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- All Subjects: Anthropology
- Creators: Hill, Kim
- Creators: Arnold III, Philip J
- Member of: Theses and Dissertations
- Resource Type: Text
Description
A variety of studies have shown that the tendency toward nicotine dependence has a genetic component. The work described in this thesis addresses three separate questions: i) are there unidentified SNPs in the nicotinic receptors or other genes that contribute to the risk for nicotine dependence; ii) is there evidence of ongoing selection at nicotinic receptor loci; and, iii) since nicotine dependence is unlikely to be the phenotype undergoing selection, is a positive effect on memory or cognition the selected phenotype. I first undertook a genome –wide association scan of imputed data using samples from the Collaborative Study of the Genetics of Nicotine Dependence (COGEND). A novel association was found between nicotine dependence and SNPs at 13q31. The genes at this newly associated locus on chromosome 13 encode a group of micro-RNAs and a member of the glypican gene family. These are among the first findings to implicate a non-candidate gene in risk for nicotine dependence. I applied several complimentary methods to sequence data from the 1000 Genomes Project to test for evidence of selection at the nicotinic receptor loci. I found strong evidence for selection for alleles in the nicotinic receptor cluster on chromosome 8 that confer risk of nicotine dependence. I then used the dataset from the Collaborative Studies on the Genetics of Alcoholism (COGA) and looked for an association between neuropsychological phenotypes and SNPs conferring risk of nicotine dependence. One SNP passed multiple test correction for association with WAIS digit symbol score. This SNP is not itself associated with nicotine dependence but is in reasonable (r 2 = 0.75) LD with SNPs that are associated with nicotine dependence. These data suggest at best, a weak correlation between nicotine dependence and any of the tested cognitive phenotypes. Given the reproducible finding of an inverse relationship between SNPs associated with risk for nicotine dependence and cocaine dependence, I hypothesize that the apparently detrimental phenotype of nicotine dependence may confer decreased risk for cocaine dependence. As cocaine use impairs the positive rewards associated with social interactions, reducing the risk of cocaine addiction may be beneficial to both the individual and the group.
ContributorsSadler, Brooke (Author) / Hurtado, Ana Magdalena (Thesis advisor) / Goate, Alison (Thesis advisor) / Hill, Kim (Committee member) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2014
Description
Early humans adapted to eating cooked food with increased energy density and absorption of macronutrients. However, in modern times many suffer from diseases like obesity and type 2 diabetes which can result from too much energy being absorbed from food. This study measures glucose responses to a high glycemic meal with a side dish of raw or cooked vegetables. There was a slight trend for raw vegetables to have decreased postprandial blood glucose responses when compared to cooked vegetables.
ContributorsWilkins, Christine Marie (Author) / Johnston, Carol (Thesis director) / Jacobs, Mark (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor)
Created2014-05
Description
This archaeological study applies a world-systems-based approach in evaluating regional economic interaction among independent polities. It focuses specifically on interaction between local polities and Teotihuacan-affiliated populations in the Western Tuxtlas Region of the Gulf Coast of Veracruz, Mexico during the Early Classic and Middle Classic periods (A.D. 300-650). Changes in regional economics followed the founding of the Teotihuacan-linked center of Matacapan in the Catemaco River Valley. To assess these changes, this research characterizes the consumption of Matacapan-produced imports in two independent neighboring polities to reconstruct regional distribution networks and assess Matacapan’s impact on the region.
The Central Highland capital of Teotihuacan had variable influence throughout Mesoamerica. One pronounced occurrence of this influence has been identified at Matacapan, which displays strong material culture and architectural connections to Teotihuacan. This research therefore employs a modified world-systems framework which removes the assumption of hierarchy and instead focuses on regional interaction within the periphery. It views the establishment of regional distribution networks centered at Matacapan that articulate with the two neighboring polities as a form of incorporation, the process wherein external groups are brought into a system.
To assess incorporation, four potential Matacapan-centered networks are analyzed. These networks consist of the distribution of two ceramic types and obsidian blades produced from two sources. Artifacts from survey, surface collection, and excavation were subjected to ceramic analysis, lithic analysis, petrography, neutron activation analysis, and X-ray fluorescence analysis to identify source, form, and production technology. These data aid in determining network participation in each polity. By assessing importation in these local polities, the form and degree of their incorporation will be identified.
Incorporation of indigenous polities into regional networks was not uniform within the Western Tuxtlas Region. Two Matacapan-centered networks were identified, and they differ in form and extent. One indigenous polity, Teotepec, participated in both networks while the other, Totocapan, participated in one. I argue that Teotepec’s incorporation into a second network was strategic in that it was mutually beneficial to both involved parties. Additionally, indigenous Tuxtlas’ polities were able to negotiate interaction with their Teotihuacan-affiliated neighbor for desired goods without forfeiting political or cultural autonomy.
