Matching Items (3)
Filtering by
- Creators: Barrett, The Honors College
- Creators: Church, Kathy
Description
We propose the Bio-HCI framework, that focuses on three major components: biological materials, intermediate platforms, and interaction with the user. In this context, "biological materials" is meant to broadly cover biological matter (DNA, RNA, enzyme), biological information (gene, epigenetic), biological process (mutation, reproduction, self assembling), and biological form. These biological materials serve as the design elements for designers to use in the same way as digital materials. Intermediate Platform focuses on methods of connecting biological materials to a user, or a digital platform that connect to users. In most current use-cases, biological materials need an intermediate platform to transfer the information to the user and transfer the user's response back to biological materials. Examples include a DNA sequencer, microscope, or petri dish. User interaction emphasizes the interactivity between a user and the biological machine (biological materials + intermediate platform). The interaction ranges from a basic human-computer interaction such as using a biological machine as a file storage to a unique interaction such as having a biological machine that evolves to solve user's task. To examine this framework further, we present four experiments which focus on the different aspect of the Bio-HCI framework.
ContributorsPataranutaporn, Pat (Author) / Finn, Edward (Thesis director) / Kusumi, Kenro (Committee member) / Ingalls, Todd (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Cancer is one of the leading causes of death in the world and represents a tremendous burden on patients, families and societies. S. Typhimurium strains are specifically attracted to compounds produced by cancer cells and could overcome the traditional therapeutic barrier. However, a major problem with using live attenuated Salmonella as anti-cancer agents is their toxicity at the dose required for therapeutic efficacy, but reducing the dose results in diminished efficacy. In this project, we explored novel means to reduce the toxicity of the recombinant attenuated Salmonella by genetically engineering those virulence factors to facilitate maximal colonization of tumor tissues and reduced fitness in normal tissues. We have constructed two sets of Salmonella strains. In the first set, each targeted gene was knocked out by deletion of the gene. In the second set, the predicted promoter region of each gene was replaced with a rhamnose-regulated promoter, which will cease the synthesis of these genes in vivo, a rhamnose-free environment.
ContributorsBenson, Lee Samuel (Author) / Kong, Wei (Thesis director) / Martin, Thomas (Committee member) / Lake, Douglas (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Center for Infectious Diseases and Vaccinology (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
Charlie Arntzen joined ASU in August 2000 as the Florence Ely Nelson Presidential Endowed Chair and retired in 2016 from the School of Life Sciences and Biodesign Institute. Charlie was the founding Director of the Biodesign Institute.
Important ASU stories include:
1) the creation of the Biodesign Institute,
2) the design and operation of the Biodesign labs,
3) the development of ZMapp to fight Ebola,
4) The New American University - a discussion of the importance of collaboration, and
5) several comments about Presidents Coor and Crow and Provost Glick
ContributorsChurch, Kathy (Interviewer) / Arizona State University Retirees Association (Producer)
Created2019-05-08