Matching Items (12)
Filtering by

Clear all filters

136012-Thumbnail Image.png
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
136167-Thumbnail Image.png
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description

This is a composition of information derived from the research conducted to produce each episode of Nefarious. As part of my final thesis project for my undergraduate degrees in criminal justice and forensic psychology, I created a podcast on the topic of true crime with an academic approach titled Nefarious.

This is a composition of information derived from the research conducted to produce each episode of Nefarious. As part of my final thesis project for my undergraduate degrees in criminal justice and forensic psychology, I created a podcast on the topic of true crime with an academic approach titled Nefarious. Each episode of Nefarious examines a particular case in relation to some academic theme learned throughout my educational career at Arizona State University. Episode one examines the life and crimes of Richard Ramirez and different criminological theories that could be used to explain his behavior. Episode two looks at the case of Brock Turner and Chanel Miller and focuses on the larger problem of rape culture in America and sexual assault on college campuses. In episode three the case of the Central Park Five is detailed in relation to false confessions and wrongful convictions within the legal system. Episode four is centered around Kyle Rittenhouse and the use of self-defense as a legal defense in the justice system as well as the political atmosphere surrounding this case. The fifth episode explores three cases of police brutality against racial minorities and the history of police in America. The final episode of Nefarious covers the life and crimes of Jeffrey Dahmer and analyzes such actions from a forensic psychology approach.

ContributorsBuche, Bailee (Author) / McClelland, Blake (Thesis director) / DeCarolis, Claudine (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2023-05
165542-Thumbnail Image.png
Description

The portrayal of those with mental health disorders in film and television, particularly those with disorders that label them as psychopaths, have often been overlooked. It is all too common for mental health disorders to be romanticized, dramatized, or simply depicted incorrectly. The historical fiction films Extremely Wicked, Shockingly Evil

The portrayal of those with mental health disorders in film and television, particularly those with disorders that label them as psychopaths, have often been overlooked. It is all too common for mental health disorders to be romanticized, dramatized, or simply depicted incorrectly. The historical fiction films Extremely Wicked, Shockingly Evil and Vile and My Friend Dahmer depict serial killers Ted Bundy and Jeffrey Dahmer respectively, and while depict historical events to a degree of accuracy, still take creative liberties. The proper definition of psychopathy must be analyzed more and the reason why films about psychopaths are popular with audiences must be as well.

ContributorsCompanik, Noah (Author) / Arce, Alma (Thesis director) / Gruber, Diane (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2022-05
Description

This thesis aims to interpret, analyze, and bring forward the connections between psychological disorders and serial murder. As part of that, the essay will be emphasizing specific diagnoses such as antisocial personality disorder, schizophrenia, bipolar disorder, and delusional disorder while profiling serial killers throughout history known to suffer from these

This thesis aims to interpret, analyze, and bring forward the connections between psychological disorders and serial murder. As part of that, the essay will be emphasizing specific diagnoses such as antisocial personality disorder, schizophrenia, bipolar disorder, and delusional disorder while profiling serial killers throughout history known to suffer from these mental illnesses. Using the accounts and known diagnoses of serial killers such as Ted Bundy, Jeffrey Dahmer, John Wayne Gacy, and others, this thesis will further reflect the psychological history and evolution of these mental health disorders. To do that, this thesis will also show the romanticization of serial killers in popular culture. Utilizing the scholarly research made available in the psychological and criminal justice literature, this thesis will further the conclusion that psychological disorders are the root of serial murder and explore the possibility that continued advances in the study of psychological disorders are the primary cause of serial murder and that criminal profiling may have the potential to reduce the incidents of murder that we do see in serial killer tendencies. We are further exploring the possibility that continued advances in the study of psychological disorders and criminal profiling can reduce the incidents we do see.

ContributorsProchaska, Remington (Author) / Niebuhr, Robert (Thesis director) / Barratt, T.M. (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2023-05
ContributorsBuche, Bailee (Author) / McClelland, Blake (Thesis director) / DeCarolis, Claudine (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2023-05
ContributorsBuche, Bailee (Author) / McClelland, Blake (Thesis director) / DeCarolis, Claudine (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2023-05
ContributorsBuche, Bailee (Author) / McClelland, Blake (Thesis director) / DeCarolis, Claudine (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2023-05
ContributorsBuche, Bailee (Author) / McClelland, Blake (Thesis director) / DeCarolis, Claudine (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2023-05