Matching Items (22)
Filtering by
- All Subjects: Arizona
- Creators: Dean, W.P. Carey School of Business
- Creators: Department of English
- Creators: School of Molecular Sciences
- Member of: Theses and Dissertations
Description
Almost every form of cancer deregulates the expression and activity of anabolic glycosyltransferase (GT) enzymes, which incorporate particular monosaccharides in a donor acceptor as well as linkage- and anomer-specific manner to assemble complex and diverse glycans that significantly affect numerous cellular events, including tumorigenesis and metastasis. Because glycosylation is not template-driven, GT deregulation yields heterogeneous arrays of aberrant intact glycan products, some in undetectable quantities in clinical bio-fluids (e.g., blood plasma). Numerous glycan features (e.g., 6 sialylation, β-1,6-branching, and core fucosylation) stem from approximately 25 glycan “nodes:” unique linkage specific monosaccharides at particular glycan branch points that collectively confer distinguishing features upon glycan products. For each node, changes in normalized abundance (Figure 1) may serve as nearly 1:1 surrogate measure of activity for culpable GTs and may correlate with particular stages of carcinogenesis. Complementary to traditional top down glycomics, the novel bottom-up technique applied herein condenses each glycan node and feature into a single analytical signal, quantified by two GC-MS instruments: GCT (time-of-flight analyzer) and GCMSD (transmission quadrupole analyzers). Bottom-up analysis of stage 3 and 4 breast cancer cases revealed better overall precision for GCMSD yet comparable clinical performance of both GC MS instruments and identified two downregulated glycan nodes as excellent breast cancer biomarker candidates: t-Gal and 4,6-GlcNAc (ROC AUC ≈ 0.80, p < 0.05). Resulting from the activity of multiple GTs, t-Gal had the highest ROC AUC (0.88) and lowest ROC p‑value (0.001) among all analyzed nodes. Representing core-fucosylation, glycan node 4,6-GlcNAc is a nearly 1:1 molecular surrogate for the activity of α-(1,6)-fucosyltransferase—a potential target for cancer therapy. To validate these results, future projects can analyze larger sample sets, find correlations between breast cancer stage and changes in t-Gal and 4,6-GlcNAc levels, gauge the specificity of these nodes for breast cancer and their potential role in other cancer types, and develop clinical tests for reliable breast cancer diagnosis and treatment monitoring based on t-Gal and 4,6-GlcNAc.
ContributorsZaare, Sahba (Author) / Borges, Chad (Thesis director) / LaBaer, Joshua (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Nations have a vital interest in creating a citizenry with certain attributes and beliefs and, since education contributes to the formation of children's national identity, government authorities can influence educational curricula to construct their ideal citizen. In this thesis, I study the educational systems of Pakistan and Arizona and explore the historical and conceptual origins of these entities' manipulation of curricula to construct a particular kind of citizen. I argue that an examination of the ethnic studies debate in Tucson, Arizona, in conjunction with Pakistan's history education policy, will illustrate that the educational systems in both these sites are developed to advance the interests of governing authorities. Resource material demonstrates that both educational systems endorse specific accounts of history, omitting information, perspectives, and beliefs. Eliminating or reimagining certain narratives of history alienates some students from identifying as citizens of the state, particularly when contributions of their ethnic, cultural, or religious groups are not included in the country's textbooks.
