Matching Items (5)
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- All Subjects: Resource allocation
- All Subjects: cluster analysis
- Creators: Bliss, Daniel
- Member of: ASU Electronic Theses and Dissertations
- Status: Published
Description
Immunosignaturing is a medical test for assessing the health status of a patient by applying microarrays of random sequence peptides to determine the patient's immune fingerprint by associating antibodies from a biological sample to immune responses. The immunosignature measurements can potentially provide pre-symptomatic diagnosis for infectious diseases or detection of biological threats. Currently, traditional bioinformatics tools, such as data mining classification algorithms, are used to process the large amount of peptide microarray data. However, these methods generally require training data and do not adapt to changing immune conditions or additional patient information. This work proposes advanced processing techniques to improve the classification and identification of single and multiple underlying immune response states embedded in immunosignatures, making it possible to detect both known and previously unknown diseases or biothreat agents. Novel adaptive learning methodologies for un- supervised and semi-supervised clustering integrated with immunosignature feature extraction approaches are proposed. The techniques are based on extracting novel stochastic features from microarray binding intensities and use Dirichlet process Gaussian mixture models to adaptively cluster the immunosignatures in the feature space. This learning-while-clustering approach allows continuous discovery of antibody activity by adaptively detecting new disease states, with limited a priori disease or patient information. A beta process factor analysis model to determine underlying patient immune responses is also proposed to further improve the adaptive clustering performance by formatting new relationships between patients and antibody activity. In order to extend the clustering methods for diagnosing multiple states in a patient, the adaptive hierarchical Dirichlet process is integrated with modified beta process factor analysis latent feature modeling to identify relationships between patients and infectious agents. The use of Bayesian nonparametric adaptive learning techniques allows for further clustering if additional patient data is received. Significant improvements in feature identification and immune response clustering are demonstrated using samples from patients with different diseases.
ContributorsMalin, Anna (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Lacroix, Zoé (Committee member) / Arizona State University (Publisher)
Created2013
Description
In this dissertation, two interrelated problems of service-based systems (SBS) are addressed: protecting users' data confidentiality from service providers, and managing performance of multiple workflows in SBS. Current SBSs pose serious limitations to protecting users' data confidentiality. Since users' sensitive data is sent in unencrypted forms to remote machines owned and operated by third-party service providers, there are risks of unauthorized use of the users' sensitive data by service providers. Although there are many techniques for protecting users' data from outside attackers, currently there is no effective way to protect users' sensitive data from service providers. In this dissertation, an approach is presented to protecting the confidentiality of users' data from service providers, and ensuring that service providers cannot collect users' confidential data while the data is processed or stored in cloud computing systems. The approach has four major features: (1) separation of software service providers and infrastructure service providers, (2) hiding the information of the owners of data, (3) data obfuscation, and (4) software module decomposition and distributed execution. Since the approach to protecting users' data confidentiality includes software module decomposition and distributed execution, it is very important to effectively allocate the resource of servers in SBS to each of the software module to manage the overall performance of workflows in SBS. An approach is presented to resource allocation for SBS to adaptively allocating the system resources of servers to their software modules in runtime in order to satisfy the performance requirements of multiple workflows in SBS. Experimental results show that the dynamic resource allocation approach can substantially increase the throughput of a SBS and the optimal resource allocation can be found in polynomial time
ContributorsAn, Ho Geun (Author) / Yau, Sik-Sang (Thesis advisor) / Huang, Dijiang (Committee member) / Ahn, Gail-Joon (Committee member) / Santanam, Raghu (Committee member) / Arizona State University (Publisher)
Created2012
Description
This thesis investigates three different resource allocation problems, aiming to achieve two common goals: i) adaptivity to a fast-changing environment, ii) distribution of the computation tasks to achieve a favorable solution. The motivation for this work relies on the modern-era proliferation of sensors and devices, in the Data Acquisition Systems (DAS) layer of the Internet of Things (IoT) architecture. To avoid congestion and enable low-latency services, limits have to be imposed on the amount of decisions that can be centralized (i.e. solved in the ``cloud") and/or amount of control information that devices can exchange. This has been the motivation to develop i) a lightweight PHY Layer protocol for time synchronization and scheduling in Wireless Sensor Networks (WSNs), ii) an adaptive receiver that enables Sub-Nyquist sampling, for efficient spectrum sensing at high frequencies, and iii) an SDN-scheme for resource-sharing across different technologies and operators, to harmoniously and holistically respond to fluctuations in demands at the eNodeB' s layer.
The proposed solution for time synchronization and scheduling is a new protocol, called PulseSS, which is completely event-driven and is inspired by biological networks. The results on convergence and accuracy for locally connected networks, presented in this thesis, constitute the theoretical foundation for the protocol in terms of performance guarantee. The derived limits provided guidelines for ad-hoc solutions in the actual implementation of the protocol.
The proposed receiver for Compressive Spectrum Sensing (CSS) aims at tackling the noise folding phenomenon, e.g., the accumulation of noise from different sub-bands that are folded, prior to sampling and baseband processing, when an analog front-end aliasing mixer is utilized.
The sensing phase design has been conducted via a utility maximization approach, thus the scheme derived has been called Cognitive Utility Maximization Multiple Access (CUMMA).
The framework described in the last part of the thesis is inspired by stochastic network optimization tools and dynamics.
While convergence of the proposed approach remains an open problem, the numerical results here presented suggest the capability of the algorithm to handle traffic fluctuations across operators, while respecting different time and economic constraints.
