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Controlling the Electrospun Scaffold Profile at the Interface between Varying Fiber Alignment

Description
Musculoskeletal heterogenous tissues are crucial for dissipating mechanical load during physical activity. Modern procedures to repair these tissues have proven inadequate to restore full functionality, thus there is a need for alternative reconstructive methods. Consequently, tissue engineered scaffolds can mimic the native structure of tissues and trigger a healing response.…

Musculoskeletal heterogenous tissues are crucial for dissipating mechanical load during physical activity. Modern procedures to repair these tissues have proven inadequate to restore full functionality, thus there is a need for alternative reconstructive methods. Consequently, tissue engineered scaffolds can mimic the native structure of tissues and trigger a healing response. Heterogenous tissues like the tendon-bone junction consist of an interdigitated fiber alignment gradient from the tendon to the bone. It has been shown that electrospun fiber alignment gradients can be fabricated from the incorporation of magnetic fields. In this study, manipulating electrostatic and magnetic interactions from various electrospinning collector arrangements were investigated for creating an interdigitated fiber alignment gradient. The collector arrangement consisting of a magnet overlaid with razor cut aluminum foil proved to provide increased control over the interfacial shape. The rapid transition at the interfacial region was verified with brightfield microscopy revealing an interdigitated gradient from highly aligned fibers to unaligned fibers.
ContributorsBusselle, Lincoln Pierce (Author) / Holloway, Julianne (Thesis director) / Tindell, Raymond (Committee member) / Chemical Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05