ContributorsFritcke, Emily Anne (Author) / Saikia, Yasmin (Thesis director) / Haines, Chad (Committee member) / Barrett, The Honors College (Contributor) / Department of English (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2014-12
Description
In Arizona, people flock the streets of Tombstone in droves, chatting in period costume while gunshots ring down the street. Others in Bisbee walk in the Queen Mine, listening to the tour guide discuss how the miners extracted ore. Still others drive up the precarious road to Jerome, passing through the famed Grand Hotel. As former Arizona mining towns, Tombstone, Jerome and Bisbee have a shared identity as former mining boomtowns, all of which experienced subsequent economic and population decline. Left with the need to reinvent themselves in order to survive, the past takes on a different role in each city. In Jerome, visitors seem content to "kill a day" against the backdrop of the historic town. In Bisbee, time seems stuck in the 1970s, the focus having shifted from the mining to the "hippies" who are considered to have resuscitated the town from near-extinction. Tombstone seem to inspire devotion, rooted in the influence of the 1993 film titled after the town. By memorializing portions of their past, these three towns have carved out new lives for themselves in the twenty-first century. As visitors are informed by the narrative of the "Old West," as shaped by the Western movie and television genre, they in turn impact how the towns present themselves in order to attract tourists. In all these sites, the past is present and like a kaleidoscope, continually recreated into new formations. While the designation of Jerome, Bisbee and Tombstone as "ghost towns" is disputed by individuals in each site, these stories of visitors and residents reveal the intricate ways in which these towns have acquired new life.
ContributorsLemme, Nicole Lee (Author) / de la Garza, Amira (Thesis director) / Paulesc, Marie Louise (Committee member) / Department of English (Contributor) / School of International Letters and Cultures (Contributor) / Hugh Downs School of Human Communication (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
DescriptionThis collection of original short fiction follows the lives of three men, Jess, Charlie, and Anthony, who are linked together by the space of the Arizona Borderlands. Through the three stories, the themes of longing and powerlessness are explored within the context of the unforgiving structure of the Arizona landscape.
ContributorsGuy, Hannah Elise (Author) / McNally, T. M. (Thesis director) / Ball, Sally (Committee member) / Barrett, The Honors College (Contributor) / School of Film, Dance and Theatre (Contributor) / Department of English (Contributor)
Created2014-05
Cultural Perceptions of Leisure and Well-being in Rock Climbing Communities of Peru and Arizona, USA
Description
In December of 2015, I made my way to rural Peru for a few weeks, my first visit to South America. While I was there, I observed a devotion to family and leisure activity, topics that were not heavily prioritized in my experience in Arizona. Upon my return, I became more involved in leisure activities, particularly running, hiking, yoga, and climbing. These involvements noticeably benefitted my health and well-being. The way the Peruvians I met prioritized these subjects fascinated me, and I wanted to study this difference between Arizona and Peru. In July of 2017, I returned to Peru for a semester abroad with my bags packed and the following research questions: 1) Are differences in motivation for rock climbing between Arizona and Peruvian climbers associated with cultural values? 2) Do leisure activities and the amount of time spent on them have an effect on quality of life? 3) Does the degree of climbing specialization impact perceptions of well-being? 4) What characteristics impact perceptions of quality of life among climbers? Are these characteristics affected by country of origin? My prediction was that Peruvians had higher quality of life due to their emphasis on leisure. Through this study, I learned that this conclusion was not as simple as I anticipated.
ContributorsMatta, Samantha Tania (Author) / Hultsman, Wendy (Thesis director) / Sampson, David (Committee member) / Lee, Rebecca (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Molecular Sciences (Contributor) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The purpose of this study is to document and analyze three women's English language learning journeys after moving from various parts of Mexico to Phoenix, Arizona. The study explores the effects of English as a Second Language (ESL) education on the social and cultural development of Mexican women students at Friendly House, whose mission is to "Empower Arizona communities through education and human services". The literature review section explores such topics as the complications and history of Mexican immigration to Phoenix and of state-funded ESL education in Phoenix. The consequent research study will entail a pair of interviews with the three beginner ESL students about their lives in Mexico compared to their lives in Phoenix, with a specific focus on aspects of their language acquisition and cultural adjustment to life in Arizona. Photos of and by the consultants add to their stories and lead to a discussion about the implications of their experiences for ESL teachers. By documenting the consultants' experiences, this study finds many gaps in ESL education in Phoenix. Suggestions about how ESL programs and teaching methods can be modified to fit student's needs form the basis for the conclusions.
