Matching Items (5)
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- All Subjects: Organic Chemistry
- All Subjects: Polymer Chemistry
- Creators: Ackerman-Biegasiewicz, Laura
- Creators: Jones, Anne
- Member of: Theses and Dissertations
- Status: Published
Targeting Tumors: Inclusion of Functional Groups on Ion-Containing Block Copolymers to Combat Cancer
Description
This research attempts to determine the most effective method of synthesizing a peptide such that it can be utilized as a targeting moiety for polymeric micelles. Two melanoma-associated peptides with high in vitro and in vivo binding affinity for TNF receptors have been identified and synthesized. Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-ToF) was used to help verify the structure of both peptides, which were purified using Reversed-Phase High Performance Liquid Chromatography (RP-HPLC). The next steps in the research are to attach the peptides to a micelle and determine their impact on micelle stability.
ContributorsMoe, Anna Marguerite (Author) / Green, Matthew (Thesis director) / Jones, Anne (Committee member) / Sullivan, Millicent (Committee member) / Chemical Engineering Program (Contributor) / School of International Letters and Cultures (Contributor) / Sandra Day O'Connor College of Law (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Due to its difficult nature, organic chemistry is receiving much research attention across the nation to develop more efficient and effective means to teach it. As part of that, Dr. Ian Gould at ASU is developing an online organic chemistry educational website that provides help to students, adapts to their responses, and collects data about their performance. This thesis creative project addresses the design and implementation of an input parser for organic chemistry reagent questions, to appear on his website. After students used the form to submit questions throughout the Spring 2013 semester in Dr. Gould's organic chemistry class, the data gathered from their usage was analyzed, and feedback was collected. The feedback obtained from students was positive, and suggested that the input parser accomplished the educational goals that it sought to meet.
ContributorsBeerman, Eric Christopher (Author) / Gould, Ian (Thesis director) / Wilkerson, Kelly (Committee member) / Mosca, Vince (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2013-05
Description
The development of sustainable catalysts that exhibit exceptional activity has become a major goal of organometallic chemists. Considering their low cost and environmentally benign nature, the use of base metals in catalysis has recently been explored. This dissertation is focused on the development of manganese catalysts for organic transformations and inorganic polymerizations. Previous advances in Mn-based hydrosilylation and hydroboration catalysis are reviewed in Chapter 1 and set the stage for the experimental work described herein.In Chapter 2, the electronic structure of [(2,6-iPr2PhBDI)Mn(μ-H)]2 is explored. This compound was evaluated by density functional theory calculations, SQUID magnetometry and EPR spectroscopy at low temperature. Single crystal X-ray diffraction data was collected for related compounds that feature bridging X-type ligands. The data revealed how bridging ligands impact the Mayer bond order between the two Mn atoms and explained why [(2,6-iPr2PhBDI)Mn(μ-H)]2 is an active catalyst for organic transformations.
Chapter 3 spotlights the first study to systematically demonstrate commercial aminosilane CVD precursor synthesis by way of SiH4 and amine dehydrocoupling using [(2,6-iPr2PhBDI)Mn(μ-H)]2. In addition, the study provided an efficient and halogen-free preparation of highly cross-linked polycarbosilazanes under ambient conditions. Furthermore, exceptionally pure perhydropolysilazane was directly prepared from ammonia and silane at room temperature through dehydrogenative coupling. These are also the first reported examples of Mn-catalyzed Si–N dehydrocoupling.
This research was then extended to the Mn-catalyzed dehydrogenative coupling of NH3 and diamines to organic silanes. Organic polysilazanes and polycarbosilazanes were synthesized and the structures were characterized by NMR, FT-IR, and MALDI-TOF spectroscopy. The thermal properties and coating applications of the products were evaluated by TGA, DSC, X-ray powder diffraction, SEM and EDX. A turnover frequency (TOF) experiment using 0.01 mol% of [(2,6-iPr2PhBDI)Mn(μ-H)]2 revealed a maximum TOF of 300 s-1, which is the highest activity ever reported for this transformation.
The last chapter highlights the first examples of nitrile dihydroboration mediated by a manganese catalyst. Using 0.5 mol% of [(2,6-iPr2PhBDI)Mn(μ-H)]2, 14 nitriles were reduced with HBPin at 80 ℃ to afford N,N-diborylamines after 24 h. A mechanism was proposed based on the isolation of [(2,6-iPr2PhBDI)Mn(NCHPh)]2 as an intermediate and further substantiated by DFT.
ContributorsNguyen, Thu Thao (Author) / Trovitch, Ryan (Thesis advisor) / Jones, Anne (Committee member) / Ackerman, Laura (Committee member) / Arizona State University (Publisher)
Created2022
Description
Marine algae are a rich source of bioactive halogenated natural products. Thepresence of these marine natural products has largely been attributed to their biosynthesis
by organisms in these environments through a variety of different halogenation
mechanisms. One of the key contributors in these halogenation processes are from the
vanadium haloperoxidases (VHPOs) class of enzymes. VHPOs perform an electrophilic
halogenation through the oxidation of halide ions with hydrogen peroxide as the terminal
oxidant. This technique produces an electrophilic halide equivalent that can directly
halogenate organic substrates. Despite the numerous known reaction capabilities of this
enzyme class, their construction of intramolecular ring formation between a carbon and
nitrogen atom has remained unreported.
Herein, this study presents a development of a ‘new to nature’ chemical reaction for lactam synthesis. In pursuit of this type of reaction, it was discovered that wild type VHPOs (e.g., Curvularia inaequalis, Corallina officinalis, Corallina pilulifera, Acaryochloria marina) produce halogenated iminolactone compounds from acyclic amides in excellent yields and selectivity greater than 99 percent yield. The extension to chlorocyclizations will also be discussed.
ContributorsMerker, Kayla Rose (Author) / Biegasiewicz, Kyle (Thesis advisor) / Ackerman-Biegasiewicz, Laura (Committee member) / Mills, Jeremy (Committee member) / Arizona State University (Publisher)
Created2022
Description
This thesis is about how Fe catalysts can be degraded using photocatalysis and how Fe catalysts can degrade small molecules in conjunction with light. The goal of this paper is to look further into more sustainable methods of organic chemistry. Many current organic chemistry practices involve the use of precious metals. Iron is a more sustainable catalyst because it is abundant and inexpensive which is important for preserving the earth and making the organic chemistry more accessible. Along the same lines, light is a renewable energy source and has demonstrated its ability to aid in reactions. Overall, the goal of this paper is to explore the more sustainable alternatives to harsh and toxic organic chemistry practices through the use of Iron and light.
ContributorsBlenker, Grace (Author) / Ackerman-Biegasiewicz, Laura (Thesis director) / Redding, Kevin (Committee member) / Biegasiewicz, Kyle (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor)
Created2022-05