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The gold standard for bone measurement is DXA (dual energy X-ray absorptiometry). Typically, to observe changes in bone by DXA, a minimum of a 4-month intervention is required. Serum osteocalcin (OST) (a bone formation marker) and quantitative ultrasound (QUS) of the calcaneus can be used as indicators of bone change

The gold standard for bone measurement is DXA (dual energy X-ray absorptiometry). Typically, to observe changes in bone by DXA, a minimum of a 4-month intervention is required. Serum osteocalcin (OST) (a bone formation marker) and quantitative ultrasound (QUS) of the calcaneus can be used as indicators of bone change but the sensitivity and time course of these indices to short term interventions are unknown. The purpose of this study was twofold: to compare monthly changes in OST and QUS in response to jump training and to evaluate the relationship between DXA, OST and QUS. Young women with QUS t-scores less than 1.0 were randomized into a jump training (J) (n=16) or control (C) (n=16). J consisted of a progressive routine of 1 and 2-footed jumping performed 3 days per week for 4 months. Body composition, QUS and OST were measured at baseline, and monthly for 4 months. DXA and 24-hour dietary recalls were completed at baseline and 4 months. Low attrition rate (12.5%) and high compliance (98%) with the exercise intervention was recorded. No significant correlations between QUS and OST existed. No significant differences were observed between groups at baseline in body composition or bone variables. Monthly increases in OST were observed but there were no significant differences over time between groups in any bone variables. OST and QUS may be indicative of short term bone changes but these variables were not specifically sensitive to the jumping intervention in this population of women.
ContributorsHeumann, Kristin Joelle (Author) / Swan, Pamela D (Thesis advisor) / Alvar, Brent (Committee member) / Chisum, Jack (Committee member) / Lee, Chong (Committee member) / Vaughan, Linda (Committee member) / Arizona State University (Publisher)
Created2011
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Description
High Intensity Interval Training (HIIT) is a phrase quickly becoming popularized through current research due to the physical and physiological success this method of training has proven to yield in both untrained and trained individuals. There is no set definition used to describe HIIT, but it typically refers to repeated

High Intensity Interval Training (HIIT) is a phrase quickly becoming popularized through current research due to the physical and physiological success this method of training has proven to yield in both untrained and trained individuals. There is no set definition used to describe HIIT, but it typically refers to repeated bouts of fairly brief intermittent exercise. A great deal of research outlines the benefits associated with utilizing HIIT in untrained and recreationally trained individuals. However, research on the effect HIIT has or could possibly have on the well-trained endurance athlete is limited, specifically in the sport of rowing. The purpose of this study was to analyze the effect of HIIT on VO2 peak and performance in trained rowers when compared to traditional, endurance training. It was hypothesized that HIIT would be just as effective at improving VO2 peak and performance as the endurance training protocol in well-trained rowers. A total of 20 high school female rowers participated in the study (mean ± SD; age = 16 ± 1). Baseline testing was comprised of a 2000m time-trial test on the Concept IIc Rowing Ergometer and a maximal exercise test, which was also completed on the Concept IIc Ergometer, in order to determine VO2 peak. Subjects were randomly assigned to a HIIT or endurance group for four weeks of intervention. Three days/week the HIIT group completed a 6 by 30second repeated Wingate protocol on the Concept II Ergometer at or above 100% VO2 peak, in which each 30s maximal effort was immediately followed by an active recovery of four-minutes. The endurance group completed 30 minutes of sub-maximal rowing at 65% of VO2 peak three days/week. After four weeks of intervention, post-testing took place, which was identical to baseline testing. Results from this study suggest HIIT was just as effective as endurance training at improving 2k time (mean ± SD; HIIT: 498.7 ± 23.1; Endurance: 497.5 ± 17.6). There were no significant within or between group differences in VO2 peak post-intervention (mean ± SD; HIIT: 44.8 ± 4.0; Endurance: 45.8 ± 5.6). The current study suggests four-weeks of HIIT training can yield similar adaptations in performance when compared to endurance training.
ContributorsCarr, Natasha (Author) / Chisum, Jack (Thesis advisor) / Campbell, Kathryn (Committee member) / Woodruff, Larry (Committee member) / Arizona State University (Publisher)
Created2011
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Description
The Western Pattern diet has been characterized by having greater than 50 percent consumption coming from fat and sugar. This macronutrient allocation has been shown to have deleterious effects on endothelial function and metabolic markers of cardiovascular disease. Exercise has been shown to improve vascular reactivity and metabolic markers related

