Matching Items (3)
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- All Subjects: Image Processing
- Genre: Masters Thesis
- Creators: Li, Baoxin
- Creators: Brunhaver, John
Description
Diabetic retinopathy (DR) is a common cause of blindness occurring due to prolonged presence of diabetes. The risk of developing DR or having the disease progress is increasing over time. Despite advances in diabetes care over the years, DR remains a vision-threatening complication and one of the leading causes of blindness among American adults. Recent studies have shown that diagnosis based on digital retinal imaging has potential benefits over traditional face-to-face evaluation. Yet there is a dearth of computer-based systems that can match the level of performance achieved by ophthalmologists. This thesis takes a fresh perspective in developing a computer-based system aimed at improving diagnosis of DR images. These images are categorized into three classes according to their severity level. The proposed approach explores effective methods to classify new images and retrieve clinically-relevant images from a database with prior diagnosis information associated with them. Retrieval provides a novel way to utilize the vast knowledge in the archives of previously-diagnosed DR images and thereby improve a clinician's performance while classification can safely reduce the burden on DR screening programs and possibly achieve higher detection accuracy than human experts. To solve the three-class retrieval and classification problem, the approach uses a multi-class multiple-instance medical image retrieval framework that makes use of spectrally tuned color correlogram and steerable Gaussian filter response features. The results show better retrieval and classification performances than prior-art methods and are also observed to be of clinical and visual relevance.
ContributorsChandakkar, Parag Shridhar (Author) / Li, Baoxin (Thesis advisor) / Turaga, Pavan (Committee member) / Frakes, David (Committee member) / Arizona State University (Publisher)
Created2012
Description
The last decade has witnessed a paradigm shift in computing platforms, from laptops and servers to mobile devices like smartphones and tablets. These devices host an immense variety of applications many of which are computationally expensive and thus are power hungry. As most of these mobile platforms are powered by batteries, energy efficiency has become one of the most critical aspects of such devices. Thus, the energy cost of the fundamental arithmetic operations executed in these applications has to be reduced. As voltage scaling has effectively ended, the energy efficiency of integrated circuits has ceased to improve within successive generations of transistors. This resulted in widespread use of Application Specific Integrated Circuits (ASIC), which provide incredible energy efficiency. However, these are not flexible and have high non-recurring engineering (NRE) cost. Alternatively, Field Programmable Gate Arrays (FPGA) offer flexibility to implement any application, but at the cost of higher area and energy compared to ASIC.
In this work, a spatially programmable architecture customized for image processing applications is proposed. The intent is to bridge the efficiency gap between ASICs and FPGAs, by offering FPGA-like flexibility and ASIC-like energy efficiency. This architecture minimizes the energy overheads in FPGAs, which result from the use of fine-grained programming style and global interconnect. It is flexible compared to an ASIC and can accommodate multiple applications.
The main contribution of the thesis is the feasibility analysis of the data path of this architecture, customized for image processing applications. The data path is implemented at the register transfer level (RTL), and the synthesis results are obtained in 45nm technology cell library from a leading foundry. The results of image-processing applications demonstrate that this architecture is within a factor of 10x of the energy and area efficiency of ASIC implementations.
In this work, a spatially programmable architecture customized for image processing applications is proposed. The intent is to bridge the efficiency gap between ASICs and FPGAs, by offering FPGA-like flexibility and ASIC-like energy efficiency. This architecture minimizes the energy overheads in FPGAs, which result from the use of fine-grained programming style and global interconnect. It is flexible compared to an ASIC and can accommodate multiple applications.
The main contribution of the thesis is the feasibility analysis of the data path of this architecture, customized for image processing applications. The data path is implemented at the register transfer level (RTL), and the synthesis results are obtained in 45nm technology cell library from a leading foundry. The results of image-processing applications demonstrate that this architecture is within a factor of 10x of the energy and area efficiency of ASIC implementations.
ContributorsSatapathy, Saktiswarup (Author) / Brunhaver, John (Thesis advisor) / Clark, Lawrence T (Committee member) / Ren, Fengbo (Committee member) / Arizona State University (Publisher)
Created2016
Description
Understanding the complexity of temporal and spatial characteristics of gene expression over brain development is one of the crucial research topics in neuroscience. An accurate description of the locations and expression status of relative genes requires extensive experiment resources. The Allen Developing Mouse Brain Atlas provides a large number of in situ hybridization (ISH) images of gene expression over seven different mouse brain developmental stages. Studying mouse brain models helps us understand the gene expressions in human brains. This atlas collects about thousands of genes and now they are manually annotated by biologists. Due to the high labor cost of manual annotation, investigating an efficient approach to perform automated gene expression annotation on mouse brain images becomes necessary. In this thesis, a novel efficient approach based on machine learning framework is proposed. Features are extracted from raw brain images, and both binary classification and multi-class classification models are built with some supervised learning methods. To generate features, one of the most adopted methods in current research effort is to apply the bag-of-words (BoW) algorithm. However, both the efficiency and the accuracy of BoW are not outstanding when dealing with large-scale data. Thus, an augmented sparse coding method, which is called Stochastic Coordinate Coding, is adopted to generate high-level features in this thesis. In addition, a new multi-label classification model is proposed in this thesis. Label hierarchy is built based on the given brain ontology structure. Experiments have been conducted on the atlas and the results show that this approach is efficient and classifies the images with a relatively higher accuracy.
ContributorsZhao, Xinlin (Author) / Ye, Jieping (Thesis advisor) / Wang, Yalin (Thesis advisor) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2016