When creating computer vision applications, it is important to have a clear image of what is represented such that further processing has the best representation of the underlying data. A common factor that impacts image quality is blur, caused either by an intrinsic property of the camera lens or by introducing motion while the camera’s shutter is capturing an image. Possible solutions for reducing the impact of blur include cameras with faster shutter speeds or higher resolutions; however, both of these solutions require utilizing more expensive equipment, which is infeasible for instances where images are already captured. This thesis discusses an iterative solution for deblurring an image using an alternating minimization technique through regularization and PSF reconstruction. The alternating minimizer is then used to deblur a sample image of a pumpkin field to demonstrate its capabilities.
In order to improve the verisimilitude of these reduced neuron models, I developed an optimizer that uses genetic algorithms to align model behaviors with those observed in experiments.
I verified that this optimizer was able to recover model parameters given only observed physiological data; however, I also found that reduced models nonetheless had limited ability to reproduce all observed behaviors, and that this varied by cell type and desired behavior.
These challenges can partly be surmounted by carefully designing the set of physiological features that guide the optimization. In summary, we found evidence that reduced neuron model optimization had the potential to produce reduced neuron models for only a limited range of neuron types.