The Western Pattern diet has been characterized by having greater than 50 percent consumption coming from fat and sugar. This macronutrient allocation has been shown to have deleterious effects on endothelial function and metabolic markers of cardiovascular disease. Exercise has been shown to improve vascular reactivity and metabolic markers related to cardiovascular health. The objective of the study was to determine if exercise training can prevent the anticipated deleterious effects of a fat-sugar supplemented diet on endothelial function and blood markers of cardiovascular risk in young men. Twenty-one, healthy college-aged males were randomly assigned to either the doughnut + exercise or doughnut only groups. Both groups were fed 2 doughnuts per day, 6 days per week, for three weeks, while maintain their current diet. The exercise group completed 4 exercise training sessions per week consisting of 2 high intensity interval training bouts (up to 95% VO2peak) on a cycle ergometer and two moderate intensity, steady-state bouts (at 75% VO2peak) on a treadmill. Changes in body weight and composition, markers of endothelial function, oxidative stress, serum lipids, and blood glucose were measured in each group. As expected, cardiovascular fitness increased significantly in the doughnut-supplemented + exercise group as compared to the doughnut-supplemented (p=0.005). Significant increases in body weight (p=0.036), fat mass (p=0.013), and body fat percentage (p=0.014) were seen in the doughnut only group as compared to the doughnut + exercise group. The doughnut + exercise group showed significant improvements in fasting serum triglycerides (p=0.036), plasma insulin (p=0.039) and insulin sensitivity (HOMA; p=0.05) as compared to the doughnut only group. The doughnut + exercise group saw a significant improvement in nitric oxide availability whereas the doughnut only group experienced a significant decline (p=0.014). There were no significant changes in other markers. Despite the addition of a fat/sugar supplement of ~11,600 kcal over three weeks, 4 exercise sessions per week were sufficient to prevent a gain in body weight and fat mass, and also improve some measures of cardiometabolic risk. These results suggest that exercise may be necessary to prevent some adverse health outcomes associated with transient periods of excessive energy consumption.
ContributorsBlack, Laurie (Author) / Gaesser, Glenn (Thesis advisor) / Cataldo, Donna (Committee member) / Sweazea, Karen (Committee member) / Vega-Lopez, Sonia (Committee member) / Swan, Pamela (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Previous research on gymnastics injuries has examined several differences in the types of injuries and event/location where injury is most likely to occur. This research shows that male gymnasts are more likely to have more upper body injuries compared to lower body injuries whereas female gymnasts are more likely to

Previous research on gymnastics injuries has examined several differences in the types of injuries and event/location where injury is most likely to occur. This research shows that male gymnasts are more likely to have more upper body injuries compared to lower body injuries whereas female gymnasts are more likely to have lower body injuries. The majority of all gymnastics injuries are sprains that are most likely to occur during the landing phase on the floor exercise during routine performance or competition. Gymnastics injuries are also more prevalent in older gymnasts, like those at the collegiate level. However, there is limited research on the effects of limb dominance on injury occurrence in both male and female gymnasts at the collegiate level. This study was designed to examine the effect of both upper and lower body limb dominance on injury occurrence in Division I male and female gymnasts at Arizona State University during competition season. Thirty-seven subjects were recruited from the Arizona State University Men's and Women's Gymnastics teams. Athletic trainers/coaches from each team were asked to record injury incidence during the 2013 competition season from January through April. Injury type, body location, event of occurrence, and location of injury (practice or competition) were recorded along with the gymnast's upper and lower body limb dominance (right or left). Statistical analysis shows that there is a significant difference between male and female gymnasts in that female gymnasts are more likely to be injured than their male counterparts (P = 0.023). However, there were no significant findings between limb dominance and injury incidence. Limb dominance did not show any relationship with side of injury, but a trend in the data shows that right-sided dominant athletes, both upper and lower body, were more likely to be injured overall than left-sided dominant athletes. A trend in the data also shows that injury is more likely to occur on the floor exercise than any other gymnastics event for both men and women.
ContributorsPrice, Callie (Author) / Chisum, Jack (Thesis advisor) / Lee, Chong (Committee member) / Campbell, Kathryn (Committee member) / Woodruff, Larry (Committee member) / Arizona State University (Publisher)
Created2013
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Description
The U.S. Surgeon General has recommended that all Americans engage in regular physical activity throughout the lifespan as a way to maintain and improve health and reduce the risk of developing cardiovascular disease, diabetes, obesity, or other chronic conditions. The recommendation for children is a minimum of 60 minutes of

