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In a healthcare setting, the Sterile Processing Department (SPD) provides ancillary services to the Operating Room (OR), Emergency Room, Labor & Delivery, and off-site clinics. SPD's function is to reprocess reusable surgical instruments and return them to their home departments. The management of surgical instruments and medical devices can impact

In a healthcare setting, the Sterile Processing Department (SPD) provides ancillary services to the Operating Room (OR), Emergency Room, Labor & Delivery, and off-site clinics. SPD's function is to reprocess reusable surgical instruments and return them to their home departments. The management of surgical instruments and medical devices can impact patient safety and hospital revenue. Any time instrumentation or devices are not available or are not fit for use, patient safety and revenue can be negatively impacted. One step of the instrument reprocessing cycle is sterilization. Steam sterilization is the sterilization method used for the majority of surgical instruments and is preferred to immediate use steam sterilization (IUSS) because terminally sterilized items can be stored until needed. IUSS Items must be used promptly and cannot be stored for later use. IUSS is intended for emergency situations and not as regular course of action. Unfortunately, IUSS is used to compensate for inadequate inventory levels, scheduling conflicts, and miscommunications. If IUSS is viewed as an adverse event, then monitoring IUSS incidences can help healthcare organizations meet patient safety goals and financial goals along with aiding in process improvement efforts. This work recommends statistical process control methods to IUSS incidents and illustrates the use of control charts for IUSS occurrences through a case study and analysis of the control charts for data from a health care provider. Furthermore, this work considers the application of data mining methods to IUSS occurrences and presents a representative example of data mining to the IUSS occurrences. This extends the application of statistical process control and data mining in healthcare applications.
ContributorsWeart, Gail (Author) / Runger, George C. (Thesis advisor) / Li, Jing (Committee member) / Shunk, Dan (Committee member) / Arizona State University (Publisher)
Created2014
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Description
The ever-changing economic landscape has forced many companies to re-examine their supply chains. Global resourcing and outsourcing of processes has been a strategy many organizations have adopted to reduce cost and to increase their global footprint. This has, however, resulted in increased process complexity and reduced customer satisfaction. In order

The ever-changing economic landscape has forced many companies to re-examine their supply chains. Global resourcing and outsourcing of processes has been a strategy many organizations have adopted to reduce cost and to increase their global footprint. This has, however, resulted in increased process complexity and reduced customer satisfaction. In order to meet and exceed customer expectations, many companies are forced to improve quality and on-time delivery, and have looked towards Lean Six Sigma as an approach to enable process improvement. The Lean Six Sigma literature is rich in deployment strategies; however, there is a general lack of a mathematical approach to deploy Lean Six Sigma in a global enterprise. This includes both project identification and prioritization. The research presented here is two-fold. Firstly, a process characterization framework is presented to evaluate processes based on eight characteristics. An unsupervised learning technique, using clustering algorithms, is then utilized to group processes that are Lean Six Sigma conducive. The approach helps Lean Six Sigma deployment champions to identify key areas within the business to focus a Lean Six Sigma deployment. A case study is presented and 33% of the processes were found to be Lean Six Sigma conducive. Secondly, having identified parts of the business that are lean Six Sigma conducive, the next steps are to formulate and prioritize a portfolio of projects. Very often the deployment champion is faced with the decision of selecting a portfolio of Lean Six Sigma projects that meet multiple objectives which could include: maximizing productivity, customer satisfaction or return on investment, while meeting certain budgetary constraints. A multi-period 0-1 knapsack problem is presented that maximizes the expected net savings of the Lean Six Sigma portfolio over the life cycle of the deployment. Finally, a case study is presented that demonstrates the application of the model in a large multinational company. Traditionally, Lean Six Sigma found its roots in manufacturing. The research presented in this dissertation also emphasizes the applicability of the methodology to the non-manufacturing space. Additionally, a comparison is conducted between manufacturing and non-manufacturing processes to highlight the challenges in deploying the methodology in both spaces.
ContributorsDuarte, Brett Marc (Author) / Fowler, John W (Thesis advisor) / Montgomery, Douglas C. (Thesis advisor) / Shunk, Dan (Committee member) / Borror, Connie (Committee member) / Konopka, John (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Buildings (approximately half commercial and half residential) consume over 70% of the electricity among all the consumption units in the United States. Buildings are also responsible for approximately 40% of CO2 emissions, which is more than any other industry sectors. As a result, the initiative smart building which aims to

