) / Voutsas, Konstandinos (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Department of Information Systems (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2022-05
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Description
Above and Beyond ASU's Campus is a blog created for college students at Arizona State University in order to suggest opportunities to explore in Arizona out of the Tempe region. The purpose of this blog is to encourage students to go and gain life experiences that cannot be found directly

Above and Beyond ASU's Campus is a blog created for college students at Arizona State University in order to suggest opportunities to explore in Arizona out of the Tempe region. The purpose of this blog is to encourage students to go and gain life experiences that cannot be found directly on campus and allow them to make the most of their time in this desert landscape. The blog is divided into three categories consisting of outdoor activities, historical locations, and popular culture events. The blog is written from both my first-person point of view along with researched information in regard to each activity. The goal of the blog is to be relatable to the student as well as be a one-stop, easy format for finding a variety of information. The blog format was chosen in order to appeal to the target audience with its appearance, simple format, and ability to write in a relatable tone.
ContributorsDollarhide, Hannah Marie (Author) / Lynch, Jacquelyn (Thesis director) / McWilliams, Claire (Committee member) / Dean, W.P. Carey School of Business (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Description
This study identifies and examines healthcare barriers experienced by the Hispanic1 population in Phoenix, Arizona. A cross-sectional survey was used to explore these barriers for 123 members of the community, and the findings reveal that the main impediments to healthcare faced by the Hispanic population are structured by their language,

This study identifies and examines healthcare barriers experienced by the Hispanic1 population in Phoenix, Arizona. A cross-sectional survey was used to explore these barriers for 123 members of the community, and the findings reveal that the main impediments to healthcare faced by the Hispanic population are structured by their language, immigration status, education level, and access to health insurance. The results of the survey were then analyzed to explore possible mechanisms of the origin or intensification of the barriers, as well as potential solutions such as educating future providers to be culturally competent, usage of integrated medical settings, and the advertisement and extension of Promotoras to the community.
ContributorsMusch, Cristina Lizbeth (Author) / Rosales, Jesus (Thesis director) / Estevez, Dulce (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of International Letters and Cultures (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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DescriptionThis paper takes a comprehensive approach to evaluate Arizona’s conformity process after the passage of TCJA in December 2017.
ContributorsBowman, Anika (Author) / Frost, Donald (Thesis director) / Dallmus, John (Committee member) / School of Accountancy (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05