Matching Items (2)
Filtering by

Clear all filters

134975-Thumbnail Image.png

The Effect of an Environmental Stimulus on a Genetic Pathway Associated with Schizophrenia

Description
Schizophrenia risk is influenced by both genetic and environmental factors. The immediate early gene early growth response 3 (Egr3), is regulated downstream of several schizophrenia risk genes and encodes a zinc-finger transcription factor protein. Previous studies from our lab indicate that Egr3 deficient (Egr3 -/-) mice exhibit schizophrenia-like phenotypes. We…

Schizophrenia risk is influenced by both genetic and environmental factors. The immediate early gene early growth response 3 (Egr3), is regulated downstream of several schizophrenia risk genes and encodes a zinc-finger transcription factor protein. Previous studies from our lab indicate that Egr3 deficient (Egr3 -/-) mice exhibit schizophrenia-like phenotypes. We also discovered decreased serotonin 2a receptors (5-HT2AR) in the Egr3 -/- mice, similar to studies that reported decreased 5-HT2ARs in schizophrenia patients. We previously reported that sleep deprivation, a mild stress, causes the over expression of Egr3 and the serotonin 2a gene (Htr2a) in the cortex. To determine whether EGR3, a transcription factor, regulates Htr2a in the prefrontal cortex after sleep deprivation, Egr3 -/-and Egr3 +/+ mice were sleep deprived for eight hours. Transgenic mice were used that expressed enhanced green fluorescent protein (EGFP) under control of the Htr2a promoter via a bacterial artificial chromosome (BAC). Immunohistochemistry was performed to identify EGFP containing cells. Data analysis revealed no significant interaction between genotype and sleep deprivation in 5-HT2AR/EGFP containing cells within the prefrontal cortex. Based on the findings of this study, more data is needed to better determine the relationship between sleep deprivation and its effect on the regulation of Htr2a through in an EGR3 dependent manner.
ContributorsReznik, Derek Lee (Author) / Wilson-Rawls, Jeanne (Thesis director) / Gallitano, Amelia (Committee member) / Anderson, Karen (Committee member) / School of Sustainability (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12

Psychological Warfare and Operations During the Korean War

Description

This paper will discuss what psychological operations (PSYOP) and psychological warfare (PSYWAR) are, emphasizing the role they played in the Korean War on soldiers and POWs. It includes two dynamic, engaging personal narratives adding relevance and intrigue to the topic examined. Two types of psychological operations will be identified and…

This paper will discuss what psychological operations (PSYOP) and psychological warfare (PSYWAR) are, emphasizing the role they played in the Korean War on soldiers and POWs. It includes two dynamic, engaging personal narratives adding relevance and intrigue to the topic examined. Two types of psychological operations will be identified and discussed, the leaflet and radio broadcast. Three methods of psychological warfare in the form of bacteriological warfare allegations, brainwashing, and sleep deprivation are analyzed and the effects of these methods during wartime. All participating countries during the Korean war either used psychological operations and warfare on their enemies, or had it used on them. The key takeaway was increased understanding that PSYOP and PSYWAR are founded on truthfulness rather than falsehoods. The paper concludes with the results of the war on the players involved and the legacy of psychological operations, encompassing how it applies to our technologically advanced world today.
ContributorsGoldsteen, Elizabeth (Author) / Niebuhr, Robert (Thesis director) / Ackerman, Heather (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2023-05