Buildings (approximately half commercial and half residential) consume over 70% of the electricity among all the consumption units in the United States. Buildings are also responsible for approximately 40% of CO2 emissions, which is more than any other industry sectors. As a result, the initiative smart building which aims to not only manage electrical consumption in an efficient way but also reduce the damaging effect of greenhouse gases on the environment has been launched. Another important technology being promoted by government agencies is the smart grid which manages energy usage across a wide range of buildings in an effort to reduce cost and increase reliability and transparency. As a great amount of efforts have been devoted to these two initiatives by either exploring the smart grid designs or developing technologies for smart buildings, the research studying how the smart buildings and smart grid coordinate thus more efficiently use the energy is currently lacking. In this dissertation, a "system-of-system" approach is employed to develop an integrated building model which consists a number of buildings (building cluster) interacting with smart grid. The buildings can function as both energy consumption unit as well as energy generation/storage unit. Memetic Algorithm (MA) and Particle Swarm Optimization (PSO) based decision framework are developed for building operation decisions. In addition, Particle Filter (PF) is explored as a mean for fusing online sensor and meter data so adaptive decision could be made in responding to dynamic environment. The dissertation is divided into three inter-connected research components. First, an integrated building energy model including building consumption, storage, generation sub-systems for the building cluster is developed. Then a bi-level Memetic Algorithm (MA) based decentralized decision framework is developed to identify the Pareto optimal operation strategies for the building cluster. The Pareto solutions not only enable multiple dimensional tradeoff analysis, but also provide valuable insight for determining pricing mechanisms and power grid capacity. Secondly, a multi-objective PSO based decision framework is developed to reduce the computational effort of the MA based decision framework without scarifying accuracy. With the improved performance, the decision time scale could be refined to make it capable for hourly operation decisions. Finally, by integrating the multi-objective PSO based decision framework with PF, an adaptive framework is developed for adaptive operation decisions for smart building cluster. The adaptive framework not only enables me to develop a high fidelity decision model but also enables the building cluster to respond to the dynamics and uncertainties inherent in the system.
ContributorsHu, Mengqi (Author) / Wu, Teresa (Thesis advisor) / Weir, Jeffery (Thesis advisor) / Wen, Jin (Committee member) / Fowler, John (Committee member) / Shunk, Dan (Committee member) / Arizona State University (Publisher)
Created2012
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Description
This dissertation presents methods for the evaluation of ocular surface protection during natural blink function. The evaluation of ocular surface protection is especially important in the diagnosis of dry eye and the evaluation of dry eye severity in clinical trials. Dry eye is a highly prevalent disease affecting vast numbers

This dissertation presents methods for the evaluation of ocular surface protection during natural blink function. The evaluation of ocular surface protection is especially important in the diagnosis of dry eye and the evaluation of dry eye severity in clinical trials. Dry eye is a highly prevalent disease affecting vast numbers (between 11% and 22%) of an aging population. There is only one approved therapy with limited efficacy, which results in a huge unmet need. The reason so few drugs have reached approval is a lack of a recognized therapeutic pathway with reproducible endpoints. While the interplay between blink function and ocular surface protection has long been recognized, all currently used evaluation techniques have addressed blink function in isolation from tear film stability, the gold standard of which is Tear Film Break-Up Time (TFBUT). In the first part of this research a manual technique of calculating ocular surface protection during natural blink function through the use of video analysis is developed and evaluated for it's ability to differentiate between dry eye and normal subjects, the results are compared with that of TFBUT. In the second part of this research the technique is improved in precision and automated through the use of video analysis algorithms. This software, called the OPI 2.0 System, is evaluated for accuracy and precision, and comparisons are made between the OPI 2.0 System and other currently recognized dry eye diagnostic techniques (e.g. TFBUT). In the third part of this research the OPI 2.0 System is deployed for use in the evaluation of subjects before, immediately after and 30 minutes after exposure to a controlled adverse environment (CAE), once again the results are compared and contrasted against commonly used dry eye endpoints. The results demonstrate that the evaluation of ocular surface protection using the OPI 2.0 System offers superior accuracy to the current standard, TFBUT.
ContributorsAbelson, Richard (Author) / Montgomery, Douglas C. (Thesis advisor) / Borror, Connie (Committee member) / Shunk, Dan (Committee member) / Pan, Rong (Committee member) / Arizona State University (Publisher)
Created2012
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Description
Project portfolio selection (PPS) is a significant problem faced by most organizations. How to best select the many innovative ideas that a company has developed to deploy in a proper and sustained manner with a balanced allocation of its resources over multiple time periods is one of vital importance to