The U.S. Surgeon General has recommended that all Americans engage in regular physical activity throughout the lifespan as a way to maintain and improve health and reduce the risk of developing cardiovascular disease, diabetes, obesity, or other chronic conditions. The recommendation for children is a minimum of 60 minutes of moderate and intense physical activity everyday. As children enter adolescence their level of physical activity often decreases; and active adults were typically active adolescents. More than 50% of adults that begin a physical activity program discontinue the behavior within 9 months. Interventions to increase physical activity have looked at self-esteem and self-efficacy. Locus of control (LOC) is a concept that people either view their own behavior as influencing the events around them (internal) or other events controlling their fate or destiny (external). This study looked at locus of control as a predictor of exercise adherence and future exercise patterns in children ages 6-12 in Mesa, AZ. Locus of control as measured by the Child Nowicki-Strickland Internal External (CNSIE) scale differed by gender and by physical activity group at school at post-intervention. Self-reported physical activity as measured by the Physical Activity Questionnaire for Older Children (PAQ-C) showed differences in physical activity (PA) levels by gender for baseline school PA, by age group for baseline non-school PA, by gender and age group for post-intervention school PA, and by gender only for post-intervention non-school PA. A secondary objective was to assess if the Think Healthy About Nutrition and eXercise (THANX) after school program influenced participants' LOC or PA patterns. This study found that the THANX program had no effect on LOC or PA level at any time point.
ContributorsAguila, Holly J (Author) / Chisum, Jack (Thesis advisor) / Woodruff, Larry (Committee member) / Campbell, Kathy (Committee member) / Arizona State University (Publisher)
Created2012
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Description
Walking interventions focused on increasing step counts are typically associated with salutary effects on glycemia, fasting insulin, insulin resistance and blood lipids which may be in turn associated with improvements in cardiorespiratory fitness (peak oxygen uptake – VO2peak) and vascular stiffness. We hypothesized that a novel 4-month, behavioral economics-based walking

Walking interventions focused on increasing step counts are typically associated with salutary effects on glycemia, fasting insulin, insulin resistance and blood lipids which may be in turn associated with improvements in cardiorespiratory fitness (peak oxygen uptake – VO2peak) and vascular stiffness. We hypothesized that a novel 4-month, behavioral economics-based walking intervention would have favorable effects on glucose homeostasis and blood lipids and that these in turn would be related to VO2peak and vascular stiffness (carotid femoral pulse wave velocity – cfPWV).

We carried out secondary analyses on a subsample of sedentary, overweight/obese adults who participated in a 4-month, 2x2, randomized-controlled walking intervention examining the effects of goal setting (static v. adaptive goals) and rewards (immediate v. delayed) on steps/day (N=96). Fasting blood samples (n=58) were collected from participants before and after the intervention. Premenopausal females were in the follicular phase of their menstrual cycles. Lipid and glucose levels were measured using an automated chemistry analyzer, while insulin was measured using radio-immunoassay. Homeostatic model of insulin resistance (HOMA-IR) was calculated using the following formula (HOMA-IR=glucose x insulin / 405). We examined associations [partial correlations (adjusted for age)] between changes in blood biomarkers and VO2peak and cfPWV, irrespective of group, and we used linear mixed models to examine between-group differences in levels of and change in biomarker outcomes.

Groups did not differ in overall levels of, or degree of change in, biomarker outcomes (all p>0.05). Mean changes, irrespective of group, in biomarkers were as follows: glucose Δ= 0.74± 4.5mg/dl; insulin Δ= 0.09 ± 4.1 µU/ml; total cholesterol Δ= 0.24 ± 20.6 mg/dl; HDL-C Δ= 0.27 ± 5.1 mg/dl; LDL-C Δ= 1.3 ± 19.9 mg/dl; triglycerides Δ= 1.7 ± 27.2 mg/dl; HOMA-IR Δ = -.0548 ± 1.05). We found no significant associations between change in biomarker levels and change in VO2peak or change in cfPWV (all correlation coefficients < 0.15; p > 0.05).

A 4-month, behavioral economics-based mHealth intervention focused on increasing steps/day did not bring about favorable changes on markers of glycemia, insulin resistance and blood lipids.
ContributorsHook, Benjamin E. (Author) / Angadi, Siddhartha (Thesis director) / Gaesser, Glenn (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
As the 7th leading cause of death in the world, with over 1.6 millions deaths attributed to it in 2016 alone, diabetes mellitus has been a rising global health concern. Type 1 diabetes is caused by lack of insulin production whereas type 2 diabetes is caused by insulin resistance. Both

