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Description
The use of synthetic cathinones or "bath salts" has risen dramatically in recent years with one of the most popular being Methylendioxypyrovalerone (MDPV). Following the temporary legislative ban on the sale and distribution of this compound , a multitude of other cathinone derivatives have been synthesized. The current study seeks to compare the abuse potential of MDPV with one of the emergent synthetic cathinones 4-methylethcathinone (4-MEC), based on their respective ability to lower current thresholds in an intracranial self-stimulation (ICSS) paradigm. Following acute administration (0.1, 0.5, 1 and 2 mg/kg i.p.) MDPV was found to significantly lower ICSS thresholds at all doses tested (F4,35=11.549, p<0.001). However, following acute administration (0.3,1,3,10,30 mg/kg i.p) 4-MEC produced no significant ICSS threshold depression (F5,135= 0.622, p = 0.684). Together these findings suggest that while MDPV may possess significant abuse potential, other synthetic cathinones such as 4-MEC may have a drastically reduced potential for abuse.
ContributorsWegner, Scott Andrew (Author) / Olive, M. Foster (Thesis director) / Presson, Clark (Committee member) / Sanabria, Federico (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
Romania is in the midst of an identity emergency due to its relatively recent departure from a communist dictatorship. This paper will take a look at identities within Romania while paying close attention to the way that emerging political, economic, religious and gender identities have been and are being used to oppress the Romanian queer population. This paper seeks to justify an application of Western values towards the call for enfranchisement of Romanian queers. Western values, in this sense, will be based on Enlightenment notions of equality in all people and based on philosophers whose writings and paradigms are centered in the Western world. Furthermore, it will discuss violence and masculinity in hopes that understanding and critically examining these topics may be used in application towards the emerging Romanian identities and statistics which highlight and implicate queer oppression. Again, this paper will not seek to definitely link as causal any one emerging identity towards the oppression of the queer minority in Romania nor will it seek to undermine any single Romanian institution, but rather question the correlative elements of Romanian society that may be implicated in potential oppression, violences, and a neglect of the Romanian queer minority.
ContributorsWoodmansee, Jon Wessley (Author) / Montesano, Mark (Thesis director) / Brake, Elizabeth (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor)
Created2014-05
Description
In recent years the abuse of synthetic cathinones, "Bath Salts," has increased. The purpose of this study was to analyze two synthetic cathinones, methylone and α-pvp, for hedonic properties or the potential to be abused. This was tested using an intracranial self-stimulation paradigm, a robust measurement for reward. It was found methylone resulted in an abuse potential similar to MDMA, ecstasy, abuse. Moreover, the results for α-pvp showed a high liability for abuse.
ContributorsJohnson, Craig Trevor (Author) / Olive, Foster (Thesis director) / Presson, Clark (Committee member) / Montesano, Mark (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor) / Department of Psychology (Contributor)
Created2013-12