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The Characterization and Development of Methylcellulose in Hydrogels

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This report provides information concerning qualities of methylcellulose and how those properties affect further experimentation within the biomedical world. Utilizing the compound’s biocompatibility many issues, ranging from surgical to cosmetic, can be solved. As of recent, studies indicate, methylcellulose has been used as a physically cross-linked gel, which…

This report provides information concerning qualities of methylcellulose and how those properties affect further experimentation within the biomedical world. Utilizing the compound’s biocompatibility many issues, ranging from surgical to cosmetic, can be solved. As of recent, studies indicate, methylcellulose has been used as a physically cross-linked gel, which cannot sustain a solid form within the body. Therefore, this report will ultimately explore the means of creating a non-degradable, injectable, chemically cross-linking methylcellulose- based hydrogel. Methylcellulose will be evaluated and altered in experiments conducted within this report and a chemical cross-linker, developed from Jeffamine ED 2003 (O,O′-Bis(2-aminopropyl) polypropylene glycol-block-polyethylene glycol-block-polypropylene glycol), will be created. Experimentation with these elements is outlined here, and will ultimately prompt future revisions and analysis.
ContributorsBundalo, Zoran Luka (Author) / Vernon, Brent (Thesis director) / LaBelle, Jeffrey (Committee member) / Overstreet, Derek (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2013-05
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Controlling Calcium Binding on NorHA Scaffolds using a Biomineralization Peptide

Description
The tendon-bone junction is essential for allowing humans to transfer mechanical loads during activities. When injury does occur to this important area, current surgical techniques improperly bypass important physical and chemical gradients and do not restore proper function. It is essential to create tissue engineered scaffolds that create proper models…

The tendon-bone junction is essential for allowing humans to transfer mechanical loads during activities. When injury does occur to this important area, current surgical techniques improperly bypass important physical and chemical gradients and do not restore proper function. It is essential to create tissue engineered scaffolds that create proper models for the region and induce healing responses for repair. To advance research into these scaffolds, electrospinning fibers and hydrogels made of norbornene functionalized hyaluronic acid (NorHA) were used to promote bone growth by adhering calcium to the material. To further improve calcium adherence, which is indicative of bone regions, a mineralization peptide was allowed to soak through the fibers. NorHA proved to be a suitable material for biomineralization experiments, showing slow calcium adherence within the first hour before accelerating in adherence over 24 hours in both fibers and hydrogels. When the mineralization peptide was implemented calcium adherence on fibers increased nearly eight times within the first 15 minutes of experimentation.
ContributorsCasey, Nathan Robert (Author) / Holloway, Julianne (Thesis director) / Tindell, Raymond (Committee member) / Fumasi, Fallon (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05