Matching Items (2)
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- All Subjects: Sleep Deprivation
- Creators: Gallitano, Amelia
- Creators: Lara, Gustavo
Description
The effects of over-the-counter drug (OTC) use on college students' health has been debated in the field of psychology with researchers arguing that poor sleep quality among college students is the result of polysubstance use. However, this explanation is not a foregone conclusion. These researchers have not adequately addressed the issue poor sleep quality among college students and its relationship to polysubstance use. This is an important issue because prolonged unsupervised OTC drug use and poor sleep quality can impact long-term health and lessen students' likelihood of being successful in college. This paper addresses the issue of OTC drug use with special attention to sleep quality. Pittsburgh Sleep Quality Index Scores were collected to assess subjective sleep quality and its relationship to OTC drug use. Several other risk factors including binge drinking, marijuana use, and illicit drug use were also accounted for in this model. This study argues that, although the current literature suggests that poor sleep quality is the effect of drug use rather than the cause; the relationships between these factors are still unclear. This study aims to fill a gap in the college drug use literature by establishing a relationship between poor sleep quality and OTC drug use in a college sample.
ContributorsLara, Gustavo (Author) / Vargas, Perla (Thesis advisor) / Burleson, Mary (Committee member) / Robles-Sotelo, Elias (Committee member) / Arizona State University (Publisher)
Created2014
Description
Schizophrenia risk is influenced by both genetic and environmental factors. The immediate early gene early growth response 3 (Egr3), is regulated downstream of several schizophrenia risk genes and encodes a zinc-finger transcription factor protein. Previous studies from our lab indicate that Egr3 deficient (Egr3 -/-) mice exhibit schizophrenia-like phenotypes. We also discovered decreased serotonin 2a receptors (5-HT2AR) in the Egr3 -/- mice, similar to studies that reported decreased 5-HT2ARs in schizophrenia patients. We previously reported that sleep deprivation, a mild stress, causes the over expression of Egr3 and the serotonin 2a gene (Htr2a) in the cortex. To determine whether EGR3, a transcription factor, regulates Htr2a in the prefrontal cortex after sleep deprivation, Egr3 -/-and Egr3 +/+ mice were sleep deprived for eight hours. Transgenic mice were used that expressed enhanced green fluorescent protein (EGFP) under control of the Htr2a promoter via a bacterial artificial chromosome (BAC). Immunohistochemistry was performed to identify EGFP containing cells. Data analysis revealed no significant interaction between genotype and sleep deprivation in 5-HT2AR/EGFP containing cells within the prefrontal cortex. Based on the findings of this study, more data is needed to better determine the relationship between sleep deprivation and its effect on the regulation of Htr2a through in an EGR3 dependent manner.
ContributorsReznik, Derek Lee (Author) / Wilson-Rawls, Jeanne (Thesis director) / Gallitano, Amelia (Committee member) / Anderson, Karen (Committee member) / School of Sustainability (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12