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Almost every form of cancer deregulates the expression and activity of anabolic glycosyltransferase (GT) enzymes, which incorporate particular monosaccharides in a donor acceptor as well as linkage- and anomer-specific manner to assemble complex and diverse glycans that significantly affect numerous cellular events, including tumorigenesis and metastasis. Because glycosylation is not

Almost every form of cancer deregulates the expression and activity of anabolic glycosyltransferase (GT) enzymes, which incorporate particular monosaccharides in a donor acceptor as well as linkage- and anomer-specific manner to assemble complex and diverse glycans that significantly affect numerous cellular events, including tumorigenesis and metastasis. Because glycosylation is not template-driven, GT deregulation yields heterogeneous arrays of aberrant intact glycan products, some in undetectable quantities in clinical bio-fluids (e.g., blood plasma). Numerous glycan features (e.g., 6 sialylation, β-1,6-branching, and core fucosylation) stem from approximately 25 glycan “nodes:” unique linkage specific monosaccharides at particular glycan branch points that collectively confer distinguishing features upon glycan products. For each node, changes in normalized abundance (Figure 1) may serve as nearly 1:1 surrogate measure of activity for culpable GTs and may correlate with particular stages of carcinogenesis. Complementary to traditional top down glycomics, the novel bottom-up technique applied herein condenses each glycan node and feature into a single analytical signal, quantified by two GC-MS instruments: GCT (time-of-flight analyzer) and GCMSD (transmission quadrupole analyzers). Bottom-up analysis of stage 3 and 4 breast cancer cases revealed better overall precision for GCMSD yet comparable clinical performance of both GC MS instruments and identified two downregulated glycan nodes as excellent breast cancer biomarker candidates: t-Gal and 4,6-GlcNAc (ROC AUC ≈ 0.80, p < 0.05). Resulting from the activity of multiple GTs, t-Gal had the highest ROC AUC (0.88) and lowest ROC p‑value (0.001) among all analyzed nodes. Representing core-fucosylation, glycan node 4,6-GlcNAc is a nearly 1:1 molecular surrogate for the activity of α-(1,6)-fucosyltransferase—a potential target for cancer therapy. To validate these results, future projects can analyze larger sample sets, find correlations between breast cancer stage and changes in t-Gal and 4,6-GlcNAc levels, gauge the specificity of these nodes for breast cancer and their potential role in other cancer types, and develop clinical tests for reliable breast cancer diagnosis and treatment monitoring based on t-Gal and 4,6-GlcNAc.
ContributorsZaare, Sahba (Author) / Borges, Chad (Thesis director) / LaBaer, Joshua (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Homelessness is one of the most visible and tragic problems facing Phoenix today. As Tucson cut its homelessness count nearly in half over the past six years, Phoenix only saw a reduction of 25%. The question remains: what is the best solution for Phoenix to reduce and eventually eliminate homelessness?

Homelessness is one of the most visible and tragic problems facing Phoenix today. As Tucson cut its homelessness count nearly in half over the past six years, Phoenix only saw a reduction of 25%. The question remains: what is the best solution for Phoenix to reduce and eventually eliminate homelessness? This paper examined costs and benefits as well as examples in other cities and states of Housing First solutions' effectiveness at reducing the number of people suffering from homelessness. It was found that Housing First solutions, namely Permanent Supportive Housing and Rapid Re-Housing, would be highly effective in combating the homelessness experienced by those in the Phoenix area.
ContributorsGhali, Zakary Hawkes (Author) / Lewis, Paul (Thesis director) / Kilman, Margaret (Committee member) / School of International Letters and Cultures (Contributor) / School of Politics and Global Studies (Contributor, Contributor) / School of Public Affairs (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
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Description
In December of 2015, I made my way to rural Peru for a few weeks, my first visit to South America. While I was there, I observed a devotion to family and leisure activity, topics that were not heavily prioritized in my experience in Arizona. Upon my return, I became