Project portfolio selection (PPS) is a significant problem faced by most organizations. How to best select the many innovative ideas that a company has developed to deploy in a proper and sustained manner with a balanced allocation of its resources over multiple time periods is one of vital importance to a company's goals. This dissertation details the steps involved in deploying a more intuitive portfolio selection framework that facilitates bringing analysts and management to a consensus on ongoing company efforts and buy into final decisions. A binary integer programming selection model that constructs an efficient frontier allows the evaluation of portfolios on many different criteria and allows decision makers (DM) to bring their experience and insight to the table when making a decision is discussed. A binary fractional integer program provides additional choices by optimizing portfolios on cost-benefit ratios over multiple time periods is also presented. By combining this framework with an `elimination by aspects' model of decision making, DMs evaluate portfolios on various objectives and ensure the selection of a portfolio most in line with their goals. By presenting a modeling framework to easily model a large number of project inter-dependencies and an evolutionary algorithm that is intelligently guided in the search for attractive portfolios by a beam search heuristic, practitioners are given a ready recipe to solve big problem instances to generate attractive project portfolios for their organizations. Finally, this dissertation attempts to address the problem of risk and uncertainty in project portfolio selection. After exploring the selection of portfolios based on trade-offs between a primary benefit and a primary cost, the third important dimension of uncertainty of outcome and the risk a decision maker is willing to take on in their quest to select the best portfolio for their organization is examined.
ContributorsSampath, Siddhartha (Author) / Gel, Esma (Thesis advisor) / Fowler, Jown W (Thesis advisor) / Kempf, Karl G. (Committee member) / Pan, Rong (Committee member) / Sefair, Jorge (Committee member) / Arizona State University (Publisher)
Created2018
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Description
The shift in focus of manufacturing systems to high-mix and low-volume production poses a challenge to both efficient scheduling of manufacturing operations and effective assessment of production capacity. This thesis considers the problem of scheduling a set of jobs that require machine and worker resources to complete their manufacturing operations.

The shift in focus of manufacturing systems to high-mix and low-volume production poses a challenge to both efficient scheduling of manufacturing operations and effective assessment of production capacity. This thesis considers the problem of scheduling a set of jobs that require machine and worker resources to complete their manufacturing operations. Although planners in manufacturing contexts typically focus solely on machines, schedules that only consider machining requirements may be problematic during implementation because machines need skilled workers and cannot run unsupervised. The model used in this research will be beneficial to these environments as planners would be able to determine more realistic assignments and operation sequences to minimize the total time required to complete all jobs. This thesis presents a mathematical formulation for concurrent scheduling of machines and workers that can optimally schedule a set of jobs while accounting for changeover times between operations. The mathematical formulation is based on disjunctive constraints that capture the conflict between operations when trying to schedule them to be performed by the same machine or worker. An additional formulation extends the previous one to consider how cross-training may impact the production capacity and, for a given budget, provide training recommendations for specific workers and operations to reduce the makespan. If training a worker is advantageous to increase production capacity, the model recommends the best time window to complete it such that overlaps with work assignments are avoided. It is assumed that workers can perform tasks involving the recently acquired skills as soon as training is complete. As an alternative to the mixed-integer programming formulations, this thesis provides a math-heuristic approach that fixes the order of some operations based on Largest Processing Time (LPT) and Shortest Processing Time (SPT) procedures, while allowing the exact formulation to find the optimal schedule for the remaining operations. Computational experiments include the use of the solution for the no-training problem as a starting feasible solution to the training problem. Although the models provided are general, the manufacturing of Printed Circuit Boards are used as a case study.
ContributorsAdams, Katherine Bahia (Author) / Sefair, Jorge (Thesis advisor) / Askin, Ronald (Thesis advisor) / Webster, Scott (Committee member) / Arizona State University (Publisher)
Created2019
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Description
The current Enterprise Requirements and Acquisition Model (ERAM), a discrete event simulation of the major tasks and decisions within the DoD acquisition system, identifies several what-if intervention strategies to improve program completion time. However, processes that contribute to the program acquisition completion time were not explicitly identified in the simulation

The current Enterprise Requirements and Acquisition Model (ERAM), a discrete event simulation of the major tasks and decisions within the DoD acquisition system, identifies several what-if intervention strategies to improve program completion time. However, processes that contribute to the program acquisition completion time were not explicitly identified in the simulation study. This research seeks to determine the acquisition processes that contribute significantly to total simulated program time in the acquisition system for all programs reaching Milestone C. Specifically, this research examines the effect of increased scope management, technology maturity, and decreased variation and mean process times in post-Design Readiness Review contractor activities by performing additional simulation analyses. Potential policies are formulated from the results to further improve program acquisition completion time.
ContributorsWorger, Danielle Marie (Author) / Wu, Teresa (Thesis director) / Shunk, Dan (Committee member) / Wirthlin, J. Robert (Committee member) / Industrial, Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2013-05
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Description
Every year, millions of guests visit theme parks internationally. Within that massive population, accidents and emergencies are bound to occur. Choosing the correct location for emergency responders inside of the park could mean the difference between life and death. In an effort to provide the utmost safety for the guests

