In Isle of Thrones, you must build up your kingdom to avoid being dominated by your opponent. Players start with a castle as their initial piece of land and draw cards from two decks, Event and Effect, which can influence the game. Each turn involves drawing an Event Card, playing Effect Cards, taking actions such as placing land tiles strategically on the board to expand territory, and potentially drawing more Effect Cards. Players earn points by placing land tiles with different named pieces of the same point value next to each other, and the game ends when the board is filled or when a player can no longer place more pieces. Land pieces can be destroyed and returned to the Land Pile, and the player with the most points at the end of the game wins.