Matching Items (3)
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- All Subjects: Control Systems
- Creators: Tsakalis, Konstantinos
Description
There is increasing interest in the medical and behavioral health communities towards developing effective strategies for the treatment of chronic diseases. Among these lie adaptive interventions, which consider adjusting treatment dosages over time based on participant response. Control engineering offers a broad-based solution framework for optimizing the effectiveness of such interventions. In this thesis, an approach is proposed to develop dynamical models and subsequently, hybrid model predictive control schemes for assigning optimal dosages of naltrexone, an opioid antagonist, as treatment for a chronic pain condition known as fibromyalgia. System identification techniques are employed to model the dynamics from the daily diary reports completed by participants of a blind naltrexone intervention trial. These self-reports include assessments of outcomes of interest (e.g., general pain symptoms, sleep quality) and additional external variables (disturbances) that affect these outcomes (e.g., stress, anxiety, and mood). Using prediction-error methods, a multi-input model describing the effect of drug, placebo and other disturbances on outcomes of interest is developed. This discrete time model is approximated by a continuous second order model with zero, which was found to be adequate to capture the dynamics of this intervention. Data from 40 participants in two clinical trials were analyzed and participants were classified as responders and non-responders based on the models obtained from system identification. The dynamical models can be used by a model predictive controller for automated dosage selection of naltrexone using feedback/feedforward control actions in the presence of external disturbances. The clinical requirement for categorical (i.e., discrete-valued) drug dosage levels creates a need for hybrid model predictive control (HMPC). The controller features a multiple degree-of-freedom formulation that enables the user to adjust the speed of setpoint tracking, measured disturbance rejection and unmeasured disturbance rejection independently in the closed loop system. The nominal and robust performance of the proposed control scheme is examined via simulation using system identification models from a representative participant in the naltrexone intervention trial. The controller evaluation described in this thesis gives credibility to the promise and applicability of control engineering principles for optimizing adaptive interventions.
ContributorsDeśapāṇḍe, Sunīla (Author) / Rivera, Daniel E. (Thesis advisor) / Si, Jennie (Committee member) / Tsakalis, Konstantinos (Committee member) / Arizona State University (Publisher)
Created2011
Description
The purpose of this dissertation is to develop a design technique for fractional PID controllers to achieve a closed loop sensitivity bandwidth approximately equal to a desired bandwidth using frequency loop shaping techniques. This dissertation analyzes the effect of the order of a fractional integrator which is used as a target on loop shaping, on stability and performance robustness. A comparison between classical PID controllers and fractional PID controllers is presented. Case studies where fractional PID controllers have an advantage over classical PID controllers are discussed. A frequency-domain loop shaping algorithm is developed, extending past results from classical PID’s that have been successful in tuning controllers for a variety of practical systems.
ContributorsSaleh, Khalid M (Author) / Tsakalis, Konstantinos (Thesis advisor) / Rodriguez, Armando (Committee member) / Si, Jennie (Committee member) / Artemiadis, Panagiotis (Committee member) / Arizona State University (Publisher)
Created2017
Description
The Inverted Pendulum on a Cart is a classical control theory problem that helps understand the importance of feedback control systems for a coupled plant. In this study, a custom built pendulum system is coupled with a linearly actuated cart and a control system is designed to show the stability of the pendulum. The three major objectives of this control system are to swing up the pendulum, balance the pendulum in the inverted position (i.e. $180^\circ$), and maintain the position of the cart. The input to this system is the translational force applied to the cart using the rotation of the tires. The main objective of this thesis is to design a control system that will help in balancing the pendulum while maintaining the position of the cart and implement it in a robot. The pendulum is made free rotating with the help of ball bearings and the angle of the pendulum is measured using an Inertial Measurement Unit (IMU) sensor. The cart is actuated by two Direct Current (DC) motors and the position of the cart is measured using encoders that generate pulse signals based on the wheel rotation. The control is implemented in a cascade format where an inner loop controller is used to stabilize and balance the pendulum in the inverted position and an outer loop controller is used to control the position of the cart. Both the inner loop and outer loop controllers follow the Proportional-Integral-Derivative (PID) control scheme with some modifications for the inner loop. The system is first mathematically modeled using the Newton-Euler first principles method and based on this model, a controller is designed for specific closed-loop parameters. All of this is implemented on hardware with the help of an Arduino Due microcontroller which serves as the main processing unit for the system.
ContributorsNamasivayam, Vignesh (Author) / Tsakalis, Konstantinos (Thesis advisor) / Rodriguez, Armando (Committee member) / Si, Jennie (Committee member) / Shafique, Md. Ashfaque Bin (Committee member) / Arizona State University (Publisher)
Created2021