Matching Items (4)
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- All Subjects: Speech therapy
- Creators: Peter, Beate
Description
Childhood Apraxia of Speech (CAS) is a severe motor speech disorder that is difficult to diagnose as there is currently no gold-standard measurement to differentiate between CAS and other speech disorders. In the present study, we investigate underlying biomarkers associated with CAS in addition to enhanced phenotyping through behavioral testing. Cortical electrophysiological measures were utilized to investigate differences in neural activation in response to native and non-native vowel contrasts between children with CAS and typically developing peers. Genetic analysis included full exome sequencing of a child with CAS and his unaffected parents in order to uncover underlying genetic variation that may be causal to the child’s severely impaired speech and language. Enhanced phenotyping was completed through extensive behavioral testing, including speech, language, reading, spelling, phonological awareness, gross/fine motor, and oral and hand motor tasks. Results from cortical electrophysiological measures are consistent with previous evidence of a heightened neural response to non-native sounds in CAS, potentially indicating over specified phonological representations in this population. Results of exome sequencing suggest multiple genetic variations contributing to the severely affected phenotype in the child and provide further evidence of heterogeneous genomic pathways associated with CAS. Finally, results of behavioral testing demonstrate significant impairments evident across tasks in CAS, suggesting underlying sequential processing deficits in multiple domains. Overall, these results have the potential to delineate functional pathways from genetic variations to the brain to observable behavioral phenotypes and motivate the development of preventative and targeted treatment approaches.
ContributorsVose, Caitlin (Author) / Peter, Beate (Thesis advisor) / Liu, Li (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2018
Description
The purpose of this study was to evaluate the effects of parent training in the Enhanced Milieu Teaching with Phonological Emphasis (EMT+PE) intervention program, using telepractice, on parent strategy use and child speech and language outcomes for children with repaired cleft palate with or without lip (CP/L). Four parent child dyads participated in the study. Child participants ranged in age from 28 to 53 months at the beginning of intervention and all had a diagnosis of nonsyndromic CP/L. Participants received two-to-three parent training sessions and twice weekly telepractice intervention sessions. Parents increased their use of EMT+PE strategies throughout intervention with the Modeling and Expansion and Prompting and Recasting strategies resulting in significant intervention effects. Moreover, parents maintained increased strategy use following the conclusion of direct intervention. A positive improvement in child speech and language outcomes was seen across intervention. This study showed that telepractice is an effective service delivery model for parent training and subsequent intervention session in EMT+PE strategy use to support the speech and language development for children with CP/L.
ContributorsEllis, Paige Kathryn (Author) / Scherer, Nancy J (Thesis advisor) / Gray, Shelley (Committee member) / Peter, Beate (Committee member) / Lien, Kari (Committee member) / Arizona State University (Publisher)
Created2022
Description
Speech sound disorders (SSDs) are the most prevalent type of communication disorder in children. Clinically, speech-language pathologists (SLPs) rely on behavioral methods for assessing and treating SSDs. Though clients typically experience improved speech outcomes as a result of therapy, there is evidence that underlying deficits may persist even in individuals who have completed treatment for surface-level speech behaviors. Advances in the field of genetics have created the opportunity to investigate the contribution of genes to human communication. Due to the heterogeneity of many communication disorders, the manner in which specific genetic changes influence neural mechanisms, and thereby behavioral phenotypes, remains largely unknown. The purpose of this study was to identify genotype-phenotype associations, along with perceptual, and motor-related biomarkers within families displaying SSDs. Five parent-child trios participated in genetic testing, and five families participated in a combination of genetic and behavioral testing to help elucidate biomarkers related to SSDs. All of the affected individuals had a history of childhood apraxia of speech (CAS) except for one family that displayed a phonological disorder. Genetic investigation yielded several genes of interest relevant for an SSD phenotype: CNTNAP2, CYFIP1, GPR56, HERC1, KIAA0556, LAMA5, LAMB1, MDGA2, MECP2, NBEA, SHANK3, TENM3, and ZNF142. All of these genes showed at least some expression in the developing brain. Gene ontology analysis yielded terms supporting a genetic influence on central nervous system development. Behavioral testing revealed evidence of a sequential processing biomarker for all individuals with CAS, with many showing deficits in sequential motor skills in addition to speech deficits. In some families, participants also showed evidence of a co-occurring perceptual processing biomarker. The family displaying a phonological phenotype showed milder sequential processing deficits compared to CAS families. Overall, this study supports the presence of a sequential processing biomarker for CAS and shows that relevant genes of interest may be influencing a CAS phenotype via sequential processing. Knowledge of these biomarkers can help strengthen precision of clinical assessment and motivate development of novel interventions for individuals with SSDs.
ContributorsBruce, Laurel (Author) / Peter, Beate (Thesis advisor) / Daliri, Ayoub (Committee member) / Liu, Li (Committee member) / Scherer, Nancy (Committee member) / Weinhold, Juliet (Committee member) / Arizona State University (Publisher)
Created2020
Description
Past studies have shown that auditory feedback plays an important role in maintaining the speech production system. Typically, speakers compensate for auditory feedback alterations when the alterations persist over time (auditory motor adaptation). Our study focused on how to increase the rate of adaptation by using different auditory feedback conditions. For the present study, we recruited a total of 30 participants. We examined auditory motor adaptation after participants completed three conditions: Normal speaking, noise-masked speaking, and silent reading. The normal condition was used as a control condition. In the noise-masked condition, noise was added to the auditory feedback to completely mask speech outputs. In the silent reading condition, participants were instructed to silently read target words in their heads, then read the words out loud. We found that the learning rate in the noise-masked condition was lower than that in the normal condition. In contrast, participants adapted at a faster rate after they experience the silent reading condition. Overall, this study demonstrated that adaptation rate can be modified through pre-exposing participants to different types auditory-motor manipulations.
ContributorsNavarrete, Karina (Author) / Daliri, Ayoub (Thesis director) / Peter, Beate (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05