The Central Highland capital of Teotihuacan had variable influence throughout Mesoamerica. One pronounced occurrence of this influence has been identified at Matacapan, which displays strong material culture and architectural connections to Teotihuacan. This research therefore employs a modified world-systems framework which removes the assumption of hierarchy and instead focuses on regional interaction within the periphery. It views the establishment of regional distribution networks centered at Matacapan that articulate with the two neighboring polities as a form of incorporation, the process wherein external groups are brought into a system.
To assess incorporation, four potential Matacapan-centered networks are analyzed. These networks consist of the distribution of two ceramic types and obsidian blades produced from two sources. Artifacts from survey, surface collection, and excavation were subjected to ceramic analysis, lithic analysis, petrography, neutron activation analysis, and X-ray fluorescence analysis to identify source, form, and production technology. These data aid in determining network participation in each polity. By assessing importation in these local polities, the form and degree of their incorporation will be identified.
Incorporation of indigenous polities into regional networks was not uniform within the Western Tuxtlas Region. Two Matacapan-centered networks were identified, and they differ in form and extent. One indigenous polity, Teotepec, participated in both networks while the other, Totocapan, participated in one. I argue that Teotepec’s incorporation into a second network was strategic in that it was mutually beneficial to both involved parties. Additionally, indigenous Tuxtlas’ polities were able to negotiate interaction with their Teotihuacan-affiliated neighbor for desired goods without forfeiting political or cultural autonomy.
ContributorsWilson, Nathan Daniel (Author) / Smith, Michael E. (Thesis advisor) / Stark, Barbara L. (Thesis advisor) / Arnold III, Philip J (Committee member) / Kintigh, Keith W. (Committee member) / Simon, Arleyn W (Committee member) / Arizona State University (Publisher)
Created2016
Description
For most of human history hunting has been the primary economic activity of men. Hunted animals are valued for their food energy and nutrients, however, hunting is associated with a high risk of failure. Additionally, large animals cannot be consumed entirely by the nuclear family, so much of the harvest may be shared to others. This has led some researchers to ask why men hunt large and difficult game. The “costly signaling” and “show-off” hypotheses propose that large prey are hunted because the difficulty of finding and killing them is a reliable costly signal of the phenotypic quality of the hunter.
These hypotheses were tested using original interview data from Aché (hunter gatherer; n=52, age range 50-76, 46% female) and Tsimané (horticulturalist; n=40, age range 15-77, 45% female) informants. Ranking tasks and paired comparison tasks were used to determine the association between the costs of killing an animal and its value as a signal of hunter phenotypic quality for attracting mates and allies. Additional tasks compared individual large animals to groups of smaller animals to determine whether assessments of hunters’ phenotypes and preferred status were more impacted by the signal value of the species or by the weight and number of animals killed.
Aché informants perceived hunters who killed larger or harder to kill animals as having greater provisioning ability, strength, fighting ability, and disease susceptibility, and preferred them as mates and allies. Tsimané informants held a similar preference for hunters who killed large game, but not for hunters targeting hard to kill species. When total biomass harvested was controlled, both populations considered harvesting more animals in a given time period to be a better signal of preferred phenotypes than killing a single large and impressive species. Male and female informants both preferred hunters who consistently brought back small game over hunters who sometimes killed large animals and sometimes killed nothing. No evidence was found that hunters should forgo overall food return rates in order to signal phenotypic qualities by specializing on large game. Nutrient provisioning rather than costly phenotypic signaling was the strategy preferred by potential mates and allies.
These hypotheses were tested using original interview data from Aché (hunter gatherer; n=52, age range 50-76, 46% female) and Tsimané (horticulturalist; n=40, age range 15-77, 45% female) informants. Ranking tasks and paired comparison tasks were used to determine the association between the costs of killing an animal and its value as a signal of hunter phenotypic quality for attracting mates and allies. Additional tasks compared individual large animals to groups of smaller animals to determine whether assessments of hunters’ phenotypes and preferred status were more impacted by the signal value of the species or by the weight and number of animals killed.
Aché informants perceived hunters who killed larger or harder to kill animals as having greater provisioning ability, strength, fighting ability, and disease susceptibility, and preferred them as mates and allies. Tsimané informants held a similar preference for hunters who killed large game, but not for hunters targeting hard to kill species. When total biomass harvested was controlled, both populations considered harvesting more animals in a given time period to be a better signal of preferred phenotypes than killing a single large and impressive species. Male and female informants both preferred hunters who consistently brought back small game over hunters who sometimes killed large animals and sometimes killed nothing. No evidence was found that hunters should forgo overall food return rates in order to signal phenotypic qualities by specializing on large game. Nutrient provisioning rather than costly phenotypic signaling was the strategy preferred by potential mates and allies.
ContributorsBishop, Andrew Phillip Carson (Author) / Hill, Kim (Thesis advisor) / Boyd, Robert (Committee member) / Trumble, Benjamin (Committee member) / Arizona State University (Publisher)
Created2019