The scheme has been named Decomposition of Infrastructure-based Dynamic Resource Allocation (DIDRA).
The proposed solution for time synchronization and scheduling is a new protocol, called PulseSS, which is completely event-driven and is inspired by biological networks. The results on convergence and accuracy for locally connected networks, presented in this thesis, constitute the theoretical foundation for the protocol in terms of performance guarantee. The derived limits provided guidelines for ad-hoc solutions in the actual implementation of the protocol.
The proposed receiver for Compressive Spectrum Sensing (CSS) aims at tackling the noise folding phenomenon, e.g., the accumulation of noise from different sub-bands that are folded, prior to sampling and baseband processing, when an analog front-end aliasing mixer is utilized.
The sensing phase design has been conducted via a utility maximization approach, thus the scheme derived has been called Cognitive Utility Maximization Multiple Access (CUMMA).
The framework described in the last part of the thesis is inspired by stochastic network optimization tools and dynamics.
While convergence of the proposed approach remains an open problem, the numerical results here presented suggest the capability of the algorithm to handle traffic fluctuations across operators, while respecting different time and economic constraints.
The scheme has been named Decomposition of Infrastructure-based Dynamic Resource Allocation (DIDRA).
ContributorsFerrari, Lorenzo (Author) / Scaglione, Anna (Thesis advisor) / Bliss, Daniel (Committee member) / Ying, Lei (Committee member) / Reisslein, Martin (Committee member) / Arizona State University (Publisher)
Created2017
Description
The radar performance of detecting a target and estimating its parameters can deteriorate rapidly in the presence of high clutter. This is because radar measurements due to clutter returns can be falsely detected as if originating from the actual target. Various data association methods and multiple hypothesis filtering approaches have been considered to solve this problem. Such methods, however, can be computationally intensive for real time radar processing. This work proposes a new approach that is based on the unsupervised clustering of target and clutter detections before target tracking using particle filtering. In particular, Gaussian mixture modeling is first used to separate detections into two Gaussian distinct mixtures. Using eigenvector analysis, the eccentricity of the covariance matrices of the Gaussian mixtures are computed and compared to threshold values that are obtained a priori. The thresholding allows only target detections to be used for target tracking. Simulations demonstrate the performance of the new algorithm and compare it with using k-means for clustering instead of Gaussian mixture modeling.
ContributorsFreeman, Matthew Gregory (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Arizona State University (Publisher)
Created2016
Description
In this dissertation, I propose potential techniques to improve the quality-of-service (QoS) of real-time applications in cognitive radio (CR) systems. Unlike best-effort applications, real-time applications, such as audio and video, have a QoS that need to be met. There are two different frameworks that are used to study the QoS in the literature, namely, the average-delay and the hard-deadline frameworks. In the former, the scheduling algorithm has to guarantee that the packet's average delay is below a prespecified threshold while the latter imposes a hard deadline on each packet in the system. In this dissertation, I present joint power allocation and scheduling algorithms for each framework and show their applications in CR systems which are known to have strict power limitations so as to protect the licensed users from interference.
A common aspect of the two frameworks is the packet service time. Thus, the effect of multiple channels on the service time is studied first. The problem is formulated as an optimal stopping rule problem where it is required to decide at which channel the SU should stop sensing and begin transmission. I provide a closed-form expression for this optimal stopping rule and the optimal transmission power of secondary user (SU).
The average-delay framework is then presented in a single CR channel system with a base station (BS) that schedules the SUs to minimize the average delay while protecting the primary users (PUs) from harmful interference. One of the contributions of the proposed algorithm is its suitability for heterogeneous-channels systems where users with statistically low channel quality suffer worse delay performances. The proposed algorithm guarantees the prespecified delay performance to each SU without violating the PU's interference constraint.
Finally, in the hard-deadline framework, I propose three algorithms that maximize the system's throughput while guaranteeing the required percentage of packets to be transmitted by their deadlines. The proposed algorithms work in heterogeneous systems where the BS is serving different types of users having real-time (RT) data and non-real-time (NRT) data. I show that two of the proposed algorithms have the low complexity where the power policies of both the RT and NRT users are in closed-form expressions and a low-complexity scheduler.
A common aspect of the two frameworks is the packet service time. Thus, the effect of multiple channels on the service time is studied first. The problem is formulated as an optimal stopping rule problem where it is required to decide at which channel the SU should stop sensing and begin transmission. I provide a closed-form expression for this optimal stopping rule and the optimal transmission power of secondary user (SU).
The average-delay framework is then presented in a single CR channel system with a base station (BS) that schedules the SUs to minimize the average delay while protecting the primary users (PUs) from harmful interference. One of the contributions of the proposed algorithm is its suitability for heterogeneous-channels systems where users with statistically low channel quality suffer worse delay performances. The proposed algorithm guarantees the prespecified delay performance to each SU without violating the PU's interference constraint.
Finally, in the hard-deadline framework, I propose three algorithms that maximize the system's throughput while guaranteeing the required percentage of packets to be transmitted by their deadlines. The proposed algorithms work in heterogeneous systems where the BS is serving different types of users having real-time (RT) data and non-real-time (NRT) data. I show that two of the proposed algorithms have the low complexity where the power policies of both the RT and NRT users are in closed-form expressions and a low-complexity scheduler.
ContributorsEwaisha, Ahmed Emad (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Ying, Lei (Committee member) / Bliss, Daniel (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2016