As the 7th leading cause of death in the world, with over 1.6 millions deaths attributed to it in 2016 alone, diabetes mellitus has been a rising global health concern. Type 1 diabetes is caused by lack of insulin production whereas type 2 diabetes is caused by insulin resistance. Both types of diabetes lead to increased glucose levels in the body if left untreated. This, in turn, leads to the development of a host of complications, one of which is ischemic heart disease. Accounting for the death of 16% of the world’s population, ischemic heart disease has been the leading cause of death since 2000. As of 2019, deaths from this disease have risen from 2 million to over 8.9 million globally. While medicine exists to counter the negative outcomes of diabetes mellitus, lower income nations suffer from the lack of availability and high costs of these medications. Therefore, this systematic review was performed to determine whether a non-medicinal treatment could provide similar therapeutic benefits for individuals with diabetes. Genistein is a phytoestrogen found in soy-based products, which has been potentially linked with preventing diabetes and improving diabetes-related symptoms such as hyperglycemia and abnormal insulin levels. We searched PubMed and SCOPUS using the terms ‘genistein’, ‘diabetes’, and ‘glucose’ and identified 32 peer-reviewed articles. In general, preclinical studies demonstrate that genistein decreases body weight as well as circulating glucose and triglycerides concentrations while increasing insulin levels and insulin sensitivity. It also delayed the onset of type 1 and type 2 diabetes. In contrast, clinical studies of genistein in general reported no significant relationship between genistein and body mass, circulating glucose, serum insulin, A1C concentrations, or onset of type 1 diabetes. However, genistein was found to improve insulin sensitivity, delay type 2 diabetes onset and improve serum triglyceride levels. In summary, preclinical and clinical studies suggest that genistein may help delay onset of type 2 diabetes and improve several symptoms associated with the disease. By translating these findings into clinical settings, genistein may offer a cost effective natural approach at mitigating complications associated with diabetes, although additional research is required to confirm these findings.
ContributorsJain, Rijul (Author) / Sweazea, Karen (Thesis director) / Al-Nakkash, Layla (Committee member) / Bolch, Charlotte (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-04-16
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Description
Sustaining a fall can be hazardous for those with low bone mass. Interventions exist to reduce fall-risk, but may not retain long-term interest. "Exergaming" has become popular in older adults as a therapy, but no research has been done on its preventative ability in non-clinical populations. The purpose was to

Sustaining a fall can be hazardous for those with low bone mass. Interventions exist to reduce fall-risk, but may not retain long-term interest. "Exergaming" has become popular in older adults as a therapy, but no research has been done on its preventative ability in non-clinical populations. The purpose was to determine the impact of 12-weeks of interactive play with the Wii Fit® on balance, muscular fitness, and bone health in peri- menopausal women. METHODS: 24 peri-menopausal-women were randomized into study groups. Balance was assessed using the Berg/FICSIT-4 and a force plate. Muscular strength was measured using the isokinetic dynamometer at 60°/180°/240°/sec and endurance was assessed using 50 repetitions at 240°/sec. Bone health was tracked using dual-energy x-ray absorptiometry (DXA) for the hip/lumbar spine and qualitative ultrasound (QUS) of the heel. Serum osteocalcin was assessed by enzyme immunoassay. Physical activity was quantified using the Women's Health Initiative Physical Activity Questionnaire and dietary patterns were measured using the Nurses' Health Food Frequency Questionnaire. All measures were repeated at weeks 6 and 12, except for the DXA, which was completed pre-post. RESULTS: There were no significant differences in diet and PA between groups. Wii Fit® training did not improve scores on the Berg/FICSIT-4, but improved center of pressure on the force plate for Tandem Step, Eyes Closed (p-values: 0.001-0.051). There were no significant improvements for muscular fitness at any of the angular velocities. DXA BMD of the left femoral neck improved in the intervention group (+1.15%) and decreased in the control (-1.13%), but no other sites had significant changes. Osteocalcin indicated no differences in bone turnover between groups at baseline, but the intervention group showed increased bone turnover between weeks 6 and 12. CONCLUSIONS: Findings indicate that WiiFit® training may improve balance by preserving center of pressure. QUS, DXA and osteocalcin data confirm that those in the intervention group were experiencing more bone turnover and bone formation than the control group. In summary, twelve weeks of strength /balance training with the Wii Fit® shows promise as a preventative intervention to reduce fall and fracture risk in non-clinical middle aged women who are at risk.
ContributorsWherry, Sarah Jo (Author) / Swan, Pamela D (Thesis advisor) / Adams, Marc (Committee member) / Der Ananian, Cheryl (Committee member) / Sweazea, Karen (Committee member) / Vaughan, Linda (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Voluntary exercise has been shown to generate post exercise improvements in executive function within the attention-deficit hyperactivity disorder (ADHD) population. Research is limited on the link between exercise and motor function in this population. Whether or not changes in executive and motor function are observed under assisted exercise conditions is