In December of 2015, I made my way to rural Peru for a few weeks, my first visit to South America. While I was there, I observed a devotion to family and leisure activity, topics that were not heavily prioritized in my experience in Arizona. Upon my return, I became more involved in leisure activities, particularly running, hiking, yoga, and climbing. These involvements noticeably benefitted my health and well-being. The way the Peruvians I met prioritized these subjects fascinated me, and I wanted to study this difference between Arizona and Peru. In July of 2017, I returned to Peru for a semester abroad with my bags packed and the following research questions: 1) Are differences in motivation for rock climbing between Arizona and Peruvian climbers associated with cultural values? 2) Do leisure activities and the amount of time spent on them have an effect on quality of life? 3) Does the degree of climbing specialization impact perceptions of well-being? 4) What characteristics impact perceptions of quality of life among climbers? Are these characteristics affected by country of origin? My prediction was that Peruvians had higher quality of life due to their emphasis on leisure. Through this study, I learned that this conclusion was not as simple as I anticipated.
ContributorsMatta, Samantha Tania (Author) / Hultsman, Wendy (Thesis director) / Sampson, David (Committee member) / Lee, Rebecca (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Molecular Sciences (Contributor) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
The growing Hispanic population in Phoenix, Arizona frequently lacks financial resources which may limit their access to health care. The goal of this study was to identify the ideal factors in a health insurance plan for the Hispanic/Latino population in Phoenix, AZ. A survey was designed to gather information regarding

The growing Hispanic population in Phoenix, Arizona frequently lacks financial resources which may limit their access to health care. The goal of this study was to identify the ideal factors in a health insurance plan for the Hispanic/Latino population in Phoenix, AZ. A survey was designed to gather information regarding demographics, health insurance, preferences, and affordability. The survey was completed by 260 participants. Several multivariate regressions were run using SAS Statistical Software. The final model generated explained 4.48% of the variation in the data set. It showed that an individual who identified as Hispanic/Latino was 8.2% less likely to have health insurance. In addition, an individual who identified as a US Citizen was 23% more likely to have health insurance. To improve access and enrollment among the Hispanic/Latino population, further investigation is needed to identify relevant communication techniques that increase enrollment among this high-risk community.
ContributorsToo, Rachel Yun-May (Author) / Whisner, Corrie (Thesis director) / Calvin, Samantha (Committee member) / Cook, Aaron (Committee member) / Economics Program in CLAS (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description

An in depth look at the rhetoric behind the campus carry debate at the University of Texas at Austin. This thesis researched and examined primary sources from The Daily Texan and The Austin-American Statesman attempting to analyze what was at stake for both sides of the argument and what the

An in depth look at the rhetoric behind the campus carry debate at the University of Texas at Austin. This thesis researched and examined primary sources from The Daily Texan and The Austin-American Statesman attempting to analyze what was at stake for both sides of the argument and what the most effective rhetorical tool was.

ContributorsBlumstein, Cory Joshua (Author) / Young, Alexander (Thesis director) / O'Flaherty, Katherine (Committee member) / School of Criminology and Criminal Justice (Contributor) / School of Public Affairs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational

As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.

ContributorsLeung, Michael (Co-author) / Kandan, Mani (Co-author) / Knox, Garrett (Co-author) / Woo, Sabrina (Co-author) / Compton, Carolyn (Thesis director) / Dudley, Sean (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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This research analyzes lesbian, gay, bisexual, transgender, and queer/ questioning (LGBTQ) students’ experiences with sex education in Arizona. This research is a grey literature review of Arizona’s previous state policies, current state sex education curricula law, and legislative proposals within the past few years. Analysis focuses on changes after the

This research analyzes lesbian, gay, bisexual, transgender, and queer/ questioning (LGBTQ) students’ experiences with sex education in Arizona. This research is a grey literature review of Arizona’s previous state policies, current state sex education curricula law, and legislative proposals within the past few years. Analysis focuses on changes after the repeal of the “no promo homo” law in 2019. Through defining the differences between abstinence only and comprehensive sex education (CSE), this will provide a framework to better understand approaches to sex education. As of now, Arizona stresses abstinence-based education. Delving into LGBTQ students’ general experiences in schools provides a foundation to better understand why these students especially benefit from CSE. Since LGBTQ students are disproportionately affected by bullying and are at increased sexual health risks, it is important to address misperceptions surrounding the LGBTQ community. The purpose of this research is to push for more LGBTQ inclusive sex education curricula in Arizona.