Every year, millions of guests visit theme parks internationally. Within that massive population, accidents and emergencies are bound to occur. Choosing the correct location for emergency responders inside of the park could mean the difference between life and death. In an effort to provide the utmost safety for the guests of a park, it is important to make the best decision when selecting the location for emergency response crews. A theme park is different from a regular residential or commercial area because the crowds and shows block certain routes, and they change throughout the day. We propose an optimization model that selects staging locations for emergency medical responders in a theme park to maximize the number of responses that can occur within a pre-specified time. The staging areas are selected from a candidate set of restricted access locations where the responders can store their equipment. Our solution approach considers all routes to access any park location, including areas that are unavailable to a regular guest. Theme parks are a highly dynamic environment. Because special events occurring in the park at certain hours (e.g., parades) might impact the responders' travel times, our model's decisions also include the time dimension in the location and re-location of the responders. Our solution provides the optimal location of the responders for each time partition, including backup responders. When an optimal solution is found, the model is also designed to consider alternate optimal solutions that provide a more balanced workload for the crews.
ContributorsLivingston, Noah Russell (Author) / Sefair, Jorge (Thesis director) / Askin, Ronald (Committee member) / Industrial, Systems and Operations Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
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Description
Commuting is a significant cost in time and in travel expenses for working individuals and a major contributor to emissions in the United States. This project focuses on increasing the efficiency of an intersection through the use of "light metering." Light metering involves a series of lights leading up to

Commuting is a significant cost in time and in travel expenses for working individuals and a major contributor to emissions in the United States. This project focuses on increasing the efficiency of an intersection through the use of "light metering." Light metering involves a series of lights leading up to an intersection forcing cars to stop further away from the final intersection in smaller queues instead of congregating in a large queue before the final intersection. The simulation software package AnyLogic was used to model a simple two-lane intersection with and without light metering. It was found that light metering almost eliminates start-up delay by preventing a long queue to form in front of the modeled intersection. Shorter queue lengths and reduction in the start-up delays prevents cycle failure and significantly reduces the overall delay for the intersection. However, frequent deceleration and acceleration for a few of the cars occurs before each light meter. This solution significantly reduces the traffic density before the intersection and the overall delay but does not appear to be a better emission alternative due to an increase in acceleration. Further research would need to quantify the difference in emissions for this model compared to a standard intersection.
ContributorsGlavin, Erin (Author) / Pavlic, Theodore (Thesis director) / Sefair, Jorge (Committee member) / Industrial, Systems and Operations Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
Assembly lines are low-cost production systems that manufacture similar finished units in large quantities. Manufacturers utilize mixed-model assembly lines to produce customized items that are not identical but share some general features in response to consumer needs. To maintain efficiency, the aim is to find the best feasible option to

Assembly lines are low-cost production systems that manufacture similar finished units in large quantities. Manufacturers utilize mixed-model assembly lines to produce customized items that are not identical but share some general features in response to consumer needs. To maintain efficiency, the aim is to find the best feasible option to balance the lines efficiently; allocating each task to a workstation to satisfy all restrictions and fulfill all operational requirements in such a way that the line has the highest performance and maximum throughput. The work to be done at each workstation and line depends on the precise product configuration and is not constant across all models. This research seeks to enhance the subject of assembly line balancing by establishing a model for creating the most efficient assembly system. Several realistic characteristics are included into efficient optimization techniques and mathematical models to provide a more comprehensive model for building assembly systems. This involves analyzing the learning growth by task, employing parallel line designs, and configuring mixed models structure under particular constraints and criteria. This dissertation covers a gap in the literature by utilizing some exact and approximation modeling approaches. These methods are based on mathematical programming techniques, including integer and mixed integer models and heuristics. In this dissertation, heuristic approximations are employed to address problem-solving challenges caused by the problem's combinatorial complexity. This study proposes a model that considers learning curve effects and dynamic demand. This is exemplified in instances of a new assembly line, new employees, introducing new products or simply implementing engineering change orders. To achieve a cost-based optimal solution, an integer mathematical formulation is proposed to minimize the production line's total cost under the impact of learning and demand fulfillment. The research further creates approaches to obtain a comprehensive model in the case of single and mixed models for parallel lines systems. Optimization models and heuristics are developed under various aspects, such as cycle times by line and tooling considerations. Numerous extensions are explored effectively to analyze the cost impact under certain constraints and implications. The implementation results demonstrate that the proposed models and heuristics provide valuable insights.
ContributorsAlhomaidi, Esam (Author) / Askin, Ronald G (Thesis advisor) / Yan, Hao (Committee member) / Iquebal, Ashif (Committee member) / Sefair, Jorge (Committee member) / Arizona State University (Publisher)
Created2023