ContributorsDriscoll, Ashley Marisa (Author) / Horan, Elizabeth (Thesis director) / O'Connor, Brendan (Committee member) / Department of English (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The growing Hispanic population in Phoenix, Arizona frequently lacks financial resources which may limit their access to health care. The goal of this study was to identify the ideal factors in a health insurance plan for the Hispanic/Latino population in Phoenix, AZ. A survey was designed to gather information regarding demographics, health insurance, preferences, and affordability. The survey was completed by 260 participants. Several multivariate regressions were run using SAS Statistical Software. The final model generated explained 4.48% of the variation in the data set. It showed that an individual who identified as Hispanic/Latino was 8.2% less likely to have health insurance. In addition, an individual who identified as a US Citizen was 23% more likely to have health insurance. To improve access and enrollment among the Hispanic/Latino population, further investigation is needed to identify relevant communication techniques that increase enrollment among this high-risk community.
ContributorsToo, Rachel Yun-May (Author) / Whisner, Corrie (Thesis director) / Calvin, Samantha (Committee member) / Cook, Aaron (Committee member) / Economics Program in CLAS (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
I am AZ is the beginning of a personal book project which explores six small town museums around the state of Arizona. They include: Cave Creek Museum (Cave Creek), Rim Country Museum (Payson), Navajo Country Historical Society (Holbrook), Superstition County Museum (Apache Junction), Bisbee Mining and Historical Museum (Bisbee), and The Powell Museum (Page). The document highlights these institutions as valuable assets to the community and state as they preserve the stories and artifacts pertaining to both state and local history. This document includes photos of the institutions, local history stories, and interviews with the directors from each of these museums. There are also descriptions of products that came as a result of this project including: postcards as a mode of relaying information about these places, a digital Arizona museum map to highlight the museums I did visit and keep a list of those I have yet to visit, and the accompanying pop-up exhibition that summarizes each place through photos and stories.
ContributorsSimpson, Jessica Mary (Author) / Sweeney, Gray (Thesis director) / Freeman, Stacey (Committee member) / Looser, Devoney (Committee member) / School of International Letters and Cultures (Contributor) / Department of English (Contributor) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.
ContributorsLeung, Michael (Co-author) / Kandan, Mani (Co-author) / Knox, Garrett (Co-author) / Woo, Sabrina (Co-author) / Compton, Carolyn (Thesis director) / Dudley, Sean (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
The history of Arizona is filled with ambitious pioneers, courageous Natives, and loyal<br/>soldiers, but there is a seeming disconnect between those who came before us and many of those<br/>who currently inhabit this space. Many historic locations that are vital to discovering the past in<br/>Arizona are both hard to find and lacking in information pertaining to what happened there.<br/>However, despite the apparent lack of history and knowledge pertaining to these locations, they<br/>are vitally present in the public memory of the region, and we wish to shed some much-needed<br/>light on a few of these locations and the historical takeaways that can be gleaned from their<br/>study. This thesis argues the significance of three concepts: place-making, public memory, and<br/>stories. Place-making is the reinvention of history in the theater of mind which creates a<br/>plausible reality of the past through what is known in the present. Public memory is a way to<br/>explain how events in a location affect the public consciousness regarding that site and further<br/>events that stem from it. Lastly, stories about a place and event help to explain its overall impact<br/>and what can be learned from the occurrences there. Throughout this thesis we will be discussing<br/>seven sites across Arizona, the events that occurred there, and how these three aspects of study<br/>can be used to experience history in a personal way that gives us a special perspective on the<br/>land around us. The importance of personalizing history lies in finding our own identity as<br/>inhabitants of this land we call home and knowing the stories gives us greater attachment to the<br/>larger narrative of humanity as it has existed in this space.
ContributorsMartin, Trevor James (Co-author) / Martin, Austin (Co-author) / Fixico, Donald (Thesis director) / O'Donnell, Catherine (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05