ContributorsHo, Jacklyn (Author) / Glegziabher, Meskerem (Thesis director) / Ruth, Alissa (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Public Affairs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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This podcast highlights the voices of organizers and activists across the nation. Representatives from various organizations and individual activists provide their experiences in working within reproductive health activist spaces. By listening to their stories and expertise, the hope is for listeners to center Reproductive Justice as a point of view.

This podcast highlights the voices of organizers and activists across the nation. Representatives from various organizations and individual activists provide their experiences in working within reproductive health activist spaces. By listening to their stories and expertise, the hope is for listeners to center Reproductive Justice as a point of view. The goal is to encourage the audience to join an organization, support their local organizations, or at the very least, learn about resources provided to them by local and national organizations.

ContributorsPerez, Maya Isabella (Co-author) / Adversario, Kim Alexis (Co-author) / Quan, H.L.T. (Thesis director) / Brian, Jennifer (Committee member) / School of Politics and Global Studies (Contributor, Contributor, Contributor, Contributor) / School of Public Affairs (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

There is a serious lack of local news in Arizona, the American Southwest, and the United States at-large. Arizonans are craving quality, factual, no-holds-barred journalism that is easy-to-read, and upfront. Quality, local news that covers the ins and outs of politics, culture, and community has an opportunity to not only

There is a serious lack of local news in Arizona, the American Southwest, and the United States at-large. Arizonans are craving quality, factual, no-holds-barred journalism that is easy-to-read, and upfront. Quality, local news that covers the ins and outs of politics, culture, and community has an opportunity to not only enhance civic life, promote community healing, and expand knowledge made available to the general public (thus serving the communities it calls home), but to also generate revenue. Further, independent and center-right leaning voters in the state of Arizona — be reminded that independents make up the second largest voting bloc among Arizonans — are often crowded out in a media environment that consists of far-left nonprofit-funded news sites like the Arizona Mirror, formerly reputable papers that have bled readership as they veer further left like the Arizona Republic, and far-right online blogs that reach a very limited audience. The Western Tribune is an Arizona-based journalistic publication. This institution is dedicated to providing high-quality, well-sourced news and commentary on statewide, regional, national, and international current affairs through the lens of good government and free enterprise — as well as Southwestern values. We are a free institution that believes in free institutions. We cover stories that go uncovered because of the corporate media’s blind spots (and they’ve got many — they’re a result of news deserts and out-of-touch coastal attitudes) with the stable support of a robust institution dedicated to Truth-seeking behind them. Our storytellers are not just good writers. We seek to recruit and form critical thinkers with skills that span trades, disciplines, and educational backgrounds. We are building an institution committed to excellence.

ContributorsRobinson, Clay (Author) / Byrne, Jared (Thesis director) / Swader, Melissa (Committee member) / Plunkett, Nina (Committee member) / Khalaf, George (Committee member) / Barrett, The Honors College (Contributor) / Thunderbird School of Global Management (Contributor) / School for the Future of Innovation in Society (Contributor) / School of Public Affairs (Contributor) / School of Politics and Global Studies (Contributor) / School of Civic & Economic Thought and Leadership (Contributor)
Created2023-05
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Description
This thesis explores the current standards and the progress being made for civic education in the state of Arizona. To develop a new model, it draws on the programs offered to students in the community of Camden, NJ by the thriving civics department at Rutgers University. Motivated by the current

This thesis explores the current standards and the progress being made for civic education in the state of Arizona. To develop a new model, it draws on the programs offered to students in the community of Camden, NJ by the thriving civics department at Rutgers University. Motivated by the current lack of civic resources in Arizona high schools, this research seeks out a practical, community-centered approach to improving the civic education standards. Arizona was one of the first states to make civic education a priority by passing the American Civics Act, but there is still a long way to go to create civically engaged classrooms for students. The proposed plan combines citizenship pedagogy with direct service opportunities, mentorship, and community projects to help students become engaged in their local communities.
ContributorsMiller, Mekenna Moriah (Author) / Simhony, Avital (Thesis director) / Lennon, Tara (Committee member) / School of Public Affairs (Contributor) / School of Social Transformation (Contributor) / School of Politics and Global Studies (Contributor, Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05