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- All Subjects: Paleopathology
- Creators: Kumar, Sudhir
- Creators: Phillips, Megann M.
Description
Studies of ancient pathogens are moving beyond simple confirmatory analysis of diseased bone; bioarchaeologists and ancient geneticists are posing nuanced questions and utilizing novel methods capable of confronting the debates surrounding pathogen origins and evolution, and the relationships between humans and disease in the past. This dissertation examines two ancient human diseases through molecular and bioarchaeological lines of evidence, relying on techniques in paleogenetics and phylogenetics to detect, isolate, sequence and analyze ancient and modern pathogen DNA within an evolutionary framework. Specifically this research addresses outstanding issues regarding a) the evolution, origin and phylogenetic placement of the pathogen causing skeletal tuberculosis in New World prior to European contact, and b) the phylogeny and origins of the parasite causing the human leishmaniasis disease complex. An additional chapter presents a review of the major technological and theoretical advances in ancient pathogen genomics to frame the contributions of this work within a rapidly developing field. This overview emphasizes that understanding the evolution of human disease is critical to contextualizing relationships between humans and pathogens, and the epidemiological shifts observed both in the past and in the present era of (re)emerging infectious diseases. These questions continue to be at the forefront of not only pathogen research, but also
bioarchaeological and paleopathological scholarship.
bioarchaeological and paleopathological scholarship.
ContributorsHarkins, Kelly M (Author) / Buikstra, Jane E. (Thesis advisor) / Stone, Anne C (Thesis advisor) / Knudson, Kelly (Committee member) / Kumar, Sudhir (Committee member) / Krause, Johannes (Committee member) / Arizona State University (Publisher)
Created2014
Description
Objectives: The objective of this research is to develop a better understanding of the ways in which Transition Analysis estimates differ from traditional estimates in terms of age-at-death point estimation and inter-observer error. Materials and methods: In order to achieve the objectives of the research, 71 adult individuals from an archaeological site in northern Sudan were subjected to Transition Analysis age estimation by the author, a beginner-level osteologist. These estimates were compared to previously produced traditional multifactorial age estimates for these individuals, as well as a small sample of Transition Analysis estimates produced by an intermediate-level investigator. Results: Transition Analysis estimates do not have a high correlation with traditional estimates of age at death, especially when those estimates fall within middle or old adult age ranges. The misalignment of beginner- and intermediate-level Transition Analysis age estimations calls into question intra-method as well as inter-method replicability of age estimations. Discussion: Although the poor overall correlation of Transition Analysis estimates and traditional estimates in this study might be blamed on the relatively low experience level of the analyst, the results cast doubt on the replicability of Transition Analysis estimations, echoing the Bethard's (2005) results on a known-age sample. The results also question the validity of refined age estimates produced for individuals previously estimated to be in the 50+ age range by traditional methods and suggest that Transition Analysis tends to produce younger estimates than its traditional counterparts. Key words: age estimation, Transition Analysis, human osteology, observer error
ContributorsPhillips, Megann M. (Author) / Baker, Brenda (Thesis director) / Norris, Annie Laurie (Committee member) / School of International Letters and Cultures (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05