Voluntary exercise has been shown to generate post exercise improvements in executive function within the attention-deficit hyperactivity disorder (ADHD) population. Research is limited on the link between exercise and motor function in this population. Whether or not changes in executive and motor function are observed under assisted exercise conditions is unknown. This study examined the effect of a six-week cycling intervention on executive and motor-function responses in young adult females with ADHD. Participants were randomized to either a voluntary exercise (VE) or an assisted exercise (AE) group. Both groups performed 30 minute cycling sessions, three times per week, at either a voluntary or assisted rate, on a modified Theracycle Model 200 motorized stationary cycle ergometer. The Mann-Whitney U tests were used to detect median differences between groups, and the Wilcoxon signed-rank tests were used to test median differences within groups. Executive function improvements were greater for AE compared to VE in activation (MDNAE = 162 vs. MDNVE = 308, U = .00, p = .076, ES = .79); planning (MDNAE = 51.0 vs. MDNAE = 40.5, U = .00, p = .083, ES = .77); attention (MDNAE = 13.0 vs. MDNVE = 10.0, U = .00, p = .083, ES = .77); and working memory (MDNAE = 10.0 vs. MDNVE = 6.5, U = .00, p = .076, ES = .79). Motor function improvements were greater for AE compared to VE in manual dexterity (MDNAE = 18 vs. MDNVE = 15.8, U = .00, p = .083, ES = .77); bimanual coordination (MDNAE = 28.0 vs. MDNVE = 25.3, U = .00, p = .083, ES = .77); and gross motor movements of the fingers, hands, and arms (MDNAE = 61.7 vs. MDNVE = 56.0, U = .00, p = .083, ES = .77). Deficits in executive and motor functioning have been linked to lifelong social and psychological impairments in individuals with ADHD. Finding ways to improve functioning in these areas is important for cognitive, emotional and social stability. Compared to VE, AE is a more effective strategy for improving executive and motor functioning in young adult females with ADHD.
ContributorsBirchfield, Natasha (Author) / Ringenbach, Shannon (Thesis advisor) / Lee, Chong (Committee member) / Chisum, Jack (Committee member) / Campbell, Kathyrn (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Although maintaining an optimal level of muscle quality in older persons is necessary to prevent falls and disability, there has been limited research on muscle quality across age and gender groups. The associations of muscle quality, muscle strength, and muscle mass also remain less explored. Purpose: This study examined

Although maintaining an optimal level of muscle quality in older persons is necessary to prevent falls and disability, there has been limited research on muscle quality across age and gender groups. The associations of muscle quality, muscle strength, and muscle mass also remain less explored. Purpose: This study examined the muscle quality differences (arm and leg) between healthy young and elderly adults across gender groups. This study also examined the associations of muscle quality, muscle strength, and muscle mass in young and elderly adults, respectively. Methods: Seventy-one total subjects were recruited for this study within age groups 20-29 years old (20 females and 20 males) and 60-80 years old (18 females and 13 males). All participants completed anthropometric measures, dual-energy x-ray absorptiometry, pulse wave velocity, handgrip strength and leg strength tests, gait speed, and sit to stand test. Results: Young male adults had a greater leg muscle quality index (leg MQI) than did elderly male adults (21.8 Nm/kg vs. 16.3 Nm/kg, p = 0.001). Similarly, young female adults had a greater leg MQI than did old female adults (21.3 Nm/kg and 15.6 Nm/kg, p<0.001). For arm muscle quality index (arm MQI), there was a gender difference in young adults (p = 0.001), but not for the elderly adults. Among elderly adults, there was a positive association between leg MQI and isometric leg strength (r = 0.79, p<0.001). Notably, there was a negative association between leg MQI and leg lean mass (r = -0.70, p<0.001) and between arm MQI and arm lean mass (r = -0.58, p = 0.001). In young adults, there was also a positive association between arm MQI and handgrip strength (r = 0.53, p<0.001) and between leg MQI and isometric leg strength (r = 0.81, p<0.001). There was no association between muscle quality and muscle mass in young adults. Conclusion: Young adults had a greater leg muscle quality than did elderly adults in both men and women. Leg muscle quality is positively associated with leg muscle strength in both young and elderly adults but is inversely associated with leg muscle mass in the elderly adults.
ContributorsDierickx, Erin (Author) / Lee, Chong (Thesis advisor) / Swan, Pamela (Committee member) / Marsit, Joseph (Committee member) / Chisum, Jack (Committee member) / Arizona State University (Publisher)
Created2017