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- All Subjects: Medical Imaging
- Genre: Masters Thesis
- Creators: Li, Baoxin
Description
Alzheimer’s Disease (AD), a neurodegenerative disease is a progressive disease that affects the brain gradually with time and worsens. Reliable and early diagnosis of AD and its prodromal stages (i.e. Mild Cognitive Impairment(MCI)) is essential. Fluorodeoxyglucose (FDG) positron emission tomography (PET) measures the decline in the regional cerebral metabolic rate for glucose, offering a reliable metabolic biomarker even on presymptomatic AD patients. PET scans provide functional information that is unique and unavailable using other types of imaging. The computational efficacy of FDG-PET data alone, for the classification of various Alzheimer’s Diagnostic categories (AD, MCI (LMCI, EMCI), Control) has not been studied. This serves as motivation to correctly classify the various diagnostic categories using FDG-PET data. Deep learning has recently been applied to the analysis of structural and functional brain imaging data. This thesis is an introduction to a deep learning based classification technique using neural networks with dimensionality reduction techniques to classify the different stages of AD based on FDG-PET image analysis.
This thesis develops a classification method to investigate the performance of FDG-PET as an effective biomarker for Alzheimer's clinical group classification. This involves dimensionality reduction using Probabilistic Principal Component Analysis on max-pooled data and mean-pooled data, followed by a Multilayer Feed Forward Neural Network which performs binary classification. Max pooled features result into better classification performance compared to results on mean pooled features. Additionally, experiments are done to investigate if the addition of important demographic features such as Functional Activities Questionnaire(FAQ), gene information helps improve performance. Classification results indicate that our designed classifiers achieve competitive results, and better with the additional of demographic features.
This thesis develops a classification method to investigate the performance of FDG-PET as an effective biomarker for Alzheimer's clinical group classification. This involves dimensionality reduction using Probabilistic Principal Component Analysis on max-pooled data and mean-pooled data, followed by a Multilayer Feed Forward Neural Network which performs binary classification. Max pooled features result into better classification performance compared to results on mean pooled features. Additionally, experiments are done to investigate if the addition of important demographic features such as Functional Activities Questionnaire(FAQ), gene information helps improve performance. Classification results indicate that our designed classifiers achieve competitive results, and better with the additional of demographic features.
ContributorsSingh, Shibani (Author) / Wang, Yalin (Thesis advisor) / Li, Baoxin (Committee member) / Liang, Jianming (Committee member) / Arizona State University (Publisher)
Created2017
Description
Increased LV wall thickness is frequently encountered in transthoracicechocardiography (TTE). While accurate and early diagnosis is clinically important,
given the differences in available therapeutic options and prognosis, an extensive workup
is often required for establishing the diagnosis. I propose the first echo-based, automated
deep learning model with a fusion architecture to facilitate the evaluation and diagnosis
of increased left ventricular (LV) wall thickness. Patients with an established diagnosis
for increased LV wall thickness (hypertrophic cardiomyopathy (HCM), cardiac
amyloidosis (CA), and hypertensive heart disease (HTN)/others) between 1/2015 to
11/2019 at Mayo Clinic Arizona were identified. The cohort was divided into
80%/10%/10% for training, validation, and testing sets, respectively. Six baseline TTE
views were used to optimize a pre-trained InceptionResnetV2 model, each model output
was used to train a meta-learner under a fusion architecture. Model performance was
assessed by multiclass area under the receiver operating characteristic curve (AUROC).
A total of 586 patients were used for the final analysis (194 HCM, 201 CA, and 191
HTN/others). The mean age was 55.0 years, and 57.8% were male. Among the individual
view-dependent models, the apical 4 chamber model had the best performance (AUROC:
HCM: 0.94, CA: 0.73, and HTN/other: 0.87). The final fusion model outperformed all the
view-dependent models (AUROC: CA: 0.90, HCM: 0.93, and HTN/other: 0.92). I
successfully established an automatic end-to-end deep learning model framework that
accurately differentiates the major etiologies of increased LV wall thickness, including
HCM and CA from the background of HTN/other diagnoses.
ContributorsLi, James Shuyue (Author) / Patel, Bhavik (Thesis advisor) / Li, Baoxin (Thesis advisor) / Banerjee, Imon (Committee member) / Arizona State University (Publisher)
Created2022