Matching Items (7)
Filtering by
- Creators: Department of Finance
- Creators: VanAuker, Michael
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Description
The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.
ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA shell surrounding the PLGA core. The microparticles were loaded with bovine serum albumin (BSA) and different volumes of ethanol were added to the PLA shell phase to alter the porosity and release characteristics of the BSA. Different amounts of ethanol varied the total loading percentage of the BSA, the release profile, surface morphology, size distribution, and the localization of the protein within the particles. Scanning electron microscopy images detailed the surface morphology of the different particles. Loading the particles with fluorescently tagged insulin and imaging the particles through confocal microscopy supported the localization of the protein inside the particle. The study suggest that ethanol alters the release characteristics of the loaded BSA encapsulated in the microparticles supporting the use of a polar, protic solvent as a tool for tuning the delayed release profile of biological proteins.
ContributorsFauer, Chase Alexander (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description
The Applied Learning Thesis is a Barrett, the Honors College thesis project in which one uses something going on in their daily lives and apply it toward a thesis project. For my project, I am using my current position as a Customer Experience Representative (CER) at BMO Harris Bank to determine whether or not the teller position is necessary in the current landscape of retail banking. Using interviews from individuals related to the industry, research primarily from internet sources, and real data given by BMO Harris Bank representatives, I will try to determine what direction future of the teller position seems to be heading.
ContributorsStangler, Nathaniel (Author) / Byrne, Jared (Thesis director) / Cook, Brent (Committee member) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Intellectual property law and the controversy surrounding its nuances, loopholes, and obscure definitions have existed and grown since the inception of the original U.S. Constitution. The original idea was to legislate a way so that innovators and inventors of every generation could be incentivised to create new products which could increase the efficiency and productivity in all aspects of American life. However, the generalizations placed in the law, perhaps for the purpose of giving inventors more leeway, has become, over time, a double-edged sword. Because lawsuits and the lucrative settlements that follow were attached to violating intellectual property law, other individuals have mischievously used this to their advantage, namely creating as many random ideas as possible and patenting them so that when someone ingeniously creates an actual product or physical manifestation, those individuals can sue that inventor for supposedly “stealing” their “idea”. These individuals are basically unable to bring their idea to life so they set traps for those who can. So the law, which originally was supposed to motivate Americans to create has now become a weapon that can be used against those true innovators. Our topic then is to look more in-depth at a specific aspect under the broad umbrella of intellectual property law: can intellectual property law apply to biotechnology? We want to look into different forms of biotechnology, medical devices, and pharmaceuticals, observe where patent law has deviated from its original path and where it is going.
ContributorsLai, Edward (Co-author) / Goudamanis, Christy (Co-author) / Takahashi, Timothy (Thesis director) / VanAuker, Michael (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
With microspheres growing in popularity as viable systems for targeted drug therapeutics, there exist a host of diseases and pathology induced side effects which could be treated with poly(lactic-co-glycolic acid) [PLGA] microparticle systems [6,10,12]. While PLGA systems are already applied in a wide variety the clinical setting [11], microparticles still have some way to go before they are viable systems for drug delivery. One of the main reasons for this is a lack of fabrication processes and systems which produce monodisperse particles while also being feasible for industrialization [10]. This honors thesis investigates various microparticle fabrication techniques \u2014 two using mechanical agitation and one using fluid dynamics \u2014 with the long term goal of incorporating norepinephrine and adenosine into the particles for metabolic stimulatory purposes. It was found that mechanical agitation processes lead to large values for dispersity and the polydispersity index while fluid dynamics methods have the potential to create more uniform and predictable outcomes. The research concludes by needing further investigation into methods and prototype systems involving fluid dynamics methods; however, these systems yield promising results for fabricating monodisperse particles which have the potential to encapsulate a wide variety of therapeutic drugs.
ContributorsRiley, Levi Louis (Author) / Vernon, Brent (Thesis director) / VanAuker, Michael (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
The goal of this research is to answer the questions 1) What is innovation? 2) Why is innovation important? 3) How does leadership impact the effectiveness in driving innovation? 4) How can insight be taught to other individuals who would like to drive innovation in their own practice? By defining leadership characteristics, actions, and attributes, a tangible framework was created which can be utilized by any leader as a guiding point to drive innovation. Data for this project was collected through two channels: a survey which was administered to individuals who identified primarily as undergraduates and professionals, then interviews were conducted with individuals who are recognized as innovative leaders. Interview participants were selected based on recommendations from peers, awards, and accolades received. The questions in the survey focused on collecting data on the general perception and understanding of what an innovative leader is compared to traditional change management elements. Interview questions honed in on specific information regarding leadership approaches, group dynamic techniques, and personal characteristics in relation to leadership style. The findings from the study can be used for positive impact on universities and organizations.
ContributorsBriones, Nicole Marie (Author) / LePine, Marcie (Thesis director) / Wilkinson, Christine Kajikawa (Committee member) / Department of Finance (Contributor) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
This report discusses the trade-offs of electric vehicles at both the macro-level and the consumer-level. The idea of this project is to address the factors that will affect many people, which are the macro-level trade-offs. Consumer-level trade-offs will address the concerns that individual consumers have when buying a car. The macro-level trade-offs that are discussed include batteries versus engines, increased weight, and strain on the power grid. Consumer-level trade-offs include price, maintenance, cost of ownership, and safety. Electric cars are the future, and although the report points out a lot of potential issues, it is not meant to detract from the adoption of electric vehicles. There are so many possibilities regarding the future of the car industry and there is a lot to look forward to despite the current and future issues that will be encountered.
ContributorsNewcomb, Matthew (Author) / Carter, Craig (Thesis director) / Arrfelt, Mathias (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor)
Created2022-12